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ARRR6_ 3302
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AR226- 3302
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Study Report
Analysis of Residual Solvent (Ethanol) ir (non-GLP study)
October 14, 2003
Chemicals Evaluation -- and Research Institute, Japan
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`ToafCbonltenets
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Tables
`Table 1: Calculating the ethanol contentfromGC results.
Figures
Fig. 1: GC chromatogram for calibration curve, and calibration curve (ethanol). Fig. 2: GC chromatogram for ethanol analysis
~ Study No. 33620
SompanySanilized. Does notcontainTSCA GBI 2
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Title:
A(nnaolny-sGisLPofstRuedsyi)dual Solvent (Ethanol) --
Commissioned by: DuPont KK 1-8-1 Shimo-meguro, Meguro-ku, Tokyo 153-0064
Testing Facility: ~~
Purposeof Study: Schedule:
Kurume Laboratory Chemicals Evaluation and Research Institute, Japan (CERI) 19-14 Chuo-machi, Kurume-shi, Fukuoka Prefecture 830-0023
To determine the level of ethanol remaining in Forafac 1157.
Study began on: Test date: Study completed on:
JJuollyy 2299,,22000033 October 14, 2003
Personnel:
RCeosoeradricnhaetro:r:
`YTaosmuokhoikMoAYTOSSUHNIODBAE, Testing Section 1
Approval of Study Report: [signed] Yasuko MATSUNOBE Study Coordinator October 14, 2003
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Company Sanitized. Does not contain TSC. 38
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* Tramlator's Note: Spellings of personal names may need to be verifid.
Study No. 33620
3
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Summary
TioflStuedy
Analysis of Residual Solvent Ethan) --
sud)
Sty Conditions
((12)) CAnoanlcyesnitsr:atiAonnaloyfssiasmopfleetfhuamnioslhbeyd:gas chr1o,m0a0t0omgrga/pLhy (GC)
TestResults
`Contentofethanol in sample fumished: 0%
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Study No. 33620
`Company Sanitized.Doesnotcontain TSCAOBI
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Na1mTees:t Substance
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Lot No ---)
2. ExecuGtaisocnhorfomSattuodgyraphy (GC) samples prepared as described in section 2.1 below ewtehraenoalnacloyntzeendtisnoafctchoerdsaanmcpelewsitfhumsiecsthieodn f2o.r2toensttihneg nweexrtepcaogme,pubtaesded upon which the 2.1 PrePpraertatrieoantmeonftSawmapslcearfrorieAdnaaslysshioswn in the flow scheme below so as o prepare GC sample for ethanol analysis.
Flow Scheme
~
SBtriirn(gmaugpnteoti1c00stmirLrer,(paubroiufited30wamtienru,tmees)asuring
flask)
Take aliquot sample of 10mL (measuring pipette)
+ Centrifugal separation (100xg, 10 minutes)
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Study No. 33620
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2.2Etha`nThoelGAnCalsyasmipslbeypGreapsaCrehdroinmastecotgiroanp2h.y1 above was analyzed for ethanol using the
qsuaamnptlietawtiavseddeetteerrmmiinnaetdibony ccoonmdpiatrioinnsgsthheowpneabkelsouwrf.acTehaereeathoannoclhcroonmcaetnotrgartaimosn fionrtahe40G.C0
mg/L standard (see Fig. 2).
solution
and
for
the
GC
sample,
and
calculating
the
ratio
between
the
two
(1) QAupapnatriattautsi:ve DetermGiansatcihornomCoantdoigtriaopnhs:
Detector:
GC-17A (Shimadzu Corp.) hydrogen flame ionization detector (FID)
CCoolluummnn:temperaturIe:NNOW4A0X,C film thickness 0.25 um (Agilent Technologies)
CSaarmrpileregianss:ertion pohretltieummperature: 200C
Hydrogen:
column 60kPa
flow
rate,
1.7
mL/min
Air:
50 kPa
Injection rate: 2 pL.
Split ratio: EN
Detector
--~ TSeenmspietrivaittuyr:e: 21030C
(2) Preparation of Standard Solution:
was preApasrteadnadsarfdolsloolwust.ion for determining the ethanol concentration in analysis samples.
1
reagenOt)newahsunpdrreceidsemliyllwiegirgahmesodfoeutthaanndoldisstsaonldvaerdd
product (Nakalsi in purified water
Tesque, Inc; grade to form a 1,000
`mg/L ethanol solution. standard solution.
This
solution
was
diluted
with
purified
water
to
form
a
40.0
mg/L
(3) Preparationof Calibration Curve: prepareSdtianndthaerdsasomleutwiaoynsashadveisncgricobnecdeinntr(a2t)iaobnosvoef. 1T0h.0e,s2e0w.e0raendth4e0n.a0nmagly/zLedweurneder the qcuuarnvteitwaatsivperdeeptaerremdinfartoimonthceonpdeiatkioanrseagsiovenneianch(1o)fabthoevec,hfroolmlaotwionggrawhsitchhusa ocbaltiabirnaetdioannd the respective solution concentrations (see Fig. 1).
--~ Study No. 33620
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23 Cal"eTuhleateitohnaonfolEctohnatneonlt Cwoanstceanlculated using the following formula.
Contentt(%)== 2AD220)100
where AADG))::
AAmmoouunnttooffeftuhmainsohleddesteacmtpeldeiunsGedCtsoapmrpelpear(emGg)C sample (100g)
3. Results of Study
`The
results"oAfmoaunnaltysoifssaarmeplgeiven
below. Amountof
| Ethanol
B
fumished (og)
ethanol dgetected | con%t)ent | Table| Fig.
[OCsample |--710010 Jo | 1[3]
AccordinAgslyis,aitppwaoruelndt farppoematrhethaatbotvheestaabmlpel,eetfhuarnnoilshweadsnfoorttdeesttiencgtewdasinfrteheeoGfCressiadmupalles. ethanol.
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Study No. 33620
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:Cocemiration of toeofser cot: 400(9/1)
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Total
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Tier . 7 TRhreoo matorroaf 6 walll s Tor ethsal.
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Translation: ~Language Services
F. Metreaud Decem4b,2e00r3
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