Document kmXB9KbLdYBv3ed11rdgzVLdJ

M am - H-25231: One-Generation Reproduction Study in Rats DuPont-9763 TRADE SECRET Study Title H-25231: One-Generation Reproduction Study in Rats Volume 2 of 3 Laboratory Project ED: DuPont-9763 A uthor: Eve Mylchreest, Ph.D. Study Completed on: January 31,2003 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratoiy for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 (M lWork Request Number Service Code Number Page 254 of 796 Company Sanitized. Does not contain 7SCA C S i H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX O INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN Pi MALE RATS 255 Com pany Sanitized. Does not contain T S C A CBJ H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN Pi MALE RATS EXPLANATORY NOTES Footnotes a = Sacrificed in extremis on test day 60. b = Motility value incorrect due to particles on slide counted as non-motile sperm; data excluded from statistical analysis. c = No analysis was performed for this animal because tissue processing for motility was interrupted by a building evacuation. d = Less than 200 sperm present; data excluded from statistical analysis, e = Accidentally killed on test day 86. f = Accidentally killed on test day 42. g = Found dead on test day 66. Abbreviation = No data 256 Com pany Sanitized. Does not contain T S C A C B 1 H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN Px MALE RATS GROUP 1-0 0 MG/KG/DAY GROUP III-O 75 MG/KG/DAY Animal Number Percent Motile Animal Number Percent Motile 657391 657392 657393 657394 657395 657396 657397 657398 657399 657400 657401 657402 657403 657404 657405 657406 657407 657408 657409a 657410 83 96 96 88 95 94 90 96 87 94 96 95 96 90 95 95 95 95 -- 98 657416b 657417e 657418 657419^ 657420 657421 657422 657423 657424 657425 657426 657427 657428 657429 657430 657431 657432 657433 657596 657435 52 -- 95 0 92 94 96 88 94 95 92 94 93 89 94 95 92 93 90 96 GROUP V-0 500 MG/KG/DAY Animal Number Percent Motile 657441b 657442 657443 657444 657445 657446 657447 657448 657449 657450 657451 657452 657453 657454 657455 657456 657457 657458 657459e 657460 47 92 89 98 95 95 95 95 93 92 64 98 91 97 91 90 95 97 -- 96 GROUP VII-0 3500 MG/KG/DAY Animal Number Percent Motile- 657466 657467 657468 657469 657470 657471 657472 657473 657474 657475 657476 657477f 657478 657479 657480b 657481 6574829 657483 657484 657485 95 91 85 96 92 82 94 97 92 89 93 -- 96 95 11 91 -- 95 94 97 257 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX P INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN PxMALE RATS 258 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P! MALE RATS EXPLANATORY NOTES Footnotes a = Sacrificed in extremis on test day 60. b = Sperm absent; 3 slides evaluated, c = Accidentally killed on test day 86. d = Accidentally killed on test day 42. e = Less than 200 sperm; 3 slides evaluated. Data excluded from the statistical analysis, f = Found dead on test day 66. Abbreviation -- = No data 259 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Px MALE RATS Group 1-0 : 0 MG/KG/DAY Animal Number Total Tail Head Tail & Head Percent Normal Abnormal Abnormal Abnormal Normal 657391 657392 657393 657394 657395 657396 657397 657398 657399 657400 657401 657402 657403 657404 657405 657406 657407 657408 195 2 198 0 200 0 199 0 199 0 197 2 198 2 200 0 200 0 197 0 200 0 199 0 198 1 197 3 198 2 197 1 197 1 197 0 657409a -- -- 657410 198 2 3 2 0 1 1 1 0 0 0 3 0 1 1 0 0 2 2 3 -- 0 0 97.5 0 99.0 0 100.0 0 99.5 0 99.5 0 98.5 0 99.0 0 100.0 0 100.0 0 98.5 0 100.0 0 99.5 0 99.0 0 98.5 0 99.0 0 98.5 0 98.5 0 98.5 ---- 0 99.0 Animal Number 657416 657417 657418 657419^ 657420 657421 657422 657423 657424 657425 657426 657427 657428 657429 657430 657431 657432 657433 657596 657435 GROUP III-O: 75 MG/KG/DAY Total Tail Head Tail & Head Percent Normal Abnormal Abnormal Abnormal Normal 198 199 196 -- 199 199 198 200 199 199 196 198 199 196 199 197 197 200 199 198 0 1 2 -- 0 0 2 0 0 1 0 1 1 1 0 0 0 0 0 0 2 0 2 -- 1 1 0 0 1 0 41 0 3 1 3 3 0 1 2 0 99.0 0 99.5 0 98.0 ---- 0 99.5 0 99.5 0 99.0 0 100.0 0 99.5 0 99.5 0 98.0 0 99.0 0 99.5 0 98.0 0 99.5 0 98.5 0 98.5 0 100.0 0 99.5 0 99.0 260 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Pi MALE RATS Group V-0: 500 MG/KG/DAY Animal Number 657441 657442 657443 657444 657445 657446 657447 657448 657449 '657450 657451 657452 657453 657454 657455 657456 657457 657458 657459C 657460 Total Normal 196 200 197 197 197 198 199 195 200 199 196 195 196 195 198 193 197 193 -- 195 Tail Abnormal 0 0 0 2 0 0 0 3 0 0 1 1 0 2 0 2 2 2 -- 2 Head Abnormal 4 0 3 1 3 2 1 2 0 1 3 4 4 3 2 5 1 5 -- 3 Tail & Head Percent Abnormal Normal 0 98.0 0 100.0 0 98.5 0 98.5 0 98.5 0 99.0 0 99.5 0 97.5 0 100.0 0 99.5 0 98.0 0 97.5 0 98.0 0 97.5 0 99.0 0 96.5 0 98.5 0 96.5 ---- 0 97.5 Animal Number 657466 657467 657468 657469 657470 657471 657472 657473 657474 657475 657476 657477*3 657478 657479 657480e 657481 657482f 657483 657484 657485 GROUP VII - 0 : 3500 MG/KG/DAY Total Tail Head Tail & Head Percent Normal Abnormal Abnormal Abnormal Normal 196 195 197 199 198 189 199 197 196 199 196 . -- 197 199 43 194 -- 195 198 198 2 0 0 0 0 2 1 1 2 0 0 -- 2 0 0 4 -- 2 0 0 2 5 3 1 2 9 2 2 1 4 -- 1 1 1 2 -- 3 2 2 0 98.0 0 97.5 0 98.5 0 99.5 0 99.0 0 94.5 0 99.5 0 98.5 0 98.0 0 99.5 0 98.0 ---- 0 98.5 0 99.5 0 .97.7 0 97.0 ---- 0 97.5 0 99.0 0 99.0 261 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats /***N., DuPont-9763 APPENDIX Q INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS IN Pi MALE RATS /""V 262 Company Sanitized. Does not contain T S C A C S f H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS IN P, MALE RATS EXPLANATORY NOTES Footnotes a = Sacrificed in extremis on test day 60. b = Accidentally killed on test day 86. c = Accidentally killed on test day 42. d = Found dead on test day 66. Abbreviation = No data 263 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (MILLIONS) IN Pi MALE RATS GROUP 1-0: 0 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda 657391 657392 657393 657394 657395 657396 657397 657398 657399 657400 657401 657402 657403 657404 657405 657406 657407 657408 657409a 657410 302.8 357.7 323.8 361.2 306.3 277.1 327.3 309.8 288.8 325.0 311.0 265.4 282.9 288.8 314.5 282.9 328.5 265.4 -- 286.4 970.7 1014.2 993.9 1301.7 878.4 970.8 1052.5 1199.8 1084.7 1238.0 957.4 928.8 888.2 1274.8 1163.8 904.4 1104.2 1052.2 -- 1153.0 Testicular Spermatids Per testis Per g testis 184.7 177.1 190.0 180.0 178.3 163.7 213.9 187.6 168.4 164.3 187.6 176.0 187.6 176.5 165.4 175.4 178.3 139.1 -- 119.8 160.2 96.4 114.2 115.4 101.7 148.9 147.8 122.3 103.3 134.2 118.0 121.4 130.2 129.7 102.2 118.7 119.1 151.9 -- 96.7 GROUP III-O : 75 MG/KG/DAY Animal Number 657416 657417 657418 657419 657420 657421 657422 657423 657424 657425 657426 657427 657428 657429 657430 657431 657432 657433 657596 657435 Epididymal Sperm Per cauda Per g cauda 313.3 333.2 315.7 3.5 343.7 314.5 295.8 304.0 298.1 312.1 326.2 271.2 282.9 293.4 280.6 288.8 306.3 326.2 322.7 291.1 1039.1 1371.6 1378.3 28.2 1238.1 1122.3 1023.4 1119.9 946.6 1083.8 1117.7 944.7 888.2 1089.6 840.5 1301.2 1330.5 1265.1 1587.0 1249.3 Testicular Spermatids Per testis Per g testis 202.8 190.0 191.2 4.7 163.1 149.1 201.1 202.8 186.5 170.1 181.8 163.7 186.5 178.3 179.5 156.1 180.0 162.5 155.5 149.1 112.2 123.5 124.5 10.5 117.5 98.1 132.1 122.4 120.6 129.5 115.6 101.4 112.1 104.5 149.1 137.0 112.8 100.2 106.9 104.6 264 Company Sanitized. Does not contain T S C A CBf H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (MILLIONS) IN Pi MALE RATS GROUP V - 0 : 500 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda Testicular Spermatids Per testis Per g testis 657441 657442 657443 657444 657445 657446 657447 657448 657449 657450 657451 657452 657453 657454 657455 657456 657457 657458 657459t1 657460 339.0 314.5 229.1 339.0 302.8 321.5 293.4 332.0 368.3 287.6 300.5 277.1 279.4 274.7 280.6 287.6 30.4 291.1 -- 318.0 1245.0 988.3 1011.1 1204.3 1042.3 1307.9 1050.6 1377.0 1608.7 922.0 1012.9 820.2 1055.1 936.3 1530.6 1108.2 106.7 1292-0 --- 1625.6 166.0 142.6 157.8 216.9 161.9 223.3 196.4 187.6 179.5 182.4 113.4 182.4 149.7 166.6 163.1 159.6 162.5 160.2 -- 167.8 95.8 92.7 129.0 115.5 109.0 127.3 110.6 124.1 122.6 106.7 138.3 130.8 102.6 142.6 125.8 97.5 109.0 108.4 -- 127.6 GROUP VII-0: 3500 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda Testicular Spermatids Per testis Per g testis 657466 657467 657468 657469 657470 657471 657472 657473 657474 657475 657476 657478 657477C 657479 657480 657481 657482*3 657483 657484 657485 326.2 295.8 305.1 326.2 300.5 111.1 326.2 289.9 289.9 296.9 296.9 285.3 -- 284.1 273.6 284.1 -- 288.8 285.3 299.3 1175.8 1051.4 1036.4 1136.0 1140.2 648.7 1605.1 1484.4 1360.5 1224.4 997.7 1024.6 -- 1303.1 1165.5 1075.2 -- 1228.7 1105.1 1230.5 174.2 219.8 159.0 188.8 165.4 187.6 206.4 158.4 169.5 184.1 146.1 170.7 -- 174.2 158.4 160.2 -- 150.8 128.6 150.2 106.6 145.8 99.1 111.2 133.0 155.2 148.8 111.5 118.4 107.4 106.0 124.7 -- 120.5 108.2 120.2 -- 108.9 106.1 94.1 265 Com pany Sanitized. Does not contain TSCA CBi H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX R INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION IN Pi FEMALE RATS 266 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION IN Pi FEMALE RATS EXPLANATORY NOTES Note Test days 76-90 = Cohabitation Period except for Animal Numbers 657510,657584, 657585 (Test Days 77-91 = Cohabitation Period) Footnotes a Evidence of copulation detected, but animal did not deliver a litter. b No evidence of copulation was found and no litter was delivered. c No evidence of copulation was found but a litter was delivered. To calculate the Precoital Interval, the day of copulation was assumed to be the last estrus during cohabitation; the days of persistent diestrus that followed were excluded from calculations since the animal was pregnant and thus, was not cycling normally. d Due to the death of the first male during cohabitation, the female was cohoused with a second male from the same group on test day 86. Abbreviation = No Data 267 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP II-O: 0 MG/KG/DAY ANIMAL NUMBER 657491 657492 657493 657494 657495 657496a 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509a 657510 NUMBER OP DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 21 19% 62% 19% 5.33 1 22 27% 55% 18% 4.00 2 22 32% 68% 0% 4.00 2 24 25% 50% 25% 4.00 4 24 25% 63% 13% 4.00 4 22 9% 77% 14% 4.25 2 24 29% 71% 0% 4.00 4 23 30% 61% 9% 4.00 3 23 13% 70% 17% 5.00 3 23 22% 61% 17% 4.00 3 23 17% 78% 4% 5.00 4 21 14% 71% 14% 4.33 1 23 22% 52% 26% 4.00 3 22 9% 77% 14% 5.00 2 24 25% 58% 17% 4.00 4 24 29% 58% 13% 5.33 4 23 22% 52% 26% 4.00 3 22 36% 59% 5% 4.00 2 22 18% 73% 9% 4.00 2 25 16% 68% 16% 4.75 5 268 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP IV-0: 75 MG/KG/DAY ANIMAL NUMBER 657516 657517 657518 657519^ 657520 657521 657522 657523 657524 657525 657526 657527 657528 657529c 657530C 657531 657532 657533 657534 657535 NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 21 24% 71% 5% 4.00 1 24 29% 50% 21% 4.00 4 23 22% 61% 17% 4.00 3 34 9% 79% 12% 4.00 -- 21 19% 62% 19% 4.00 1 24 33% 58% 8% 4.00 4 24 33% 58% 8% 4.00 4 23 26% 74% 0% 4.00 3 25 24% 60% 16% 5.00 5 21 19% 62% 19% 4.00 1 22 14% 73% 14% 5.00 2 21 24% 71% 5% 4.00 1 22 36% 59% 5% 4.00 2 34 18% 63% 9% 4.40 4 34 9% 68% 15% 4.00 5 27 22% 63% 15% 4.60 7 24 29% 50% 21% 4.00 4 21 24% 76% 0% 4.00 1 25 28% 72% 0% 4.00 5 24 29% 58% 13% 4.00 4 269 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 ANIMAL NUMBER 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550e 657551e 657552 657553 657554 657555 657556 657557b 657558 657559< 657560 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP VI-0: 500 MG/KG/DAY NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 24 25% 75% 0% 4.00 4 23 22% 61% 17% 4.00 3 22 23% 77% 0% 4.00 2 24 25% 50% 25% 4.00 4 21 14% 67% 19% 4.33 1 23 22% 61% 17% 4.00 3 24 25% 54% 21% 4.00 4 28 4% 82% 14% 5.25 8 22 23% 64% 14% 4.00 2 34 26% 65% 0% 4.00 6 34 18% 58% 12% 4.00 4 24 21% 71% 8% 4.00 4 24 29% 58% 13% 4.20 4 21 33% 52% 14% 4.00 1 23 30% 61% 9% 4.00 3 22 23% 50% 27% 4.00 2 34 21% 79% 0% 4.00 -- 22 18% 64% 18% 4.67 2 31 23% 65% 13% 4.60 1 23 26% 65% 9% 4.00 3 270 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 ANIMAL NUMBER 657566e 657567s 657568 657569s 657570 657571e 657572 657573 657574 657575s 657576 657577 657578s 657579 657580 657581 657582s 657583 657584 657585 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP VIII-0: 3500 MG/KG/DAY NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 34 9% 75% 9% 10.00 4 34 15% 76% 9% 4.75 14 21 24% 52% 24% 4.00 1 27 26% 67% 7% 4.00 7 22 23% 68% 9% 4.00 2 34 18% 64% 9% 4.40 5 22 23% 77% 0% 4.00 2 23 13% 78% 9% 4.00 3 24 38% 63% 0% 4.00 4 33 73% 25% 3% 5.00 13 21 10% 67% 24% 4.33 1 23 26% 52% 22% 4.00 3 21 24% 76% 0% 4.00 1 21 24% 48% 29% 4.00 1 23 13% 74% 13% 5.00 3 24 42% 50% 8% 4.50 4 22 32% 50% 18% 4.00 2 21 24% 67% 10% 4.00 1 26 19% 77% 4% 4.00 5 24 17% 83% 0% 4.00 3 271 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX S INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION IN Pi FEMALE RATS 272 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION IN Pi FEMALE RATS Notes EXPLANATORY NOTES Test Days 56-76 = Premating Test days 76-90 = Cohabitation Period except for Animal Numbers 657510,657584,657585 (Test Days 77-91 = Cohabitation Period) Abbreviations D = Diestrus E = Estrus P = Proestrus X = No sample or stage could not be defined from sample. Footnotes a Evidence of copulation detected but animal did not deliver a litter. b No evidence of copulation was detected and no litter was delivered, c No evidence of copulation was detected but a litter was delivered. 273 Company Sanitized. Does not contain T S C A CBS H-25231: One-Generation Reproduction Study in Rats_______________________ DuPont-9763 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP II-O: 0 MG/KG/DAY ANIMAL NUMBER 657491 56 57 58 59 60 61 !`52 1 P : E . D * D D P E-v 657492 P E liS 657493 D D E 657494 E _ gg: D 657495 E D d ' d 657496a E. D d 657497 E d PE 'E ' p E: D E . d' > . D E D D D _. I TEST DAYS 66 63 69 1 70 171 PE S . : E_ D i B l e | D P ____ _ D D _____ D_ D )e ; D D Dp D D P -E D PE PE D t> 1 D DJ D D !D P -E P E. D P sm D WB P D D p E D ill D I888lgllJ P E P D E E D ED DD DD d Ji D DD D P , E- 1 8 1 . p D D l" E Bll PE Er Lr j 'D :e ?pE E Em D 1818181 D E E - 1D D il; liil " p ~D~! E 1 3 D I P D E D E r'E D ISBijfill P E 1811 D fl||j P :E. 1 D~ D D E E D? D rr DE DD D PE P E D D D D D D 79 80 81 DD D-D D DD D D 'D D D ,L: DD 274 Company Sanitized. Does not contain TSCA CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL ESTROS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP IV-0: 75 MG/KG/DAY ANIMAL TEST DAYS NUMBER 657516 657517 657518 n56 ] ! 60 i61 62 631(64 i651ll5 1 68 69 70 71 7 I'7'3 74 75 Til 77 78 79 80 81 82 83 84 85 86 87 88 89 D D| D D Q W . 533 E ; D D DD DD P eD D P -E D Si P -E D' B P E D D P E U S P E D D P E DD PDD D E 'D D E 657519b D D D D D 657520 D 657521 D D DDD 1111 D D P E `D D D P 'P - D D D- D D D D D DD P D T7 E D D E 657522 D' DD DD D ,T)\ E D . D" E 657523 J) D E D. D- E 657524 65752 657526 D D DD D D D D` D D D i E d'D D H DDP Sglppg DDDD 657527 D D \-:M DD D D D" 657528 D D D DD EDDD 657529e D D -llj oD 6 5 7 5 3 Q c H llj D D JD- 657531 H D D D D d` D DD D 657532 D D p ;Ei D d " P E D D p E D-. D ! 657533 D !_ D D D ;E. D D E . D D DD E' P D D P :B D D D ' D D D D D D D D P E D D D :P D D D D D D D D D P E D D P :E 'D -D D PDD PE 1_ D D 657534 D E D D D E . D D D E D< D I I E657535 L5_ D P E _p d P E DD 1 D DH 1D D H DDD D 275 Company Sanitized. Does not contain T S C A CBI H-2S231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP VI-0: 500 MG/KG/DAY TEST DAYS Z i 80 81 82 83 84 85 86 87 88 89 D H r r H I___ D :P SB ft DsD D :E D H i 111 `p 1 8 8 P H P "p j! D 1 nD D _P_ D D DD d ' D i> D _D_ D; sii D D P D D _D_ P : E 276 C0SDpany Sanitized- Does not contain TSCA C B l H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP VTII-0: 3500 MG/KG/DAY ANIMAL NUMBER 657566e 657567a 657568 657569a 657570 657571e 657572 657573 657574 TEST DAYS 57 58l59|60 tli ? 3 65166 !P 7p ir 2?p73 74 I7 5 I76 3 CO 80 81 82 83 84 `85 3? 87 88 OD kJ J D D D D D _D_ V D 'tp ,D V . D-i D D P E D D p E D D D _D_ D D D D D D d D ID DD PE ]E`d D E E D f D p E _D_ D r_ D D' 1D 1D 'D D D D iD D D 0 B &E D P E D- D mm? E - y --D BE D D p D P E D Bl D DDP D D D E Eil D Ds E E D D U L* D P E .Q P E <:n D D E L D 1 DD H S SD D U P E D D p E tD- D D D P E D D b H _D_fm D D 2_ D|D D [d T E Id "p. D E d; 'D;B D -D D E 3 _ D D, D L2i P E ;D- D; P E d ,D-y o -5_ D D D D' D ,D D D EEDD E P.E E E E E E E E E E E E . E E E. E E . E E E. DDDD DD 657579 657580 657581 657582a D D EDD P DID D DDD 657583 657584 657585 Hai#111 mi DDD DDDD D 277 COKipany Sanm" d- Doss not contain TSCA CBI H-25231: One-Generation Reproduction Study in Rats /'**% DuPont-9763 APPENDIX T INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION 278 Company Sanitized. Does not contain TS C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION EXPLANATORY NOTES Abbreviation -- = No Data Company Sanitized, does not contain TSCA CB| H-25231: One-Generation Reproduction Study in Rats DuPont-9763 FEMALE ANIMAL# 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509 657510 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: 11-0,1-0 DOSE: 0 MG/KG/DAY MALE #1 ANIMAL# 657391 657392 657393 657394 657395 657396 657397 657398 657399 657400 657401 657402 657403 657404 657405 657406 657407 657408 657410 657391 PLUG/SPERM OBSERVED + 4* + 4* + + + 4* 444- + 44444* 4- + + MALE #2 ANIMAL# PLUG/ SPERM LITTER OBSERVED PRODUCED + + 4* 4- + 444- + + 444- + + 44* + GESTATION LENGTH(days) 23 2222 22 22 23 23 22 22 22 22 22 23 22 22 22 22 23 280 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 FEMALE ANIMAL# 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534 657535 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: IV-0,III-0 DOSE: 75 MG/KG/DAY MALE #1 ANIMAL# 657416 657417 657418 657419 657420 657421 657422 657423 657424 657425 657426 657427 657428 657429 657430 657431 657432 657433 657435 657596 PLUG/SPERM OBSERVED + f -- + + + + + + + + + -- -- + + + + + MALE #2 ANIMAL# PLUG/SPERM LITTER OBSERVED PRODUCED + + -- + + + + + + + + + + + + + + + + GESTATION LENGTH(days) 22 22 22 -- 23 22 22 23 23 23 23 22 22 _a _a 23 22 23 23 22 a Gestation length could not be calculated since no evidence of copulation was observed. 281 Company Sanitized. Does not contain T S C A C8I H-25231: One-Generation Reproduction Study in Rats DuPont-9763 FEMALE ANIMAL# 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557 657558 657559* 657560 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: VI-0,V-0 DOSE: 500 MG/KG/DAY MALE #1 ANIMAL# 657441 657442 657443 657444 657445 657446 657447 657448 657449 657450 657451 657452 657453 657454 657455 657456 657457 657458 657459 657460 PLUG/SPERM OBSERVED + + + + + + + + __ -- + + + + + -- + -- MALE #2 ANIMAL# 657458 PLUG/SPERM LITTER OBSERVED PRODUCED + + + + + + + + + + + f + + + + -- ++ + GESTATION LENGTH(days) 21 22 22 22 22 22 22 23 22 _a _a 23 22 23 23 22 -- 22 22 22 a Gestation length could not be calculated since no evidence of copulation was observed. - b Female was cohabited with a second male due to accidental death of first male. 282 Company Sanitized. Does not contain T S C A CBS H-25231: One-Generation Reproduction Study in Rats DuPont-9763 FEMALE ANIMAL# 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 657576 657577 657578 657579 657580 657581 657582 657583 657584 657585 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: VIII-0,VII-0 DOSE: 3500 MG/KG/DAY MALE #1 ANIMAL# 657466 657467 657468 657469 657470 657471 657472 657473 657474 657475 657476 657478 657479 657480 657481 657483 657484 657485 657468 657476 PLUG/SPERM OBSERVED _______ + + + + -- + + + + + + + + + + + + + + MALE #2 ANIMAL# PLUG/SPERM LITTER OBSERVED PRODUCED + -- + -- + + + -- + + -- + + + -- f GESTATION LENGTH(days) _a -- 22 -- 23 _a 22 22 22 -- 23 22 -- 23 22 22 -- 23 22 22 a Gestation length could not be calculated since no evidence of copulation was observed. 