Mary Dominiak/DC/USEPA/US@EPA o r 02/ 27/ 2 0 0 1 0 4 :21:35 PM To: "Larsen, Don" < DLarsen@CGAIaska.USCG.mil> cc: Doug.Dierdorf@mlq.afrl.af.mil, NCIC OPPT/DC/USEPA/US@EPA Subject: AR226: AFFF and Perfluorooctyl Sulfonates Dear Mr.

Aft z z - 1077 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES er:: MEMORANDUM SUBJECT: Draft Hazard Assessment O fPerfluorooctanoic Acid And Its Salts FROM: TO: Charles M.

P Generation Maa> _ 11 Group Summary Group Group 1 Group II Group III Group IV Group V NUMBER OF DAYS OF DATA COLLECTION NUMBER OF DAYS IN % OF DAYS ESTRUS IN ESTRUS 21 9 43% 21 8 41% 21 9 42% 21 8 39% 21 9 42% NUMBER OF DAYS IN % OF DAYS DIESTRUS IN DIESTRUS NUMBER OF % OF DAYS DAYS IN IN PROESTRUS PROESTRUS 9 41% 9 45% 9 45% 10 45% 9 43% 3 16% 3 14% 3 13% 3 15% 3 15% N- FOR MEAN CYCLE MEAN CYCLE NUMBER OF LENGTH LENGTH CYCLES 30 4.3 4.6 30 4.0 4.6 28 4.1 4.3 30 4.3 4.4 29 4.1 4.6 6S --8 V Z - -iU 000050 P Generation nimal 1D 13801 13802 13803 13804 13805 13806 13807 13808 13809 13810 13811 13812 13813 13814 13815 13816 13817 13818 13819 13820 13821 13822 13823 13824 13825 13826 13827 13828 13829 13830 13831 13832 13833 13834 13835 13836 13837 13838 13839 13840 13841 13842 13843 13844 13845 13846 13847 13848 Group 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 MEAN CYCLE LENGTH 3.75 3.20 3.75 3.67 3.75 5.33 4.00 4.25 4.25 4.25 4.50 9.00 4.00 5.00 5.00 4.33 4.00 4.00 4.00 4.00 4.25 4.00 4.00 3.40 4.67 3.75 4.25 3.75 4.00 4.00 3.67 4.25 4.00 3.75 4.00 4.00 4.00 4.50 3.75 4.33 3.75 4.00 4.25 3.75 4.00 4.00 4.00 4.00 NUMBER OF CYCLES 5.00 6.00 5.00 4.00 5.00 3.00 5.00 4.00 5.00 5.00 4.00 2.00 5.00 4.00 4.00 5.00 5.00 5.00 5.00 4.00 5.00 5.00 5.00 6.00 5.00 5.00 5.00 4.00 4.00 5.00 5.00 5.00 5.00 5.00 5.00 2.00 5.00 2.00 5.00 5.00 4.00 4.00 5.00 4.00 4.00 5.00 4.00 5.00 000051 P Generation 13849 2 4.00 5.00 13850 2 4.25 6.00 13851 2 3.25 6.00 13852 2 3.75 5.00 13853 2 4.00 4.00 13854 2 4.00 5.00 13855 2 3.75 5.00 13856 2 3.75 4.00 13857 2 4.50 4.00 13858 2 4.00 5.00 13859 2 3.80 5.00 13860 2 4.25 5.00 13861 3 5-00 3.00 13862 3 3.75 5.00 13863 3 4.00 5.00 13864 3 4.67 4.00 13865 3 4.00 4.00 13866 3 4.67 3.00 13867 3 4.00 5.00 13868 3 3.75 5.00 13869 3 4.00 5.00 13870 3 4.00 4.00 13871 3 3.75 5.00 13872 3 3.75 5.00 13873 3 4.00 5.00 13874 3 5.00 3.00 13875 3 4.00 4.00 13876 3 3.75 4.00 13877 3 4.25 4.00 13878 3 4.25 5.00 13879 3 4.00 6.00 13880 3 4.00 4.00 13881 3 5.00 4.00 13882 3 4.00 5.00 13883 3 3.75 5.00 13884 3 4.00 5.00 13885 3 #DIV/0!

'Ui /Y R a 1 6 - 1176 2003 JH 15 IN THE CIRCUIT COURT OF WOOD COUNTY, WEST VIRGINIA JACK W.

Northwest Bioanalytical A6_ IAH Study No.

74*UA6_ I3/ 1V # &J 4-f/ March 21,2003 1301 K STREET.

/ K U & 6 - - >`2 g ' / Telomer Research Program Annual Report of A ctivities for TRP Grant to University of Toronto; Scott Mabury, PI Project years: 1 September, 2001 to 1 September, 2002.

(SlJPfc Haskell Laboratory for Health and Environmental Sciences 1090 Elkton Road Newark, DE 19714 AR226-1307-6 From: Robin C.

mm vSTABUSHcD ICC* , I. du Pont de N em ours & C ompany INCORPORATED P .O .

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6 0 P- 31 October 2003 AR226-1642 To: Mary F.

Katherine E.

-4H2ll- I7S T-6295.28 Final Report T-6295.28: Analysis of Liver Enzymes, Glycogen, and Perfluorooctane Sulfonate (PFOS) Concentration in Samples from T-6295.25: One-Generation Reproduction Study of PFOS - Mevalonic Acid/Cholesterol challenge and NOEL Investigation in Rats.