N-EtFOSA Acute Toxicity - / 000466 Acute Oral Toxicity Screen with T-306700C in Albino Bats i No.

BOILING POINT TEST SUBSTANCE Id e n tity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-O ctanesulfonicacid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Rem arks: Testing was not conducted.

STL Burlington Colchester, Vermont Extended Data Package SDG: 117522 Case Narrative Chain of C ustody........................................................................................................

BACK TO MAIN Centre Analytical Laboratories.

BACK TO MAIN ENVIRONMENTAL LABORATORY AOUATIC TOXICITY DATA SHEET EXPLORATORY (RANGE-FINDING TEST) LR f s/t lr Z Type T e st A U ^ S ^ S s O S - a t e r i a l T ested Test O rganism ^ S o u rc Xf' X' OM HX OC/3) ____ D a tc R o c ' d ` Avg.

A fm G - c r a G -s ' Final Report Unscheduled DNA Synthesis in Rat Liver Primary Cell Cultures With PFOS PREPARED FOR: 3M Corporate Toxicology COVANCE STUDY NUMBER: 20784-0-447 THE DEVELOPMENT SERVICES COMPANY FINAL REPORT UNSCHEDULED DNA SYNTHESIS IN RAT LIVER PRIMARY CELL CULTURES WITH PFOS AUTHOR Maria A.

TSCA NCIC Notification Form for CBI Documents Docket Number: _ f i t ?

_ 14fe D u P on t-13309 Perfluorooctanoic Acid: Lactational and Placental Transport Pharmacokinetic Study in Rats Work Request Number 14787 Service Code 1569 Protocol Haskell Animal W elfare Committee Number: <> -1- RECEIVED 0PPTNC1C 2803SEP -* AH 8*1* 5 Perfluorooctanoic Acid: Lactational and Placental Transport Phannacokinetic Study in Rats D u P on t-13309 TABLE OF CONTENTS Page INTRODUCTION...............................................................................................................................3 OBJECTIVE........................................................................................................................................ 3 SPONSOR AND TEST FACILITY............. ....................................................................................3 REGULATORY COMPLIANCE.....................................................................................................3 STUDY DESIGN................................................................................................................................4 A.

^2Z&~ l72(p Determination of Possible Interference of Perfluorooctane Sulfonic Acid Potassium Salt with Rat Cholesterol Date: 8/17/99 Study: 6329 263 Serum Vehicle Blank Blank 0 ug/mL 0 ug/mL 1.08 mg 3.23 mg 6.46 mg /mL_______/mL_____ /mL mg/dL #1 mg/dL #2 mg/dL #3 68 66 66 65 67 66 66 65 65 65 65 65 66 66 65 mean s.d. 66.33333 65.66667 65.66667 65.33333 65.66667 1.527525 0.57735 0.57735 0.57735 1.154701 Method Principle (Trinder reaction) Cholesterol esters present in serum or plasma are hydrolyzed qualitatively in to free cholesterol and fatty acids by microbial cholesterol esterase.

PERFLUOROOCTANESULFONYL FLUORIDE (POSF; T-7661.4) TOXICITY STUDY BY INHALATION ADMINISTRATION TO CD RATS FOR 13 WEEKS FOLLOWED BY A 4 WEEK RECOVERY PERIOD Volume 2 MIN 313/023622 PERFLUOROOCTANESULFONYL FLUORIDE (POSF; T-7661.4) TOXICITY STUDY BY INHALATION ADMINISTRATION TO CD RATS FOR 13 WEEKS FOLLOWED BY A 4 WEEK RECOVERY PERIOD Volume 2 Sponsor 33BMUSMMtuSNPiAlaCCd5.uieo5nlnr,1gpt3eo23rr2,-a30t2e-22TE0o,-x0i2c,ology, Research Laboratory HWAHCPEENaluuocm2nnGoo8ttbnliiLlnnrb4eAigguHydddNrgSRyooeD,,nnos,.haLdiri,efe, Sciences Ltd., Report issued: 28 September 2005 Page 366 of 740 MIN 313/023622 CONTENTS Page CONTENTS................................................................................................................................... 2 COMPLIANCE WITH GOOD LABORATORY PRACTICE.................................................... 4 QUALITY ASSURANCE STATEMENT................................................................................... 5 CONTRIBUTING SCIENTISTS.................................................................................................. 6 SUMMARY................................................................................................................................... 7 INTRODUCTION......................................................................................................................... 9 EXPERIMENTAL PROCEDURE................................................................................................

P roven Results.

# AR226-2878 Copies to: E.

FOR DD PONT SE ONLY AR226-2906 E.

M am - H-25231: One-Generation Reproduction Study in Rats DuPont-9763 TRADE SECRET Study Title H-25231: One-Generation Reproduction Study in Rats Volume 2 of 3 Laboratory Project ED: DuPont-9763 A uthor: Eve Mylchreest, Ph.D.

ARRA - Environmental fate of Fluorotelomer Based Substances Derek Muir Aquatic Ecosystem Protection Research Division Water Science and Technology Directorate Science and Technology Branch Environment Canada Burlington ON Environment Environnement Canada Canada 000134 Outline 1) Conversion of `fluorotelomer alcohols' to PFCAs Atmospheric degradation of "Residual FTOHs" Atmospheric measurements (air, precipitation) Biological degradation of FTOHs Biodegradation of fluorotelomer polymers?