283 Com pany Sanitized. Does not contain 1S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX U INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Pi GENERATION 284 Company Sanitized. Does not contain T S C A CBJ H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Pj. GENERATION GROUPS: II-O DOSE: 0 MG/KG/DAY Animal Number Pups Born Number of Implantation Sites Implantation Efficiency 657491 657492 657493 657494 657495 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657510 4 18 11 15 12 16 14 13 11 14 13 13 15 12 10 14 15 12 4 18 12 15 12 17 14 13 12 14 14 16 15 12 10 15 15 12 100.0 100.0 91.7 100.0 100.0 94.1 100.0 100.0 91.7 100.0 92.9 81.3 100.0 100.0 100.0 93.3 100.0 100.0 285 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Pi GENERATION GROUPS: IV-0 DOSE: 75 MG/KG/DAY Animal Number Pups Born Number of Implantation Sites Implantation Efficiency- 657516 657517 657518 657520 657521 657522 657523 657524 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534 657535 13 13 13 11 12 9 2 16 11 9 16 16 13 15 8 5 14 4 16 13 13 14 11 12 9 2 17 15 9 16 16 14 15 9 5 14 4 16 100.0 100.0 92.9 100.0 100.0 100.0 100.0 94.1 73.3 100.0 100.0 100.0 92.9 100.0 88.9 100.0 100.0 100.0 100.0 286 Company Sanitized. Does not contain T S C A C B I H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Px GENERATION GROUPS: VI-0 DOSE: 500 MG/KG/DAY Animal Number Pups Born Number of Implantation Sites Implantation Efficiency 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657558 657559 657560 11 13 14 15 13 15 11 8 12 11 12 14 14 10 13 15 12 9 13 13 15 14 15 17 15 11 8 12 12 12 15 15 13 13 16 12 11 13 84.6 86.7 100.0 100.0 76.5 100.0 100.0 100.0 100.0 91.7 100.0 93.3 93.3 76.9 100.0 93.8 100.0 81.8 100.0 287 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Pi GENERATION GROUPS: VIII-0 DOSE: 3500 MG/KG/DAY Animal Number Pups Born Number of Implantation Sites Implantation Efficiency 657566 657568 657570 657571 657572 657573 657574 657576 657577 657579 657580 657581 657583 657584 657585 12 12 16 13 12 9 13 13 12 12 16 14 14 12 14 13 13 18 13 14 10 13 13 13 15 16 14 16 14 14 92.3 92.3 88.9 100.0 85.7 90.0 100.0 100.0 92.3 80.0 100.0 100.0 87.5 85.7 100.0 288 Com pany Sanitized. Does not contain T S C A CS H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX V INDIVIDUAL PUP SURVIVAL: Fi GENERATION /*SP**!N 289 Com pany Sanitized. Does not contain T S C A CBI H-25231 : One-Generation Reproduction Study in Rats INDIVIDUAL PUP SURVIVAL: Fj GENERATION EXPLANATORY NOTES Abbreviation No Data DuPont-9763 290 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 ANIMAL NUMBER 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509 657510 ANIMAL NUMBER 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509 657510 BORN INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 4 444 4 4 4 18 18 18 8 8 8 8 11 11 11 8 8 8 8 15 15 15 8 8 8 8 12 11 11 8 8 8 8 - - - ---- 16 16 16 8 8 8 8 14 14 14 8 8 8 8 13 13 13 8 8 8 8 11 11 11 8 8 8 8 14 13 13 8 8 8 8 13 13 13 8 8 8 8 13 13 13 8 8 8 8 15 15 15 8 8 8 8 12 12 11 8 8 8 8 10 10 10 8 8 8 8 14 14 14 8 8 8 8 15 15 15 8 8 8 8 - - - ---- 12 12 12 8 8 8 8 BORN NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 2 222222 8 884444 8 885555 55544 44 7 6644 44 - - - - - - - 77744 44 77744 44 8 884 4 4 4 6 664 44 4 6 664 4 44 6 664 4 4 4 6 664 4 4 4 9994444 66644 44 77755 55 10 10 10 4 4 4 4 6 664 4 44 - - - ---- 8 884 4 44 291 Com pany Sanitized. Does not contain T S C A C B i H-25231: One-Generation Reproduction Study in Rats DuPont-9763 ANIMAL NUMBER 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509 657510 ANIMAL NUMBER 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509 657510 BORN INDIVIDUAL PUP SURVIVAL: F i GENERATION GROUP: I I - 0 DOSE: 0 MG/KG/DAY____ NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 222 10 10 10 33 3 10 10 10 55 5 99 9 77 7 55 5 555 87 7 77 7 77 7 66 6 66 5 33 3 44 4 999 -- 44 4 22 44 33 44 44 44 44 44 44 44 44 44 44 44 33 44 44 -- 44 22 44 33 44 44 44 44 44 44 44 44 44 44 44 33 44 44 -- 44 NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0 - 4 DAY VIABILITY LACTATION INDEX 0.50 0.44 0.73 0.33 0.58 - 0.44 0.50 0.62 0.55 0.43 0.46 0.46 0.60 0.50 0.70 0.71 0.40 - 0.67 100.0 100.0 100.0 100.0 91.7 - 100.0 100.0 100.0 100.0 92.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 91.7 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 292 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats_________________________________________DuPont-9763 ANIMAL NUMBER 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509 657510 ANIMAL NUMBER 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509 657510 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY NUMBER OF MALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 85.7 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 % BORN ALIVE NUMBER OF FEMALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 87.5 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 83.3 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 10-0.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 293 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 ANIMAL NUMBER 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534 657535 ANIMAL NUMBER 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534 657535 BORN 13 13 13 - 11 12 9 2 16 11 9 16 16 13 15 8 5 14 4 16 BORN 8 9 8 - 3 7 5 1 9 8 6 10 7 10 8 6 1 6 4 10 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: IV-0 DOSE: 75 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 13 13 8 8 8 13 13 8 8 8 13 13 8 8 8 - ----- 11 11 8 8 8 12 12 8 8 8 99888 22 2 2 2 16 16 8 8 8 11 11 8 8 8 99888 16 16 8 8 8 15 15 8 8 8 13 13 8 8 8 15 15 8 8 8 8888 8 55555 14 14 8 8 8 44 4 4 4 16 15 8 8 8 NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 884 4 4 994 44 884 44 - - ---- 333 3 3 774 44 554 4 4 111 1 1 994 44 885 5 5 665 5 5 10 10 4 4 4 664 4 4 10 10 5 5 5 884 44 666 6 6 111 11 664 44 4 44 4 4 10 9 4 4 4 DAY 21 8 8 8 -- 8 8 8 2 8 8 8 8 8 8 8 8 5 8 4 8 DAY 21 4 4 4 3 4 4 1 4 5 5 4 4 5 4 6 1 4 4 4 294 Com pany Sanitized. Does not contain T S C A C 3 I H-25231: One-Generation Reproduction Study in Rats DuPont-9763 ANIMAL NUMBER 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534 657535 ANIMAL NUMBER 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534 657535 BORN 5 4 5 8 5 4 1 7 3 3 6 9 3 7 2 4 8 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: IV-0 DOSE: 75 MG/KG/DAY NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 55 44 44444 554 44 885 5 5 55444 44444 11 11 1 77444 33333 33 33 3 6644 4 99444 33333 774 44 2222 2 44444 884 4 4 DAY 21 4 4 5 4 4 1 4 3 3 4 4 3 4 2 4 4 NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY 0.62 0.69 0.62 - 0.27 0.58 0.56 0.50 0.56 0.73 0.67 0.63 0.44 0.77 0.53 0.75 0.20 0.43 1.00 0.63 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.8 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 93.8 LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 295 Company Sanitized. Does not contain T S C A C B l H-25231: One-Generation Reproduction Study in Rats ANIMAL NUMBER 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534 657535 ANIMAL NUMBER 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534 657535 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: IV-0 DOSE: 75 MG/KG/DAY NUMBER OF MALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 85.7 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 90.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 % BORN ALIVE 0 1 tf*. NUMBER OF FEMALE PUPS DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 _ 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 _ 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 DuPont-9763 296 Com pany Sanitized. Does not contain T S C A C B I /****\ H-25231: One-Generation Reproduction Study in Rats DuPont-9763 ANIMAL NUMBER 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552a 657553 657554 657555 657556 657557 657558 657559 657560 BORN 11 13 14 15 13 15 11 8 12 11 12 14 14 10 13 15 - 12 9 13 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VI-0 DOSE: 500 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 11 11 8 8 8 13 13 8 8 8 14 14 8 8 8 15 15 8 8 8 13 13 8 8 8 15 15 8 8 8 11 11 8 8 8 88888 12 12 8 8 8 11 10 8 8 8 12 12 8 8 8 13 13 8 8 8 14 14 8 8 8 10 10 8 8 8 13 13 8 8 8 15 15 8 8 8 - ---- 12 12 8 8 8 998 88 13 13 8 8 8 DAY 21 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 ANIMAL NUMBER 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557 657558 657559 657560 BORN 6 8 5 6 5 7 9 3 8 4 5 4 10 3 7 8 - 9 2 9 NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 6 64 4 8844 5 54 4 6 64 4 5544 7 74 4 9966 333 3 8 84 4 4444 5544 4 44 4 10 10 4 4 3333 7744 8 84 4 -- - - 9955 222 2 9 94 4 DAY 14 DAY 21 44 44 44 44 44 44 66 33 44 4 44 44 44 33 44 44 -55 22 44 a One dead pup was unsexable at birth. 297 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 ANIMAL NUMBER 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557 657558 657559 657560 ANIMAL NUMBER 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557 657558 657559 657560 BORN INDIVIDUAL PUP SURVIVAL: F i GENERATION GROUP: V I - 0 DOSE: 5 0 0 MG/KG/DAY NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 5554 44 4 5554 44 4 9994 44 4 9994 44 4 8884 44 4 8884 44 4 2222 22 2 5555 55 5 4444 44 4 7 7 64 4 4 4 7774 44 4 99 94 44 4 4444 44 4 7775 55 5 6664 44 4 7774 44 4 -3 333 3 3 3 7776 66 6 44 44 44 4 NUMBER OF PUPS SEX RATIO (MALES) BORN ALIVE 0 - 4 DAY VIABILITY LACTATION INDEX 0.55 0.62 0.36 0.40 0.38 0.47 0.82 0.38 0.67 0.36 0.42 0.31 0.71 0.30 0.54 0.53 0.75 0.22 0.69 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 92.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 90.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 298 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats________________________________________ DuPont-9763 ANIMAL NUMBER 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557 657558 657559 657560 ANIMAL NUMBER 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557 657558 657559 657560 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: V I -0 DOSE: 500 MG/KG/DAY NUMBER OF MALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 _ 100.0 100.0 100.0, % BORN ALIVE NUMBER OF FEMALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 85.7 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 299 Com pany Sanitized. Does not co ntain T S C A C B I H-25231: One-Generation Reproduction Study in Rats DuPont-9763 ANIMAL NUMBER 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 657576 657577 657578 657579 657580 657581 657582 657583 657584 657585 ANIMAL NUMBER 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 657576 657577 657578 657579 657580 657581 657582 657583 657584 657585 BORN INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VIII-0 DOSE: 3500 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 12 12 12 8 8 8 8 - ---- -- 12 12 12 8 8 8 8 - ---- -- 17 16 15 8 8 8 8 13 13 13 8 7 7 7 12 12 12 8 8 8 8 99988 88 13 13 13 8 8 8 8 - --- - - - 13 13 13 8 8 8 8 12 12 12 8 8 8 8 ----- -- 12 8 7 7 7 7 7 16 15 15 8 8 8 8 14 14 14 8 8 8 8 - --- - - - 14 14 14 8 8 8 8 12 11 11 8 8 8 8 14 14 14 8 8 8 8 BORN NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 6 6 64 4 4 4 - --- - -- 9995555 ------- 7774444 6 6644 44 3333333 55 544 44 4444444 - - - - - 5 5544 44 55 544 44 ------- 3222222 11 11 11 4 4 4 4 7 7744 44 - - -- - -- 77 74444 4 4 44 4 4 4 88 844 44 300 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 ANIMAL NUMBER 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 657576 657577 657578 657579 657580 657581 657582 657583 657584 657585 ANIMAL NUMBER 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 657576 657577 657578 657579 657580 657581 657582 657583 657584 657585 BORN INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VIII-0 DOSE: 3500 MG/KG/DAY NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 4 3 10 9 8 444 777 4333 999 555 5 444 44 4 4 9 99 4 4 4 4 888 4 44 4 7774 444 9655555 544 4444 777 44 44 7774 4 44 877 4 4 4 4 6664 4 44 NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 0.50 - 0.75 - 0.41 0.46 0.25 0.56 0.31 - 0.38 0.42 - 0.25 0.69 0.50 0.50 0.33 0.57 100.0 - 100.0 - 94.1 100.0 100.0 100.0 100.0 100.0 100.0 66.7 93.8 100.0 100.0 91.7 100.0 100.0 - 100.0 - 93.8 100.0 100.0 100.0 100.0 100.0 100.0 87.5 100.0 100.0 100.0 ioo.o 100.0 100.0 - 100.0 100.0 87.5 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 301 Company Sanitized. Does not contain T S C CBI H-25231: One-Generation Reproduction Study in Rats ANIMAL NUMBER 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 657576 657577 657578 657579 657580 657581 657582 657583 657584 657585 ANIMAL NUMBER 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 657576 657577 657578 657579 657580 657581 657582 657583 657584 657585 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VIII-0 DOSE: 3500 MG/KG/DAY NUMBER OF MALE PUPS % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 100.0 _ 100.0 - 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 - 66.7 100.0 100.0 - 100.0 100.0 100.0 100.0 - 100.0 - 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 - 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 - 100.0 - 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 - 100.0 100.0 100.0 - 100.0 100.0 100.0 % BORN ALIVE NUMBER OF FEMALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 - 100.0 - 90.0 100.0 100.0 100.0 100.0 - 100.0 100.0 66.7 80.0 100.0 - 100.0 87.5 100.0 - 100.0 100.0 - 88.9 100.0 100.0 100.0 100.0 100.0 100.0 83.3 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 - 100.0 75.0 100.0 100.0 100.0 - 100.0 100.0 - 100.0 100.0 100.0 _ 100.0 100.0 100.0 DuPont-9763 ' 302 Company Sanitized. Does not contain T S C A CB H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX W INDIVIDUAL PUP WEIGHTS: Fi GENERATION 303 Com pany Sanitized. DoOs not contain T S C A CB1 H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Animal Number 657491 657492 657493 657494 657495 657496s 657497 657498 657499* 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509s 657510 Individual Pup Weights (grains): Fi Gnration Lactation Day 0 Group: II-O Dose: 0 mg/kg/day Pup Number Sex 1 2 3 4 5 6 7 8______ 9_____ 10 < 8.2 8.4 CO cn to to ? 7.3 8.4 <5 6.7 6.6 6.5 7.0 6.4 6.6 5.5 9 6.1 6.1 6.0 6.0 6.0 6.0 6.3 6.9 6.2 6.3 7.1 7.3 6.4 6.6 6.7 6.7 7.3 7.0 2 6.8 6.3 5.4 3 6.6 6.3 7.0 6.8 7.5 2 6.6 5.7 6.2 6.2 6.7 6.8 6.1 5.7 6.5 6.8 3 7.5 7.0 6.2 7.2 7.5 7.5 2 6.8 6.6 6.8 6.5 6.2 3 2 3 7.0 7.8 7.6 6.5 7.3 6.4 2 6.6 6.5 5.9 6.9 5.9 7.2 6.6 5.9 7.7 3 7.5 6.9 7.0 6.7 7.3 6.7 7.9 2 7.2 6.9 7.1 6.4 7.2 7.0 6.5 3 7.0 7.3 7.3 6.7 6.9 7.2 7.3 2 7.7 7.0 6.8 6.6 6.5 7.1 3 7.1 7.5 7.4 7.7 7.2 8.2 9 7.4 7.1 7.1 6.8 7.3 3 6.4 6.3 6.7 6.7 7.1 7.4 2 6.3 5.9 6.3 6.4 6.7 6.4 6.4 3 7.6 6.7 6.8 5.9 6.8 6.7 2 6.8 6.7 6.6 6.3 6.3 7.1 6.9 3 6.3 6.5 6.0 6.4 6.2 6.7 9 6.1 6.0 6.8 6.1 6.5 5.8 6.0 S 8.1 7.8 6.9 6.0 8.1 6.9 6.4 7.5 7.5 2 6.9 5.2 5.8 6.4 6.4 6.7 3 6.6 6.5 7.5 6.6 7.3 7.0 2 5.9 6.3 6.6 6.5 6.1 6.5 3 6.9 7.4 7.4 7.4 7.4 7.0 7.3 2 7.2 6.9 6.5 o> 00 3 7.3 6.3 6.8 7.0 6.9 6.2 6.8 6.5 7.1 2 6.6 6.2 6.4 6.2 3 7.0 6.8 7.0 7.0 7.4 6.9 2 6.4 6.6 6.8 6.6 6.3 6.3 6.8 6.7 6.4 <5 2 <5 7.7 7.7 7.1 7.0 9 5.5 7.4 6.3 7.0 o CO 8.0 7.1 7.0 a No litter delivered. b One pup was missexed; data excluded from mean male and female pup weights. 304 Com pany Sanitized. Does not contain T S C A CBJ H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Animal Number 657516 657517 657518 657519s 657520* 657521* 657522 657523 657524 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534e 657535 Individual Pup Weights (grams): Fi Gnration Lactation Day 0 Group: IV-0 Dose: 75 mg/kg/day Pup Pup Number Sex 1 2 3 4 5 6 7 8 3 6.1 6.0 6.3 6.2 6.3 6.5 6.6 6.5 9 6.0 6.0 6.5 6.1 5.7 3 8.2 7.0 7.9 7.3 7.7 7.0 8.0 6.1 9 7.6 7.5 7.7 7.1 3 6.7 6.1 7.3 6.5 6.5 6.5 6.4 6.8 9 6.7 6.2 6.4 5.8 6.7 3 9 3 8.1 8.1 7.9 8.4 9 7.5 7.6 6.3 6.5 6.0 5.7 7.6 3 6.4 6.5 6.9 7.0 6.8 6.9 9 6.3 6.9 6.4 6.2 6.3 5.9 3 6.8 6.6 7.3 7.0 6.9 9 7.0 6.5 6.3 6.3 3 8.5 9 8.1 3 7.0 7.9 7.0 7.2 7.5 7.5 7.3 7.6 9 6.6 7.0 7.5 6.7 7.5 7.6 6.7 3 7.3 7.1 7.2 7.4 7.9 7.4 7.3 7.8 9 7.8 7.6 7.6 3 8.1 7.7 7.9 7.2 8.0 8.1 9 7.4 7.2 7.8 3 7.1 6.3 6.3 6.3 6.5 6.3 7.0 6.0 9 5.7 6.0 5.8 6.4 6.2 6.0 3 6.2 5.4 ' 6.5 6.5 6.5 6.3 9 5.8 6.0 6.2 5.9 6.7 5.8 6.1 5.8 3 6.8 6.8 6.7 6.8 6.1 6.7 6.6 6.7 9 6.0 6.8 6.2 3 5.0 6.6 6.5 6.5 6.7 6.0 7.1 7.2 9 6.3 6.5 5.2 5.6 6.1 6.1 5.9 3 7.4 8.4 8.3 8.5 7.6 8.3 9 8.2 7.5 3 7.7 9 8.3 8.3 7.7 8.0 3 7.1 7.3 7.0 6.9 7.3 7.6 9 7.1 6.6 7.0 6.6 7.3 7.0 6.5 7.3 3 8.4 7.7 8.9 9.2 9 3 6.3 6.3 3.8 5.5 6.3 6.3 6.2 6.8 9 6.1 5.5 6.0 5.6 6.1 6.2 9 7.5 8.9 6.3 5.7 6.8 6.4 a No litter delivered. b One pup was missexed; data excluded from mean male and female pup weights, c No female pups. 305 Com pany Sanitized. Does not contain T S C A C8I H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Animal Number 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557a 657558 657559 657560 Individual Pup Weights (grams) : Fi Gnration Lactation Day 0 Group : VI-0 Dose : 500 mg/kg/day Pup Pup Number Sex 1 2 3 4 5 6 7 8 3 6.6 6.5 7.3 6.5 5.5 5.7 2 6.3 5.7 6.0 6.9 7.0 3 7.1 7.0 7.2 6.2 6.9 6.4 6.9 6.9 2 6.9 6.2 6.7 6.7 6.5 3 6.4 6.4 7.0 6.4 6.7 ? 6.7 6.4 6.4 6.1 6.7 6.1 6.4 4.8 3 6.7 6.2 6.5 6.3 5.9 5.6 2 5.9 6.1 6.3 5.9 6.0 5.9 6.4 6.3 3 6.8 7.1 6.0 6.8 6.8 2 6.8 6.7 6.7 6.6 6.5 6.8 5.8 6.8 3 6.2 6.3 6.2 6.3 6.0 6.0 6.0 2 6.0 5.9 5.9 5.8 5.6 6.2 5.5 6.5 3 6.7 6.5 7.0 7.0 6.4 7.2 7.1 6.6 2 6.3 6.6 3 8.0 8.7 7.7 2 8.2 8.2 8.5 8.3 8.0 3 6.9 6.8 7.0 6.6 5.7 5.5 6.7 6.5 2 6.2 6.4 6.0 6.2 3 8.6 7.9 8.0 7.5 2 8.1 7.6 8.1 6.7 7.8 7.4 7.6 5 7.4 6.8 7.1 7.3 6.9 2 6.7 6.9 7.0 6.7 6.2 7.0 7.1 3 7.5 6.7 7.1 6.4 2 6.1 7.1 6.9 5.9 5.9 7.0 7.4 7.4 d 6.3 6.6 7.1 6.7 6.9 6.4 6.4 6.7 2 6.0 6.6 6.7 6.8 d 7.9 6.2 8.1 2 8.0 7.8 6.8 7.4 7.4 8.0 7.7 8.3 7.2 8.3 8.1 7.9 7.8 8.0 2 7.4 7.5 7.7 7.3 7.1 7.0 d 6.9 6.6 6.4 6.6 6.7 6.0 6.0 6.9 2 6.5 6.3 5.8 6.3 6.0 5.8 6.7 3 2 <? 6.6 6.3 6.0 6.8 6.5 6.7 5.2 5.6 2 5.8 5.8 5.9 d 7.9 7.5 2 7.2 7.5 7.5 6.9 6.9 7.2 7.6 3 6.2 5.4 6.9 6.8 7.1 6.6 7.6 7.1 2 6.9 6.0 6.7 6.2 9 6.7 6.3 6.6 7.7 6.9 6.2 6.5 a No litter delivered. 306 Com pany Sanitized. Does not contain T S C A C B I H-25231: One-Generation Reproduction Study in Rats Individual Pup Weights (grams): Fi Generation Lactation Day 0 Group : VIII-0 Dose : 3500 mg/kg/day Animal Pup Pup Number Number Sex l 2 3 4 5 6 7 8 657566 3 6.9 6.9 6.6 6.3 6.8 7.3 9 5.9 6.0 6.1 6.2 6.1 5.9 657567s <3 657568 9 3 6.1 6.5 6.3 6.2 6.2 5.3 6.3 6.5 9 5.9 6.7 6.1 657569s 3 657570 657571 9 3 6.5 5.5 6.9 6.1 6.7 6.8 5.9 9 6.0 6.2 5.7 5.8 6.5 5.0 6.5 6.4 3 6.0 6.4 5.5 6.3 6.4 6.3 9 5.4 6.0 6.0 5.5 5.3 6.1 2.8 657572 3 7.7 7.0 6.9 9 5.9 6.7 6.9 6.5 7.1 6.8 6.4 6.4 657573 3 6.3 7.1 6.2 6.4 6.6 9 6.7 6.0 6.7 6.3 657574 3 6.2 6.7 9 6.4 6.5 6.7 6.4 6.4 6.0 6.5 6.1 6.2 6.2 657575s 3 9 657576 3 7.6 6.9 7.4 8.1 7.3 9 7.3 7.1 7.1 7.4 7.4 7.4 7.2 7.1 657577 3 6.4 6.3 6.8 6.6 6.6 9 5.9 6.6 6.8 6.5 5.8 6.2 6.8 657578s <3 9 657579 657580 <3 5.3 5.5 9 5.4 5.8 5.2 4.6 5.2 5.6 <3 5.9 6.6 5.8 6.4 6.5 6.7 6.0 3.8 657581 9 6.3 5.7 5.5 6.1 3 6.2 6.3 6.5 6.0 6.4 5.9 6.0 9 6.0 5.8 5.9 5.6 6.0 6.0 5.8 657582s <3 657583 9 3 7.0 6.5 7.0 6.1 6.3 6.3 5.7 9 5.5 6.4 6.3 6.9 6.4 6.3 7.1 657584 657585 <3 7.0 7.2 7.4 6.9 9 6.7 6.6 6.6 6.2 6.6 6.9 6.9 3 5.9 6.5 6.7 6.0 6.3 6.5 6.6 6.9 9 5.9 6.2 6.3 6.0 6.5 6.1 DuPont-9763 10 11 6.7 7.0 a No litter delivered. 307 Com pany Sanitized. Does not contain T S C A C B I H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Group: II-O Dose: 0 mg/kg/day Animal Number 657491 657492 657493 657494 657495 657496-3 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509s 657510 Pup Pup Number Sex 1 2 3 4 5 6 7 8 9 10 d 9 <5 2 3 2 3 2 3 2 3 2 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 9 d .2 3 2 3 O d 2 15.0 14.0 9.6 9.9 10.9 10.9 9.2 10.7 12.3 9.4 10.3 9.9 12.8 10.6 11.4 12.3 11.6 11.8 10.4 9.8 11.9 10.1 10.9 9.8 13.3 11.6 11.4 10.2 11.4 10.3 11.0 10.9 11.7 11.7 10.0 8.2 15.1 14.5 11.8 8.5 10.8 8.1 10.3 8.8 11.0 11.0 9.7 11.4 11.8 11.4 10.1 11.6 12.4 11.2 10.8 10.4 10.9 10.3 11.1 10.1 10.7 12.1 11.3 10.3 11.6 11.7 11.6 10.1 12.0 10.7 11.4 10.8 10.2 10.2 10.9 10.1 11.8 9.0 12.2 11.2 13.0 9.8 10.8 11.2 12.0 11.5 12.0 12.3 11.0 9.7 9.5 10.7 9.9 9.9 12.2 11.0 10.6 11.2 11.9 11.1 10.1 10.3 12.3 11.6 11.1 9.6 9.2 9.4 10.9 10.4 9.5 12.7 11.3 10.4 9.4 10.0 10.6 11.3 11.5 12.0 11.1 10.3 9.9 9 .3 11.3 11.5 11.1 13.4 8.9 10.9 10.3 11.6 9.8 10.4 12.1 11.0 9.7 10.2 9.4 10.2 8.3 10.4 9.9 10.3 11.2 10.2 9.2 12.7 11.4 11.4 10.6 12.7 11.6 10.9 10.7 8.3 10.0 10.7 9.0 11.9 11.6 10.9 9.8 12.3 9.6 11.7 12.0 11.4 12.0 11.7 11.7 9.9 11.8 11.1 11.2 10.4 11.1 12.6 11.7 10.8 10.3 10.7 10.8 10.4 10.6 10.5 10.2 11.9 11.8 11.3 11.3 10.3 9.9 9.3 9.2 11.1 8.9 11.6 9.9 11.5 10.5 10.9 10.2 10.5 10.6 11.9 12.2 11.5 10.6 10.3 10.7 11.1 11.6 9.1 10.5 10.9 11.1 10.3 11.5 11.6 9.5 10.3 9.5 12.3 11.3 12.3 11.6 10.0 10.6 a No litter delivered. 