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FOR DU FONT USE ONLY AR226-2755 Copies co:' E.

AR226-2807 TRADE SECRET DuPont-12737 Study Title H-25538 : Corrositex In Vitro Test Laboratory Project ID : DuPont-12737 AUTHOR : Carol Finlay, B .A .

AR226-2842 SwSu&t^, BIO-TEST AA^zA^A Sw. \ 1810 FRONTAGE ROAD NohTMBROOK.

FOR bU FONT USE ONLY AR226-2885 Copies to' E.

B105EARCH INCORPORATED P.O.

CCR Cytotest Cell Research GmbH & Co.

TRADE SECRET AR226-3077 Study Title H-22762: EYE IRRITATION TEST IN RABBITS LABORATORY PROJECT ID: HL-1997-00735 AUTHOR: Carol Fmlay, B.A.

AR226-3109 FILE No. 715 02/12 '99 09:19 ID:DUPOMT JACKSON LflB RUllO 609 540 4463 ltd FEBfl-1999 CONFIDENTIAL ^Jn<<fc,hi ^0^.

TRADE SECRET Study Title H-24001: Biopersistence Screening 10-Dose Oral Gavage Study in Rats Laboratory Project ID: DuPont-2924 AR226-3156 DuPont-2924 AUTHOR: CarolFinlay,B.A.

R226 _ 327 401 AR2A6 - 3219 Duron 5990 TRADE SECRET Study Title H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats `with One-Generation Reproduction Evaluations Volume 1 of 5 LaboratoryProjectID: DuPont-5990 "TesT GUIDELINES: U.S.

AR226-3371 DuPont Central Research and Development April 11, 1994 3M Center Bldg?

3M MMDICAL DEPARTTYIENT TOXICOLOGY SERVICES cc:John Butenhoff From: Marv Case Subject: Covance Study6329-222 Date: 27 July1998 On 22 July1998 when I was atCovance Madison, I reviewedthemicroscopiclivertissue sectionsof themonkeys on the4-week oralrangefmderstudyofPFOS (Covance study 6329-222).There was no evidenceof compound-relatedeffectisntheliveerven inthe highdose animals.Our toxicologyconsultanthsad askedthequestionwhetherthehigh dose monkeys had any evidenceoflivernecrosisor any othermicroscopicevidence adverselivereffects.The answer isnegative.

Argus PK Outline 5/03/2000 One Generation -R-eproductioSntudy of PFOS in Itats Pharmacoldnetic Analy Study Outline Study Objectives:This studywillserveasa follow-upstudyto Combined Oral(gavagg) EtrlW.