Summary Report 104-Week DietaryChronicToxicityand CarcinogenicitSytudy withPerfluorooctanSeulfonicAcid Potassium Salt(PFOS: T-6295) inRats PREPARED FOR: 3M COVANCE STUDY NUMMER: 6329-183 SUMMARY REPORT -WEEK 53 104Week DietarTyoxiciatnydCarcinogeniSctiutdyywithPerfluorooctane SulfonicAcid PotassiumSalt(PFOS; T-6295)inRats Timeline Covance 6329-183: In-lifsetartdate:April20, 1998 Week 53 completed:April25, 1999 Introduction The purposeofthisstudyisto assessthechronictoxicitaynd carcinogeniciotfythetest materialT,-6295 (PerfluorooctanseulfoniaccidpotassiumsaltP,FOS), when administered inthedietto ratsforatleast104 weeks.

Data from Fathead saltof PFOS inIP ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity:PerfluorooctanesulfonatAem,monium salt;may also be referred to as PFOS NH44saltorPC-93. (1-Octanesulfoniaccid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafalmumornoi-u,m salt,CAS # 29081-56-9) Remarks: Test sample was takenfrom 3M productionlot#1.

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32) Differential Scanning Calorimetry (DSC), Melting point (273 C) Filename: Data Collected: Operalor ID: Sample ID: Sample Weight: Comment: C:\PE\Pyris\Da. ..\111269-48KOT10001DSCR.dsd 11/13/01 1:55:00 PM TAK GID #26596 SB "LOT 10001(NB#I 11269-48)" 7.894 mg 75 70 65 I 60 I 55 - E a 3 3 50 C W z - lL 5 45 I 40 Peak = 24.337 " C Area = 259.{59 rnJ - t Delta H = 32.906 Jlg 717 "C I Area = 2421134 rnJ Delta H = 30.673 Jlg 35 ~______.

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3M Environmental Laboratory Final Report- Analytical Study Single-Dose Intravenous Pharmacokinetic Study of T-6052 in Rabbits In-Vivo Study Reference Number: HWI#6329-134 TSetsutdySuNbusmtbanecre:: FACM-D1T2-011(T1-669045.2)1 Name and Address of Sponsor: 3M SCD Division 367 Grove Street St.

, 3M MEDICAL DEPARTMENT, CORPORATE TOXICOLOGY Protocol for Study No.

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3M Medical Department Study: T-6316.5 3M Medical Department Study: T-6316.5 Analytical Study: FACT-TOX-013 LRN-U2095 Analytical Report: FACT TOX-013 LRN-U2095 Study Title Analytical Study 2(N-Ethylperfluorooctanesu1fonamido)-ethanol in Two Generation Rat Reproduction Amended Analytical Laboratory Report Determination of the Presence and Concentration of PFOS, M556, PFOSAA, and PFOSA in the Liver and PFOS, M556, PFOSAA, PFOSA, and EtFOSE-OH in the Sera of Crl:CD@BR VAF/PIUS@Rats Exposed to EtFOSE-OH Data Requirement Not Applicable Author 3M Environmental Laboratory Study Completion Date MAayt s3ig1n,in2g001 Performing Laboratories Sera Analyses Liver Analyses 3M Environmental Laboratory Building2-3E-09, 935 Bush Avenue St.

Final Report 28-Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats Fraunhofer ITEM - Study No.: 01G 00 0 02 Original ... of 2 Test Facility: Fraunhofer Institute of Toxicology and Experimental Medicine [Fraunhofer ITEM] Nikolai-Fuchs-Str. 1 30625 Hannover Germany Director: Prof.

Fraunhofer ITEM Fi nal R ep ort 0 1 G 0 0 0 0 2 [Appendices A-D ] 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Daw ley Rats P ag e 1 of 5 6 _____________________________________________________________________________________________________________ Appendix A: T es t S a m pl e R e-a na l y s is [p e r f o r m e d b y 3 M ] Fraunhofer ITEM Fi nal R ep ort 0 1 G 0 0 0 0 2 [Appendices A-D ] 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Daw ley Rats P ag e 2 of 5 6 _____________________________________________________________________________________________________________ Appendix A1: 1st T e s t S a m p l e R e -a n a l y s i s In te rn a l C o rre s p o n d e n c e 3M TO : J o h n B u te n h o ff N ovem ber 14,2000 FRO M : Fred L.