308 Com pany Sanitized. Does not contain T S C A CBS H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Animal Number 657516 657517 657518 657519a 657520 657521 657522 657523 657524* 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534er 657535 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Group: IV-0 Dose: 75 mg/kg/day Pup Pup Number Sex 1 2 3 4 5 6 7 8 9 3 11.5 10.6 10.7 10.0 10.4 11.3 11.1 10.6 9 10.4 11.1 11.1 9.8 10.1 3 11.0 11.3 10.9 10.0 10.8 8.9 10.4 9.7 10.6 9 9.9 10.8 9.4 10.9 3 10.5 10.2 10.1 11.1 9.8 12.0 11.6 9.5 9 11.0 9.0 10.6 9.4 10.7 3 O 3 14.6 14.3 13.9 9 13.5 12.4 13.9 13.2 13.8 11.3 11.7 10.9 3 11.4 10.8 10.3 10.5 11.3 10.8 10.9 9 10.8 10.8 10.3 10.7 10.2 3 13.6 12.5 13.1 12.6 12.4 9 12.0 12.2 12.1 12.3 3 12.5 9 11.2 3 12.3 16.2 12.6 13.1 16.1 11.2 15.2 11.9 14.5 9 14.0 14.1 13.1 14.5 8.6 13.4 12.2 3 13.4 12.3 12.4 12.4 12.0 12.3 12.7 12.5 9 12.9 12.9 11.3 3 12.5 12.1 11.2 12.8 13.0 12.7 9 11.8 12.1 12.0 3 8.6 10.6 9.2 10.8 10.5 10.5 10.5 11.4 10.5 9 9.4 10.1 10.1 9.1 9.1 10.0 <J 10.0 9.1 10.8 9.7 11.0 10.6 9 10.3 8.6 10.3 9.0 10.5 11.2 9.9 10.4 9.8 10.4 9.7 10.3 10.0 9.8 10.0 10.5 10.8 10.2 9 9.5 10.0 9.5 <? 9.4 10.6 10.7 8.5 9.4 9.9 10.6 10.5 9 8.6 9.5 8.7 9.0 9.9 9.0 8.0 3 14.4 14.7 14.5 14.0 14.2 12.8 9 13.2 14.3 3 12.2 9 13.2 11.3 12.4 13.9 <J 12.7 12.5 12.6 12.0 11.9 11.6 9 11.3 10.9 10.7 11.4 11.8 10.8 10.8 11.0 15.2 14.7 16.6 16.6 o <? 9.0 9.8 10.0 9.8 10.6 11.1 9.3 8.4 8.8 9 9.6 9.1 9.6 9.2 9.4 10.2 a No litter delivered. b Pups were inadvertently culled and weighed on Day 6; data excluded from statistical analysis, c No female pups. 309 Com pany Sanitized. Does not contain T S C A CBI /""N H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Animal Number 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557s 657558 657559 657560 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Group: VI-0 Dose: 500 mg/kg/day Pup Pup Number Sex 1 2 3 4 5 6 7 8 9 d 13.0 11.4 10.0 9.4 12.1 11.7 9 12.0 11.6 12.2 10.8 10.6 d 11.0 9.4 10.7 10.7 11.1 10.5 10.7 10.9 9 10.3 10.1 10.5 10.4 10.4 3 9.9 11.2 10.1 11.6 10.7 9 11.0 11.0 10.2 10.9 10.2 8.9 9.4 11.6 10.8 3 9.4 9.8 9.6 8.9 9.8 10.0 9 9.9 9.8 10.4 10.6 8.9 10.1 9.6 9.8 9.5 3 12.1 10.5 11.9 8.9 11.2 9 12.5 12.1 10.3 10.7 9.9 9.8 12.6 12.1 <3 8.9 9.2 10.5 10.1 10.1 8.9 10.5 9 9.1 9.8 11.3 9.4 10.2 9.1 9.3 8.4 3 10.4 10.8 10.4 10.8 10.6 10.7 10.4 11.1 10.7 9 9.6 10.3 d 15.1 15.9 16.9 9 16.1 15.8 15.3 16.5 15.8 d 12.3 11.5 10.4 11.4 10.0 11.6 11.2 11.7 9 10.6 11.2 11.0 10.9 d 13.7 14.2 13.7 15.0 9 13.6 13.5 14.4 13.1 13.6 12.9 d 10.8 10.2 10.9 11.1 10.8 9 10.1 10.8 10.2 10.8 11.1 10.6 10.8 d 12.5 10.6 11.0 11.6 9 11.8 10.8 11.4 12.1 11.4 12.0 9.8 9.9 12.3 d 10.6 10.9 11.1 10.9 12.0 11.0 10.4 10.5 10.6 9 11.3 10.3 9.3 10.1 d 14.4 14.0 10.6 9 13.3 13.3 14.2 14.1 13.1 12.0 13.9 d 13.1 13.9 13.8 13.1 14.0 13.2 12.2 9 12.9 12.7 12.0 11.7 12.3 12.5 d 9.6 9.3 11.2 10.3 8.6 9.7 10.1 9.8 9 9.6 9.6 9.8 9.2 10.3 9.6 8.3 d 9 d 11.*8 10.9 10.6 11.5 9.4 9.7 11.1 11.6 9.3 9 9.5 10.8 10.0 d 15.0 13.4 9 13.7 13.9 13.3 14.1 13.0 13.7 14.2 d 11.4 12.0 11.4 10.7 11.4 10.4 10.5 9.3 10.4 9 9.3 10.6 9.9 11.0 a No litter delivered. 310 Com pany Sanitized. Does not contain T S C A CBf H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Individual Pup Weights (grains) : Fi Generation Lactation Day 4 Preculling Group : VIII -0 Dose: 3500 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 8 9 10 .657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 657576 657577 657578 657579 . 657580 657581 657582 657583 657584 657585 S ? 3 $ 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 10.9 10.4 11.0 10.3 12.1 11.9 10.4 9.5 7.6 8.3 10.1 9.6 13.2 12.3 11.0 11.0 9.1 9.1 8.5 9.5 10.1 9.9 12.9 10.2 11.2 11.2 8.4 9.1 13.3 11.9 9.7 9.5 12.2 12.7 9.2 8.8 10.4 10.4 8.6 8.7 9.7 8.4 9.7 9.9 8.8 8.2 8.9 9.1 9.6 10.8 11.8 10.5 9.1 9.7 10.3 8.6 11.3 10.8 9.4 9.8 10.3 10.6 10.2 11.0 8.7 8.6 9.6 8.9 11.8 12.7 11.5 11.3 9.2 9.3 12.9 13.6 9.6 10.0 10.0 9.4 8.3 7.7 7.5 9.1 9.6 10.8 10.7 9.4 9.2 11.8 9.8 11.9 10.3 11.6 10.2 9.6 8.3 10.2 10.4 9.7 7.1 10.6 10.5 11.9 11.4 11.1 9.9 9.2 11.2 12.2 8.2 12.2 12.6 9.6 8.0 13.7 13.1 9.4 9.7 10.7 9.2 9.4 9.4 8.3 9.9 4.4 8.7 8.6 10.4 9.7 11.4 9.3 10.0 9.3 9.9 10.4 11.2 9.8 9.4 11.2 10.1 11.1 11.6 7.8 8.5 10.3 9.3 8.9 9.0 5.6 11.2 12.3 9.3 9.6 13.2 13.0 9.0 8.3 8.7 8.4 9.2 8.8 8.5 .7.4 8.8 9.5 9.8 10.2 10.9 8.8 8.8 11.1 9.8 11.2 8.3 10.2 8.7 12.7 8.5 9.2 10.7 10.7 8.3 9.1 8.6 11 8.5 a No litter delivered. 311 Com pany Sanitized. Does not contain T S C A CBf H-25231: One-Generation Reproduction Study in Rats Animal Number 657491 657492 657493 657494 657495 657496s 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509s 657510 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group : II-O Dose : 0 mg/kg/day Pup Sex 1 Pup Number 234 3 15.0 15.1 9 14.0 14.5 3 11.8 9.2 9.4 10.7 9 8.5 10.2 10.2 9.2 3 10.8 10.9 10.9 11.7 9 10.9 8.1 10.1 6 10.3 11.8 10.4 10.4 9 8.8 9.5 9.9 9.9 3 12.3 11.0 12.7 10.3 9 9.4 11.0 11.2 11.3 3 9 <5 10.3 10.4 10.2 11.1 9 11.4 9.8 11.2 9.5 3 12.8 10.0 12.7 10.4 9 11.2 10.6 11.4 10.5 d 11.4 10.1 11.4 12.6 9 11.6 11.5 11.5 10.6 a 12.4 12.0 12.0 11.7 9 11.8 11.2 12.3 11.1 3 10.4 11.0 10.3 10.9 9 10.4 9.7 10.3 10.2 d 10.9 9.5 9.3 8.3 9 10.3 10.7 11.3 10.0 d 10.9 11.1 11.5 10.7 9 9.8 10.1 9.0 10.6 d 12.2 13.4 11.9 11.9 9 11.6 12.1 11.0 10.2 d 10.6 10.9 10.9 11.9 9 10.2 10.3 11.2 10.3 d 11.4 11.6 11.9 11.6 9 10.3 11.7 11.1 d 11.6 11.5 10.3 10.6 9 10.9 10.1 10.3 10.4 d 11.7 12.3 11.7 11.3 9 11.6 11.0 10.3 11.5 d 9 d 11.4 11.1 9.9 10.3 9 8.2 10.8 9.6 10.2 DuPont-9763 11.1 12.3 a No litter delivered. 312 Company Sanitized, Does not cr-.fain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Animal Number 657516 657517 657518 657519a 657520 657521 657522 657523 657524*' 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534e 657535 Individual Pup Weights (grains): Fi Gnration Lactation Day 4 Postculling Pup Sex Group: IV-0 1 2 Dose : 75 mg/kg/day Pup Number 34 5 3 11.5 10.6 11.3 11.1 ? 10.4 11.1 11.1 9.8 3 11.3 10.0 8.9 9.7 2 9.9 10.8 9.4 10.9 3 10.2 11.1 12.0 11.6 2 9.0 10.6 9.4 10.7 3 2 3 14.6 14.3 13.9 2 12.4 13.2 13.8 11.3 11.7 3 10.8 10.3 11.3 10.9 2 10.8 10.3 10.7 10.2 3 13.6 13.1 12.6 12.4 2 12.0 12.2 12.1 12.3 3 12.5 2 11.2 3 12.3 16.2 12.6 15.2 2 14.0 14.1 14.5 8.6 3 12.3 12.4 12.4 12.0 12.7 2 12.9 12.9 11.3 3 12.5 12.1 11.2 12.8 13.0 2 11.8 12.1 12.0 <3 10.6 10.8 10.5 11.4 2 10.1 10.1 9.1 9.1 3 10.0 9.1 9.7 11.0 2 10.3 8.6 9.9 10.4 3 10.3 10.0 9.8 10.0 10.2 2 9.5 10.0 9.5 <3 10.7 8.5 9.9 10.5 2 9.5 8.7 9.0 9.9 3 14.4 14.7 14.5 14.0 14.2 2 13.2 14.3 d 12.2 2 13.2 11.3 12.4 13.9 3 12.7 12.5 11.9 11.6 2 10.9 11.8 10.8 11.0 <3 15.2 14.7 16.6 16.6 2 <3 9.8 10.0 9.8 10.6 2 9.6 9.2 9.4 10.2 a No litter delivered. b Pups were inadvertently culled and weighed on day 6; data excluded from statistical analysis. c No female pups. 313 Com pany Sanitised. Does not contain T S C A C B I H-25231: One-Generation Reproduction Study in Rats_______ _________________________________ DuPont-9763 Animal Number 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557s 657558 657559 657560 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group: VI-0 Dose : 500 mg/kg/day Pup Sex 3 ? 3 9 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 d 2 d 2 d 2 3 2 <5 2 d 2 3 2 1 11.4 12.0 9.4 10.1 9.9 11.0 9.4 10.6 10.5 12.5 8.9 9.8 10.4 9.6 15.1 16.1 11.5 10.6 13.7 13.6 10.8 10.1 12.5 10.8 12.0 11.3 14.4 13.3 13.9 12.9 11.2 9.6 10.9 9.5 15.0 13.7 11.4 9.3 2 10.0 11.6 10.7 10.5 10.1 10.2 9.8 10.1 11.9 12.1 10.5 9.4 10.8 10.3 15.9 15.8 10.4 11.2 14.2 13.1 10.2 10.8 10.6 12.1 11.0 10.3 14.0 14.2 13.1 12.7 10.3 9.8 10.6 10.8 13.4 13.9 12.0 10.6 Pup Number 34 9.4 12.2 10.5 10.4 11.6 8.9 9.8 9.6 8.9 9.9 8.9 10.2 10.8 12.1 10.8 10.9 10.4 10.7 10.8 10.0 9.8 11.2 9.8 10.5 9.3 10.6 16.9 15.3 10.0 11.0 13.7 13.6 10.9 10.8 11.0 11.4 10.4 9.3 10.6 14.1 14.0 12.3 8.6 9.2 16.5 11.2 10.9 15.0 12.9 11.1 10.6 11.6 9.8 10.5 10.1 13.1 12.2 12.5 9.7 10.3 11.5 10.0 13.3 11.4 9.9 9.7 14.1 10.5 11.0 5 10.7 15.8 13.9 11.6 13.0 6 10.4 13.7 a No litter delivered. 314 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats Animal Number 657566 657567s 657568 657569s 657570 657571 657572 657573 657574 657575s 657576 657577 657578s 657579 657580 657581 657582s 657583 657584 657585 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group: VIII-0 Dose: 3500 mg/kg/day Pup Sex 1 3 11.0 2 10.3 3 2 3 10.4 2 11.9 3 2 3 7.6 2 8.3 3 9.6 2 9.9 3 13.2 2 12.7 3 11.0 2 11.0 3 9.1 2 9.1 3 2 3 13.3 2 11.9 3 9.2 2 9.5 3 2 3 10.4 2 10.4 3 8.6 2 8.7 3 9.7 2 9.1 3 2 3 9.6 2 10.8 3 11.8 2 10.8 3 9.4 2 9.7 2 10.3 10.6 Pup Number 3 11.8 9.8 4 11.2 10.3 11.6 9.5 10.2 11.0 11.6 8.5 8.6 10.2 8.9 12.9 11.9 11.2 11.2 8.4 9.2 9.7 8.3 10.6 10.5 11.8 11.2 11.5 11.3 9.2 8.2 7.8 8.5 10.3 9.3 12.3 12.2 11.1 9.9 9.3 12.2 12.7 9.6 10.0 12.2 12.6 9.6 9.7 13.7 13.2 9.4 8.3 9.7 9.9 10.0 10.7 8.8 4.4 8.4 8.2 8.3 9.4 8.9 7.7 9.2 7.5 8.3 7.4 10.3 8.6 11.3 10.7 10.0 9.2 9.1 9.6 10.8 11.2 9.8 9.3 9.5 9.7 11.4 10.9 8.8 8.8 DuPont-9763 5 11.2 10.7 9.9 -------------------------------a No litter delivered. 315 Com pany Sanitized. Does not contain T S C A CBS H-25231: One-Generation Reproduction Study in Rats Animal Number 657491 657492 657493 657494 657495 657496a 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509a 657510 Individual Pup Weights (grams): F Generation Lactation Day 7 Group: II-O Dose: 0 mg/kg/day Pup Sex 1 Pup Number 234 3 21.7 21.6 5 21.4 18.7 3 15.5 19.4 17.1 17.6 9 15.9 16.0 16.1 17.4 3 17.4 16.1 15.4 16.5 9 15.3 12.6 16.2 3 16.5 16.5 19.2 16.8 9 15.7 16.3 14.2 16.9 3 16.4 17.6 19.4 19.1 9 17.5 17.2 17.4 14.9 3 9 3 20.2 17.9 17.3 17.7 9 17.4 16.0 15.6 17.7 <? 16.1 18.4 17.5 17.4 9 17.5 17.3 17.4 17.6 3 18.5 19.6 18.4 20.2 9 18.6 17.7 18.5 18.4 3 19.3 18.1 19.1 18.5 9 19.2 17.9 19.1 18.0 3 16.2 16.6 16.4 17.1 9 15.0 15.7 15.9 16.2 3 14.1 16.9 16.5 16.1 9 15.7 17.8 16.3 17.7 3 18.4 18.0 16.0 18.8 9 16.2 15.1 17.5 16.4 3 20.1 19.6 20.1 21.4 9 17.3 18.1 19.8 18.0 d 17.8 16.5 16.3 16.0 9 15.3 15.3 15.5 17.0 3 16.9 16.2 17.1 16.0 9 15.8 17.0 14.6 3 19.0 18.9 17.2 19.4 9 17.0 17.4 18.5 18.0 3 19.4 19.1 17.9 19.2 9 18.7 16.8 18.1 18.4 3 9 18.5 15.0 17.4 18.3 9 12.8 17.4 16.0 15.3 DuPont-9763 16.3 16.5 si No litter delivered. 316 Com pany Sanitized. Does not contain T S C A CB? H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Animal Number 657516 657517 657518 657519a 657520 657521 657522 657523 657524-h 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534e 657535 Individual Pup Weights (grams): Fl Generation Lactation Day 7 Group: IV-0 Dose: 75 mg/kg/day Pup Pup Number Sex 1 2 3 4 5 a 18.0 $ 17.4 a 15.4 ? 16.9 a 20.1 9 16.3 3 9 3 21.9 9 20.7 3 18.3 9 16.9 3 18.8 9 18.3 3 17.0 9 16.5 3 18.0 9 11.5 3 19.2 9 17.6 3 19.4 9 17.7 3 17.9 9 15.9 3 16.6 9 15.9 3 17.1 9 16.4 3 16.8 9 14.5 3 20.1 9 20.1 3 17.5 9 15.8 3 19.3 9 17.9 3 23.3 9 3 15.9 9 14.9 17.5 16.4 15.4 15.6 19.0 17.5 22.6 17.7 17.6 16.2 19.0 18.1 19.3 17.9 19.3 19.5 17.2 17.5 18.4 17.0 18.5 17.2 15.5 15.8 14.7 14.3 19.2 20.7 19.4 20.2 18.2 24.0 16.6 15.3 17.6 17.1 17.6 14.9 18.6 16.2 21.8 18.2 17.5 17.6 19.3 18.7 15.1 16.6 18.9 20.0 17.7 17.3 17.4 17.1 16.9 14.9 15.2 14.8 16.9 15.3 20.9 19.6 18.7 18.1 22.8 16.6 15.9 18.5 17.7 14.0 15.6 17.4 17.1 21.2 16.7 17.3 19.2 18.5 15.4 17.1 19.3 18.7 17.7 16.1 15.0 16.8 16.2 15.9 15.6 20.8 18.0 19.9 20.1 22.3 17.4 15.7 19.5 18.5 19.4 16.4 21.8 a No litter delivered. b Pups were inadvertently culled and weighed on day 6; data excluded from statistical analysis, c No female pups . 317 Com pany Sanitized. Does not contain T S C A C BI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Animal Number 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557a 657558 657559 657560 Individual Pup Weights (grams): Fi Generation Lactation Day 7 Group: V I -0 Dose: 500 mg/kg/day Pup Sex 3 2 2 3 2 S 2 5 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 <3 2 <3 2 3 2 <3 2 3 2 1 15.2 18.7 18.0 17.4 18.1 13.6 16.6 16.3 18.4 16.4 15.6 16.1 16.5 16.0 24.8 23.7 15.3 17.5 21.4 21.0 17.4 17.4 18.0 18.0 18.9 17.3 16.8 20.2 21.2 19.4 16.2 14.2 15.2 16.2 21.6 21.0 17.9 15.3 2 16.9 18.3 15.4 17.3 16.0 14.7 17.5 16.9 15.4 19.3 17.8 16.9 16.2 15.5 24.1 22.7 16.5 17.0 23.0 22.3 17.2 16.2 17.5 18.7 17.5 19.0 20.7 21.0 21.5 19.8 13.9 15.8 17.5 16.4 22.5 20.4 19.6 17.9 Pup Number 34 14.4 16.3 16.7 16.9 15.9 17.4 13.5 16.2 18.1 16.1 17.8 15.9 16.4 17.6 17.6 16.6 16.1 16.1 17.9 16.5 15.6 19.0 19.4 15.6 17.4 16.5 21.8 24.0 17.9 17.4 20.6 20.9 17.0 15.8 18.6 15.7 18.0 14.9 21.4 20.6 19.5 21.0 18.4 15.2 23.7 17.5 16.3 22.0 21.0 16.9 16.7 19.8 16.7 20.5 17.2 21.1 20.4 19.3 17.3 16.2 17.9 16.4 20.0 17.4 17.7 17.7 21.3 18.1 16.2 5 16.6 23.8 20.7 17.7 20.6 16.7 20.8 / '" " 'N i ---------------------------------------- ---------- a No litter delivered. 318 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats Animal Number 657566 657567s 657568 657569s 657570 657571 657572 657573 657574 657575s 657576 657577 657578s 657579 657580 657581 657582s 657583 657584 657585 Individual Pup Weights (grams): Fi Gnration Lactation Day 7 Group: VIII-0 Dose: 3500 mg/kg/day Pup Sex 1 d 17.4 9 16.5 d 2 d 17.2 2 13.9 d 9 3 13.3 9 12.1 3 17.6 2 17.2 3 18.6 2 17.6 d 16.1 2 16.1 3 15.1 2 13.4 d 2 d 18.5 9 19.5 d 14.2 2 14.5 d 2 d 14.9 2 15.1 d 11.5 2 12.3 d 13.1 2 10.5 d 2 d 14.3 2 12.9 d 17.2 2 16.6 d 15.1 2 12.9 2 16.5 15.0 Pup Number 3 17.2 15.9 4 17.7 16.2 17.3 16.3 16.3 16.4 15.3 9.2 12.6 16.9 15.1 20.2 19.6 16.4 15.4 13.7 13.4 10.4 9.8 16.1 16.4 20.2 19.3 17.9 15.4, 12.1 12.3 9.1 11.0 16.6 17.0 16.1 15.3 12.6 13.0 20.2 18.7 14.1 12.5 17.8 18.9 14.7 14.2 19.3 17.6 14.6 14.6 14.5 14.3 6.4 11.9 11.0 10.9 13.8 14.3 18.0 18.0 15.0 14.3 15.6 12.6 11.6 13.9 13.0 15.7 16.3 17.2 16.8 13.3 15.6 14.4 12.8 12.8 12.3 11.7 . 13.0 13.2 18.1 16.9 14.7 14.9 DuPont-9763 13.8 18.8 13.8 --------------------------------a No litter delivered. 319 Com pany Sanitized. Does not contain T S C A C B f H-25231: One-Generation Reproduction Study in Rats Animal Number 657491 657492 657493 657494 657495 657496^ 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509a 657510 Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group: II-O Dose: 0 mg/kg/day Pup Sex 1 Pup Number 234 d 38.6 36.5 2 36.8 35.4 d 41.7 38.8 35.4 38.2 ? 37.3 36.5 38.4 34.4 34.4 36.2 34.0 35.7 ? 35.3 34.0 29.7 S 34.9 35.5 38.6 35.4 2 35.5 32.0 35.0 33.4 d 38.1 37.0 40.2 39.7 2 37.7 37.9 38.1 34.4 d 2 d 39.5 37.2 36.5 38.6 2 35.8 36.6 34.3 35.9 d 38.2 39.1 35.8 39.3 2 39.1 37.0 37.0 37.6 d 40.0 38.2 39.0 37.7 2 37.9 38.9 38.5 38.6 d 38.0 38.0 38.4 39.5 2 37.9 35.8 37.8 35.5 d 35.9 38.3 35.1 35.4 2 36.3 34.9 34.7 35.2 d 33.2 36.8 34.3 35.1 2 37.3 34.5 35.1 36.4 d 35.2 38.7 38.3 37.9 2 37.7 35.8 33.2 35.5 d 46.0 43.0 42.5 40.8 2 37.1 38.7 37.8 39.3 d 35.7 37.3 38.9 36.6 2 36.0 33.7 34.7 35.4 d 33.3 36.6 35.0 34.7 2 34.4 34.8 32.4 d 37.7 38.0 38.9 39.2 2 36.6 36.6 37.0 37.1 d 41.7 *40.8 42.6 39.7 2 40.8 40.3 38.8 41.8 d 2 d 33.9 36.7 39.4 34.3 2 27.6 33.9 34.9 30.5 DuPont-9763 5 36.5 35.8 a No litter delivered. 320 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Animal Number 657516 657517 657518 657519a 657520 657521 657522 657523 657524h 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534e 657535 Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group: IV-0 Dose: 75 mg/kg/day Pup Sex 3 ? 3 2 S 2 3 2 3 2 $ 2 3 2 3 2 3 2 3 2 <? 2 3 2 d 2 3 2 6 2 2 d 2 a 2 S 2 <3 2 1 38.1 36.2 32.6 30.7 37.8 34.0 41.5 39.0 34.2 33.9 27.0 25.5 31.0 31.4 41.1 36.4 38.2 39.9 34.7 34.1 39.1 36.7 34.6 34.1 35.8 32.2 34.2 33.4 38.4 38.5 35.2 34.1 37.6 35.9 45.1 37.2 34.8 2 36.4 36.1 30.4 31.0 40.1 34.0 41.9 39.8 34.2 35.3 27.6 26.1 35.3 37.7 34.9 36.5 35.1 33.5 38.9 36.2 34.7 34.4 32.5 34.2 33.6 32.9 37.7 38.6 36.9 39.5 37.6 41.5 37.3 33.6 Pup Number 34 36.3 35.2 29.1 28.1 39.5 35.5 36.0 34.5 30.7 28.7 37.5 36.2 41.9 32.6 36.0 34.2 26.2 24.6 34.0 33.8 33.0 27.3 25.1 34.3 36.6 35.8 35.5 35.9 34.2 38.1 38.9 37.7 33.4 34.6 33.6 33.5 33.0 39.3 38.4 29.7 37.8 37.5 38.0 35.4 32.0 36.2 33.8 31.2 30.9 38.8 38.9 39.6 35.4 41.9 37.0 33.5 38.3 37.5 36.9 42.4 35.8 34.1 5 37.6 35.0 34.5 35.0 38.5 a No litter delivered. b Pups were inadvertently culled and weighed on day 6; data excluded from statistical analysis. c No female pups. 321 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Animal Number 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557 657558 657559 657560 Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group: VI-0 Dose: 500 mg/kg/day Pup Sex 3 9 3 9 3 9 3 9 3 9 3 9 3 9 d 9 3 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 d 9 1 29.5 34.4 33.4 34.8 33.5 34.5 32.5 35.7 38.7 35.2 32.0 33.2 32.9 31.5 43.2 42.4 35.9 34.5 43.4 41.7 34.8 " 34.2 32.5 29.1 35.0 34.6 40.6 38.1 39.0 38.5 34.6 33.9 34.6 31.5 41.5 40.6 37.0 33.5 2 29.7 32.8 32.6 33.4 33.5 29.3 37.2 35.7 37.1 35.6 34.8 34.6 32.3 32.2 43.3 43.6 35.7 33.0 40.4 41.0 35.1 32.8 33.6 32.0 36.3 36.8 35.1 38.9 41.0 39.3 36.4 33.2 33.9 34.0 41.5 40.1 36.4 33.6 Pup Number 34 32.7 32.9 35.5 34.3 33.0 32.9 35.3 34.6 33.9 39.1 33.2 33.6 33.6 33.4 31.0 36.2 36.4 35.1 36.0 36.1 33.3 38.4 39.2 35.1 33.9 34.0 38.3 41.6 32.7 34.0 41.3 40.6 34.6 33.6 31.8 31.8 36.2 30.1 41.2 39.4 39.7 39.2 36.1 31.9 40.2 33.3 34.6 42.5 41.8 34.4 35.2 31.6 28.7 37.0 34.7 39.1 41.6 39.1 28.1 32.6 36.4 30.8 38.0 36.4 36.7 32.3 38.7 38.0 35.6 5 32.1 40.6 39.2 34.0 41.4 31.9 39.7 a Mo litter delivered. 322 Com pany Sanitized. Does not contain T S C A CBf H-25231: One-Generation Reproduction Study in Rats Animal Number 657566 657567a 657568 657569a 657570 657571 657572 657573 657574 6575753 657576 657577 6575783 657579 657580 657581 6575823 657583 657584 657585 Individual Pup Weights (grams): Fi Gnration Lactation Day 14 Group: VIII-0 Dose: 3500 mg/kg/day Pup Sex 1 3 31.2 9 27.0 3 ? 3 27.0 5 31.0 3 9 3 25.5 9 22.1 3 32.5 9 31.6 <3 32.2 9 32.8 3 32.1 9 27.9 3 22.2 9 23.5 <3 9 3 33.0 9 31.3 3 29.4 9 28.2 3 9 3 29.3 9 28.9 3 15.8 9 26.8 3 28.7 9 27.8 3 9 3 25.3 9 26.2 3 31.0 9 32.1 3 28.6 9 25.5 2 30.6 30.3 Pup Number 3 29.9 30.7 4 31.0 28.4 30.7 30.8 32.1 29.0 33.2 19.7 25.9 31.1 30.7 34.7 32.3 31.5 28.8 27.2 25.3 17.8 19.0 29.9 28.6 34.1 31.0 29.8 28.5 23.1 25.7 20.7 29.9 31.8 34.7 28.8 29.0 26.7 24.6 35.6 32.2 28.6 29.9 30.0 33.1 28.5 28.9 32.1 33.0 30.4 26.4 28.2 29.3 26.9 22.6 26.9 23.3 28.8 26.2 22.3 24.3 24.3 28.8 24.3 24.1 26.6 22.3 28.6 29.9 31.3 29.5 28.4 26.3 30.3 26.9 30.7 30.3 25.4 26.5 27.6 27.1 31.2 30.2 28.1 28.3 DuPont-9763 31.7 35.0 27.0 / ' " ' N ---------------------------------------a No litter delivered. 323 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats Animal Number 657491 657492 657493 657494 657495 657496a 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509a 657510 Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group: II-O Dose: 0 mg/kg/day Pup Sex 1 3 57.9 2 56.9 3 59.2 9 53.2 3 64.3 9 53.3 3 55.9 9 56.4 3 62.8 9 60.3 <5 9 3 60.9 9 57.6 3 64.2 9 61.5 3 63.3 9 63.0 3 60.7 9 59.3 3 61.9 9 58.0 3 60.4 9 53.1 3 55.0 9 53.6 3 66.7 9 60.2 3 62.5 9 54.8 3 55.2 9 51.8 3 60.5 9 58.3 <J 64.6 9 60.1 S 9 <3 61.5 9 45.4 2 61.6 57.9 66.9 58.4 59.5 58.3 59.9 55.9 64.9 57.8 Pup Number 3 64.7 57.8 58.5 46.5 62.2 58.6 63.4 54.4 4 55.6 57.1 56.7 56.1 50.3 60.3 59.5 60.1 58.0 62.8 61.6 63.9 59.6 61.3 56.8 57.7 60.4 54.7 58.4 57.9 53.0 66.5 63.1 56.0 58.0 57.1 57.6 58.0 55.4 65.1 63.4 63.9 58.7 61.3 56.8 62.6 62.5 63.4 56.5 57.6 55.8 53.3 59.0 56.1 58.6 67.5 60.1 63.1 50.5 57.9 52.3 58.1 56.2 62.7 62.6 63.9 60.1 56.0 55.2 62.6 59.2 63.3 59.0 56.6 56.5 52.5 54.4 60.4 53.2 69.6 60.0 58.2 57.0 55.9 56.1 57.2 66.5 63.6 64.5 55.7 54.1 56.3 55.8 51.6 DuPont-9763 5 57.8 58.6 _____________________ a No litter delivered. 