Document 069mZY5RN3oRKzJbB0mD3KkvO
AR226-1894
Reproductive Effects of C8
James Dahigren, MD Pamela Anderson-Mahoney, PhD
November 2004
Reproductive Hormones Male C8 Workers
Increased PFOA Levels
Lower
Testosterone Prolactin
Higher
Estrogen Prolactin if high alcohol intake
Health Study in Residents Near a Large C8 Source
Methods
301 females and 296 males with documented PFOA--Exposu re ~0.05 ug/L in drinking water
standardized questionnaire SEER prevalence data were used for
comparison
Demographics for Residential Study Participants
Age Category 20--34 35--44 45--54 55--64
65-8()
Gender Male
Female
Race/Ethnicity White
African
Others
American
Education Level
Less than 9~grade
9-- 1 l'~'grade
-
til
.
,
College ( ~radua~c
No.
105 104 135 154 80
284 294
558 6 9
17 59 430 65
%
18.17 17.99
23.36
26.64 13.84
49.13 50.87
97.38 1.05 1.57
2.98 10.33 75.31 11.38
Demographics for Residential Study Participants
No.
%
Body Mass Index Underweight (<23) Average (23--28) Overweight (>28)
106
18.53
190
33.22'
276
48.25
Smoking Status Never smoked Smoked less than 15 years Smoked more than 15 years
252
60.58
72
17.31
92
22.12
Work History Plant 1 Plant 2 No plant work
54
9.42
19
3.32
500
87.26
Reproductive Cancers in Residents Near a C8 Source
Number Observed
Expected
CANCER TYPE
of
Ratesa
Ratesb
Cancers (per 100,000) (per 100,000) PR
Uterine/Cervical
9
3,061
96
33.12
Breast
5
1,701
1,579
1.12
Prostate
9
3,169
1633
1.96
dC
17.03 ~~64.41* 0.46--2.71 0.98--3.92
Uterine/Cervical Cancer in Residents Near a C8 Source
Age Category
20-29 30-39 40-49 50-59 60+
#of Cancers
0 2 2 3 2
N
PR
P-value
34
0
38
56.40
0.0002
64
25.02
0.0008
84
34.18
0.00001
74
31.83
0.0005
Total
9
294
Age at Menopause in Residents Near a C8 Source
Age
By By By By
Category 38 43 49 54
U.S.
Population* 10% 20% 50% ` 90%
PFOA Exposed
31% 44% 66% 93%
* http ://www. cdc. gov/nchs/data/series/sr_1 1/sri 1_Ui9. pdf
Prostate Cancer in Workers at the C8 Source
Cancer
OR
Prostate
<21 years employe&'
1.0
21--29
2.68
30--50
8.71
95% CI
-
0.82--8.79 2.63--28.83
P-Value'
0.0002
-
0.10 0.0004
Conclusions
~--~----~
-~---
These data indicate a strong effect of C8 on uterine/cervical cancer in women
Together with previous research,
these findings strongly implicate a causal relationship between C8 and prostate cancer in men