f t k 26 - 0 ^ 0 0 BIODEGRADATION (MANOMETRIC RESPIROMETRY - ANAEROBIC) TEST SUBSTANCE___________________________________________ Identity: A mixture containing perfluorooctanesulfonate;, which may also be referred to as PFOS, FC-95, or as a component of FC-3041. (1Octanesulfonic acid) (CAS # 2795-39-3).

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FINAL REPORT /t 3 2 -o ?

3M Larry R.

* 6ft Aazi6_ ior*> EPA / SPI FMG Meeting January 30, 2002 Agenda Introduction Toxicology/PK Program Studies underway Progress Time line r-o cr-i cr O -n c\n ro r ,3 C.O ' rn Environmental Effects/Fate Testing program Environmental distribution Summary I PROJECT SUMMARY REF: APFO - 2 SPONSOR APME PTFE Committee Members and APFO Suppliers (Asahi Glass, DuPont, Dyneon, Daikin, Ausimont, Solvay, AtoFina 3M, Miteni) CHEMICAL Ammonium Perfluoro-octanoate (APFO - FC143) STUDY Preliminary 4 week oral toxicity study in Cynomolgus monkeys. 6 month oral toxicity study in Cynomolgus monkeys to include an additional 13 week recovery period .

iff Larry R.

3M Medical Department Corporate Toxicology 3M Center, Building 220-2E-02 St.

/V P Ce: R.

ffi'ZS. _ 13 II UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 A P R 1 5 2003 M "O O ro ZS3 TO "O m ~oo -irn ~zxo O p<n oO ro XT MEMORANDUM SUBJECT: Preliminary Risk Assessment of the Developmental Toxicity Associated with PFOA (Perfluorooctanoic Acid) anthitrSaits FROM: Kevin Y.

'.'.CO* A.

6; . m-78 A Simple, Conservative Compartmental Model to Relate Ammonium Perfluorooctanoate (APFO) Exposure to Estimates of Perfluorooctanoate (PFO) Blood Levels in Humans Paul M.

3M Specialty Materials 3M Center St Paul, MN 55144-1000 651 733 1110 im r " c -

CC: ERD Division Directors R.

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Toxicological Summary AR226-1746 PFOS Dietary Acute Northern Bobwhite Study Test Substance: Perfluorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, potassium salt, CAS# 2795-39-3 Remarks: The test substance is a white powder (3M lot #217).