324 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Animal Number 657516s 657517 657518 657519* 657520 657521 657522 657523 657524e 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534* 657535 Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group: IV-0 Dose: 75 mg/kg/day Pup Sex 3 2 3 $ 3 9 3 9 S 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 3 9 1 58.3 _ 53.5 49.7 60.9 49.5 68.5 56.2 56.4 51.5 49.4 46.9 52.4 53.8 60.9 61.7 57.7 55.8 60.2 59.3 56.9 50.9 58.4 54.5 58.9 54.5 51.6 54.9 67.4 64.6 66.7 67.6 64.5 59.6 72.4 58.2 54.3 2 60.5 56.2 49.5 53.2 56.2 51.3 70.0 66.3 55.1 54.4 51.4 48.5 57.1 59.7 57.8 60.0 61.2 57.9 55.0 50.8 61.7 55.9 56.1 58.3 54.7 51.3 67.1 66.1 64.7 60.9 57.9 73.5 58.7 52.8 Pup Number 34 60.2 57.3 53.3 48.4 57.8 54.5 64.8 55.9 56.2 52.7 62.3 55.7 68.0 60.2 59.6 52.5 50.8 47.4 53.6 57.3 54.7 50.8 46.9 64.2 60.4 62.5 55.6 63.4 56.4 53.6 56.0 54.9 57.1 59.4 56.4 56.2 51.4 67.5 65.1 45.8 56.4 59.8 57.4 50.1 56.2 54.1 58.6 56.6 50.7 69.8 66.3 66.1 61.3 71.0 59.9 52.0 63.5 62.9 56.2 70.0 60.6 54.7 5 65.7 63.3 59.4 56.6 65.9 a One pup was inadvertently not weighed. b No litter delivered. c Pups were inadvertently culled and weighed on day 6; data excluded from statistical analysis. d No female pups. 325 Com pany Sanitized, Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 Animal Number 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557s 657558 657559 657560 Individual Pup Weights (grams): Fi Gnration Lactation Day 21 Group: VI-0 Dose: 500 mg/kg/day Pup Sex 3 $ 3 2 3 2 3 2 s 2 3 2 3 2 <3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 3 2 1 47.3 50.2 54.5 56.6 59.0 56.6 53.0 53.7 58.3 62.6 47.4 48.4 55.9 53.6 64.1 66.6 62.5 54.3 75.6 66.2 55.0 53.2 56.2 50.7 59.9 53.5 55.9 60.7 62.7 59.2 60.4 55.9 49.4 54.7 67.5 63.4 55.8 53.3 2 56.5 54.7 54.9 58.8 56.6 50.8 52.4 52.6 54.4 52.8 56.3 49.0 53.3 49.9 71.0 70.9 50.7 54.2 68.3 67.7 54.3 52.7 56.0 53.8 54.7 46.6 64.3 63.0 65.2 61.1 55.6 51.4 55.9 51.4 71.4 63.4 60.9 54.3 Pup Number 34 46.9 55.3 55.6 53.0 56.9 47.3 52.3 52.1 56.9 60.3 56.0 52.3 56.1 53.7 55.8 56.7 51.8 56.6 60.5 44.8 50.2 60.4 50.9 52.1 52.3 54.4 72.9 69.3 55.9 54.7 72.1 68.3 56.2 56.6 54.6 46.3 57.2 57.6 65.4 63.5 67.0 60.5 45.6 52.2 72.2 58.9 55.1 65.5 67.2 55.0 50.7 57.7 54.2 58.6 52.5 62.4 62.3 60.4 57.5 50.7 54.6 50.4 64.3 61.5 60.2 54.6 60.6 57.5 55.1 5 55.0 68.4 58.9 51.2 65.9 54.6 63.9 ' a No litter delivered. 326 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats Animal Number 657566 657567^ 657568 657569a 657570 657571 657572 657573 657574 657575a 657576 657577 657578a 657579 657580 657581 6575823 657583 657584 657585 Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group: VIII-0 Dose: 3500 mg/kg/day Pup Sex 1 Pup Number 234 3 48.3 46.2 46.6 48.0 9 46.0 41.0 44.9 47.0 <J 9 5 44.4 48.6 52.7 52.4 9 4.8.6 47.0 47.5 6 9 S 23.1 9 26.0 6 51.5 9 43.1 a 54.5 9 51.4 3 49.7 9 47.0 $ 41.1 9 36.2 <5 9 3 52.7 9 56.6 S 44.5 9 39.5 23.3 32.5 50.6 52.6 53.5 50.5 50.8 43.6 32.6 33.9 57.1 55.8 47.3 38.9 27.3 31.1 53.3 49.5 49.0 54.2 49.6 42.1 41.5 36.8 57.3 57.7 43.9 48.2 37.6 33.0 51.3 47.5 45.8 45.4 34.3 39.4 61.7 52.7 42.3 42.7 9 a 46.6 44.7 9 40.3 46.5 47.2 47.7 <3 24.8 36.7 42.9 41.9 9 39.9 36.5 35.4 39.1 3 42.2 35.2 40.7 38.1 9 31.3 35.6 40.8 34.8 <3 9 (3 45.9 9 42.2 43.7 40.1 39.8 45.2 44.2 48.5 49.7 50.8 51.4 50.5 9 51.7 48.4 48.8 46.5 47.1 49.0 41.6 47.6 9 44.8 47.5 44.0 44.0 DuPont-9763 45.4 49.4 49.4 i a No litter delivered. 327 Company Sanitized. Does not contain T S C A CBJ H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX X INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fx GENERATION 328 Company Sanitized. Does not contain T S C A C B i H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fx GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL LACTATION SIGN NUMBER DAY INCIDENCE OBSERVATIONS 6 5 7 4 9 1 NO ABNORMALITIES DETECTED 6 5 7 4 9 2 NO ABNORMALITIES DETECTED 6 5 7 4 9 3 NO ABNORMALITIES DETECTED 6 5 7 4 9 4 NO ABNORMALITIES DETECTED 6 5 7 4 9 5 NO ABNORMALITIES DETECTED 6 5 7 4 9 7 NO ABNORMALITIES DETECTED 6 5 7 4 9 8 NO ABNORMALITIES DETECTED 6 5 7 4 9 9 NO ABNORMALITIES DETECTED 6 5 7 5 0 0 NO ABNORMALITIES DETECTED 6 5 7 5 0 1 NO ABNORMALITIES DETECTED 6 5 7 5 0 2 NO ABNORMALITIES DETECTED 6 5 7 5 0 3 NO ABNORMALITIES DETECTED 6 5 7 5 0 4 NO ABNORMALITIES DETECTED 6 5 7 5 0 5 NO ABNORMALITIES DETECTED 6 5 7 5 0 6 NO ABNORMALITIES DETECTED 6 5 7 5 0 7 NO ABNORMALITIES DETECTED 6 5 7 5 0 8 NO ABNORMALITIES DETECTED 6 5 7 5 1 0 NO ABNORMALITIES DETECTED ! 329 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fx GENERATION GROUP: IV-0 DOSE: 75 MG/KG/DAY ANIMAL LACTATION SIGN NUMBER DAY INCIDENCE OBSERVATIONS 6 5 7 5 1 6 NO ABNORMALITIES DETECTED 6 5 7 5 1 7 NO ABNORMALITIES DETECTED 6 5 7 5 1 8 NO ABNORMALITIES DETECTED 6 5 7 5 2 0 NO ABNORMALITIES DETECTED 6 5 7 5 2 1 NO ABNORMALITIES DETECTED 6 5 7 5 2 2 NO ABNORMALITIES DETECTED 6 5 7 5 2 3 NO ABNORMALITIES DETECTED 6 5 7 5 2 4 NO ABNORMALITIES DETECTED 6 5 7 5 2 5 NO ABNORMALITIES DETECTED 6 5 7 5 2 6 NO ABNORMALITIES DETECTED 6 5 7 5 2 7 NO ABNORMALITIES DETECTED 6 5 7 5 2 8 NO ABNORMALITIES DETECTED 6 5 7 5 2 9 NO ABNORMALITIES DETECTED 6 5 7 5 3 0 NO ABNORMALITIES DETECTED 6 5 7 5 3 1 NO ABNORMALITIES DETECTED 6 5 7 5 3 2 NO ABNORMALITIES DETECTED 6 5 7 5 3 3 NO ABNORMALITIES DETECTED 6 5 7 5 3 4 NO ABNORMALITIES DETECTED 6 5 7 5 3 5 NO ABNORMALITIES DETECTED 330 Com pany Sanitized. Does not contain T S C A CB1 H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fj. GENERATION GROUP: V I - 0 DOSE: 5 0 0 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 6 5 7 5 4 1 NO ABNORMALITIES DETECTED 6 5 7 5 4 2 NO ABNORMALITIES DETECTED 6 5 7 5 4 3 NO ABNORMALITIES DETECTED 6 5 7 5 4 4 NO ABNORMALITIES DETECTED 6 5 7 5 4 5 NO ABNORMALITIES DETECTED 6 5 7 5 4 6 NO ABNORMALITIES DETECTED 6 5 7 5 4 7 NO ABNORMALITIES DETECTED 6 5 7 5 4 8 NO ABNORMALITIES DETECTED 6 5 7 5 4 9 NO ABNORMALITIES DETECTED 6 5 7 5 5 0 NO ABNORMALITIES DETECTED 6 5 7 5 5 1 NO ABNORMALITIES DETECTED 6 5 7 5 5 2 NO ABNORMALITIES DETECTED 6 5 7 5 5 3 NO ABNORMALITIES DETECTED 6 5 7 5 5 4 NO ABNORMALITIES DETECTED 6 5 7 5 5 5 NO ABNORMALITIES DETECTED 6 5 7 5 5 6 NO ABNORMALITIES DETECTED 6 5 7 5 5 8 NO ABNORMALITIES DETECTED 6 5 7 5 5 9 NO ABNORMALITIES DETECTED 6 5 7 5 6 0 NO ABNORMALITIES DETECTED / '" 'N 331 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fi GENERATION GROUP: VIII-0 DOSE: 3500 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 6 5 7 5 6 6 NO ABNORMALITIES DETECTED 6 5 7 5 6 8 NO ABNORMALITIES DETECTED 6 5 7 5 7 0 NO ABNORMALITIES DETECTED 6 5 7 5 7 1 NO ABNORMALITIES DETECTED 6 5 7 5 7 2 NO ABNORMALITIES DETECTED 6 5 7 5 7 3 NO ABNORMALITIES DETECTED 6 5 7 5 7 4 NO ABNORMALITIES DETECTED 6 5 7 5 7 6 NO ABNORMALITIES DETECTED 6 5 7 5 7 7 NO ABNORMALITIES DETECTED 6 5 7 5 7 9 DAY 0 DAY 7 DAY 1 4 1 OF 8 1 OF 7 1 OF 7 1 OF 7 1 OF 7 SUBCUTANEOUS HEMORRHAGE RIGHT REAR LEG(S ) SORE RIGHT REAR LEG( S ) DISCHARGE RIGHT REAR LEG{S ) SORE RIGHT REAR LEG(S ) RIGHT REAR PAW MISSING 6 5 7 5 8 0 DAY 7 DAY 14 1 OF 8 1 OF 8 SMALL WHOLE BODY SMALL WHOLE BODY 6 5 7 5 8 1 NO ABNORMALITIES DETECTED 6 5 7 5 8 3 NO ABNORMALITIES DETECTED 6 5 7 5 8 4 NO ABNORMALITIES DETECTED 6 5 7 5 8 5 NO ABNORMALITIES DETECTED 332 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX Y INDIVIDUAL BODY WEIGHTS OF Fi MALE AND FEMALE RATS 333 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHTS OF Fi MALE AND FEMALE RATS EXPLANATORY NOTES Abbreviations SD = Sacrificed by design FD = Found dead 334 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHTS (grams) OF Fx MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660574 660575 660576 660577 660578 660579 660580 660581 660582 660583 660584 660585 660586 660587 660588 660589 660590 660591 1 61.6 55.6 57.8 56.1 60.3 63.9 56.0 62.6 63.3 56.6 52.5 60.4 69.6 58.2 58.6 56.1 66.5 55.8 8 108.1 92.5 100.6 101.7 102.7 95.8 93.5 107.9 115.8 94.8 86.4 106.2 115.3 105.5 101.4 101.8 111.0 97.6 15 169.8 151.6 162.5 156.8 163.3 158.2 149.8 172.1 181.3 142.6 142.9 171.7 182.7 171.9 160.0 168.5 184.8 154.0 22 240.8 205.5 227.9 212.0 228.9 221.5 209.5 249.3 241.0 195.1 194.7 233.4 257.9 245.5 223.1 233.8 253.2 218.5 29 300.0 265.6 293.7 271.3 296.0 273.9 260.2 326.4 311.5 251.3 244.2 300.4 341.9 315.8 286.9 300.1 321.8 273.4 36 365.7 324.9 360.8 334.5 370.8 333.9 327.2 403.2 373.4 313.6 293.9 367.9 438.3 388.0 354.7 360.4 395.4 333.1 SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) SD (DAY 4 0 ) /""N 335 Company Sanitized. Does not contain T S C A C S i H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHTS (grams) OF Fx MALE RATS GROUP: III-l DOSE: 75 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660592 660593 660594 660595 660596 660597 660598 660599 660600 660601 660602 660603 660604 660605 660606 660607 660608 660609 660610 1 8 15 22 64..8 56..2 62 .,3 68..0 57..3 50..8 52..4 65..1 63,.3 59,.4 57 .4 56 .2 56 .6 56 .6 65,.8 66 .7 62 .9 70 .0 60 .6 116..1 101..6 108.,4 116.,9 98.,6 89.,5 96..5 114..6 102..4 107..8 89,.8 92,.5 98 .0 96 .6 106,.7 119,.0 107,.3 120,.7 103,.8 172..6 163..5 165..5 182..7 149..8 146..2 157..8 180..5 158..1 172..6 146,.8 145..7 155 .1 158 .2 168,.2 188,.4 157 .0 186 .3 165 .5 231.5 236.6 227.2 249.3 210.5 205.9 218.2 244.6 218.2 234.9 207.2 201.1 213.9 225.4 231.0 252.4 227.7 255.7 232.9 29 296.3 300.5 284.4 309.1 280.2 255.3 277.9 310.6 284.2 294.7 267.0 257.6 258.2 292.7 298.2 315.9 287.6 324.0 293.2 36 361.0 367.0 345.0 371.8 346.6 319.9 326.3 367.4 360.1 346.7 336.7 310.9 320.4 361.2 358.5 377.1 352.2 383.5 364.2 SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) 336 Company Sanitized. Does not contain T S C A CB1 H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHTS (grams) OF Fx MALE RATS GROUP: V-l DOSE: 500 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660611 660612 660613 660614 660615 660616 660617 660618 660619 660620 660621 660622 660623 660624 660625 660626 660627 660628 660629 1 53.7 56.7 56.6 44.8 60.4 52.1 54.6 72.9 58.9 65.5 55.0 57.7 58.6 65.4 62.3 57.5 51.2 71.4 57.5 8 94.1 98.5 97.9 86.5 97.0 89.3 95.7 111.3 103.2 113.1 98.6 107.2 100.3 104.3 111.5 94.9 70.9 113.6 98.3 15 155.9 153.1 153.6 147.0 164.6 140.3 154.0 171.4 159.2 177.7 159.8 171.3 160.4 159.2 172.8 157.0 99.5 175.5 161.9 22 222.4 215.4 208.5 208.1 235.4 198.5 221.4 228.4 213.5 236.2 228.0 240.2 223.2 219.4 241.6 229.0 138.9 240.4 230.3 29 284.8 274.1 261.6 269.2 293.3 246.3 284.1 289.4 276.3 297.8 298.9 303.5 283.3 274.6 301.3 297.6 196.7 315.3 287.2 36 347.2 330.6 325.9 326.7 350.2 298.4 351.6 340.8 325.9 347.0 364.9 359.9 345.3 335.1 372.3 363.9 255.7 377.8 345.4 SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) 337 Company Sanitized. Does not contain T S C A C B i H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHTS (grams) OF Fx MALE RATS GROUP: VII-1 DOSE: 3500 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660630 660631 660632 660633 660634 660635 660636 660637 660638 660639 660640 660641 660642 660643 660644 1 48.0 45.4 37.6 51.3 49.0 45.8 34.3 61.7 42.3 44.7 41.9 38.1 44.2 50.5 47.6 8 89.3 79.3 68.7 89.0 84.9 83.5 56.5 105.0 78.3 40.8 77.4 68.6 72.4 93.4 78.0 15 22 145.5 141.0 107.9 148.7 141.3 138.1 101.4 172.5 123.8 89.4 130.7 124.9 117.1 159.9 127.6 206.2 206.8 160.5 215.8 203.2 199.0 154.7 242.2 180.2 147.4 188.3 190.5 165.0 225.1 188.8 29 263.4 267.6 217.5 273.5 264.0 264.6 210.6 312.5 230.7 205.7 244.6 249.5 211.7 287.3 240.6 36 331.7 339.1 274.6 333.5 330.2 329.4 269.0 388.2 280.4 260.6 312.1 310.0 259.3 343.1 300.1 SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) 338 Company Sanitized. Does not contain T S C A CBS H-25231: One-Generation Reproduction Study in Rats DuPont-9763 _ INDIVIDUAL BODY WEIGHTS (grams) OF Fx FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660645 660646 660647 660648 660649 660650 660651 660652 660653 660654 660655 660656 660657 660658 660659 660660 660661 660662 1 57.9 57.1 46.5 50.3 59.5 60.1 55.2 59.2 59.0 56.5 54.4 53.2 60.0 57.0 52.3 57.2 63.6 51.6 8 91.6 94.5 73.7 78.8 97.3 97.4 95.9 97.7 99.3 89.9 90.8 98.7 108.9 96.9 91.3 88.2 105.5 89.5 15 22 129.7 143.7 123.8 126.3 149.0 146.7 142.9 141.9 135.9 132.3 133.7 134.7 164.3 137.2 137.8 144.2 154.8 127.7 162.5 182.4 161.6 160.9 191.9 176.0 176.1 183.0 169.2 160.4 153.9 165.8 210.5 161.5 178.6 206.0 187.3 157.6 29 181.9 198.2 193.3 185.1 212.1 187.1 198.6 218.6 194.7 186.4 178.9 197.3 237.2 195.4 209.9 233.9 211.1 178.8 36 209.5 220.6 227.9 209.6 235.2 200.4 227.6 239.8 218.4 204.8 208.1 213.8 270.2 223.9 248.7 276.9 237.1 213.0 SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) 339 Com pany Sanitized. D oes not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHTS (grams) OF Fi FEMALE RATS GROUP : IV-1 DOSE: 75 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660663 660664 660665 660666 660667 660668 660669 660670 660671 660672 660673 660674 660675 660676 660677 660678 660679 660680 1 55.9 52.7 55.7 65.7 54.7 46.9 53.8 45.8 55.6 56.4 50.1 54.1 56.4 50.7 66.1 63.5 56.2 54.7 8 95.7 84.3 95.3 107.9 90.7 80.4 89.6 81.7 90.1 96.1 88.6 84.9 95.2 85.4 114.5 110.1 89.6 85.2 15 144.9 115.7 136.9 154.6 124.8 126.5 132.3 129.6 132.0 147.3 138.2 123.1 143.2 135.3 150.0 166.4 133.2 126.9 22 177.5 152.8 175.2 192.1 152.2 156.8 166.6 165.7 160.2 179.0 178.9 163.0 178.8 179.8 186.0 196.5 161.4 163.3 29 197.6 167.7 204.1 201.3 171.3 179.4 192.0 189.2 170.5 205.7 215.0 190.2 200.4 205.2 224.4 202.7 179.4 179.6 36 223.3 185.1 228.9 243.2 189.7 200.7 216.3 216.1 198.6 229.0 256.8 210.9 227.8 229.5 241.9 224.3 203.7 197.3 SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) 340 Company Sanitized. Does not conta:n T S C A CBI /" '"N H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHTS (grams) OF Fa FEMALE RATS GROUP: VI-1 DOSE: 500 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660681 660682 660683 660684 660685 660686 660687 660688 660689 660690 660691 660692 660693 660694 660695 660696 660697 660698 660699 1 55.8 51.8 60.5 50.2 50.9 52.3 49.9 68.4 55.1 67.2 50.7 54.2 52.5 58.9 60.4 50.7 50.4 63.9 55.1 8 97.7 80.5 92.7 75.9 93.1 91.9 87.3 104.0 90.5 104.4 87.3 92.1 86.7 94.8 99.4 77.9 66.9 97.2 97.6 15 144.2 123.3 142.9 126.7 141.1 137.1 129.9 151.5 132.9 146.0 136.7 143.7 123.7 133.2 150.7 122.1 110.7 148.0 143.7 22 182.7 157.8 187.9 171.3 177.9 175.3 161.7 180.8 156.1 175.4 182.0 179.7 152.3 171.2 187.4 162.6 154.4 190.4 169.7 29 224.5 183.1 204.0 196.8 198.9 196.2 184.6 211.7 172.6 208.6 213.3 210.7 173.3 195.1 205.3 184.3 184.9 224.9 201.1 36 261.5 210.3 236.0 226.7 227.4 220.1 202.4 232.4 199.1 234.4 249.3 231.9 200.1 225.4 227.4 216.1 210.0 257.9 226.9 SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) 341 Company Sanitized D oes nof contain TSCA CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHTS (grams) OF Fx FEMALE RATS GROUP: VIII-1 DOSE: 3500 MG/KG/DAY DAYS ON TEST: ANIMAL N O . 660700 660701 660702 660703 660704 660705 660706 660707 660708 660709 660710 660711 660712 660713 660714 1 8 15 47.0 47.5 33.0 49.5 49.4 45.4 39.4 52.7 42.7 49.4 39.1 34.8 48.5 46.5 44.0 83.4 125.8 89.5 139.0 46.3 80.6 88.6 137.3 FD (DAY 7) 78.4 115.8 62.9 101.3 82.3 123.1 78.2 120.7 83.3 124.5 74.5 114.5 62.3 104.0 85.1 138.6 83.5 129.1 75.4 118.9 22 163.6 170.0 122.3 180.0 145.5 138.5 159.6 149.6 161.2 149.5 146.0 179.7 167.6 155.4 29 192.7 197.0 158.8 207.9 162.1 166.4 181.3 173.9 195.4 182.7 170.1 206.0 199.8 174.7 36 222.6 221.7 183.0 242.2 SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) 196.0 187.6 209.2 208.2 222.3 209.9 197.7 242.7 229.7 202.3 SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) SD (DAY 40) 342 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX Z INDIVIDUAL BODY WEIGHT GAINS OF lh MALE AND FEMALE RATS 343 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHT GAINS OF FxMALE AND FEMALE RATS EXPLANATORY NOTES Abbreviation = No data 344 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660574 660575 660576 660577 660578 660579 660580 660581 660582 660583 660584 660585 660586 660587 660588 660589 660590 660591 1-8 8-15 15-22 22-29 29-36 1-36 46.5 36.9 42.8 45.6 42.4 31.9 37.5 45.3 52.5 38.2 33.9 45.8 45.7 47.3 42.8 45.7 44.5 41.8 61.7 59.1 61.9 55.1 60.6 62.4 56.3 64.2 65.5 47.8 56.5 65.5 67.4 66.4 58.6 66.7 73.8 56.4 71.0 53.9 65.4 55.2 65.6 63.3 59.7 77.2 59.7 52.5 51.8 61.7 75.2 73.6 63.1 65.3 68.4 64.5 59.2 60.1 65.8 59.3 67.1 52.4 50.7 77.1 70.5 56.2 49.5 67.0 84.0 70.3 63.8 66.3 68.6 54.9 65.7 59.3 67.1 63.2 74.8 60.0 67.0 76.8 61.9 62.3 49.7 67.5 96.4 72.2 67.8 60.3 73.6 59.7 304.1 269.3 303.0 278.4 310.5 270.0 271.2 340.6 310.1 257.0 241.4 307.5 368.7 329.8 296.1 304.3 328.9 277.3 345 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fj, MALE RATS GROUP: III-l DOSE: 75 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660592 660593 660594 660595 660596 660597 660598 660599 660600 660601 660602 660603 660604 660605 660606 660607 660608 660609 660610 1-8 8-15 15-22 22-29 29-36 1-36 51.3 45.4 46.1 48.9 41.3 38.7 44.1 49.5 39.1 48.4 32.4 36.3 41.4 40.0 40.9 52.3 44.4 50.7 43.2 56.5 61.9 57.1 65.8 51.2 56.7 61.3 65.9 55.7 64.8 57.0 53.2 57.1 61.6 61.5 69.4 49.7 65.6 61.7 58.9 73.1 61.7 66.6 60.7 59.7 60.4 64.1 60.1 62.3 60.4 55.4 58.8 67.2 62.8 64.0 70.7 69.4 67.4 64.8 63.9 57.2 59.8 69.7 49.4 59.7 66.0 66.0 59.8 59.8 56.5 44.3 67.3 67.2 63.5 59.9 68.3 60.3 64.7 66.5 60.6 62.7 66.4 64.6 48.4 56.8 75.9 52.0 69.7 53.3 62.2 68.5 60.3 61.2 64.6 59.5 71.0 296.2 310.8 282.7 303.8 289.3 269.1 273.9 302.3 296.8 287.3 279.3 254.7 263.8 304.6 292.7 310.4 289.3 313.5 303.6 346 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fa MALE RATS GROUP: V-l DOSE: 500 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660611 660612 660613 660614 660615 660616 660617 660618 660619 660620 660621 660622 660623 660624 660625 660626 660627 660628 660629 1-8 8-15 15-22 22-29 29-36 1-36 40.4 41.8 41.3 41.7 36.6 37.2 41.1 38.4 44.3 47.6 43.6 49.5 41.7 38.9 49.2 37.4 19.7 42.2 40.8 61.8 54.6 55.7 60.5 67.6 51.0 58.3 60.1 56.0 64.6 61.2 64.1 60.1 54.9 61.3 62.1 28.6 61.9 63.6 66.5 62.3 54.9 61.1 70.8 58.2 67.4 57.0 54.3 58.5 68.2 68.9 62.8 60.2 68.8 72.0 39.4 64.9 68.4 62.4 58.7 53.1 61.1 57.9 47.8 62.7 61.0 62.8 61.6 70.9 63.3 60.1 55.2 59.7 68.6 57.8 74.9 56.9 62.4 56.5 64.3 57.5 56.9 52.1 67.5 51.4 49.6 49.2 66.0 56.4 62.0 60.5 71.0 66.3 59.0 62.5 58.2 293.5 273.9 269.3 281.9 289.8 246.3 297.0 267.9 267.0 281.5 309.9 302.2 286.7 269.7 310.0 306.4 204.5 306.4 287.9 347 Com pany Sanitized. Does not contain T S C A CBf H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx MALE RATS GROUP: VII-1 DOSE: 3500 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660630 660631 660632 660633 660634 660635 660636 660637 660638 660639 660640 660641 660642 660643 660644 1-8 8-15 15-22 22-29 29-36 1-36 41.3 33.9 31.1 37.7 35.9 37.7 22.2 43.3 36.0 -3.9 35.5 30.5 28.2 42.9 30.4 56.2 61.7 39.2 59.7 56.4 54.6 44.9 67.5 45.5 48.6 53.3 56.3 44.7 66.5 49.6 60.7 65.8 52.6 67.1 61.9 60.9 53.3 69.7 56.4 58.0 57.6 65.6 47.9 65.2 61.2 57.2 60.8 57.0 57.7 60.8 65.6 55.9 70.3 50.5 58.3 56.3 59.0 46.7 62.2 51.8 68.3 71.5 57.1 60.0 66.2 64.8 58.4 75.7 49.7 54.9 67.5 60.5 47.6 55.8 59.5 283.7 293.7 237.0 282.2 281.2 283.6 234.7 326.5 238.1 215.9 270.2 271.9 215.1 292.6 252.5 348 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660645 660646 660647 660648 660649 660650 660651 660652 660653 660654 660655 660656 660657 660658 660659 660660 660661 660662 1-8 8-15 15-22 22-29 29-36 1-36 33.7 37.4 27.2 28.5 37.8 37.3 40.7 38.5 40.3 33.4 36.4 45.5 48.9 39.9 39.0 31.0 41.9 37.9 38.1 49.2 50.1 47.5 51.7 49.3 47.0 44.2 36.6 42.4 42.9 36.0 55.4 40.3 46.5 56.0 49.3 38.2 32.8 38.7 37.8 34.6 42.9 29.3 33.2 41.1 33.3 28.1 20.2 31.1 46.2 24.3 40.8 61.8 32.5 29.9 19.4 15.8 31.7 24.2 20.2 11.1 22.5 35.6 25.5 26.0 25.0 31.5 26.7 33.9 31.3 27.9 23.8 21.2 27.6 22.4 34.6 24.5 23.1 13.3 29.0 21.2 23.7 18.4 29.2 16.5 33.0 28.5 38.8 43.0 26.0 34.2 151.6 163.5 181.4 159.3 175.7 140.3 172.4 180.6 159.4 148.3 153.7 160.6 210.2 166.9 196.4 219.7 173.5 161.4 349 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHT GAINS (grains) OF Fi FEMALE RATS GROUP: IV-1 DOSE: 75 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660663 660664 660665 660666 660667 660668 660669 660670 660671 660672 660673 660674 660675 660676 660677 660678 660679 660680 1-8 8-15 15-22 22-29 29-36 1-36 39.8 31.6 39.6 42.2 36.0 33.5 35.8 35.9 34.5 39.7 38.5 30.8 38.8 34.7 48.4 46.6 33.4 30.5 49.2 31.4 41.6 46.7 34.1 46.1 42.7 47.9 41.9 51.2 49.6 38.2 48.0 49.9 35.5 56.3 43.6 41.7 32.6 37.1 38.3 37.5 27.4 30.3 34.3 36.1 28.2 31.7 40.7 39.9 35.6 44.5 36.0 30.1 28.2 36.4 20.1 14.9 28.9 9.2 19.1 22.6 25.4 23.5 10.3 26.7 36.1 27.2 21.6 25.4 38.4 6.2 18.0 16.3 25.7 17.4 24.8 41.9 18.4 21.3 24.3 26.9 28.1 23.3 41.8 20.7 27.4 24.3 17.5 21.6 24.3 17.7 167.4 132.4 173.2 177.5 135.0 153.8 162.5 170.3 143.0 172.6 206.7 156.8 171.4 178.8 175.8 160.8 147.5 142.6 350 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHT GAINS (grains) OF Fx FEMALE RATS GROUP: V I -1 DOSE: 500 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660681 660682 660683 660684 660685 660686 660687 660688 660689 660690 660691 660692 660693 660694 660695 660696 660697 660698 660699 1-8 8-15 15-22 22-29 29-36 1-36 41.9 28.7 32.2 25.7 42.2 39.6 37.4 35.6 35.4 37.2 36.6 37.9 34.2 35.9 39.0 27.2 16.5 33.3 42.5 46.5 42.8 50.2 50.8 48.0 45.2 42.6 47.5 42.4 41.6 49.4 51.6 37.0 38.4 51.3 44.2 43.8 50.8 46.1 38.5 34.5 45.0 44.6 36.8 38.2 31.8 29.3 23.2 29.4 45.3 36.0 28.6 38.0 36.7 40.5 43.7 42.4 26.0 41.8 25.3 16.1 25.5 21.0 20.9 22.9 30.9 16.5 33.2 31.3 31.0 21.0 23.9 17.9 21.7 30.5 34.5 31.4 37.0 27.2 32.0 29.9 28.5 23.9 17.8 20.7 26.5 25.8 36.0 21.2 26.8 30.3 22.1 31.8 25.1 33.0 25.8 205.7 158.5 175.5 176.5 176.5 167.8 152.5 164.0 144.0 167.2 198.6 177.7 147.6 166.5 167.0 165.4 159.6 194.0 171.8 351 Company Sanitized. Does not contain T S C A C B I