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20 7 Ssaomen ifOo T ounLamanoCuSEPAVSGEPA -- Co voneuietySos LocoAIDGISEPAVS onGITZO00 PH TL"CCharssAue am TToo gomalCemeRty@GusadEupePntcAom . Ni PalDCIUSEPAUS@ERA, Baars apr ICSE SEER LeczynskiDC/USEPAIUS@EPA evict 528v 3=38%= 2o 2E5= 3$ Dear Gerry, aAnsydoitshceurssreedleovnanAtpriinlfo1r3mabtyiopnhoinney,ouErPpAosnseeesdssiotno orrevcioenwtoclomopnlectaerbcooxpyileasteodf afinndalsruelpfoorntas.taend d perfluorochemicals, `with initial focus on PFOA (perfluoro octanoic acid). effects studies (including.pharmacokinetics), The requested environmental effects iSntufdoiremsa,teinovniirnocnlmuednetsalhefaaltteh studies Studies and information, including maonnditionrfionrgm.atiIoffni,naalndehpourmtasnaraendnoetnvaviariolnambelne,t al exposure we request t ha t pYroouvcildaeriufsy wtihtehttahtulaotfesatnayndonmgoositngcosmtupdlieestwvietrhsiroengoafrdanypprroejleicmtiednacroymrpelpeotritosnindaytoeurand possession orcontrol. `We request that you provide us with the. above information on PFOA by May 26,2000. iReognaridcinagcitdhe(sPuFlOfSon)ataendd pweerfrleuqoureoscthetmhaitcaylosu, poruorviindietiatlheinatberoevset iisnffoorcmuasteidonono`npePrfElOuoSroboyctAyplril 28,2000. 1you have anyof the above information on other carboxylated or sulfo rochemicals , we request that, by April 28, 2000, you initially identify the chemicals to the requested information in your possession allow us to confirm or control on other our interest, and then provide sulfonatedperfluorochemicals by May 19, 2000 and on other carboxylated perfluorochemicals bbey parwoeviedkedlatienr,chMeamyic2a6l,s2p0e0i0f.icThiencirnefmoernmtastiaonthoenytahreeseco`madpdliettieonda,l wcihtehmiccoamlpslectainomnoosftthuseffuullly submissions by the dates requested. A few points of clarification regarding this request: >duPont need not resubmit copies of studies already provided to EPA (e.g, under TSCA 8(e), 1 o4sFFtYheIss,tuudnideesralFrIeFaRdyA)suablmtihtotuegdhswoewdeocraenqcuehsetckthtahtisyoaugapirnsotvioduerahoclodmipnrgesh.ensive bibliography ceopeieds ofianctuhteeDsaytsateAmpdipecrqotuoaaxcichcyiatlaylnssdttuurddoiibeeussstwciaslnlumbbemealcriimytietdgeuditindoabaintbchleeikdoeegyvreaolprohpcieicdtclfiaoslrtistnhtgeuadHlitePhsVoausgChhfaullllenge cPeorpoisgersamcb.ayndUbinfedfeleriremnitttheirsdouattoesstourdi(e2s)wrheipocrht (o1b)sseerrvveed0effiedcetnstiwfhyilcohwedsitff(erif.rommostthoosxeisce)enletihnasltduodisees (using the same route) submitted under (1). +<yssktienmaincdtoexyieciitnya(tici.onssutbumdiitescocpainebsnedofhotathnhdelekeeidryriiontraatrmiioantncsnateludrisetcsuodnwisheisistcwehhnitschwhiotwsheertfvhfeaetcttoosustwelthii0ncehd tfdhioefrfaecrute afrtoim othnospeotreenptoiratledofinthseubcmhietmtiecdalstaudies). "hoenduienitteidalprreiqoure0st 1is97g6e,newraaerlelaayss:kligfmeoirnteaetdibcitbotlosxitioucgdiritayep;shscyuolbnicdshutricnotgneiadlcldtusortxuiidcniigetsyo;raranefdperfroord1u9uc7lt6li.vceoFptoiorxeissctioutfdyi;setsudies evethleopfmolelnotwailngtoexnidcpitoyi:ntimmunotoxicity; uptake/metabolism; chronic toxicitycarcinogenicity; neurotoxicity. rpeegasrdfoiunngdeixnptohseurUesienafonrdmaEtxipoons,uwreeIaanrnfedomriomnsafttoiriomnnattePrireoosnftloeden(irnUesEruIelcPte;soivftihenexgpUioEnsIfuPorrhmeaasolfib`oemnoeannniutdsoderaditn0agof the `SiSonuncpdlpiuoedrsitnhSguIdmDeSatanialssasnoedsnsepmnrevonictresodniumnreetnshteaalUn)dS,)mientchluoddisngusfeuldl cfoorpiseasmpolfisntgudaineds awnhaelryseiasv,aiWlaeblaereanadlso Interested in studics relating to the ultimate environmental fate and distributionof these chemicals. CInheomridcearlto23maaisnetpaairnattehe"FionrteYgiotuayrnyoIfnpfyrooiorurmrasstuuibbommnii"ss(ssiiFooYnn)ss,bspyulbeymaoisusesriscouonb.mmpiYatonayull muinandfyeorramlTsaoStiCsouAnbom$ni8t(aet)ghieven prfeloliratcmiaanbtgliteoontphraeossceesducuphrpeelmsei.cmaeIlnsft.ysotAuoshaavlewaaynsy, qauneystCiBoInsmwuistthbreegsaurbdmtiottehde isnubamcicsorsdiaonncperowcietdhures, or You wish to work out the arrangements in advance, please contact Terry O'Bryan (202-260-3483). (12y0o2-u26h0a-v3e74a9n)y.ge1nterhaalnkquyeosutiionnasdrveagnacredifnogr this request, please your cooperation. contact me by email or phone COChfhaferimlcieecosafMl.PCooAlnlutuertroi,lonDDiiPrvreeicvsteionortnion and Toxics OPPTS/EPA &