Item 10: Monitoring - Fluoropolymers EPA Data Needs: (Draft 9-21-03) Data Need LOl Commitment MRealenausfeascturing Dwaastateownatreerl,ealasnesdftiollaliera,cwhaatteer, Irwamlffneariaraolnfca,eosmdinatwlrfeuismitwafelilaetaaeocstltrietfeo,uaPrnrc,iFhnoOagntAe to Creolenatisneused monitoring of MSitaensufacturing Concentration of 'PslgbmfauaFrinoraocOfdntiuaalfAunic,itfdleiwlaeiwcnwslaetasuaaattiterecreirw,hnr,,agasttoeeirla,,t wScmouaanrsnfctaueecwfneatacrwtateutarirto,iennlrags,ngsadirtftoeiluslnldewacahtaetre, Limited biota data Modeling ofPFOA in air AnededdistiboenyaolnddatLaOl EPA Proposal to Address Data Needs Manufacturing none McPaodFondOncitAieitonontirrneaadlatiibori,nosstoaoilf, Scocnreceennitnragtiloenvealnmdoenxitteonrting ofPFOA in air to quantify Samqcaurneauetifncaincstgpuerlceinivegesl,fmapcloialnnitititseo,srhinegrboivfoPrFesO,Aaviinanb,iotetrare(esgtr,iafilsshpaencideso)thaetr AR226-2340 EXP000011 - 1- EXP000012 r~~ Item 10: Monitoring - Fluoropolymers EPA Data Needs: (Draft 9-21-03) Data Need MOfafnSuitfeacftruorming CPsgagmfuaFnrororcaadOnfuindaclAbnuiiceetidfenionaiewtntwtcsraaatfaaurttditeiorreooirm,rnw,n,gsnoofil, LOI Commitment Anededdistiboenyaol nddatLaOI PsgmuFraorOfnuauAncfdeacwcwotanuatcrteeiernrnfgtarronsamidttieosns in McPaodFondOncitiAeitnootnirrneaadltaibiori,nosstoaoilf, Limited biota data Modelingofair contamination EPA Proposal to Address Data Needs Monitoring of PFOA in air to quantify concentration and extent ofoffsite contamination AWabtedoadcdriokdtilsiol,teintcooatnleqadgulrtaoomnutdaniefndytuwefPraamFtceOtirunAremintoihgnneisgteiortxoertisuen.nngdGt,wasrnioamdtuenilrledaovwrfeftaleotroetWerf ccaoosnhntitanamgmtiomnnaattiioonn apytoB iJesite...^........

AR226-2455 Ohio River monthly average flows at Cincinnati, OH River flow data from <ftp://www.lrd-wc.usace.army.mil/Monthly_htm/> Assume: 1 ft3/sec= 0.0283m3/sec; 1 m3 = 1*10A6 cm3; 1 cm3 - 1 mL Estimated Estimated Estimated Mo-Yr Measured Long-term normal flow, of normal, flow, ft3/sec % ft3/sec normal flow. m3/sec normal Estimated flow, normal m3/mo flow, L/mo Jun-98 131,400 175 75086 2.12E+03 S.51E+09 5.51E+12 Jul-98 94,452 211 44764 1.27E+03 3.39E+09 3.39E+12 Aug-98 28,387 80 35484 1.00E+Q3 2.69E+09 2.69E+12 Sep-98 21,200 74 28649 8.11E+02 2.10E+09 2.10E+12 Oct*98 21,065 77 27357 7.74E+02 2.07E+09 2.07E+12 Nov-98 21,400 40 53500 1.51 +03 3.92E+09 3.92E+12 Dec-98 34,548 35 98709 2.79E+03 7.48E+09 7.48E+12 Jan-99 178,190 131 136023 3.85E+03 1.03E+10 1.03E+13 Feb-99 134,860 81 166494 4.71E+03 1.14E+10 1.14E+13 Mar-99 180,260 85 212071 6.00E+03 1.61E+10 1.61E+13 Apr-90 118000 66 178788 5.06E+03 1.31E+10 1.31E+13 May-99 60226 49 122910 3.481+03 9.32E+09 9.32E+12 Total 1.02E+06 1.18E+06 3.34E+04 8.74E+10 8.74E+13 C8 discharge to Ohio River in 1996, ibs 40600 RJZ0154QO EID137010 t C "t Estimated C8 C8 discharge concentration to Ohio River in Ohio River, in 1996, kg kg/L Estim ated C8 concentration in Ohio River, mg/L Estimated C8 concentration in Ohio River, ug/L 18416 2.11E-10 2.11E-Q4 0,211 RI2015401 BXD137011

AR226-2802 DuPont-5206 TRADE SECRET Study Title H-24648 and H1-42-4D0a2y0:FeReedpinegatSedtu-Ddyosine MOriacleToxicity Study Laboratory Project ID: DuPont-5206 A uth o r: Susan A.

TRADE SECRET AR226-3165 DuPont-2926 Study Title H-24002: Biopersistence Screening 10-Dose Oral Gavage Study in Rats Laboratory Project ID: DuPont-2926 Author: Carol Finlay, B.A.

TRADE SECRET AR226-3196 DuPont-8862 Study Title H-25134: Static, Acute, 48-Hour Screening Test to Daphnia magna Laboratory Project ED: DuPont-8862 A u t h o r : Laurie D.

Manuscript Submitted 250ct2004 AR226-3362 Thermal Degradation of Fluorotelomer Treated Articles and Related Materials Takahiro Yamada1Philip H Taylor1*, Robert C.

AR226-3387 A 90-Day Gavage Study with One-Generation Reproduction Evaluations in Rats with a Fluoroalkylethanol Mixture E.

AfUAG- 3lf7 / 0 a*K 000152 ftW 6 - RESEARCH i Prets Research.

JO Katherine E.

3M ENVIRONMENTAL LABORATORY REPORT NO.

3M ENVIRONMENTAL LABORATORY REPORT NO.

STLS F.

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A R -o l lo EnviroSystems Study Number 90171-3 RESOURCE ANALYSTS, INCORPORATED ENVIROSYSTEMS DIVISION PRODUCT REGISTRATION LABORATORY AQUATIC TOXICOLOGY STUDY PROTOCOL Static Acute Toxicity Test With FM 3820 And The Daphnid, Daphaia aagna Sponsor 3M Conpany PO Box 33428 St.

f\RM >-o\G\ SUMMARY OF THE EFFECTS OF PFC's ON MITOCHONDRIAL BIOENERGETICS IN VITRO The attached diagram describes the metabolic relationship for the various PFC's that were selected for inclusion in this study.