H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fj. FEMALE RATS GROUP: VIII-1 DOSE: 3500 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660700 660701 660702 660703 660704 660705 660706 660707 660708 660709 660710 660711 660712 660713 660714 1-8 8-15 15-22 22-29 29-36 1-36 36.4 42.0 13.3 39.1 33.0 23.5 29.6 35.5 33.9 35.4 27.5 36.6 37.0 31.4 42.4 49.5 34.3 48.7 37.4 38.4 40.8 42.5 41.2 40.0 41.7 53.5 45.6 43.5 37.8 31.0 41.7 42.7 29.7 37.2 36.5 28.9 36.7 35.0 42.0 41.1 38.5 36.5 29.1 27.0 36.5 27.9 16.6 27.9 21.7 24.3 34.2 33.2 24.1 26.3 32.2 19.3 29.9 24.7 24.2 34.3 33.9 21.2 27.9 34.3 26.9 27.2 27.6 36.7 29.9 27.6 175.6 174.2 150.0 192.7 150.6 148.2 156.5 165.5 172.9 170.8 162.9 194.2 183.2 158.3 352 C om pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX AA INDIVIDUAL FOOD CONSUMPTION OF Fi MALE AND FEMALE RATS 353 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL FOOD CONSUMPTION OF Fi MALE AND FEMALE RATS EXPLANATORY NOTES Abbreviation = No data 354 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL FOOD CONSUMPTION (grams/day) OF Fx MALE RATS GROUP : 1-1 DOSE:: 0 MG/KG/DAY DAYS ON TEST: .ANIMAL NO. 660574 660575 660576 660577 660578 660579 660580 660581 660582 660583 660584 660585 660586 660587 660588 660589 660590 660591 1-8 8-15 15-22 22-29 29-36 1-36 12.6 10.3 12.6 13.0 12.9 10.2 11.4 13.2 14.1 12.5 9.3 13.2 14.1 12.6 13.4 12.0 12.0 12.4 20.0 17.6 20.6 20.8 18.6 18.1 18.2 20.3 20.6 16.0 18.3 20.1 22.6 21.2 18.8 20.9 22.1 18.4 26.4 21.5 25.1 25.7 24.5 23.5 23.7 27.3 25.3 20.3 21.9 25.8 30.0 29.5 24.5 25.3 26.8 23.4 28.3 24.3 28.0 25.9 28.7 25.4 25.4 32.4 27.8 22.5 23.1 27.0 33.8 30.4 26.5 27.9 29.9 25.6 29.8 27.1 30.5 28.5 33.1 28.0 28.7 36.3 30.2 26.3 25.5 31.8 41.4 34.7 30.4 30.9 33.4 29.1 23.4 20.2 23.3 22.8 23.6 21.0 21.5 25.9 23.6 19.5 19.6 23.6 28.4 25.7 22.7 23.4 24.8 21.8 355 Com pany Sanitized. Does not contain T S C A CB H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL FOOD CONSUMPTION (grams/day) OF Fa MALE RATS GROUP: III-l DOSE: 75 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660592 660593 660594 660595 660596 660597 660598 660599 660600 660601 660602 660603 660604 660605 660606 660607 660608 660609 660610 1-8 8-15 15-22 22-29 29-36 1-36 14.9 13.6 13.5 14.1 11.7 11.3 11.9 12.9 13.0 14.5 10.2 19.4 13.3 12.7 12.4 15.9 11.4 15.4 12.3 22.3 18.7 17.9 21.1 17.2 18.4 18.8 21.7 19.9 21.6 18.4 17.2 18.4 19.1 19.5 23.1 16.7 23.1 19.0 25.5 25.7 24.7 26.5 23.3 24.8 24.7 27.2 24.9 26.3 21.3 21.7 23.1 25.7 25.7 28.5 25.0 28.5 25.2 28.2 27.2 25.6 28.4 27.1 25.0 26.6 29.6 29.2 27.6 24.9 24.8 24.7 28.4 29.5 30.1 26.1 30.5 27.9 31.6 30.6 29.4 30.9 31.2 29.4 28.4 31.2 33.8 29.4 28.7 26.6 26.9 31.3 32.2 32.6 30.7 32.5 31.6 24.5 23.1 22.2 24.2 22.1 21.8 22.1 24.5 24.1 23.9 20.7 21.9 21.3 23.4 23.8 26.0 22.0 26.0 23.2 356 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL FOOD CONSUMPTION (grams/day) OF Fx MALE RATS GROUP: V-l DOSE: 500 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660611 660612 660613 660614 660615 660616 660617 660618 660619 660620 660621 660622 660623 660624 660625 660626 660627 660628 660629 1-8 8-15 15-22 22-29 29-36 1-36 11 .8 12 .0 19 .3 11 .4 11 .1 11 .5 12 .4 12 .0 14 .4 12 .6 11 .8 14 .1 13 .1 12 .1 14 .8 10 .8 7 .7 14 .5 12 .5 19 .9 17 .0 17 .6 17 .6 20 .1 16 .5 18 .8 21 .1 20 .9 20 .1 19 .1 20 .5 19 .4 18 .5 20 .5 18 .4 14 .0 22 .0 21 .1 27.4 24.8 22.4 23.8 25.4 21.9 25.4 23.5 23.6 6.6 25.4 25.8 24.1 23.1 26.0 25.0 _a 26.8 26.7 28.8 26.2 24.4 26.4 26.3 24.7 27.7 27.3 27.0 27.5 28.8 26.6 27.0 25.4 29.4 28.4 _a 32.9 28.4 31.2 30.0 28.1 29.0 28.1 27.1 31.6 30.1 28.3 30.1 33.7 28.6 29.8 30.1 33.1 31.4 26.4 32.3 32.3 23.8 22.0 22.4 21.6 22.2 20.3 23.2 22.8 22.8 19.4 23.8 23.1 22.7 21.9 24.7 22.8 _a 25.7 24.2 a Food consumption inadvertently not collected on test day 22. 357 Com pany Sanitized. Does not contain T S C A CBt H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL POOD CONSUMPTION (grams/day) OF Fx MALE RATS GROUP: VII-1 DOSE: 3500 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660630 660631 660632 660633 660634 660635 660636 660637 660638 660639 660640 660641 660642 660643 660644 1-8 8-15 15-22 22-29 29-36 1-36 11.8 9.9 9.9 11.4 10.3 11.1 7.5 12.2 9.9 4.5 10.1 9.4 9.9 11.3 11.1 18.0 18.1 14.4 17.9 17.2 17.9 13.0 20.1 15.5 12.5 16.1 16.2 16.1 19.5 15.8 24.7 23.0 19.0 25.5 23.0 24.1 18.2 27.4 22.6 18.4 21.5 24.1 20.2 26.1 23.2 25.6 26.5 23.4 27.8 26.3 27.2 22.9 29.8 24.5 24.0 24.1 27.2 23.9 30.8 27.1 31.5 31.5 26.5 29.7 28.1 29.6 27.0 34.4 27.4 27.5 28.1 29.4 26.3 30.4 30.3 22.3 21.8 18.6 22.5 21.0 22.0 17.7 24.8 20.0 17.4 20.0 21.3 19.3 23.6 21.5 358 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL FOOD CONSUMPTION (grams/day) OF Fx FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660645 660646 660647 660648 660649 660650 660651 660652 660653 660654 660655 660656 660657 660658 660659 660660 660661 660662 1-8 8-15 15-22 22-29 29-36 1-36 10.9 10.4 9.4 10.9 11.2 12.2 12.5 11.8 11.7 10.8 9.9 14.0 13.6 12.2 11.5 9.1 12.2 10.8 15.4 16.1 16.8 15.8 16.3 17.5 17.4 17.5 15.2 15.5 17.3 16.6 20.5 15.8 16.9 18.1 18.7 15.5 16.9 19.7 19.8 18.9 21.9 18.8 20.4 20.0 17.0 17.6 16.2 19.4 25.3 17.0 20.2 23.6 20.7 17.1 18.3 19.3 22.7 19.6 19.9 17.1 20.6 21.6 17.3 18.0 18.1 20.1 22.2 17.9 19.9 22.8 20.5 19.0 18.8 20.7 22.9 20.0 20.2 17.1 22.1 21.5 18.5 19.0 19.3 20.7 24.6 19.8 21.9 24.7 27.7 20.1 16.1 17.2 18.3 17.0 17.9 16.5 18.6 18.5 15.9 16.2 16.2 18.2 21.3 16.5 18.1 19.7 20.0 16.5 359 Com pany Sanitized. Does not contain T S C A C B i H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL FOOD CONSUMPTION (grams/day) OF Fa FEMALE RATS GROUP: IV-1 DOSE: 75 MG/KG/DAY DAYS ON TEST: .ANIMAL NO. 660663 660664 660665 660666 660667 660668 660669 660670 660671 660672 660673 660674 660675 660676 660677 660678 660679 660680 1-8 8-15 15-22 22-29 29-36 1-36 12.0 10.7 12.3 13.0 10.9 10.2 11.5 10.1 11.7 12.7 10.8 10.3 12.1 11.4 14.3 13.8 10.7 11.5 18.7 13.6 16.6 20.8 15.1 16.1 15.6 16.8 16.6 19.8 17.0 14.9 17.5 18.2 19.1 20.4 15.5 16.4 19.8 17.8 19.4 23.7 16.8 17.6 18.3 20.0 17.1 21.7 19.6 17.6 20.2 20.5 22.2 21.0 18.0 20.6 13.9 16.5 19.8 24.2 16.5 17.7 18.3 20.0 14.5 22.7 24.7 18.7 20.3 21.7 22.4 20.0 18.5 18.4 40.9 17.2 21.9 22.8 15.8 18.3 19.2 21.7 18.6 22.6 22.4 19.7 20.9 15.5 22.8 20.7 20.4 18.0 21.1 15.2 18.0 20.9 15.0 16.0 16.6 17.7 15.7 19.9 18.9 16.3 18.2 17.5 20.1 19.2 16.6 17.0 360 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL FOOD CONSUMPTION (grams/day) OF Fx FEMALE RATS GROUP : VI-1 DOSE : 500 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660681 660682 660683 660684 660685 660686 660687 660688 660689 660690 660691 660692 660693 660694 660695 660696 660697 660698 660699 1-8 8-15 15-22 22-29 29-36 1-36 12.9 8.9 10.6 9.1 11.6 11.8 11.2 11.1 12.6 12.6 10.6 11.2 10.8 11.8 12.2 9.6 8.3 10.8 13.2 17.2 14.8 17.5 16.9 17.8 17.1 15.9 18.7 17.6 16.7 16.5 16.6 15.5 16.6 17.1 14.6 14.5 20.3 18.3 19.7 18.0 20.7 23.2 20.0 19.7 17.5 22.7 18.6 18.4 19.3 19.9 17.9 20.0 19.7 18.6 13.9 22.2 20.1 22.5 18.2 19.6 21.0 20.6 19.6 17.9 23.6 20.5 21.4 20.1 20.5 17.9 21.9 19.4 18.9 19.8 22.9 19.2 23.1 19.7 20.8 21.4 20.0 20.9 17.6 23.8 19.2 22.6 22.3 19.8 19.0 22.2 19.9 20.1 20.6 23.0 21.7 19.1 15.9 17.8 18.3 18.0 17.8 16.0 20.0 17.7 18.3 17.7 17.6 16.2 18.5 17.7 16.4 15.4 19.9 18.5 361 C mpa" y oes no. c o n TSCA c m H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL FOOD CONSUMPTION (grams/day) OF Fx FEMALE RATS GROUP: VIII-1 DOSE: 3500 MG/KG/DAY DAYS ON TEST: ANIMAL NO. 660700 660701 660702 660703 660704 660705 660706 660707 660708 660709 660710 660711 660712 660713 660714 1-8 8-15 15-22 22-29 29-36 1-36 11.0 12.1 6.2 11.4 - 11.0 8.6 10.1 9.5 12.5 10.2 8.5 11.6 10.4 11.0 15.8 17.9 12.0 17.3 - 15.5 12.9 15.4 15.5 16.4 15.0 13.9 18.0 16.9 14.8 19.2 19.2 15.0 20.4 16.3 16.4 18.6 17.4 20.1 17.3 18.4 22.3 18.9 .18.4 20.4 19.1 18.6 21.7 17.5 17.8 18.2 19.1 21.8 19.3 19.3 25.4 20.1 17.6 21.6 21.1 18.5 23.6 18.8 19.0 21.8 21.4 23.1 20.1 20.1 25.6 22.6 19.9 17.6 17.9 14.0 18.9 _ 15.8 14.9 16.8 16.6 18.8 16.4 16.0 20.6 17.8 16.3 362 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX BB INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Ft MALE AND FEMALE RATS 363 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN FxMALE AND FEMALE RATS EXPLANATORY NOTES Note Test Day 1 ==Postnatal Day 21 364 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Fx MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 660574 660575 660576 660577 660578 660579 660580 660581 660582 660583 660584 660585 660586 660587 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 22 22 22 22 25 25 23 23 22 22 23 23 23 23 22 22 22 22 21 21 23 23 23 23 23 23 21 21 365 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Fj. MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY .ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 660588 660589 660590 660591 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 22 22 21 21 23 23 29 29 366 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Fj. MALE RATS GROUP: III-l DOSE: 75 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 660592 660593 660594 660595 660596 660597 660598 660599 660600 660601 660602 660603 660604 660605 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 23 23 21 21 21 21 23 23 22 22 24 24 21 21 21 21 22 22 21 21 25 25 22 22 23 23 22 22 367 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN F i MALE RATS GROUP: III-l DOSE: 75 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 660606 660607 660608 660609 660610 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 20 20 22 22 22 22 21 21 21 21 368 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Fi MALE RATS GROUP: V-l DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 660611 660612 660613 660614 660615 660616 660617 660618 660619 660620 660621 660622 * 660 623 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE ALOPECIA RIGHT FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 21 21 22 22 25 25 22 22 23 23 27 27 22 22 20 20 23 23 21 21 40 40 23 23 22 22 40 40 25 25 369 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Fi MALE RATS GROUP: V-l DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 660624 660625 660626 660627 660628 660629 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 STAINED UNDERBODY YELLOW PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 22 22 22 22 24 24 8 15 32 32 25 25 28 28 370 Com pany Sanitized. Does not contain T S C A CB8 H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN F i MALE RATS GROUP: V I I - 1 DOSE: 3 5 0 0 MG/KG/DAY .ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 660630 660631 660632 660633 660634 660635 660636 660637 660638 660639 660640 660641 660642 660643 660644 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 HUNCHED OVER WEAK PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 23 24 31 22 26 22 25 23 25 6 6 30 28 28 25 25 23 23 24 31 22 26 22 25 23 25 6 6 30 28 28 25 25 23 Company Sanitized. Does not contain T S C A C B I H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Fx FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 660645 660646 660647 660648 660649 660650 660651 660652 660653 660654 660655 660656 660657 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 ALOPECIA BOTH FRONT PAW(S) VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 SWOLLEN LEFT FRONT PAW(S) VAGINAL PATENCY COMPLETE SWOLLEN LEFT FRONT TOE(S) SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 10 10 14 14 11 11 13 13 11 11 12 12 10 10 11 15 11 11 13 13 13 13 11 11 9 22 11 11 29 40 11 11 372 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Fi FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 660658 660659 660660 660661 660662 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 12 12 10 10 13 13 13 13 12 12 373 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Fi FEMALE RATS GROUP: IV-1 DOSE: 75 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 660663 660664 660665 660666 660667 660668 660669 660670 660671 660672 660673 660674 660675 660676 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 10 10 11 11 13 13 10 10 10 10 18 18 18 18 14 14 11 11 10 10 12 12 22 22 12 12 13 13 374 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Fi FEMALE RATS GROUP: IV-1 DOSE: 75 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 660677 660678 660679 660680 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 99 12 12 12 12 12 12 375 Company Sanitized. D oes not contain T S C A C B l H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Fi FEMALE RATS GROUP: VI-1 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 660681 660682 660683 660684 660685 660686 660687 660688 660689 660690 660691 660692 660693 660694 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 16 16 17 17 15 15 14 14 11 11 11 11 13 13 40 40 11 11 11 11 14 14 15 15 11 11 18 18 10 10 376 Com pany Sanitized, Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Fi FEMALE RATS GROUP: VI-1 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 660695 660696 660697 660698 660699 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 12 12 15 15 17 17 99 13 13 377 Company Sanitized. Does not contain T S C A C B i H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Fx FEMALE RATS GROUP: VIII-1 DOSE: 3500 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 660700 660701 660702 660703 660704 660705 660706 660707 660708 660709 660710 660711 660712 660713 660714 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 HUNCHED OVER WEAK FOUND DEAD TEST DAY 7 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 13 12 21 10 6 6 13 . 12 14 13 12 13 15 13 12 20 13 12 21 10 6 6 13 12 14 13 12 13 15 13 12 20 378 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX CC INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA - PxADULTS 379 Com pany Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA - Pj ADULTS Notes EXPLANATORY NOTES Test Days 1-75 Test Days 76-90 = Premating period = Cohabitation period When individual animal data are not reported, it may be due to one of the following reasons or other reasons, all of which are explained in the study records: the sample was clotted (CLOT) there was insufficient sample for testing (QNS) a valid result could not be obtained (RNV) the sample was not suitable for testing the animal died prior to sample collection no sample was available for testing (NSR) Abbreviations: General: ADEQ - adequate DECR - decreased OK - sample condition OK for testing RNV - result not valid UTD - unable to determine Individual Hematology Values: COND - sample condition RBC - red blood cell count HGB - hemoglobin HCT - hematocrit MCV - mean corpuscular volume MCH - mean corpuscular hemoglobin MCHC - mean corpuscular hemoglobin concentration RDW - red cell distribution width ARET - absolute reticulocyte count PLT - platelet count WBC - white blood cell count ANEU - absolute neutrophil (all forms) ALYM - absolute lymphocyte AMON - absolute monocyte AEOS - absolute eosinophil ABAS - absolute basophil ALUC - absolute large unstained cell 380 Company Sanitized. Does not contain T S C A C B l H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA - Pi ADULTS Abbreviations (Continued): EXPLANATORY NOTES Individual Red Blood Cell Morphology Values: NORM - Normal ANIS - anisocytosis MIC - microcytes MAC - macrocytes POLY - polycbromasia HYPO - hypochromasia ECHI - echinocytes ACAN - acanthocytes TARG - Target cells RX - rouleaux HJB - Howell-Jolly body Individual White Blood Cell / Platelet Morphology Values: NORM - Normal SM - Smudge white blood cells TOX - toxic neutrophils DB - Dhle bodies VC - vacuolated cytoplasm BC - basophilic cytoplasm PCE - platelet clumps / estimate GP - giant platelets BP - bizarre platelets Individual Serum and Plasma Chemistry Values: SHEM - serum hemolysis SLIP - serum lipemia SICT - serum icterus AST - aspartate aminotransferase ALT - alanine aminotransferase SDH - sorbitol dehydrogenase PHEM - plasma hemolysis from blood sample for fluoride determination PLIP - plasma lipemia from blood sample for fluoride determination PICT - plasma icterus from blood sample for fluoride determination PFLU - plasma fluoride Individual Urinalysis Values: VOL - volume UFLU - urine fluoride 381 Company Sanitized. D oes n t contain TSCA CBf H-25231: One-Generation Reproduction Study in Rats Animal Number COND RBC xlO //L HGB g/dL ale, Group I - 0 mg/kg/day - Day 74 HOT % 657391 657392 657393 657394 657395 657396 657397 657398 657399 657400 OK OK OK OK OK OK OK OK OK OK 8.40 8.75 8.77 8.45 8.34 8.00 8.24 8.03 8.07 8.45 16.4 16.0 16.4 15.6 16.1 15.3 16.1 14.9 15.8 15.6 48.3 46.2 48.5 45.8 46.6 44.8 47.1 43.4 45.9 46.1 ale, Group III - 75 mg/kg/day - Day 74 657416 657417 657418 657419 657420 657421 657422 657423 657424 657425 OK OK OK OK OK OK OK OK OK OK 8.29 8.21 8.12 8.17 7.81 7.72 8.57 7.80 7.80 7.89 16.5 15.2 15.4 15.7 15.4 14.2 16.1 15.0 15.1 14.8 49.5 45.5 45.1 46.7 44.7 42.7 47.0 43.4 44.0 44.0 Individual Hematology Values MCV MCH MCHC RDW ft, pg g/dL % ARET PLT WBC Xl09/L xl03/fil> xloViiL 57.5 52.8 55.2 54.2 55.9 56.0 57.2 54.1 56.8 54.5 19.6 18.3 18.7 18.4 19.3 19.1 19.5 18.6 19.6 18.4 34.0 34.6 33.8 34.0 34.6 34.1 34.2 34.4 34.5 33.8 12.3 13.5 12.3 13.1 13.0 12.4 12.4 13.1 12.4 13.5 196.8 223.9 180.8 212.1 235.3 193.6 181.5 230.0 160.7 226.8 1178 1260 890 1206 1399 1531 1184 1436 1154 1269 14.75 17.24 15.79 16.72 10.39 18.67 18.92 11.16 11.77 11.07 59.7 55.4 55.6 57.1 57.3 55.3 54.8 55.7 56.5 55.8 19.9 18.6 18.9 19.3 19.7 18.4 18.8 19.3 19.4 18.8 33.4 33.5 34.0 33.7 34.4 33.3 34.3 34.6 34.3 33.7 11.6 13.4 12.3 12.5 11.6 13.8 11.7 12.1 12.6 13.4 209.4 193.3 165.6 190.4 211.4 237.1 176.1 139.3 185.0 234.1 1169 1123 1284 1366 1140 1538 1088 1254 1264 1430 11.83 9.33 18.07 17.08 17.24 11.97 13.72 10.32 12.73 19.68 DuPont-9763 382 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats Animal ANEU ALYM AMON AEOS Number xlOJ/(iL xl03/h xlOV/xL XlO3/h ale. Group I - 0 mg/kg/day - Day 74 657391 657392 657393 657394 657395 657396 657397 657398 657399 657400 1.21 1.70 3.99 2.13 1.59 2.39 2.26 1.70 2.07 1.67 12.SI 14.68 11.17 13.66 8.37 15.62 16.09 9.12 9.21 9.03 0.18 0.43 0.22 0.54 0.15 0.41 0.30 ` 0.20 0.23 0.15 0.09 0.25 0.16 0.19 0.19 0.07 0.10 0.07 0.17 0.09 ale, Group III - 75 mg/kg/day - Day 74 657416 657417 657418 657419 657420 657421 657422 657423 657424 657425 1.49 0.83 2.43 1.44 2.21 1.40 1.53 1.15 1.47 2.86 9.88 8.13 15.02 15.09 14.31 10.07 11.80 8.87 10.82 16.12 0.16 0.14 0.18 0.19 0.47 0.31 0.18 0.14 0.24 0.35 0.14 0.08 0.23 0.19 0.12 0.09 0.10 0.10 0.11 0.14 Individual Hematology Values ABAS ALUC XlO3/h x 103/m 0.19 0.10 0.19 0.09 0.04 0.10 0.08 0.03 0.05 0.06 0.11 0.08 0.06 0.11 0.05 0.08 0.08 0.04 0.05 0.06 0.10 0.12 0.14 0.08 0.06 0.07 0.06 0.03 0.05 0.12 0.06 0.03 0.07 0.09 0.07 0.04 0.05 0.03 0.04 0.09 DuPont-9763 383 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats Animal Number COND RBC ' HGB x 106/m L g/dL ale, Group V - 500 mg/kg/day - Day 74 657441 657442 657443 657444 657445 657446 657447 657448 657449 657450 OK OK OK OK OK OK OK OK OK OK 7.85 8.18 8.21 8.05 7.44 8.29 8.24 7.88 8.05 8.17 14.8 16.0 15.2 15.4 14.3 15.2 16.0 14.7 15.2 15.2 ale, Group VII - 3500 mg/kg/day - Day 657466 657467 657468 657469 657470 657471 657472 657473 657474 657475 OK OK OK OK OK OK OK OK OK OK 8.18 7.77 7.91 8.06 7.73 7.90 8.23 8.03 8.13 7.77 14.9 15.0 15.7 15.6 14.1 14.7 14.8 14.1 15.6 14.7 HCT % 43.9 47.2 44.6 45.1 42.7 45.1 48.4 43.5 45.8 44.6 45.3 43.3 45.7 45.9 42.2 43.9 43.0 41.9 45.8 44.2 Individual Hematology MCV MCH MCHC RDW ARET PLT WBC fL pg g/dL % x 109/L xl03/ML xl03/nL 55.9 57.6 54.4 56.0 57.4 54.4 58.7 55.2 56.9 54.5 18.8 19.6 18.5 19.2 19.3 18.3 19.4 18.7 18.9 18.6 33.7 34.0 34.0 34.2 33.5 33.6 33.0 33.9 33.3 34.1 13.4 12.4 13.4 13.1 13.3 13.3 11.4 12.7 13.5 12.5 179.9 161.7 181.1 202.7 159.9 158.9 181.6 189.2 225.4 169.6 1186 1091 1291 1125 1248 1240 1216 1381 RNV 1238 14.83 11.98 12.99 19.22 12.47 18.29 15.10 11.94 17.28 22.53 55.4 55.7 57.8 57.0 54.5 55.5 52.3 52.2 56.4 56.9 18.2 19.3 19.9 19.4 18.3 18.7 17.9 17.5 19.2 18.9 32.9 34.6 34.4 34.0 33.5 33.6 34.3 33.5 34.0 33.2 14.9 14.7 12.3 13.7 16.8 12.6 13.9 14.6 12.9 13.2 235.0 204.4 153.8 185.5 286.6 147.9 188.1 203.4 152.6 124.5 1163 1404 1159 1224 1421 1259 1277 1412 1205 1010 18.13 15.58 23.14 14.43 18.02 14.30 11.70 15.63 16.22 16.70 DuPont-9763 384 Company Sanitized. Does not contain TS CA CB i H-25231: One-Generation Reproduction Study in Rats Animal Number ANEU ALYM AMON AEOS x 103/m L x 103/iL x 103/m L Xl03/ML ale, Group V - 500 mg/kg/day - Day 74 657441 657442 657443 657444 657445 657446 657447 657448 657449 657450 2.47 0.78 1.18 2.16 1.43 1.21 1.58 3.08 1.88 1.81 