E.I. duPont deNemours and Company Haskell Laboratory for Health and Environmental Sciences 2 December 2004 iToxicokinetics in the Rat: Pilot results Study Director: W.J.

3M Environmental L boratory FinalReport- AnalyticalStudy Single-doseDermal Absorption/ToxicitSytudy ofT-6049 inRabbits In-Vivo Study ReferenceNumber: HWI#6329-130 Study Number: AMDT-020895.1 Test Substance: FC-95 (T-6049) Name and Address of Sponsor: 3M SCD Division 367 Grove Street St.Paul,MN 55106 Name and Address of Testing Facility: 3M Environmental Technology & Services 935 Bush Avenue St.Paul,MN 55106 Method Numbers AMDT-M-1-0, AMDT-M-2-0, ANMT-M-4-0, AMDT-M-5-0, and Revisions: Thermal Extractionof Fluorideby Means of a Modi:fied Dohrmann DX2000 Organic Halide Analyzer-Liver FluorideMeasurement by Means of an Orion EA940 Expandable Ion Analyzer Extractionof Fluorochemicalsfrom Rabbit Liver Analysisof RabbitLiver ExtractforFluorochemicalsUsing ElectrosprayMass Spectrometry InitiationDate: See attachedprotocol Author: James D.

PffYSICAL - CIffEIN/fICALPROPERTT-ES A Robust Summary, FinalReport, and Protocol on the physical-cbemicaplropertiesof perfluorooctanesulfonataere includedfor each of the followingparameters: PAR-KWTER DATE OF REPORT RESULTS ;MeltingPoint/MeltingPointRange Vapor Pressure n-Octanol/Water PartitionCoefficient Air-Water PartitionCoefficient Solubilitiyn ppre water SolubilityMeasurements on FC-95 2/24/99 5/5/99 2/11/00 3119/00 5/3/99 2/6/81 4000C 3.31x 104p (4@200C Not calculablet;hr" 0(<2xlO-) 570mg/l 1080mg/l phases The data presentedinthe study "SolubilitMyeasurements on FC-95," was determined by indirectmeasurement, not by actualanalysis.Therefore,the data isnot reliable.

ATTACHMENT TO LETTER TO C.AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION FOSA or PFOSA Perfluorooctanesulfonamide MedicalSurveillanacnedEpidemiologic See item I under PFOS: InterimReport #1,Determinationof Serum Half-Livesof SeveralFluorochemicals,June 8,2000.

._ _-____ 8) OECD 407, Repeat dose oral toxicity (with FOB & histopathology), 132-007 SANITIZED JAN 0 9 2004 A 28-Dav Oral Toxicitv Studv in SPraque-Dawlev Rats Studv Number: 132-007 SAN ITlZED A 28-DAY ORAL (GAVAGE) TOXICITY STUDY OF T-7485 IN SPRAGUE-DAWLEY RATS STUDY NUMBER: 132-007 SPONSOR 3M Corporate Toxicology 3M Center, Building 220-2E-02 P.O.

18 pp AR 2&6 1217 To: oe nossmiveronias Mary Dominiak/DC/USEPAIUS@EPA,oppl.ncic@epamail.epa gov.

ACUTE TOXICITY TO AQUATIC INVERTEBRATES (COROPHIUM VOLUTATOR) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, oras a component ofFC-602. (1Octanesulfoniaccid)(CAS # 2795-39-3).

September 29, 2006 Page 3 ATTACHMENT 2 Tables and excerpts from the draft protocols that contain raw data C-8 blood levels .

NEW SOLUTIONS, Vol_ 18(2) 129-143, 2008 AR-22b-3829 ii e# 73 l .

Co Maa6- 1477 TAFT, STETTINIUS & HOLLISTER LLP ComGTOnERY hor 4ros \ TE fl r EeEreEaen 425 WALNUT STREET, SUITE 1800 symm CINCINNATI, OHIO 45202-3957 F-- AX 313-- 3610205 ---- wengaamon BEfR-Bo- 373 8EHR - 0803 -- 00373 August 7, 2003 TELECOPY AND FEDERAL EXPRESS i$ 2070, ree JOR...L Fax S EH.

02/28/2001 ~ ~ ENVIRONMENTAL LABORATORY ARCHIVED FINAL REPORT B1ACK TO MAIN LAB REQUEST NO. 8442 REQUESTOR NAME: EAR DEPARTMENT: 0535 PROJECT NO: 9970012600 DATE RECEIVED: 0 9 / 0 7 / 1 9 8 2 DESC: ENVIRONMENTAL SCREEN ON L-6778 CONTRACT LAB(S): EXP COMP DATE: 11/12/1982 DATE COMPLETED: 1 1 / 0 9 / 1 9 8 2 PROJECT LEAD: PHONE NO: 3M FAX NO: 651-778-6176 EVAPORATE TO DRYNESS UNDER AIR OR N2.

BACK TO MAIN SOLUBILITY IN PURE WATER, METHA NOL, AND ACETONE - SHAKE FLASK METHOD TEST SUBSTANCE Identity: Perfluorooctanoic acid, ammonium salt; may also be referred to as PFOA, PFOA ammonium salt, Ammonium perfluorooctanoate, FC-116, FC-126, FC-169, or FC-143.

"_ _ 3M Special/3' Maleria|s July 16, 2002 3M Cenler St.

3M Medical Department Study: T-6295.22 Analytical Report: FACT-TOX- 160 LIMS E00-1668 3M Medical Department Study: T-6295.22 Analytical Report: FACTTOX-160 LIMS E00-1668 Study Title Extended Recovery Study Followinga 26-Week Capsule Toxicity Study (FACT-TOX-030) with Perfluorooctane SulfonateAcid Potassium Salt (PFOS; T-6295.22) in Cynomolgus Monkeys Analytical Laboratory Report Title Determination of the Presence and Concentration of PFOS in Serum and Liver Samples of Cynomolgus Monkeys Data Requirement Not Applicable Author 3M Environmental Laboratory Study Completion Date May 3, 2002 Performing Sera and Liver Analyses 3M EnvironmentaLlaboratory Building2-3E-09,935 BushAvenue St.

) \ 155% Je MedicalCenter NEARS HATH SCE CENTER June 18,2004 ROLEAG WICTOHOLO John L.