AR226-3395 Repeated Dose Oral Toxicity of 8-2 Telomer B Alcohol Range-Finding Study in Rats G.L.

CorporatHeealthPhysics 3M Center2,20-2E-02 CorporatoeccupationMaeldicine PO Box33220 CorporatPeroductResponsibility st.PaulM,N 55133-3220 CorporatTeoxicology 6517331110 3M MedicalDepartment IdentificatoifFolnuorochemicailnHsuman Tissue Theobjcetiovfethisstudyistodetermitnheeconcentratriaotnioisn,humans,oflivetro serum,livertobileand biletoserum forperfluorooctanesulfon(aPtFeOS).

3M General Oflrices 3M Center St.Paul,MN 55144-1000 6127331110 May 4,2000 VIA FEDERAL EXPRESS Dr.CharlesAuer Director Chemical ControlDivision OfficeOf PollutioPnreventionAnd To)Cics UnitedStatesEnvironmentalProtectioAngency. 401 M Street,Southwest Room 403 EastTower (MailCode 7405) Washington,D.

Design DESIGN AND STRUCTURE OF MULTI-CITY STUDY submittedto 3M EnvironmentalLaboratory 935 Bush Avenue St.Paul,MN 55144 submitted by Marcia Nishioka,MS and Warren StrviussM,S Atmospheric Sciencesand Applied Technology Department Statisticasnd Data AnalysisDepartment BATTELLE MEMORIAL INSTITUTE 505 King Avenue Columbus, OH 43201 May 1,2000 Purpose The Multi-Cisttyudywasdesignetdoobtaipnreliminadraytaaboutdispersioofn fluorochemicalcompounds intheenvironment,uptakeintofoods and presencein drinkingwater,and tounderstandthepotentiaslourcesofhuman exposuresthatmight resultfrom thisqW of dispersion.

Corporate Health Physics Corporate IndustrialHygiene & Ergonomics Corporate Occupational Medicine Corporate Toxicology 3M Medical Department 3M Center,Building220-2E-02 PO Box 33220 - St.Paul,MN 55133-3220 651 733 1110 May 3, 2000 Facsimile Dr.

3M EnvironmentaLlaboratory FinalReport-AnalyticSatludy Single-DoDsermalAbsorption/ToxiSctiutdyyofT-6053inRabbits In-VivSotudyReferencNeumber:HWI#6329-137 StudyNumber: AMDT-022195.1 TestSubstanceF:C-99(T-6053) Name andAddressofSponsor: 3M SCD Division 367 Grove Street St.Paul,MN 55106 Name and Address ofTestingFacility: 3M EnvironmentalTechnology& Services 935 Bush Avenue St.Paul,MN 55106 Method Numbers AMDT-M-1-0, AMDT-M-2-0, AMDT-M-4-0, AMDT-M-5-0, AMDT-M-8-0, and Revisions: Thermal Extractionof Fluorideby Means of a Modified Dohrmann DX2000 OrganicHalideAnalyzer-Liver FluorideMeasurement by Means ofan Orion EA940 Expandable Ion Analyzer ExtractionofFluorochemicalsfrom RabbitLiver AnalysisofRabbitLiverExtractforFluorochemicalsUsing ElectrospraMyass Spectrometry Analysisof FluorideUsing the SkalarSegmented Flow Analyzer with Ion SelectivEelectrode InitiatioDnate: See attachedprotocol Author:James D.

3M General Ofrices 3M Center St.Paul,MN 55144-1000 612733 1110 May 25, 2000 VIA EXPRESS MAIL Dr.Charles Auer Director Chemical ControlDivision OfficeOf PollutionPreventionAnd Toxics UnitedStates EnvironmentalProtectionAgency 401 M Street,Southwest Room 403 East Tower (MailCode 7405) Washington, D.

ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity:Perfluorooctanoiaccid,ammonium saft;may alsobe referredto as PFOA ammonium saltA,mmonium perfluorooctanoateP,FO, FC116, FC-126, FC-169, FC-143 or as the major component ofFC1015.

ACUTE TOXICITY TO AQUATIC INVERTEBRATES (DAPHNIA MAGNA) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may also be referredto as PFOS, FC-95, or as a component ofFC-203. (1Octanesulfonicacid)(CAS # 2795-39-3).

TOXICITY TO AQUATIC PLANTS TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonawthei,ch may alsobe referredtoas PFOS, FC-95,oras a component ofFC-203. (1Octanesulfoniaccid)(CAS # 2795-39-3).

TOXICITY TO AQUATIC PLANTS TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatmea;y alsobe referredtoas PFOS, FC-95, oras a component ofFC-206C and 81-2/8.(1-Octanesulfoniaccid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafploutoarsos-i,um salt,CAS # 2795-39-3) Remarks: The testsample isFC-206C.

ACUTE TOXICITY TO AQUATIC INVERTEBRATES (DAPHNIA MAGNA) TEST SUBSTANCE Identity:Mixturecontainingperfluorooctanesulfonawtheich may alsobe referredto as PFOS, FC-95, or as a component of FC-3003. (1Octanesulfoniaccid)(CAS # 2795-39-3).

PRARMACOKINETIC STUDY OF POSF IN RATS - STUDY OUTLINE 06/22/00 T-7098.1 POSF PK Study Objective: The objectiveof thisstudy isto assessthepotentialfororal absorption,urinai@v and fecalclearanceand biologicaplersistencoefperfluorooctanseulfonylfluoride(POSF) in male Sprague Dawley ratsaftera singleoraldose.

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