11.82 10.82 11.36 16.39 10.72 16.64 13.06 8.33 14.63 19.95 0.26 0.11 0.13 0.25 0.13 0.16 0.19 0.33 0.24 0.39 0.14 0.10 0.15 0.19 0.06 0.11 0.15 0.10 0.39 0.11 ale, Group VII - 3500 mg/kg/day - Day 74 Individual Hematology Values ABAS ALUC x 103/m L x 103/m L 0.08 0.10 0.11 0.13 0.07 0.09 0.05 0.04 0.05 0.13 0.06 0.07 0.07 0.11 0.05 0.09 0.07 0.05 0.08 0.14 657466 657467 657468 657469 657470 657471 657472 657473 657474 657475 3.76 2.19 1.71 2.57 2.72 1.12 1.75 2.21 2.25 2.47 13.59 12.85 20.75 11.28 14.63 12.84 9.41 12.74 13.44 13.62 0.30 0.20 0.21 0.23 0.33 0.15 0.28 0.40 0.32 0.25 0.24 0.18 0.20 0.13 0.07 0.07 0.15 0.16 0.09 0.11 0.14 0.08 0.13 0.14 0.15 0.07 0.06 0.06 0.05 0.10 0.10 0.08 0.14 0.07 0.12 0.06 0.05 0.06 0.08 0.15 DuPont-9763 385 Company Sanitized. Does not contain TS CA CBI H-25231: One-Generation Reproduction Study in Rats Animal Number COND RBC x 106/mL HGB g/dL HCT % Female, Group II - 0 mg/kg/day - Day 75 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 OK OK OK OK OK OK OK OK OK OK 7.44 7.93 8.47 7.87 8.26 7.94 7.88 8.39 8.42 7.92 15.3 16.3 16.3 15.7 15.8 15.3 16.0 17.1 16.5 15.5 43.6 46.5 47.5 44.3 45.1 43.2 45.4 48.3 46.8 43.4 Female, Group IV - 75 mg/kg/day - Day 75 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 OK OK OK OK OK OK OK OK OK OK 8.00 7.80 7.89 7.89 8.11 8.14 7.60 8.04 8.26 8.50 16.0 16.0 15.6 15.5 16.0 15.9 14.8 16.4 16.6 16.8 47.4 44.6 43.7 44.4 46.7 44.5 42.5 46.0 46.7 46.9 Individual Hematology Values MCV MCH MCHC RDW fL pg g/dL % ARET X l 0 9/L PLT x 1 0 3/m L WBC x 1 0 3/ m L 58.6 58.6 56.1 56.2 54.6 54.4 57.6 57.6 55.6 54.8 20.5 20.6 19.3 19.9 19.1 19.2 20.3 20.4 19.6 19.6 35.0 35.2 34.4 35.5 34.9 35.3 35.2 35.5 35.3 35.7 10.7 11.2 11.3 10.7 11.1 11.1 10.9 10.8 11.6 12.0 124.2 120.7 194.2 160.1 164.9 140.7 157.1 208.7 155.6 193.1 RNV 1249 964 1441 1280 998 RNV 959 1330 1172 9.30 9.33 11.41 9.57 13.07 8.08 10.95 7.10 9.40 8.43 59.2 57.2 55.4 56.3 57.5 54.7 56.0 57.2 56.6 55.2 20.0 20.5 19.8 19.7 19.8 19.6 19.4 20.4 20.1 19.8 33.7 35.9 35.8 35.0 34.4 35.8 34.7 35.7 35.5 35.8 10.8 11.2 11.3 11.6 11.2 10.9 11.1 11.0 10.7 10.5 110.6 190.3 228.4 117.5 173.9 179.0 135.6 203.5 179.9 153.8 1087 1000 1311 RNV 1036 1101 1171 1169 1209 RNV 9.57 13.22 12.09 12.76 11.28 10.40 11.79 15.03 12.04 10.65 DuPont-9763 386 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats Animal Number ANEU ALYM AMON AEOS xl03/ML x I O V m L x 103/m L x 103/m L Female, Group II - 0 mg/kg/day - Day '75 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 0.90 0.52 1.36 1.03 1.57 0.73 0.93 0.62 0.69 1.38 7.96 8.37 9.56 8.05 10.93 6.97 9.58 6.24 8.44 6.81 0.20 0.14 0.22 0.18 0.22 0.15 0.11 0.08 0.10 0.08 0.17 0.14 0.13 0.19 0.12 0.13 0.17 0.07 0.12 0.09 Female, Group IV - 75 mg/kg/day - Day 75 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 0.29 1.79 1.36 0.45 0.98 1.12 0.65 0.64 0.63 0.54 8.81 11.01 10.29 11.89 9.81 8.96 10.73 13.94 11.00 9.50 0.20 0.21 0.22 0.16 0.20 0.12 0.09 0.11 0.14 0.30 0.14 0.09 0.10 0.10 0.15 0.10 0.10 0.12 0.11 0.17 Individual Hematology Values ABAS ALUC x 103/m L x 103/m L 0.03 0.09 0.04 0.08 0.14 0.06 0.09 0.05 0.02 0.03 0.05 0.06 0.09 0.06 0.09 0.04 0.06 0.04 0.02 0.04 0.05 0.06 0.08 0.10 0.10 0.04 0.13 0.09 0.09 0.06 0.07 0.06 0.05 0.06 0.05 0.06 0.09 0.12 0.08 0.08 DuPont-9763 387 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats Animal Number COND RBC xlOVuL HGB g/dL HCT % smale, Group VI - 500 mg/kg/day - Day 75 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 OK OK OK OK OK OK OK OK OK OK 8.12 7.98 8.34 8.73 7.30 8.24 8.28 7.45 8.46 8.25 16.7 15.3 16.2 16.4 15.5 16.0 *15.4 15.2 16.9 16.2 48.6 44.2 46.0 47.6 43.1 47.0 44.9 42.6 47.9 46.6 amale, Group VIII - 3500 mg/kg/day - Day 75 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 OK OK OK OK OK OK OK OK OK OK 7.81 7.71 8.13 7.55 7.55 8.15 7.66 7.93 8.00 8.20 15.3 14.7 16.2 14.7 15.6 16.4 15.0 14.8 15.9 16.1 44.5 42.5 45.1 42.2 43.8 47.0 42.8 43.0 45.2 45.8 Individual Hematology Values MCV MCH MCHC RDW L pg g/dL % ARET Xl09/L PLT WBC x 103//iL xl03/ML 59.9 55.4 55.2 54.6 59.1 57.0 54.3 57.2 56.6 56.4 20.5 19.2 19.4 18.8 21.2 19.4 18.5 20.4 20.0 19.6 34.2 34.7 35.1 34.5 35.9 34.1 34.2 35.7 35.4 34.8 11.4 11.6 10.9 11.0 11.2 10.8 11.0 10.9 10.8 11.1 187.6 155.4 204.3 152.1 197.1 193.9 213.9 164.9 135.5 138.1 887 1096 1125 970 1265 1223 1403 1420 1084 929 10.82 7.95 14.17 10.55 9.85 9.42 15.64 11.27 11.45 15.30 57.0 55.1 55.4 55.9 58.0 57.7 55.8 54.3 56.5 55.9 19.6 19.1 19.9 19.5 20.6 20.2 19.5 18.6 19.9 19.6 34.3 34.7 35.9 34.9 35.5 35.0 35.0 34.3 35.2 35.0 12.1 11.7 11.6 12.0 10.8 11.5 11.1 11.6 11.4 11.1 222.7 158.4 147.4 210.8 154.9 146.8 155.9 169.8 183.2 115.8 1024 1249 1091 996 1174 1235 1315 1278 883 841 12.11 15.64 11.56 12.05 12.79 12.54 11.87 13.63 16.63 7.45 DuPont-9763 388 Company Sanitized. Does not contain TSCA CBJ H-25231: One-Generation Reproduction Study in Rats Animal Number ANEU ALYM AMON AEOS x 103//jL xl03/,ul, xl0V/iL x I O V m L Female, Group VI - 500 mg/kg/day - Day 75 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 1.51 0.50 4.03 0.63 1.06 1.52 5.67 0.49 1.15 1.14 8.83 7.13 9.31 9.41 8.42 7.58 9.15 10.36 9.54. 13.59 0.21 0.14 0.41 0.23 0.14 0.16 0.58 0.09 0.34 0.15 0.21 0.09 0.30 0.16 0.11 0.07 0.14 0.18 0.24 0.27 Female, Group VIII - 3500 mg/kg/day - Day 75 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 1.09 1.53 2.08 1.17 1.64 1.22 1.49 1.50 1.86 0.94 10.55 13.42 8.76 10.39 10.59 10.85 9.77 11.31 14.11 6.15 0.12 0.27 0.26 0.15 0.21 0.20 0.33 0.55 0.28 0.12 0.19 0.18 0.32 0.20 0.17 0.13 0.14 0.27 0.19 0.14 Individual Hematology Values ABAS ALUC x 103/m L xlO3/L 0.02 0.06 0.06 0.09 0.09 0.06 0.06 0.07 0.10 0.07 0.04 0.04 0.06 0.04 0.03 0.03 0.04 0.07 0.09 0.07 0.08 0.14 0.09 0.07 0.09 0.09 0.08 0.00 0.13 0.07 0.07 0.10 0.04 0.08 0.08 0.05 0.06 0.00 0.06 0.05 DuPont-9763 389 Company Sanitized. Does not contain TSCA CBI H-25231: One-Generation Reproduction Study in Rats Individual Red Blood Cell Morphology Values Animal Number NORM ANIS MIC MAC POLY HYPO ECHI ACAN TARG Male/ Group I - 0 mg/kg/day - Day 74 657391 NO - - - TRACE FEW 657392 NO - - - TRACE TRACE FEW - 657393 NO - - - TRACE _ TRACE TRACE - 657394 NO - _ - TRACE - - MANY - 657395 NO - _ _ TRACE - - FEW - 657396 NO - _ TRACE - FEW FEW - 657397 NO - - - TRACE - FEW FEW - 657398 NO - - FEW - - MANY - 657399 NO - _ TRACE 657400 NO TRACE _ MODERATE MANY _ ale, Group III - 75 mg/kg/day* - Day 74 657416 NO _ _ _ TRACE -- -- -- -- 657417 NO - - - TRACE - MODERATE MANY - 657418 NO - - - TRACE - - TRACE - 657419 NO - - _ FEW - - MODERATE - 657420 NO - - - TRACE - FEW FEW _ 657421 NO - _ _ FEW - - MANY - 657422 NO - - _ TRACE - - TRACE - 657423 NO - - _ TRACE - - MODERATE - 657424 NO - - - TRACE - FEW MANY - 657425 NO - - ~ TRACE - TRACE MODERATE - RX HJB - -. - - - - - - _ ----------- DuPont-9763 390 Company Sanitized. Does not contain TS CA CBI )--------- ------------- ' 1 H-25231: One-Generation Reproduction Study in Rats_____________________ Animal Number NORM ANIS MIC Individual Red Blood Cell Morphology Values MAC POLY HYPO ECHI ACAN TARG Male, Group V - 500 mg/kg/day - Day 74 657441 657442 657443 657444 657445 657446 657447 657448 657449 657450 NO NO NO NO NO NO NO NO NO NO TRACE - - TRACE - - - - - ~ - _ - - - - - TRACE TRACE TRACE FEW TRACE TRACE TRACE FEW TRACE TRACE _ TRACE MODERATE - - FEW FEW - - - MANY - - _ FEW - - - MANY - - FEW MANY - -- - - - MODERATE - - MANY - - - FEW - Male, Group VII - 3500 mg/kg/day - Day 74 657466 657467 657468 657469 657470 657471 657472 657473 657474 657475 NO NO NO NO NO NO NO NO NO NO TRACE - TRACE TRACE - - _ TRACE *TRACE - - - - TRACE - - - - FEW TRACE TRACE TRACE FEW TRACE TRACE FEW TRACE TRACE FEW FEW FEW - - - - - TRACE FEW - - FEW - MANY MANY MODERATE MANY FEW MANY MANY MODERATE FEW - - - RX - - - HJB - - _ - DuPont-9763 391 Compan, s .,, Bi2ed. o ., not CM,ata ^ ^ y-- -- " ' ) H-25231: One-Generation Reproduction Study in Rats_____________________ Individual Red Blood Cell Morphology Values Animal Number NORM ANIS MIC MAC POLY HYPO ECHI ACAN TARG RX HJB Female, Group II - 0 mg/kg/day - Day 75 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 NO NO NO NO NO NO NO NO NO NO --- - -1- ----- -- - - - - - TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE - FEW TRACE - ---- _- - - - TRACE TRACE -- ---- ~--- ---- - FEW TRACE - - - MODERATE - Female, Group IV - 75 mg/kg/day - Day 75 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 NO NO NO NO NO NO NO NO NO NO _ ~ - _ -- _ - TRACE TRACE FEW TRACE TRACE TRACE TRACE TRACE TRACE TRACE _ -- TRACE TRACE TRA- CE - TRACE TRACE TRA- CE FE- W TRA- CE - - -- - -_ ---------- ------ TRACE --~ --- DuPont-9763 392 Company Sanitized. Does not contain TS CA CBl H-25231: One-Generation Reproduction Study in Rats Individual Red Blood cell Morphology Values Animal Number NORM ANIS MIC MAC POLY HYPO ECHI ACAN TARG RX HJB Female, Group VI - 500 mg/kg/day - Day 75 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 NO NO NO NO NO NO NO NO NO NO - - - - - - - - Female, Group VIII - 3500 mg/kg/day - Day 75 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 NO NO NO NO NO NO NO NO NO NO _ - _ - _ - _ - TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE - MODERATE - - - TRACE - TRACE TRACE -- - ~-- -_- - FEW TRACE - - TRACE --- - - TRACE _ TRACE TRACE _ - FEW --- - TRACE - --- -- - -- - - - FEW - - TRACE - - TRACE _ - - - - - - ----- TRACE ------ ---- --- -- -- -- -- -- DuPont-9763 393 Company Sanitized. Does not contain TSCA CBI H-25231: One-Generation Reproduction Study in Rats Individual White Blood Cell / Platelet Morphology Values Animal NORM SM TOX DB VC BC PCE GP BP Number Male, Group I - 0 mg/kg/day - Day 74 657391 YES - - - - -- -- 657392 YES - - - - ---- 657393 YES - - - - - -- 657394 YES - ~- --- -- 657395 YES - _ _ -__ -_ 657396 YES - - _ - _ - - _ 657397 YES - - _ -_ ___ 657398 YES - - _ -_ -__ 657399 YES - _ -_ _ ,, _ 657400 YES " - - - - - - - Male, Group III - 75 mg/kg/day - Day 74 657416 YES _ _ _ ___ _ _ 657417 YES - - _-_ _-- 657418 YES __- _ _ _ - 657419 YES - _ _ -_ _ _ 657420 YES - _ _ _ _ _- 657421 YES - _ - - _ _ _ - 657422 YES - _ _ _ _ _- 657423 YES - _ _ - - _ _ - 657424 YES ,, __- _ __ 657425 YES _ _ _ __ __ DuPont-9763 394 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats Individual White Blood Cell / Platelet Morphology Values Animal NORM SM TOX DB VC BC PCE GP BP Number Male, Group V - 500 mg/kg/day - Day 74 657441 YES - ---- -- 657442 YES - - - - - - - - 657443 YES - _ _ - _ _ _ - 657444 YES - ----- -- 657445 YES - -- - - 657446 YES - --_ __ 657447 YES - - _ - - - - - 657448 YES - - - - - - - - 657449 NO - _ _ - - YES/DECK - - 657450 YES -- --- -- Male, Group VII - 3500 mg/kg/day - Day 74 657466 YES _ _ _ ___ _ 657467 YES - - - - - - - - 657468 YES -_-- - -- 657469 YES - __- - -- - 657470 YES - -_----- 657471 YES - - - - - - - - 657472 YES - _ - _ --- 657473 YES - _ - _ - - - - 657474 YES _ _ -- - -- 657475 YES _ _ ____ - DuPont-9763 395 Company Sanitized. Does not contain T S C A CBI ;3 1 J H-25231: One-Generation Reproduction Study in Rats_____________________ Individual White Blood Cell / Platelet Morphology Values Animal NORM SM TOX DB VC BC PCE GP BP Number Female, Group II - 0 mg/kg/day - Day 75 657491 NO - - - - - YES/UTD - - 657492 YES - - - - - - - - 657493 YES - _ _ - - - - - 657494 YES - _ _ _ - - - - 657495 YES - _ _ _ - - _ - 657496 YES - - - - - -- 657497 NO - - - - - YES/DECR - - 657498 YES - - - - - - - - 657499 YES - - -- _ -- 657500 YES - - _ - - _ - - Female, Group IV - 75 mg/kg/day - Day 75 657516 YES - - - - - - - - 657517 YES - _ - _ - - - - 657518 YES ~ -_ -_ - 657519 NO - - - - - YES/ADEQ - - 657520 YES - - - - - _ - - 657521 YES - - - _ - -- 657522 YES - - - - - - - - 657523 YES - - - ~ - _ - - 657524 YES - _ - - _ -- 657525 NO - - - _ - YES/UTD - - )` DuPont-9763 396 Company Sanitized. Does not contain TSCACBI H-25231: One-Generation Reproduction Study in Rats Animal Number NORM SM Individual White Blood Cell / Platelet Morphology Values TOX DB VC BC PCE GP BP Female, Group VI - 500 mg/kg/day - Day 75 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 YES YES YES YES YES NO YES YES YES YES ___ ___ ___ - ,___ ___ --- -___ - -- _ _ _ _ _ - _ ___ ___ ___ _ _ _ _ _ -- _ -- ___ TRACE ---- ___ -- - Female, Group VIII - 3500 mg/kg/day - Day 75 657566 YES - - - - - - - - 657567 YES - - - - - - - - 657568 YES - - - - - - - - 657569 YES - 657570 YES - - - - - - - - 657571 YES 657572 YES _ _______ 657573 YES - 657574 YES - -- -- -- - 657575 YES - -- -- -- - DuPont-9763 Company Sanilfced. D o conlain TSCA CBI H-25231: One-Generation Reproduction Study in Rats Animal Number SHEM SLIP SICT Individual Serum and Plasma Chemistry Values AST ALT SDH U/L U/L U/L Male, Group I - 0 mg/kg/day - Day 74 657391 657392 657393 657394 657395 657396 657397 657398 657399 657400 NONE TRACE NONE TRACE SMALL NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 70 100 74 65 80 80 80 73 84 84 28 11.8 32 1.2 37 17.9 33 11.3 29 8.8 31 14.1 38 13.0 28 11.6 26 10.4 25 9.2 Male, Group III - 75 mg/kg/day - Day 74 657416 657417 657418 657419 657420 657421 657422 657423 657424 657425 SMALL NONE TRACE TRACE NONE TRACE NONE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 76 66 72 97 114 79 98 90 67 88 33 11.1 31 13.8 35 9.9 37 8.7 51 29.8 38 12.7 47 13.4 34 19.1 34 12.4 50 15.5 DuPont-9763 398 Company Sanitized. Does not contain TS CA CBf H-25231: One-Generation Reproduction Study in Rats Animal Number SHEM SLIP SICT Individual Serum and Plasma Chemistry Values AST ALT SDH U/L U/L U/L Male, Group V - 500 mg/kg/day - Day 74 657441 657442 657443 657444 657445 657446 657447 657448 657449 657450 TRACE NONE TRACE NONE NONE NONE SMALL TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE _ NONE ' NONE 86 80 67 72 70 71 73 114 116 60 49 11.7 30 13.6 29 11.8 35 13.7 36 15.7 34 11.2 29 12.9 61 15.3 60 29.7 27 12.0 Male, Group VII - 3500 mg/kg/day - Day 74 657466 657467 657468 657469 657470 657471 657472 657473 657474 657475 NONE TRACE TRACE SMALL SMALL NONE TRACE NONE SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 69 94 75 92 82 81 71 67 67 102 45 15.0 39 6.9 32 13.0 54 7.5 40 12.7 43 18.0 39 16.0 35 14.2 35 6.7 37 16.1 DuPont-9763 399 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats Animal Number PHEM PLIP PICT individual Serum and Plasma Chemistry Values PFLU Mg/mL Male, Group I - 0 mg/kg/day - Day 116 657391 657392 657393 657394 657395 657396 657397 657398 657399 657400 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Male, Group III - 75 mg/kg/day - Day 116 657416 657417 657418 657419 657420 657421 657422 657423 657424 657425 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.1 DuPont-9763 400 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats Individual Serum and Plasma Chemistry Values Animal Number PHEM PLIP PICT PPLU Mg/mL Male, Group V - 500 mg/kg/day - Day 116 657441 657442 657443 657444 657445 657446 657447 657448 657449 657450 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.2 0.2 0.2 0.2 0.2 0.2 0.1 0.2 0.2 Male, Group VII - 3500 mg/kg/day - Day 116 657466 657467 657468 657469 657470 657471 657472 657473 657474 657475 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE .NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.3 0.5 0.5 0.5 0.4 0.4 0.3 0.2 0.3 0.5 DuPont-9763 Company Sanitized. Does not contain TSCA CBI H-25231: One-Generation Reproduction Study in Rats Animal Number SHEM SLIP SICT Individual Serum and Plasma Chemistry Values AST ALT SDH U/L U/L U/L Female, Group II - 0 mg/kg/day - Day 75 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 NONE NONE NONE NONE NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 78 78 109 113 71 95 75 114 83 89 Female, Group IV - 75 mg/kg/day - Day 75 43 15.4 31 15.2 34 9.0 32 11.8 32 11.9 52 13.0 28 17.0 52 12.2 26 14.3 25 12.2 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 77 83 83 95 118 65 62 70 96 81 36 13.6 31 13.5 46 15.7 38 18.4 73 17.8 34 12.2 32 9.9 35 11.1 51 19.1 25 13.8 DuPont-9763 402 Company Sanitized. Does not contain TSCA CBJ H-25231: One-Generation Reproduction Study in Rats Individual Serum and Plasma Chemistry Values Animal SHEM SLIP SICT AST ALT SDH Number U/L U/L U/L Female, Group VI - 500 mg/kg/day - Day 75 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 101 59 83 77 87 69 80 70 84 75 33 23.6 33 16.1 35 14.3 41 14.7 45 17.8 30 11.8 36 15.6 25 13.2 37 12.7 31 13.3 Female, Group VIII - 3500 mg/kg/day - Day 75 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE . NONE NONE NONE NONE 81 74 80 92 74 90 127 87 90 221 29 10.8 34 13.4 33 12.0 30 9.7 28 14.4 51 18.0 63 22.1 40 12.8 51 20.5 131 59.5 DuPont-9763 403 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats Animal Number UFLU M9 Male, Group I - 0 mg/kg/day - Day 116 657391 657392 657393 657394 657395 657396 657397 657398 657399 657400 11.8 17.1 21 9.8 9.9 8.7 9.4 8.6 14.2 10.4 Male, Group III - 75 mg/kg/day - Day 116 657416 657417 657418 657419 657420 657421 657422 657423 657424 657425 46.6 50.4 40.9 61.8 50.4 70.3 54.9 58.5 43 61.7 Individual Urinalysis Values DuPont-9763 404 Company Sanitized. Does not contain TSCA CBI ) H-25231: One-Generation Reproduction Study in Rats ) Animal Number UFLU ng Male, Group V - 500 mg/kg/day - Day 116 657441 657442 657443 657444 657445 657446 657447 657448 657449 657450 122.9 156.3 198.4 174.3 200.6 132.6 220.5 136.8 235.8 183.1 Male, Group VII - 3500 mg/kg/day - Day 116 657466 657467 657468 657469 657470 657471 657472 657473 657474 657475 441.7 789.7 526.3 503.3 439.9 375.2 508.8 530.1 528.6 480.7 Individual Urinalysis Values ) DuPont-9763 405 Company Sanitized. Does not contain TSCA CB I H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX DD INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS 406 Company Sanitized. Does not contain T S C A CBI i-,tffKik H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pj. ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grains) FROM MALE RATS GROUP : ANIMAL NUMBER 657391 657392 657393 657394 657395 657396 657397 657398 657399 657400 657401 657402 657403 657404 657405 657406 657407 657408 657410 I-0 - 0 mg/kg/day FINAL BODY . LIVER 571.2 605.2 597.3 632.7 579.9 558.1 482.3 593.8 558.8 550.4 607.4 555.3 521.5 752.6 667.9 689.6 656.7 538.3 549.9 15.017 18.906 15.077 16.847 15.191 14.429 12.496 16.220 15.593 13.369 19.982 18.107 14.512 24.917 23.362 23.011 21.694 17.058 19.181 KIDNEYS 3.766 4.527 4.139 3.582 3.937 4.056 3.206 3.826 3.751 3.334 3.798 3.912 3.417 4.266 4.244 4.490 4.670 3.238 28.170 THYROID GLAND 0.025 0.026 0.022 0.026 0.027 0.034 NW 0.022 0.024 0.023 0.019 0.020 0.027 0.030 0.037 0.025 0.029 0.022 0.021 SEMINAL TESTES EPIDIDYMIDES VESICLES 3.658 4.050 3.824 3.766 3.886 3.514 3.222 3.628 4.060 3.559 4.087 3.391 3.596 3.285 3.752 3.429 3.849 3.099 3.443 1.894 1.736 1.803 1.628 1.779 1.705 0.298 1.430 1.581 1.516 1.669 1.485 1.605 1.548 1.571 1.626 1.725 1.362 1.468 3.172 3.013 3.087 2.372 2.496 2.909 2.405 2.778 2.959 2.497 2.151 2.516 2.447 3.489 2.938 2.453 3.025 2.038 1.812 PROSTATE 0.927 0.806 1.126 1.002 0.962 0.826 0.679 0.879 0.806 0.911 0.838 0.979 1.098 1.530 1.018 0.971 0.766 0.914 0.525 NW = NOT WEIGHED BRAIN 2.231 2.196 2.256 2.112 2.165 2.170 2.074 2.280 2.381 2.117 2.095 2.160 2.192 2.369 2.321 2.350 2.386 2.057 2.189 407 Company Sanitized, Does not contain TSCA CBI Company Sanitized, D o m ______ H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grains) FROM MALE RATS GROUP : III-O - 75 mg/kg/day ANIMAL NUMBER 657416 657417 657418 657419 657420 657421 657422 657423 657424 657425 657426 657427 657428 657429 657430 657431 657432 657433 657435 657596 FINAL BODY 521.7 559.0 513.5 572.6 516.2 607.8 500.6 608.8 569.0 758.4 565.4 625.1 610.0 713.0 647.0 654.8 755.6 683.2 509.6 446.8 LIVER 15.262 18.992 14.868 13.933 15.329 18.624 14.123 14.785 17.243 24.831 20.632 20.206 21.686 25.605 26.295 24.553 28.893 21.772 17.489 16.076 KIDNEYS 3.684 4.107 3.971 4.235 4.219 4.217 3.498 4.031 4.272 5.049 4.403 4.086 4.495 4.722 4.177 4.261 4.650 4.054 3.521 3.240 THYROID GLAND 0.025 0.019 0.030 0.030 0.017 0.026 0.021 0.021 0.022 0.018 0.031 0.025 0.026 0.033 0.039 0.020 0.042 0.029 0.017 0.031 SEMINAL TESTES EPIDIDYMIDES VESICLES 3.875 3.491 3.560 1.941 3.730 3.450 3.451 3.839 3.877 3.988 3.645 3.474 3.723 3.799 3.453 2.815 3.669 3.772 3.276 5.648 1.507 1.547 1.375 0.736 1.664 1.433 1.440 1.501 1.636 1.683 1.560 1.599 1.573 1.550 1.579 1.260 1.465 1.462 1.382 1.304 2.545 2.807 2.497 2.937 3.036 3.150 3.091 2.967 2.972 3.725 2.995 3.442 2.653 2.730 2.874 2.532 2.521 2.459 2.356 2.384 PROSTATE 0.597 0.687 0.929 0.976 0.703 0.937 0.993 0.883 1.035 0.794 0.900 1.639 1.015 0.743 0.971 0.943 0.886 0.715 0.874 0.817 BRAIN 2.151 2.097 1.968 2.332 2.213 2.335 2.212 2.061 2.251 2.404 2.358 2.183 2.173 2.186 2.180 2.034 2.231 2.116 2.159 1.954 408 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL FINAL BO D Y A N D ORGAN WEIGHTS - Pi ADULTS f i n a l b o d y AND ABSOLUTE O R G A N WEIGHTS (grams) FRO M M AL E RATS GROUP : V-0 - 500. 