Document mqbGpkV0GdJ6nrYENEy3kd81J

FY1-050-0 1378 At t achments Studies to Letter to C. Auer dated and Other Information on May 18,2000 Certain ( 8S0TT00TP0/0 ) Perfluorooctane Sulfonate-Related Compounds contd, ARYG-02) 9. N-MeFOSE alcohol | N-methylperfiuorooctane sulfonamidoethanol Acute Toxicity 1) Acute Oral Toxicity - Rats, Biosearch, Inc., 3M Ref. T-2038CoC (L-4309, FC-5160) (75% in 25% CaCOs), Study No. 78-1161A, Feb. 2, 1978 2) Primary Eye Irritation 4309, FC-5160) (75% Study ~ in 25% Rabbits, CaCO), Biosearch, Study No. Inc., 3M Ref. T-2038CoC 78-1614, Feb. 2, 1978, (L- 3) Primary Skin Irritation Study ~ Rabbits, Biosearch, Inc., 3M Ref. T-2038CoC (L4309, FC-5160) (75% in 25% CaCOy), Study No. 78-1161A, Feb. 2, 1978 4) Acute Oral Toxicity Screen with T-2574CoC in Albino Rats, Riker Laboratories, Inc., Experiment 0979AR0037, September 26, 1979 Genotoxicity 1) aGenndoCteolslicPirtolyiTfeesrattoionnTA-s5s7a1y1s.1ininRattheLiInveVriCveol/lIsn, VHiatzreoltUonnscWhaesdhuilnegdtoDn,NAHWSyAntShtesuidsy No. 15515-0-494, September 14, 1993, and attached protocol 2) MWuatsahgienngitcoint,yHTeWstAoSntTu-d5y7N1o1.i1n5a5n15I-n0V-i4v54o,RAaptriMlic3r0o,n1u9c9l3e,usanAdssaatyt,acHhaezdePlrtootnocol and memorandum containing analytical data 3) TEevsatlu(awtiitohnIonfdethpeenMduetnatgeRenpiecatA)c,tiNviotTyoofxTP-r5oj8e7c4t 1in15t9h3e2A,mNeosToSxalSmuobnsetlalnac/eMi3c8r1o87s,ome 3M Reference T-5874.1, April 19, 1994 4) PEevrailpuhaetriaolnoHfutmhaenAbLiylmiptyhoofcyTt-e5s87(w4ittoh IInndduecpeenCdherntomRoepseoamt)e,ANboerTroaxtiPornosjienctCu1l1t5u9r1e9d, NoTox Substance 38187, 3M Reference T-5874.2, May 5, 1994 5) Evaluationof the Mutagenic Activity ofT-5874 in an In Vitro Mammalian Cell Gene NMuotTaotxioPnrTojeescttw1i1t5h9L215,17N8oYToMxouSsuebsLtaynmcpeh3o8m18a7,Ce3llMs (RweiftehreInncdeepTe-n5d8e7n4t.3R,epAeparti)l,19, 1994 004364 -18- . AttPaecrShftmlueudnoirteossoactontadLneOetttSheurelrftooInCna.ftoeAr-umReaertliadotaentdoend CMearyta1i8n, 2000 Compounds Repeated:Dose Toxicity 633:s1v4ie.c1OkSDEi:taTr6y3T1o4x)iciintRyaSttsu,dCyovwiatnhceN-SMteutdhyyN!o.Pe6r3f2l0u.o5r2o5o,ct3an1esRuleonpamoidepEetthanol a)) PLAeuItdDtie.trerSdtoDumrdayfAtDnidRrerepecotwrotrM,.aMtSaCeoyavc2aa5tn,,ceP1,h9.9rD9e.garSdtiundgycMroonristoirn,d0rafPterteeproJr.tThomford, Mechanistic pa{rasoltmyoicsoinlsgaotnfndTaI-n5na7l.y9t4FiicinanalaldRaCetepalolrPtr,olHifWerAatiSotnudAyssNao.y i1n5R8a.t20L7i,vaernCetl,2H0ag1elimonang 2) piarlnotygosctiolosanonf,d1aI5nna8l.7yt8FiicinanalladRaCetlpalorPtr,olHifWerAatSiotnudAyssNoa.y i1n5R4.a20L9i,vNeroCevlles,mHazsealmtosn, and -19. 004365 lo Submitted to: BIOSEARCH. INC. po. box 8598 philadelphia, telephone: Pennsylvania 1910] Project Number: 78(-1211651) 848.4499 3H Company s3SstMi.oCrePanutle,r Minnesota Material: 3M Company - T-2038cec Sample Received: Date of Report: 1/3/78 2/2/78 Study initiated: 1/9/78 Study completed: 1/23/78 Tests Object of Test: Acute Oral Toxicity - Rats Tobjaudr the acute oral subject material. toxicity in rats of the Procedure: STOhoR0eSth2Se0,rdo.Su3h0e0rofmgann5-wumeiarsletearandStr5aifnemwaelieghailnbginvo erartso Toe for jac 24 were depriveedmpolfoyefdoodinbutthisnopsoruapyt:er mwiiean"Ssiuafhhfoeiudcriseannptdrigporlroauctneodd deoixsnpienargni.miesnoEtlaaaclthimoaannciemerayslse) Smtgoixeeeadxtpewriitmhenotaatlmeamlatetroiaalc.hievTehe ara5t.s0 vgemrpborttiioonned TIhhee 211 ecOxaFpgeeCtrhhiebemoetmmntiitoxxamttlsuurrmweeaetrwdeeaursrieiaxnclaogmnihstanuhdemededbneteexo1ntnbeeo2a4lt1cheeonrcu:ioronstc,ss. . FfFoo5orr0s"8dsmiaFionenndrigowdaatdednurirniiandsgtr1wabhtiiitcouhnnttifhnoeer antthhieenalf1sa}tstwaewyreeroemafmilocwiecd Results: See Tables o1.f toxicity and morcal;eias' covered RConecluksioan: gffrheeemaatljeeurb3ie1tcbhtainnoma5t.re0artsiganylhiacsgw.haenn asctuurdaiedareinn Lmoagtge oafng ---------- 004366 DKiarrlectLo.rGabriel, v.n.p., php. mate 1 Rete oral Tica ar Company T1036, 25 traces h JSeoernse lMaer POEM Bseme S g8 CresroraSptiiiciees nny aWPhE, 000000000000000000 400p,00,y TrrohsarserPwTehiRreaelLo1005a0iucissueaagrnleiamsttearivoitnohrasns)5e.o0nnoms/kignn.ctes, Ht ae e r 9 r p-i v wa 5 wo a