Sa (4 IN] 3 etm' AR226- 1078 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 5 628 Dear Interested Party: MAR 28 2002 PRETVEoNTnIOoNr,SrUiPBcESeSToTArNCCEEESSMO Attached is a copy in PDF file format (389KB)ofthe DraftHazard Assessment Of Perfluorooctanoic Acid (PFOA) And Its Salts, prepared by the Risk Assessment Divisionof the EPA Office of Pollution Prevention and Toxics.

. & a : WN; AR 226 _ 1142 UNITED STATESWEANSVHIINRGOTNOMNE,NTDA.CL.

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: 331SpectayMteras rSomeite AR296_ S12 3M "VIA HAND DELIVERY July 9, 2003 Document Control Office (7407M) ODfofcikceeotfARP-o2ll2u6tion Prevention and Toxics (OPPT) `EPA East, Room 6428 1201 Constitution Avenue, NW Washington, DC 20460 Phone: 202-564-8930 Attention: ODPPTock No.eAR-t 226 I' 82 om a) [Xt =z o2m8 @ Re: Information on Perfluorooctane Sulfonate, Perfluorooctanoic Acid, and Related Compounds Dear Sir or Madam: `This continues 3M's voluntary submissionsofdata on perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and related compounds, as part ofour ongoing dialogue with EPA regarding perfluorochemicals.

20 7 Ssaomen ifOo T ounLamanoCuSEPAVSGEPA -- Co voneuietySos LocoAIDGISEPAVS onGITZO00 PH TL"CCharssAue am TToo gomalCemeRty@GusadEupePntcAom .

BACK TO MAIN STABILITY IN WATER (PHOTOLYSIS) TEST SUBSTANCE Identity: Remarks: N-ethylperfluorooctane sulfonamidoethanol; may also be referred to as N-EtFOSE alcohol. (1-Octanesulfonamide, N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-N-(2hydroxyethyl)-, CAS # 1691-99-2).

BACK TO MAIN SOIL ADSORPTION TEST SUBSTANCE Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The test substance is a white powder.

.J SRPT T-76G( MIN 3141022208 PERFLUOROOCTANESESULFONYLFLUORIDE OSF') T 7 b t l .a BACTERIAL REVERSE MUTATION TEST Sponsor 3M Center 3M Corporate Toxicology Building 220-2E-02 St Paul MN 55133-3220 USA Research Laboratory HuntingdonLife SciencesLtd.

February 11,2005 Dr.

AR226-1894 Reproductive Effects of C8 James Dahigren, MD Pamela Anderson-Mahoney, PhD November 2004 Reproductive Hormones Male C8 Workers Increased PFOA Levels Lower Testosterone Prolactin Higher Estrogen Prolactin if high alcohol intake Health Study in Residents Near a Large C8 Source Methods 301 females and 296 males with documented PFOA--Exposu re ~0.05 ug/L in drinking water standardized questionnaire SEER prevalence data were used for comparison Demographics for Residential Study Participants Age Category 20--34 35--44 45--54 55--64 65-8() Gender Male Female Race/Ethnicity White African Others American Education Level Less than 9~grade 9-- 1 l'~'grade - til

TestResults AR226-2118 fle:///C|/WlNDOWS/TEMP7C-8 Per 1-1-70 thro 8-12-81.htm 1 of 9 ''^iiiy Test Results SampiB Data Range Concentration Range Action Level Industrial Hygiene 1/1/70 8/12/81 100% Sample Dt Sample # Duration Type Employee Name Pers 8TO: LOG: 04 POWER & SERVICES 074 INCINERATOR AREA - GENERAL 4/13/81 32328 P none Chemical Cone Unit Percent G-8 0.0012 PPM 4/15/81 32329 none C-8 0.0008 PPM 0.0% BTO: LOG : 08 TEFLON 802 P/S - FINE POWDER DRYER OPERATOR (08PI) 10/23/79 33473 P "one 10/28/79 33474 P "one 10/30/79 33475 P, none 3/18/80 33476 3/20/80 33477 none 3/21/80 33478 3/21/80 33479 none 3/22/80 33480 3/22/80 33481 3/23/80 33482 3/25/80 33483 3/26/80 33484 C-8 0.001 PPM 0.0% C-8 0.0009 PPM 0,0% C-8 <0.0001 PPM 0.0% C-8 0.0009 PPM 0,0% C-8 0.0009 PPM 0.0% C-8 0.0023 PPM 0.0% C-8 0.0016 PPM 0.0% C-8 0.0025 PPM 0.0% ;> C-8 0,0026 PPM 0 0.0% ^ K> C-8 0.0015 PPM Is) ^ 0.0% C-8 0.0011 PPM 0.0% C-8 0.0006 PPM 8/9/2001 3:49 PM EID139466 TestResutts 3/26/80 33485 P 3/27/80 33486 P 3/27/80 33487 P 3/28/80 33488 P 9/3/80 33489 P 9/4/BO 33490 P 9/4/80 33491 P 9/4/80 33492 P 9/5/80 33493 P 9/6/80 33494 P 9/7/80 33495 P 9/8/80 33496 P 9/9/80 33497 P 9/10/80 33498 6/13/81 33493 Thursday, August OS, 2001 3:17:45 PM file:///C|/WINDOWS/TEMP/C-8 Per 1-1-70 Ihru 8-l2.81.htm none none none none none none none none none none none none none C-8 C-8 C-8 08 C-8 C-8 C-8 C.8 C-8 C-8 C-8 C-8 C-8 C-8 C-8 0,0004 PPM 0.001 PPM 0.0022 PPM 0.0001 PPM 0.0003 PPM 0-0004 PPM 0.0006 PPM 0.0004 PPM 0.0001 PPM 0,0002 PPM 0.0002 PPM 0.0001 PPM <0.0001 PPM 0.0001 PPM 0.001 PPM 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% Page!

: Tier cuicinson ARR26. 3550 wf STToRNEYS AT Law mes Anthony F.

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Katherine E .

~~ 3M p. 1 Katherine E .