0 MG/K ANIMAL NUMBER 657441 657442 657443 657444 657445 657446 657447 657448 657449 657450 657451 657452 657453 657454 657455 657456 657457 657458 657460 FINAL BODY 527.4 397.2 557.0 636.7 552.2 437.1 534.9 538.5 544.7 514.0 652.1 590.7 584.7 581.2 491.0 573.3 725.1 552.6 530.2 LIVER 16.774 12.540 19.073 19.416 16.446 13.630 17.540 17.783 17.958 17.645 27.589 24.550 23.757 23.371 21.218 26.215 27.995 23.010 19.697 KIDNEYS 3.695 3.458 4.042 4.930 3.880 3.742 4.105 4.012 4.460 4.189 4.968 5.152 4.319 3.951 3.740 4.627 5.090 4.322 3.745 THYROID GLAND 0.025 0.017 0.021 0.015 0.017 0.023 0.029 0.018 0.029 0.030 0.028 0.026 0.026 0.017 0.014 0.031 0.036 0.015 0.026 SEMINAL TESTES EPIDIDYMIDES VESICLES 3.714 3.633 3.310 4.079 3.562 3.812 4.040 4.009 3.680 3.877 3.586 3.794 3.911 3.494 3.321 3.705 3.796 3.438 3.256 1.574 1.465 1.339 1.574 1.654 1.433 1.537 1.659 1.404 1.628 1.531 1.622 1.595 1.491 1.436 1.583 1.362 1.381 1.410 2.649 2.203 2.205 2.759 2.899 2.356 3.347 3.017 2.268 2.757 2.182 2.023 2.631 2.729 2.383 2.750 3.058 2.857 2.115 PROSTATE 0.994 0.897 0.613 0.699 0.927 0.668 0.603 0.784 0.851 0.904 0.687 1.068 0.869 0.983 1.065 0.946 1.038 0.906 0.780 BRAIN 2.003 2.065 2.125 2.222 2.141 2.077 2.252 2.300 2.215 2.090 2.212 2.326 2.237 2.231 2.273 2.134 2.445 2.193 1.972 409 Company Sanitized. Does not contain TS C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL FINAL BODY.AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORG A N WEIGHTS (grams) FROM M AL E RATS GROUP : VII-0 - 3500.0 MG/ ANIMAL NUMBER 657466 657467 657468 657469 657470 657471 657472 657473 657474 657475 657476 657478 657479 657480 657481 657483 657484 657485 FINAL BODY 485.0 377.6 426.9 461.8 399.4 359.8 508.1 473.2 420.2 402.6 466.8 603.5 429.3 476.1 661.3 497.3 531.6 519.1 LIVER 23.708 17.867 19.998 17.968 18.396 15.310 24.786 23.846 18.948 18.103 24.411 34.047 22.808 24.854 32.720 27.447 27.801 33.347 KIDNEYS 4.641 3.535 4.658 4.600. 3.793 3.566 4.341 4.923 4.379 4.052 4.514 4.945 3.859 3.498 4.801 4.484 4.703 4.528 THYROID GLAND 0.021 0.026 0.017 0.009 0.017 0.024 0.022 0.017 0.020 0.027 0.033 0.037 0.017 0.028 0.031 0.022 0.027 0.021 SEMINAL TESTES EPIDIDYMIDES VESICLES 3.602 3.517 4.251 3.878 2.903 3.578 3.423 3.329 3.429 3.832 3.659 4.103 3.711 2.829 3.748 3.445 3.745 3.669 1.399 1.407 1.577 1.475 1.282 1.227 1.430 1.342 1.399 1.344 1.460 1.456 1.417 1.182 1.594 1.265 1.549 1.389 1.858 2.314 2.658 2.575 2.724 2.032 2.065 1.872 2.518 2.273 2.584 2.903 2.042 2.390 2.982 2.126 1.757 3.169 PROSTATE 0.578 0.526 0.856 0.772 0.617 0.575 0.754 0.626 0.582 0.708 0.693 1.075 0.690 0.924 1.299 0.918 0.742 0.687 BRAIN 2.156 1.870 2.223 2.370 2.004 2.049 2.120 2.071 2.135 2.244 2.128 2.039 2.114 2.061 2.138 2.253 2.199 1.924 410 Company Sanitized. Does not contain T S C A C B i H-25231: One-Generation Reproduction Study in Rats ) INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP : 1-0 - 0 mg/kg/day ANIMAL NUMBER 657391 657392 657393 657394 657395 657396 657397 657398 657399 657400 657401 657402 657403 657404 657405 657406 657407 657408 657410 LIVER 2.629 3.124 2.524 2.663 2.620 2.585 2.591 2.732 2.790 2.429 3.290 3.261 2.783 3.311 3.498 3.337 3.303 3.169 3.488 KIDNEYS 0.659 0.748 0.693 0.566 0.679 0.727 0.665 0.644 '0.671 0.606 0.625 0.704 0.655 0.567 0.635 0.651 0.711 0.602 5.123 THYROID GLAND 0.004 0.004 0.004 0.004 0.005 0.006 NW 0.004 0.004 0.004 0.003 0.004 0.005 0.004 0.006 0.004 0.004 0.004 0.004 SEMINAL TESTES EPIDIDYMIDES VESICLES 0.640 0.669 0.640 0.595 0.670 0.630 0.668 0.611 0.727 0.647 0.673 0.611 0.690 0.436 0.562 0.497 0.586 0.576 0.626 0.332 0.287 0.302 0.257 0.307 0.306 0.062 0.241 0.283 0.275 0.275 0.267 0.308 0.206 0.235 0.236 0.263 0.253 0.267 0.555 0.498 0.517 0.375 0.430 0.521 0.499 0.468 0.530 0.454 0.354 0.453 0.469 0.464 0.440 0.356 0.461 0.379 0.330 PROSTATE 0.162 0.133 0.189 0.158 0.166 0.148 0.141 0.148 0.144 0.166 0.138 0.176 0.211 0.203 0.152 0.141 0.117 0.170 0.095 NW = NOT WEIGHED BRAIN 0.391 0.363 0.378 0.334 0.373 0.389 0.430 0.384 0.426 0.385 0.345 0.389 0.420 0.315 0.348 0.341 0.363 0.382 0.398 DuPont-9763 41 Company Sanitized. Does not contain TS C A CB i H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY A ND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP : III-O - 75 mg/kg/day ANIMAL NUMBER 657416 657417 657418 657419 657420 657421 657422 657423 657424 657425 657426 657427 657428 657429 657430 657431 657432 657433 657435 657596 LIVER 2.925 3.397 2.895 2.433 2.970 3.064 2.821 2.429 3.030 3.274 3.649 3.232 3.555 3.591 3.600 3.750 3.824 3.187 3.432 3.598 KIDNEYS 0.706 0.735 0.773 0.740 0.817 0.694 0.699 0.662 0.751 0.666 0.779 0.654 0.737 0.662 0.646 0.651 0.615 0.593 0.691 0.725 THYROID GLAND 0.005 0.003 0.006 0.005 0.003 0.004 0.004 0.003 0.004 0.002 0.005 0.004 0.004 0.005 0.006 0.003 0.006 0.004 0.003 0.007 SEMINAL TESTES EPIDIDYMIDES VESICLES 0.743 0.625 0.693 0.339 0.723 0.568 0.689 0.631 0.681 0.526 0.645 0.556 0.610 0.533 0.534 0.430 0.486 0.552 0.643 1.264 0.289 0.277 0.268 0.129 0.322 0.236 0.288 0.247 0.288 0.222 0.276 0.256 0.258 0.217 0.244 0.192 0.194 0.214 0.271 0.292 0.488 0.502 0.486 0.513 0.588 0.518 0.617 0.487 0.522 0.491 0.530 0.551 0.435 0.383 0.444 0.387 0.334 0.360 0.462 0.534 PROSTATE 0.114 0.123 0.181 0.170 0.136 0.154 0.198 0.145 0.182 0.105 0.159 0.262 0.166 0.104 0.150 0.144 0.117 0.105 0.172 0.183 BRAIN 0.412 0.375 0.383 0.407 0.429 0.384 0.442 0.339 0.396 0.317 0.417 0.349 0.356 0.307 0.337 0.311 0.295 0.310 0.424 0.437 DuPont-9763 412 Company Sanitized. Does not contain TS C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP : V-0 - 500.0 MG/K ANIMAL NUMBER 657441 657442 657443 657444 657445 657446 657447 657448 657449 657450 657451 657452 657453 657454 657455 657456 657457 657458 657460 LIVER 3.181 3.157 3.424 3.049 2.978 3.118 3.279 3.302 3.297 3.433 4.231 4.156 4.063 4.021 4.321 4.573 3.861 4.164 3.715 KIDNEYS 0.701 0.871 0.726 0.774 0.703 0.856 0.767 0.745 0.819 0.815 0.762 0.872 0.739 0.680 0.762 0.807 0.702 0.782 0.706 THYROID GLAND 0.005 0.004 0.004 0.002 0.003 0.005 0.005 0.003 0.005 0.006 0.004 0.004 0.004 0.003 0.003 0.005 0.005 0.003 0.005 SEMINAL TESTES EPIDIDYMIDES VESICLES 0.704 0.915 0.594 0.641 0.645 0.872 0.755 0.744 0.676 0.754 0.550 0.642 0.669 0.601 0.676 0.646 0.524 0.622 0.614 0.298 0.369 0.240 0.247 0.300 0.328 0.287 0.308 0.258 0.317 0.235 0.275 0.273 0.257 0.292 0.276 0.188 0.250 0.266 0.502 0.555 0.396 0.433 0.525 0.539 0.626 0.560 0.416 0.536 0.335 0.342 0.450 0.470 0.485 0.480 0.422 0.517 0.399 PROSTATE 0.188 0.226 0.110 0.110 0.168 0.153 0.113 0.146 0.156 0.176 0.105 0.181 0.149 0.169 0.217 0.165 0.143 0.164 0.147 BRAIN 0.380 0.520 0.382 0.349 0.388 0.475 0.421 0.427 0.407 0.407 0.339 0.394 0.383 0.384 0.463 0.372 0.337 0.397 0.372 DuPont-9763 413 Company Sanitized. Does not contain TS C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP : VII-0 - 3500.0 MG/ ANIMAL NUMBER 657466 657467 657468 657469 657470 657471 657472 657473 657474 657475 657476 657478 657479 657480 657481 657483 657484 657485 LIVER 4.888 4.732 4.684 3.891 4.606 4.255 4.878 5.039 4.509 4.497 5.229 5.642 5.313 5.220 4.948 5.519 5.230 6.424 KIDNEYS 0.957 0.936 1.091 0.996 0.950 0.991 0.854 1.040 1.042 1.006 0.967 0.819 0.899 0.735 0.726 0.902 0.885 0.872 THYROID GLAND 0.004 0.007 0.004 0.002 0.004 0.007 0.004 0.004 0.005 0.007 0.007 0.006 0.004 0.006 0.005 0.004 0.005 0.004 SEMINAL TESTES EPIDIDYMIDES VESICLES 0.74-3 0.931 0.996 0.840 0.727 0.994 0.674 0.704 0.816 0.952 0.784 0.680 0.864 0.594 0.567 0.693 0.704 0.707 0.288 0.373 0.369 0.319 0.321 0.341 0.281 0.284 0.333 0.334 0.313 0.241 0.330 0.248 0.241 0.254 0.291 0.268 0.383 0.613 0.623 0.558 0.682 0.565 0.406 0.396 0.599 0.565 0.554 0.481 0.476 0.502 0.451 0.428 0.331 0.610 PROSTATE 0.119 0.139 0.201 0.167 0.154 0.160 0.148 0.132 0.139 0.176 0.148 0.178 0.161 0.194 0.196 0.185 0.140 0.132 BRAIN 0.445 0.495 0.521 0.513 0.502 0.569 0.417 0.438 0.508 0.557 0.456 0.338 0.492 0.433 0.323 0.453 0.414 0.371 DuPont-9763 414 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats - INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS GROUP : i-O - 0 mg/kg/day ANIMAL NUMBER 657391 657392 657393 657394 657395 657396 657397 657398 657399 657400 65.7401 657402 657403 657404 657405 657406 657407 657408 657410 LIVER 6.731 8.609 6.683 7.977 7.017 6.649 6.025 7.114 6.549 6.315 9.538 8.383 6.620 10.518 10.065 9.792 9.092 8.293 8.762 NW = NOT WEIGHED KIDNEYS 1.688 2.061 1.835 1.696 1.818 1.869 1.546 1.678 1.575 1.575 1.813 1.811 1.559 1.801 1.829 1.911 1.957 1.574 12.869 THYROID GLAND 0.011 0.012 0.010 0.012 0.012 0.016 NW 0.010 0.010 0.011 0.009 0.009 0.012 0.013 0.016 0.011 0.012 0.011 0.010 SEMINAL TESTES EPIDIDYMIDES VESICLES 1.640 . 1.844 1.695 1.783 1.795 1.619 1.554 1.591 1.705 1.681 1.951 1.570 1.641 1.387 1.617 1.459 1.613 1.507 1.573 0.849 0.791 0.799 0.771 0.822 0.786 0.144 0.627 0.664 0.716 0.797 0.688 0.732 0.653 0.677 0.692 0.723 0.662 0.671 1.422 1.372 1.368 1.123 1.153 1.341 1.160 1.218 1.243 1.179 1.027 1.165 1.116 1.473 1.266 1.044 1.268 0.991 0.828 PROSTATE 0.416 0.367 0.499 0.474 0.444 0.381 0.327 0.386 0.339 0.430 0.400 0.453 0.501 0.646 0.439 0.413 0.321 0.444 0.240 DuPont-9763 415 Company Sanitized. Does not contain TS C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS GROUP : III-O - 75 mg/kg/day ANIMAL NUMBER 657416 657417 657418 657419 657420 657421 657422 657423 657424 657425 657426 657427 657428 657429 657430 657431 657432 657433 657435 657596 LIVER 7.095 9.057 7.555 5.975 6.927 7.976 6.385 7.174 7.660 10.329 8.750 9.256 9.980 11.713 10.686 12.071 12.951 10.289 8.101 8.227 KIDNEYS 1.713 1.959 2.018 1.816 1.906 1.806 1.581 1.956 1.898 2.100 1.867 1.872 2.069 2.160 1.916 2.095 2.084 1.916 1.631 1.658 THYROID GLAND 0.012 0.009 0.015 0.013 0.008 0.011 0.009 0.010 0.010 0.007 0.013 0.011 0.012 0.015 0.018 0.010 0.019 0.014 0.008 0.016 SEMINAL TESTES EPIDIDYMIDES VESICLES 1.801 1.665 1.809 0.832 1.685 1.478 1.560 1.863 1.722 1.659 1.546 1.591 1.713 1.738 1.584 1.384 1.645 1.783 1.517 2.890 0.701 0.738 0.699 0.316 0.752 0.614 0.651 0.728 0.727 0.700 0.662 0.732 0.724 0.709 0.724 0.619 0.657 0.691 0.640 0.667 1.183 1.339 1.269 1.259 1.372 1.349 1.397 1.440 1.320 1.550 1.270 1.577 1.221 1.249 1.318 1.245 1.130 1.162 1.091 1.220 PROSTATE 0.278 0.328 0.472 0.419 0.318 0.401 0.449 0.428 0.460 0.330 0.382 0.751 0.467 0.340 0.445 0.464 0.397 0.338 0.405 0.418 DuPont-9763 416 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS GROUP : V-0 - 500.0 MG/K ANIMAL NUMBER 657441 657442 657443 657444 657445 657446 657447 657448 657449 657450 657451 657452 657453 657454 657455 657456 657457 657458 657460 LIVER 8.374 6.073 8.976 8.738 7.681 6.562 7.789 7.732 8.107 8.443 12.472 10.555 10.620 10.476 9.335 12.284 11.450 10.492 9.988 KIDNEYS 1.845 1.675 1.902 2.219 1.812 1.802 1.823 1.744 2.014 2.004 2.246 2.215 1.931 1.771 1.645 2.168 2.082 1.971 1.899 THYROID GLAND 0.012 0.008 0.010 0.007 0.008 0.011 0.013 0.008 0.013 0.014 0.013 0.011 0.012 0.008 0.006 0.015 0.015 0.007 0.013 SEMINAL TESTES EPIDIDYMIDES VESICLES 1.854 1.759 1.558 1.836 1.664 1.835 1.794 1.743 1.661 1.855 1.621 1.631 1.748 1.566 1.461 1.736 1.553 1.568 1.651 0.786 0.709 0.630 0.708 0.773 0.690 0.683 0.721 0.634 0.779 0.692 0.697 0.713 0.668 0.632 0.742 0.557 0.630 0.715 1.323 1.067 1.038 1.242 1.354 1.134 1.486 1.312 1.024 1.319 0.986 0.870 1.176 1.223 1.048 1.289 1.251 1.303 1.073 PROSTATE 0.496 0.434 0.288 0.315 0.433 0.322 0.268 0.341 0.384 0.433 0.311 0.459 0.388 0.441 0.469 0.443 0.425 0.413 0.396 DuPont-9763 417 Company Sanitized. Does not contain TS CA CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS GROUP : VII-0 - 3500.0 MG/ ANIMAL NUMBER 657466 657467 657468 657469 657470 657471 657472 657473 657474 657475 657476 657478 657479 657480 657481 657483 657484 657485 LIVER 10.996 9.555 8.996 7.581 9.180 7.472 11.692 11.514 8.875 8.067 11.471 16.698 10.789 12.059 15.304 12.182 12.643 17.332 KIDNEYS 2.153 1.890 2.095 1.941 1.893 1.740 2.048 2.377 2.051 1.806 2.121 2.425 1.825 1.697 2.246 1.990 2.139 2.353 THYROID GLAND 0.010 0.014 0.008 0.004 0.008 0.012 0.010 0.008 0.009 0.012 0.016 0.018 0.008 0.014 0.014 0.010 0.012 0.011 SEMINAL TESTES EPIDIDYMIDES VESICLES 1.671 1.881 1.912 1.636 1.449 1.746 1.615 1.607 1.606 1.708 1.719 2.012 1.755 1.373 1.753 1.529 1.703 1.907 0.649 0.752 0.709 0.622 0.640 0.599 0.675 0.648 0.655 0.599 0.686 0.714 0.670 0.574 0.746 0.561 0.704 0.722 0.862 1.237 1.196 1.086 1.359 0.992 0.974 0.904 1.179 1.013 1.214 1.424 0.966 1.160 1.395 0.944 0.799 1.647 PROSTATE 0.268 0.281 0.385 0.326 0.308 0.281 0.356 0.302 0.273 0.316, 0.326 0.527 0.326 0.448 0.608 0.407 0.337 0.357 DuPont-9763 418 Company Sanitized. Does not contain TS CA CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP : II-O - 0 mg/kg/day ANIMAL NUMBER 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509 657510 FINAL BODY NW 381.6 NW 317.1 315.6 277.8 326.1 301.6 332.5 356.0 336.7 310.1 330.6 352.6 324.0 357.9 334.6 354.0 286.3 286.7 LIVER 1?.271 18.902 15.250 16.649 15.180 11.115 15.760 14.370 15.383 15.013 15.993 14.813 13.522 14.493 15.624 15.494 16.031 19.081 10.178 13.275 KIDNEYS 2.235 2.577 2.486 2.386 2.163 2.049 2.532 2.411 2.529 2.658 2.268 2.461 2.954 2.486 2.381 2.376 2.615 3.205 2.025 2.286 THYROID GLAND 0.027 0.021 0.026 0.029 0.027 0.012 0.028 0.025 0.028 0.031 NW 0.023 0.026 0.024 0.020 0.032 0.021 0.028 0.007 0.016 UTERUS 0.466 0.355 0.514 0.574 0.558 0.712 0.663 0.400 0.331 0.540 0.407 0.608 0.436 0.575 0.849 0.629 0.842 0.663 0.603 0.331 OVARIES 0.118 0.187 0.233 0.210 0.127 0.084 0.124 0.143 0.095 0.162 0.105 - 0.161 0.222 0.165 0.135 0.099 0.128 0.198 0.095 0.107 NW = NOT WEIGHED BRAIN 1.899 2.186 1.995 2.062 1.871 1.748 1.812 1.853 1.938 1.931 1.921 1.886 1.997 2.055 1.854 1.916 1.837 2.217 1.786 1.817 DuPont-9763 419 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP : IV-0 - 75 mg/kg/day ANIMAL NUMBER 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534 657535 FINAL BODY 328.7 300.0 322.6 332.0 323.4 330.5 348.4 323.4 368.9 321.8 341.1 333.0 351.6 302.7 355.3 341.4 343.3 296.1 343.4 342.3 LIVER 13.878 13.052 15.172 11.675 14.115 15.875 18.025 11.483 18.442 15.243 18.221 16.076 17.188 13.026 18.163 14.281 14.029 13.620 14.217 16.421 KIDNEYS 2.289 2.380 2.781 2.585 1.848 2.631 2.651 2.163 3.498 2.625 3.010 2.622 3.016 2.185 2.650 2.629 2.365 2.506 3.047 2.674 THYROID GLAND 0.029 0.024 0.021 0.011 0.021 0.033 0.030 0.031 0.024 0.020 0.027 0.027 0.032 0.023 0.019 0.026 0.037 0.019 0.020 0.021 UTERUS 0.828 0.466 0.424 0.670 0.360 0.411 0.322 0.412 0.654 0.739 0.492 0.500 0.509 0.710 0.433 0.557 0.484 0.414 0.488 0.413 OVARIES 0.095 0.140 0.224 0.167 0.141 0.161 0.109 0.121 0.199 0.173 0.198 0.143 0.205 0.099 0.174 0.179 0.145 0.186 0.184 0.186 BRAIN 1.823 1.894 2.169 2.073 1.849 2.094 1.950 1.901 2.044 2.034 2.073 2.193 2.185 1.807 2.185 1.934 1.977 1.961 2.154 2.046 DuPont-9763 420 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP : VI-0 - 500 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND UTERUS 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 65-7555 657556 657557 657558 657559 657560 319.0 327.2 312.8 308.0 328.7 326.1 291.7 359.1 301.7 310.9 316.1 351.6 317.4 306.6 329.1 378.6 299.5 314.4 374.3 343.6 15.762 16.002 15.085 13.234 14.670 16.190 13.064 19.303 13.990 14.737 15.005 16.344 15.963 17.347 17.451 19.739 11.041 16.359 17.442 16.185 2.558 2.741 2.283 2.612 2.611 2.339 2.333 2.962 2.360 2.955 2.813 2.784 2.569 2.359 2.601 4.189 2.290 2.269 3.005 2.678 0.018 0.023 0.026 0.032 0.031 0.016 0.031 0.033 0.022 0.031 0.022 0.021 0.016 0.028 NW 0.027 0.012 0.024 0.024 0.021 0.529 0.564 0.574 0.751 0.516 0.398 0.470 0.451 0.666 0.708 0.420 0.405 0.485 0.749 0.656 0.753 0.642 0.622 0.434 0.486 NW = NOT WEIGHED OVARIES 0.161 0.169 0.137 0.175 0.122 0.117 0.178 0.169 0.118 0.187 0.182 0.099 0.132 0.119 0.190 0.186 0.106 0.115 0.126 0.090 BRAIN 1.988 1.912 1.868 2.057 1.963 1.831 1.933 2.108 1.829 2.153 2.092 1.935 1.846 1.918 2.144 2.214 1.823 1.914 2.046 1.947 DuPont-9763 421 Company Sanitized. Does not contain TS CA CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL PINAL BODY A N D ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP : VIII-0 - 3500 mg/kg/day ANIMAL NUMBER 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 657576 657577 657578 657579 657580 657581 657582 657583 657584 657585 FINAL BODY 321.6 315.2 337.6 264.6 325.7 290.0 343.4 313.9 340.3 321.0 360.9 333.4 281.4 326.1 340.3 301.9 267.7 347.7 349.0 306.8 LIVER 17.059 13.695 17.510 12.341 16.982 15.429 17.871 16.016 19.237 14.867 1^.109 18.484 14.281 19.025 17.687 15.412 12.534 19.639 19.667 16.715 KIDNEYS 2.610 2.822 2.864 2.239 2.836 2.601 2.820 2.110 2.759 2.782 2.754 2.447 2.552 2.801 2.649 2.503 2.211 2.819 3.185 2.657 THYROID GLAND 0.027 0.015 0.031 0.012 0.022 0.021 0.029 0.025 0.029 0.013 0.018 0.021 0.010 0.032 0.026 0.019 0.014 0.028 0.028 0.033 UTERUS 0.468 0.565 0.633 1.507 0.519 0.423 0.714 0.734 0.499 0.646 0.458 0.362 0.626 0.497 0.302 0.413 0.625 0.626 0.536 0.513 OVARIES 0.115 0.177 0.192 0.065 0.133 0.142 0.117 0.107 0.196 0.096 0.138 0.104 0.086 0.153 0.106 0.160 0.101 0.169 0.147 0.147 BRAIN 1.919 1.957 2.080 1.846 1.843 1.959 1.912 1.934 2.074 2.004 1.960 1.828 1.766 2.072 1.871 2.163 1.864 1.951 2.023 1.722 DuPont-9763 422 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY A N D ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM FEMALE RATS GROUP : II-O - 0 mg/kg/day ANIMAL NUMBER 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509 657510 LIVER NW 4.953 NW 5.250 4.810 4.001 4.833 4.765 4.626 4.217 4.750 4.777 4.090 4.110 4.822 4.329 4.791 5.390 3.555 4.630 KIDNEYS NW 0.675 NW 0.752 0.685 0.738 0.776 0.799 0.761 0.747 0.674 0.794 0.894 0.705 0.735 0.664 0.782 0.905 0.707 0.797 THYROID GLAND NW 0.006 NW 0.009 0.009 0.004 0.009 0.008 0.008 0.009 NW 0.007 0.008 0.007 0.006 0.009 0.006 0.008 0.002 0.006 UTERUS NW 0.093 NW 0.181 0.177 0.256 0.203 0.133 0.100 0.152 0.121 0.196 0.132 0.163 0.262 0.176 0.252 0.187 0.211 0.115 OVARIES NW 0.049 NW 0.066 0.040 0.030 0.038 0.047 0.029 0.046 0.031 0.052 0.067 0.047 0.042 0.028 0.038 0.056 0.033 0.037 NW = NOT WEIGHED BRAIN NW 0.573 NW 0.650 0.593 0.629 0.556 0.614 0.583 0.542 0.571 0.608 0.604 0.583 0.572 0.535 0.549 0.626 0.624 0.634 DuPont-9763 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY A ND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM FEMALE RATS GROUP : IV-0 - 75 mg/kg/day ANIMAL NUMBER 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534 657535 LIVER 4.222 4.351 4.703 3.517 4.365 4.803 5.174 3.551 4.999 4.737 5.342 4.82 8 4.889 4.303 5.112 4.183 4.087 4.600 4.140 4.797 KIDNEYS 0.696 0.793 0.862 0.779 0.571 0.796 0.761 0.669 0.948 0.816 0.882 0.787 0.858 0.722 0.746 t).770 0.689 0.846 0.887 0.781 THYROID GLAND 0.009 0.008 0.007 0.003 0.006 0.010 0.009 0.010 0.007 0.006 0.008 0.008 0.009 0.008 0.005 0.008 0.011 0.006 0.006 0.006 UTERUS 0.252 0.155 0.131 0.202 0.111 0.124 0.092 0.127 0.177 0.230 0.144 0.150 0.145 0.235 0.122 0.163 0.141 0.140 0.142 0.121 OVARIES 0.029 0.047 0.069 0.050 0.044 0.049 0.031 0.037 0.054 0.054 0.058 0.043 0.058 0.033 0.049 0.052 0.042 0.063 0.054 0.054 BRAIN 0.555 0.631 0.672 0.624 0.572 0.634 0.560 0.588 0.554 0.632 0.608 0.659 0.621 0.597 0.615 0.566 0.576 0.662 0.627 0.598 DuPont-9763 424 Company Sanitized. Does not contain TS C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS {% of body weight) FROM FEMALE RATS GROUP : VI-0 - 500 mg/kg/day ANIMAL NUMBER 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557 657558 657559 657560 LIVER 4.941 4.891 4.823 4.297 4.463 4.965 4.479 5.375 4.637 4.740 4.747 4.648 5.029 5.658 5.303 5.214 3.686 5.203 4.660 4.710 KIDNEYS 0.802 0.838 0.730 0.848 *0.794 0.717 0.800 0.825 0.782 0.950 0.890 0.792 0.809 0.769 0.790 1.106 0.765 0.722 0.803 0.779 THYROID GLAND 0.006 0.007 0.008 0.010 0.009 0.005 0.011 0.009 0.007 0.010 0.007 0.006 0.005 0.009 NW 0.007 0.004 0.008 0.006 0.006 UTERUS 0.166 0.172 0.184 0.244 0.157 0.122 0.161 0.126 0.221 0.228 0.133 0.115 0.153 0.244 0.199 0.199 0.214 0.198 0.116 0.141 OVARIES 0.050 0.052 0.044 0.057 0.037 0.036 0.061 0.047 0.039 0.060 0.058 0.028 0.042 0.039 0.058 0.049 0.035 0.037 0.034 0.026 BRAIN 0.623 0.584 0.597 0.668 0.597 0.561 0.663 0.587 0.606 0.693 0.662 0.550 0.582 0.626 0.651 0.585 0.609 0.609 0.547 0.567 NW = NOT WEIGHED DuPont-9763 425 Company Sanitized. Does