Document NEB6wX9QOZZBzoLjX1GJwzdrR
AR226-2744
K. -rial Tested:
Submitted by:
E. I. du Pout de Hemours and Co.
Haskell Laboratory for Toxicology and Industrial Medicine
HASKELL LABORATORY REPORT HO. 55-61
Annonium Perfluorocaprylate ^Polycheaicals Department
Haskell No.: Other Codes:
3035
Acute Oral Test
Procedure; Test material was administered by stomach tube in aqueous solution as a single dose to Ch The survivors were killed 14-15 days lateir.
Aqueous
Solution, %
30
20 30
10
10
10
10 3
1,
1
0.1
Dosage
WlW
2250
1500 1000
670
450
300
200 120
40 12
1.5
Mortality
1/1
1/1 1/1
1/1
0/1
0/1
0/1 0/1 0/1 0/1 0/1
Toxic Signs
Inactivity, red discharge around nose died within 18 hours
11
Discomfort, inactivity, initial wt.
loss, died within 23 hours
Irritability, red discharge around
nose, wt. loss, died within 43 hrs.
Ruffled fur, periceal discoloration, wt. loss for 3 days
Ruffled fur, perineal discoloration,
wt. loss for
days
Height loss for
days
Inactivity, ruffled fur
Ht. loss for
days
Hone
Hone
WeiRht When Killed Liver (g.) Body (p.
28.2
25.2
30.6 16.2 24.1 25.2 24.1
452
474
342 374 530 598 592
Company ^^-OO""01""""^0
AoooniuB perfluorocapylfc4|------|k-- n Approxiaate Oral Lachal Dpe (ALD) of 670 weight. Clinical signs of toxicity included inactivity, a red difcharge around the noaa, parine and weight loa Aniaalci killed 14-15 day after having received doae down to and including 00
enlarged liven when ewpared to eontzol rata weighing betueen 5UO-550 grani with livar veighta. CBd 21*7 graoB and liver wightiybaAy weight, pereentagea of'4.2, 3.8, 3*6. and 3.8, respectively.
ia aleo suspicious.in rata. dosed beldw 200 oe/kg but additional teat--and control rata would have In order to eitablish whether thia ie a fact.
Report by; Approved by:
W ^ J /^
0
'7^>. 73
H>-/u
HS:hah
November 8, 1961
Company Sanitized. Does net coniain TSC