not contain TSCA CB I H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY A N D ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM FEMALE RATS GROUP : VIII-0 - 3500 mg/kg/day ANIMAL NUMBER 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 657576 657577 657578 657579 657580 657581 657582 657583 657584 657585 LIVER 5.304 4.345 5.187 4.664 5.214 5.320 5.204 5.102 5.653 4.631 5.295 5.544 5.075 5.834 5.197 5.105 4.682 5.648 5.635 5.448 KIDNEYS 0.812 0.895 0.848 0.846 0.871 0.897 0.821 0.672 0.811 0.867 0.763 0.734 0.907 0.859 0.778 0.829 0.826 0.811 0.913 0.866 THYROID GLAND 0.008 0.005 0.009 0.005 0.007 0.007 0.008 0.008 0.009 0.004 0.005 0.006 0.004 0.010 0.008 0.006 0.005 0.008 0.008 0.011 UTERUS 0.146 0.179 0.188 0.570 0.159 0.146 0.208 0.234 0.147 0.201 0.127 0.109 0.222 0.152 0.089 0.137 0.233 0.180 0.154 0.167 OVARIES 0.036 0.056 0.057 0.025 0.041 0.049 0.034 0.034 0.058 0.030 0.038 0.031 0.031 0.047 0.031 0.053 0.038 0.049 0.042 0.048 BRAIN 0.597 0.621 0.616 0.698 0.566 0.676 0.557 0.616 0.609 0.624 0.543 0.548 0.628 0.635 0.550 0.716 0.696 0.561 0.580 0.561 DuPont-9763 426 Company Sanitized. Does not contain TS C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS: (organ to brain weight ratio) FROM FEMALE RATS GROUP : II-0 - 0 mg/kg/day ANIMAL NUMBER LIVER THYROID KIDNEYS! GLAND UTERUS OVARIES 657491 657492 657493 657494 657495 657496 657497 657498 657499 657500 657501 657502 657503 657504 657505 657506 657507 657508 657509 657510 6.462 8.647 7.644 8.074 8.113 6.359 8.698 7.755 7.938 7.775 8.325 7.854 6.771 7.053 8.427 8.087 8.727 8.607 5.699 7.306 1.177 1.179 1.246 1.157 1.156 1.172 1.397 1.301 1.305 1.376 1.181 1.305 1.479 1.210 1.284 1.240 1.424 1.446 1.134 1.258 0.014 0.010 0.013 0.014 0.014 0.007 0.015 0.013 0.014 0.016 NW 0.012 0.013 0.012 0.011 0.017 0.011 0.013 0.004 0.009 0.245 0.162 0.258 0.278 0.298 0.407 0.366 0.216 0.171 0.280 0.212 0.322 0.218 0.280 0.458 0.328 0.458 0.299 0.338 0.182 0.062 0.086 0.117 0.102 0.068 0.048 0.068 0.077 0.049 0.084 0.055 0.085 0.111 0.080 0.073 0.052 0.070 0.089 0.053 0.059 NW = NOT WEIGHED DuPont-9763 427 Company Sanitized. Does not contain TSCACBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP : IV-0 - 75 mg/kg/day ANIMAL NUMBER 657516 657517 657518 657519 657520 657521 657522 657523 657524 657525 657526 657527 657528 657529 657530 657531 657532 657533 657534 657535 LIVER 7.613 6.891 6.995 5.632 7.634 7.581 9.244 6.041 9.023 7.494 8.790 7.331 7.866 7.209 8.313 7.384 7.096 6.945 6.600 8.026 KIDNEYS 1.256 1.257 1.282 1.247 0.999 1.256 1.359 1.138 1.711 1.291 1.452 1.196 1.380 1.209 1.213 1.359 1.196 1.278 1.415 1.307 THYROID GLAND 0.016 0.013 0.010 0.005 0.011 0.016 0.015 0.016 0.012 0.010 0.013 0.012 0.015 0.013 0.009 0.013 0.019 0.010 0.009 0.010 UTERUS 0.454 0.246 0.195 0.323 0.195 0.196 0.165 0.217 0.320 0.363 0.237 0.228 0.233 0.393 0.198 0.288 0.245 0.211 0.227 0.202 OVARIES 0.052 0.074 0.103 0.081 0.076 0.077 0.056 0.064 0.097 0.085 0.096 0.065 0.094 0.055 0.080 0.093 0.073 0.095 0.085 0.091 DuPont-9763 428 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY A ND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP : VI-0 - 500 mg/kg/day ANIMAL NUMBER 657541 657542 657543 657544 657545 657546 657547 657548 657549 657550 657551 657552 657553 657554 657555 657556 657557 657558 657559 657560 LIVER 7.929 8.369 8.075 6.434 7.473 8.842 6.758 9.157 7.649 6.845 7.173 8.447 8.647 9.044 8.139 8.916 6.057 8.547 8.525 8.313 KIDNEYS 1.287 1.434 1.222 1.270 1.330 1.277 1.207 1.405 1.290 1.373 1.345 1.439 1.392 1.230 <1.213 1.892 1.256 1.185 1.469 1.375 THYROID GLAND 0.009 0.012 0.014 0.016 0.016 0.009 0.016 0.016 0.012 0.014 0.011 0.011 0.009 0.015 NW 0.012 0.007 0.013 0.012 0.011 UTERUS 0.266 0.295 0.307 0.365 0.263 0.217 0.243 0.214 0.364 0.329 0.201 0.209 0.263 0.391 0.306 0.340 0.352 0.325 0.212 0.250 OVARIES 0.081 0.088 0.073 0.085 0.062 0.064 0.092 0.080 0.065 0.087 0.087 0.051 0.072 0.062 0.089 0.084 0.058 0.060 0.062 0.046 NW = NOT WEIGHED DuPont-9763 429 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP : VIII-0 - 3500 mg/kg/day ANIMAL NUMBER LIVER KIDNEYS THYROID GLAND UTERUS OVARIES 657566 657567 657568 657569 657570 657571 657572 657573 657574 657575 657576 657577 657578 657579 657580 657581 657582 657583 657584 657585 8.890 6.998 8.418 6.685 9.214 7.876 9.347 8.281 9.275 7.419 9.749 10.112 8.087 9.182 9.453 7.125 6.724 10.066 9.722 9.707 1.360 1.442 1.377 '1.213 1.539 1.328 1.475 1.091 1.330 1.388 1.405 1.339 1.445 1.352 1.416 1.157 1.186 1.445 1.574 1.543 0.014 0.008 0.015 0.007 0.012 0.011 0.015 0.013 0.014 0.006 0.009 0.011 0.006 0.015 0.014 0.009 0.008 0.014 0.014 0.019 0.244 0.289 0.304 0.816 0.282 0.216 0.373 0.380 0.241 0.322 0.234 0.198 0.354 0.240 0.161 0.191 0.335 0.321 0.265 0.298 0.060 0.090 0.092 0.035 0.072 0.072 0.061 0.055 0.095 0.048 0.070 0.057 0.049 0.074 .0.057 0.074 0.054 0.087 0.073 0.085 DuPont-9763 430 Company Sanitized. Does not contain T S C A CBi H-25231: One-Generation Reproduction Study in Rats DuPont-9763 APPENDIX EE INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - FxADULTS Co*npany Sanitized. D oes not contain TSCA C B l H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY A ND ABSOLUTE ORGAN WEIGHTS (grams) FROM M ALE RATS GROUP : 1-1 - 0 mg/kg/day ANIMAL NUMBER 660574 660575 660576 660577 660578 660579 660580 660581 660582 660583 660584 660585 660586 660587 660588 660589 660590 660591 FINAL BODY 386.6 344.6 381.5 371.4 406.8 352.4 350.6 436.2 411.2 287.2 322.9 394.9 472.7 428.1 385.6 394.3 414.1 365.1 LIVER 18.106 16.518 17.807 15.452 18.072 15.217 14.500 21.979 18.233 10.525 14.204 16.819 22.955 22.990 16.799 17.988 20.251 15.340 KIDNEYS 3.289 2.806 3.098 2.860 3.746 3.259 3.258 3.693 3.512 2.751 3.443 3.373 3.812 3.683 3.309 3.494 3.984 3.032 THYROID GLAND 0.027 0.025 0.015 0.023 0.021 0.022 0.020 0.021 0.022 0.018 0.018 0.021 0.026 0.026 0.018 0.024 0.026 0.018 SEMINAL TESTES EPIDIDYMIDES VESICLES 3.061 3.232 3.187 2.920 3.451 3.245 3.197 3.639 3.278 2.910 3.061 3.312 2.813 2.694 2.733 3.607 3.371 2.811 0.893 0.682 0.732 0.709 0.912 0.953 0.658 0.779 0.789 0.628 0.794 0.731 0.715 0.716 0.625 0.804 0.909 0.787 1.747 1.045 1.258 0.990 1.499 1.221 0.583 1.514 1.268 1.258 1.465 1.253 1.325 1.377 0.996 1.321 1.669 1.357 PROSTATE 0.589 0.318 0.400 0.444 0.592 0.449 0.443 0.457 0.447 0.365 0.458 0.423 0.417 0.566 0.473 0.601 0.734 0.391 BRAIN 2.223 1.985 1.755 1.887 2.102 1.943 1.977 2.088 2.095 1.854 2.047 1.929 1.914 1.897 1.905 2.168 2.044 1.999 432 Company S anili *. Dobs n o lco n w ,, T S C A CSI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL FINAL BODY AN D ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP : III-l - 75 mg/kg/day ANIMAL NUMBER 660592 660593 660594 660595 660596 660597 660598 660599 660600 660601 660602 660603 660604 660605 660606 660607 660608 660609 660610 FINAL BODY 398.4 399.8 371.7 397.0 383.9 352.5 354.5 393.9 386.2 374.0 371.5 337.6 345.2 399.9 395.7 415.8 371.0 413.5 398.7 LIVER 17.226 17.138 16.399 17.948 16.573 15.393 14.022 17.662 18.790 19.123 14.638 15.830 15.899 18.257 19.593 19.694 17.124 17.483 18.121 KIDNEYS 3.174 3.033 3.458 3.192 3.156 3.078 3.080 3.804 3.324 3.771 2.952 3.370 3.021 3.342 3.573 3.608 3.745 3.607 3.233 THYROID GLAND 0.024 0.036 0.023 0.020 0.017 0.026 0.029 0.024 0.018 0.027 0.020 0.022 0.017 0.022 0.023 0.038 0.024 0.022 0.013 SEMINAL TESTES EPIDIDYMIDES VESICLES 3.057 3.048 2.901 3.454 2.803 3.416 3.370 3.570 2.963 3.091 3.139 3.434 3.082 3.241 2.872 3.539 3.560 3.175 3.294 0.654 0.639 0.732 0.822 0.715 0.885 0.735 0.998 0.648 0.749 0.829 0.808 0.725 0.707 0.718 0.911 0.883 0.927 0.731 1.244 1.072 1.512 1.423 1.206 1.309 1.041 1.712 1.112 1.261 1.496 1.440 1.172 1.413 1.426 1.449 1.559 1.853 1.484 PROSTATE 0.303 0.262 0.464 0.464 0.324 0.477 0.504 0.693 0.470 0.489 0.560 0.477 0.315 0.422 0.375 0.684 0.429 0.691 0.596 BRAIN 1.903 2.016 2.200 2.070 1.899 2.169 1.921 2.122 1.826 1.886 1.942 2.184 2.021 2.005 1.979 2.068 2.075 2.182 2.036 433 Company Sanitized. Does not contain TS C A CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL FINAL BODY AN D ORGAN WEIGHTS - Fi ADULTS FINAL BODY AN D ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP : v -1 - 500 mg/kg/day ANIMAL NUMBER 660611 660612 660613 660614 660615 660616 660617 660618 660619 660620 660621 660622 660623 660624 660625 660626 660627 660628 660629 FINAL BODY 361.9 371.0 347.3 354.3 380.8 320.0 384.2 353.9 352.8 385.8 402.4 386.9 380.7 360.5 403.6 383.2 277.8 413.2 374.3 LIVER 15.391 18.500 15.417 13.699 15.749 15.098 15.885 15.942 14.440 19.402 20.544 14.047 15.866 16.296 17.053 18.718 13.170 18.341 14.890 KIDNEYS 3.213 3.408 2.845 3.094 3.143 3.283 3.093 3.389 3.219 3.508 3.914 3.380 3.341 3.208 3.077 3.807 2.749 3.738 2.971 THYROID GLAND 0.024 0.022 0.014 0.031 0.017 0.022 0.016 0.021 0.024 0.020 0.020 0.028 0.023 0.024 0.024 0.023 0.020 0.028 0.023 SEMINAL TESTES EPIDIDYMIDES VESICLES 3.035 3.057 2.964 2.912 2.716 3.328 3.558 3.253 2.837 3.227 3.057 3.464 3.154 3.214 3.291 3.041 2.475 3.044 2.872 0.639 0.857 0.613 0.614 0.762 0.787 0.859 0.754 0.804 0.859 0.865 0.900 0.597 0.772 0.781 0.670 0.496 0.676 0.682 1.220 1.434 1.055 1.414 1.715 1.246 1.590 1.125 1.317 1.682 1.429 1.490 1.179 1.245 1.213 1.426 0.643 1.196 1.165 PROSTATE 0.466 0.586 0.363 0.397 0.425 0.368 0.583 0.458 0.528 0.596 0.621 0.491 0.352 0.432 0.283 0.418 0.246 0.423 0.326 BRAIN 1.876 2.010 1.917 1.906 1.952 1.938 1.906 2.023 2.113 2.054 2.126 1.932 1.933 2.073 2.078 1.927 1.783 2.098 1.960 434 Company Sanitized. Does not contain TSCA CBI H-25231: One-Generation Reproduction Study in Rats DuPont-9763 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP : VII-1 - 3500 mg/kg/day ANIMAL NUMBER 660630 660631 660632 660633 660634 660635 660636 660637 660638 660639 660640 660641 660642 660643 660644 FINAL BODY 360.3 365.2 301.5 358.5 363.8 366.1 304.2 410.0 310.9 292.4 342.6 345.1 281.1 371.7 330.4 LIVER 17.812 18.090 l'3.731 14.330 17.140 16.895 14.460 17.697 13.541 16.566 14.613 15.788 13.405 16.573 13.971 KIDNEYS 3.404 3.549 2.675 3.113 3.040 3.515 2.722 3.424 2.752 3.083 3.154 2.785 2.787 3.773 2.960 THYROID GLAND 0.015 0.019 0.024 NW 0.019 0.020 0.023 0.027 0.022 0.018 0.021 0.024 0.016 0.024 0.024 SEMINAL TESTES EPIDIDYMIDES VESICLES 2.823 3.103 2.200 2.652 3.148 2.515 2.440 3.288 3.138 2.423 3.265 2.714 2.507 3.472 3.036 0.635 0.819 0.465 0.648 0.710 0.534 0.532 0.679 0.593 0.597 0.815 0.720 0.614 0.886 0.636 1.009 1.512 0.845 1.151 1.101 0.929 1.333 1.319 1.222 1.138 1.679 1.054 1.276 1.746 1.124 PROSTATE 0.352 0.385 0.349 0.310 0.302 0.380 0.313 0.498 2.177 0.359 0.647 0.294 0.302 0.568 0.348 BRAIN 1.829 2.097 1.678 1.889 1.977 2.039 1.839 2.021 1.801 1.937 2.037 1.980 1.750 1.991 1.833 NW = NOT WEIGHED 435 Pany Sanifeed. Does not contain TSGA CBI H-25231: One-Generation Reproduction Study in Rats < INDIVIDUAL ANIMAL FINAL BODY A N D ORG A N WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP : 1-1 - 0 mg/kg/day ANIMAL NUMBER 660574 660575 660576 660577 660578 660579 660580 660581 660582 660583 660584 660585 660586 660587 660588 660589 660590 660591 LIVER 4.683 4.793 4.668 4.160 4.442 4.318 4.136 5.039 4.434 3.665 4.399 4.259 4.856 5.370 4.357 4.562 4.890 4.202 KIDNEYS 0.851 0.814 0.812 0.770 0.921 0.925 0.929 0.847 0.854 0.958 1.066 0.854 0.806 0.860 0.858 0.886 0.962 0.830 THYROID GLAND 0.007 0.007 0.004 0.006 0.005 0.006 0.006 0.005 0.005 0.006 0.006 0.005 0.006 0.006 0.005 0.006 0.006 0.005 SEMINAL TESTES EPIDIDYMIDES VESICLES 0.792 0.938 0.835 0.786 0.848 0.921 0.912 0.834 0.797 1.013 0.948 0.839 0.595 0.629 0.709 0.915 0.814 0.770 0.231 0.198 0.192 0.191 0.224 0.270 0.188 0.179 0.192 0.219 0.246 0.185 0.151 0.167 0.162 0.204 0.220 0.216 0.452 0.303 0.330 0.267 0.368 0.346 0.166 0.347 0.308 0.438 0.454 0.317 0.280 0.322 0.258 0.335 0.403 0.372 PROSTATE 0.152 0.092 0.105 0.120 0.146 0.127 0.126 0.105 0.109 0.127 0.142 0.107 0.088 0.132 0.123 0.152 0.177 0.107 BRAIN 0.575 0.576 0.460 0.508 0.517 0.551 0.564 0.479 0.509 0.646 0.634 0.488 0.405 0.443 0.494 0.550 0.494 0.548 DuPont-9763 436 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AN D ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP : III-l - 75 mg/kg/day ANIMAL NUMBER 660592 660593 660594 660595 660596 660597 660598 660599 660600 660601 660602 660603 660604 660605 660606 660607 660608 660609 660610 LIVER 4.324 4.287 4.412 4.521 4.317 4.367 3.955 4.484 4.865 5.113 3.940 4.689 4.606 4.565 4.951 4.736 4.616 4.228 4.545 KIDNEYS 0.797 0.759 0.930 0.804 0.822 0.873 0.869 0.966 0.861 1.008 0.795 0.998 0.875 0.836 0.903 0.868 1.009 0.872 0.811 THYROID GLAND 0.006 0.009 0.006 0.005 0.004 0.007 0.008 0.006 0.005 0.007 0.005 0.007 0.005 0.006 0.006 0.009 0.006 0.005 0.003 SEMINAL TESTES EPIDIDYMIDES VESICLES 0.767 0.762 0.780 0.870 0.730 0.969 0.951 0.906 0.767 0.826 0.845 1.017 0.893 0.810 0.726 0.851 0.960 0.768 0.826 0.164 0.160 0.197 0.207 0.186 0.251 0.207 0.253 0.168 0.200 0.223 0.239 0.210 0.177 0.181 0.219 0.238 0.224 0.183 0.312 0.268 0.407 0.358 0.314 0.371 0.294 0.435 0.288 0.337 0.403 0.427 0.340 0.353 0.360 0.348 0.420 0.448 0.372 PROSTATE 0.076 0.066 0.125 0.117 0.084 0.135 0.142 0.176 0.122 0.131 0.151 0.141 0.091 0.106 0.095 0.165 0.116 0.167 0.149 BRAIN 0.478 0.504 0.592 0.521 0.495 0.615 0.542 0.539 0.473 0.504 0.523 0.647 0.585 0.501 0.500 0.497 0.559 0.528 0.511 DuPont-9763 437 Company Sanitized. Does not contain T S C A C B i ) H-25231: One-Generation Reproduction Study in Rats_________ ) INDIVIDUAL ANIMAL FINAL BOD Y AN D ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP : v-1 - 500 mg/kcf/day ANIMAL NUMBER 660611 660612 660613 660614 660615 660616 660617 660618 660619 660620 660621 660622 660623 660624 660625 660626 660627 660628 660629 LIVER 4.253 4.987 4.439 3.866 4.136 4.718 4.135 4.505 4.093 5.029 5.105 3.631 4.168 4.520 4.225 4.885 4.741 4.439 3.978 KIDNEYS 0.888 0.919 0.819 0.873 0.825 1.026 0.805 0.958 0.912 0.909 0.973 0.874 0.878 0.890 0.762 0.993 0.990 0.905 0.794 THYROID GLAND 0.007 0.006 0.004 0.009 0.004 0.007 0.004 0.006 0.007 0.005 0.005 0.007 0.006 0.007 0.006 0.006 0.007 0.007 0.006 SEMINAL TESTES EPIDIDYMIDES VESICLES 0.839 0.824 0.853 0.822 0.713 1.040 0.926 0.919 0.804 0.836 0.760 0.895 0.828 0.892 0.815 0.794 0.891 0.737 0.767 0.177 0.231 0.177 0.173 0.200 0.246 0.224 0.213 0.228 0.223 0.215 0.233 0.157 0.214 0.194 0.175 0.179 0.164 0.182 0.337 0.387 0.304 0.399 0.450 0.389 0.414 0.318 0.373 0.436 0.355 0.385 0.310 0.345 0.301 0.372 0.231 0.289 0.311 PROSTATE 0.129 0.158 0.105 0.112 0.112 0.115 0.152 0.129 0.150 0.154 0.154 0.127 0.092 0.120 0.070 0.109 0.089 0.102 0.087 BRAIN 0.518 0.542 0.552 0.538 0.513 0.606 0.496 0.572 0.599 0.532 0.528 0.499 0.508 0.575 0.515 0.503 0.642 0.508 0.524 DuPont-9763 438 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reprodudtion Study in Rats_________ INDIVIDUAL ANIMAL FINAL B O D Y A N D ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP : VII-1 - 3500 mg/kg/day ANIMAL NUMBER 660630 660631 660632 660633 660634 66,0635 660636 660637 660638 660639 660640 660641 660642 660643 660644 LIVER 4.944 4.953 4.554 3.997 4.711 4.615 4.753 4.316 4.355 5.666 4.265 4.575 4.769 4.459 4.229 KIDNEYS 0.945 0.972 0.887 0.868 0.836 0.960 0.895 0.835 0.885 1.054 0.921 0.807 0.991 1.015 0.896 THYROID GLAND 0.004 0.005 0.008 NW 0.005 0.005 0.008 0.007 0.007 0.006 0.006 0.007 0.006 0.006 0.007 SEMINAL TESTES EPIDIDYMIDES VESICLES 0.784 0.850 0.730 0.740 0.865 0.687 0.802 0.802 1.009 0.829 0.953 0.786 0.892 0.934 0.919 0.176 0.224 0.154 0.181 0.195 0.146 0.175 0.166 0.191 0.204 0.238 0.209 0.218 0.238 0.192 0.280 0.414 0.280 0.321 0.303 0.254 0.438 0.322 0.393 0.389 0.490 0.305 0.454 0.470 0.340 PROSTATE 0.098 0.105 0.116 0.086 0.083 0.104 0.103 0.121 0.700 0.123 0.189 0.085 0.107 0.153 0.105 NW = NOT WEIGHED BRAIN 0.508 0.574 0.557 0.527 0.543 0.557 0.605 0.493 0.579 0.662 0.595 0.574 0.623 0.536 0.555 DuPont-9763 439 Company Sanitized. Does not contain T S C A C B i H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BOD Y A N D ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS GROUP : i-i - o mg/kg/day ANIMAL NUMBER 660574 660575 660576 660577 660578 660579 660580 660581 660582 660583 660584 660585 660586 660587 660588 660589 660590 660591 LIVER 8.145 8.321 10.146 8.189 8.598 7.832 7.334 10.526 8.703 5.677 6.939 8.719 11.993 12.119 8.818 8.297 9.908 7.674 KIDNEYS 1.480 1.414 1.765 1.516 1.782 1.677 1.648 1.769 1.676 1.484 1.682 1.749 1.992 1.941 1.737 1.612 1.949 1.517 THYROID GLAND 0.012 0.013 0.009 0.012 0.010 0.011 0.010 0.010 0.011 0.010 0.009 0.011 0.014 0.014 0.009 0.011 0.013 0.009 SEMINAL TESTES EPIDIDYMIDES VESICLES 1.377 1.628 1.816 1.547 1.642 1.670 1.617 1.743 1.565 1.570 1.495 1.717 1.470 1.420 1.435 1.664 1.649 1.406 0.402 0.344 0.417 0.376 0.434 0.490 0.333 0.373 0.377 0.339 0.388 0.379 0.374 0.377 0.328 0.371 0.445 0.394 0.786 0.526 0.717 0.525 0.713 0.628 0.295 0.725 0.605 0.679 0.716 0.650 0.692 0.726 0.523 0.609 0.817 0.679 PROSTATE 0.265 0.160 0.228 0.235 0.282 0.231 0.224 0.219 0.213 0.197 0.224 0.219 0.218 0.298 0.248 0.277 0.359 0.196 DuPont-9763 440 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL B O D Y AN D ORG A N WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS GROUP : III-I - 75 mg/kg/day ANIMAL NUMBER 660592 660593 660594 660595 660596 660597 660598 660599 660600 660601 660602 660603 660604 660605 660606 660607 660608 660609 660610 LIVER 9.052 8.501 7.454 8.671 8.727 7.097 7.299 8.323 10.290 10.139 7.538 7.248 7.867 9.106 9.900 9.523 8.253 8.012 8.900 KIDNEYS 1.668 1.504 1.572 1.542 1.662 1.419 1.603 1.793 1.820 1.999 1.520 1.543 1.495 1.667 1.805 1.745 1.805 1.653 1.588 THYROID GLAND 0.013 0.018 0.010 0.010 0.009 0.012 0.015 0.011 0.010 0.014 0.010 0.010 0.008 0.011 0.012 0.018 0.012 0.010 0.006 SEMINAL TESTES EPIDIDYMIDES VESICLES 1.606 1.512 1.319 1.669 1.476 1.575 1.754 1.682 1.623 1.639 1.616 1.572 1.525 1.616 1.451 1.711 1.716 1.455 1.618 0.344 0.317 0.333 0.397 0.377 0.408 0.383 0.470 0.355 0.397 0.427 0.370 0.359 0.353 0.363 0.441 0.426 0.425 0.359 0.654 0.532 0.687 0.687 0.635 0.604 0.542 0.807 0.609 0.669 0.770 0.659 0.580 0.705 0.721 0.701 0.751 0.849 0.729 PROSTATE 0.159 0.130 0.211 0.224 0.171 0.220 0.262 0.327 0.257 0.259 0.288 0.218 0.156 0.210 0.189 0.331 0.207 0.317 0.293 DuPont-9763 441 Company Sanitized. Does not contain T S C A C B i H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY A N D ORG A N WEIGHTS - Ft ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS GROUP : V-l - 500 mg/kg/day ANIMAL NUMBER 660611 660612 660613 660614 660615 660616 660617 660618 660619 660620 660621 660622 660623 660624 660625 660626 660627 660628 660629 LIVER 8.204 9.204 8.042 7.187 8.068 7.791 8.334 7.880 6.834 9.446 9.663 7.271 8.208 7.861 8.206 9.714 7.386 8.742 7.597 KIDNEYS 1.713 1.696 1.484 1.623 1.610 1.694 !..623 1.675 1.523 1.708 1.841 1.749 1.728 1.548 1.481 1.976 1.542 1.782 1.516 THYROID GLAND 0.013 0.011 0.007 0.016 0.009 0.011 0.008 0.010 0.011 0.010 0.009 0.014 0.012 0.012 0.012 0.012 0.011 0.013 0.012 SEMINAL TESTES EPIDIDYMIDES VESICLES 1.618 1.521 1.546 1.528 1.391 1.717 1.867 1.608 1.343 1.571 1.438 1.793 1.632 1.550 1.584 1.578 1.388 1.451 1.465 0.341 0.426 0.320 0.322 0.390 0.406 0.451 0.373 0.381 0.418 0.407 0.466 0.309 0.372 0.376 0.348 0.278 0.322 0.348 0.650 0.713 0.550 0.742 0.879 0.643 0.834 0.556 0.623 0.819 0.672 0.771 0.610 0.601 0.584 0.740 0.361 0.570 0.594 PROSTATE 0.248 0.292 0.189 0.208 0.218 0.190 0.306 0.226 0.250 0.290 0.292 0.254 0.182 0.208 0.136 0.217 0.138 0.202 0.166 DuPont-9763 442 Company Sanitized. Does not contain TS C A CBJ H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BO D Y A N D ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS GROUP : VII-1 - 3500 mg/kg/day ANIMAL NUMBER 660630 660631 660632 660633 660634 660635 660636 660637 660638 660639 660640 660641 660642 660643 660644 LIVER 9.739 8.627 8.183 7.586 8.670 8.286 7.863 8.757 7.519 8.552 7.174 7.974 7.660 8.324 7.622 KIDNEYS 1.861 1.692 1.594 1.648 1.538 1.724 1.480 1.694 1.528 1.592 1.548 1.407 1.593 1.895 1.615 THYROID GLAND 0.008 0.009 0.014 NW 0.010 0.010 0.013 0.013 0.012 0.009 0.010 0.012 0.009 0.012 0.013 SEMINAL TESTES EPIDIDYMIDES VESICLES 1.543 1.480 1.311 1.404 1.592 1.233 1.327 1.627 1.742 1.251 1.603 1.371 1.433 1.744 1.656 0.347 0.391 0.277 0.343 0.359 0.262 0.289 0.336 0.329 0.308 0.400 0.364 0.351 0.445 0.347 0.552 0.721 0.504 0.609 0.557 0.456 0.725 0.653 0.679 0.588 0.824 0.532 0.729 0.877 0.613 PROSTATE 0.192 0.184 0.208 0.164 0.153 0.186 0.170 0.246 1.209 0.185 0.318 0.148 0.173 0.285 0.190 NW = NOT WEIGHED DuPont-9763 443 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY A N D ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grains) FROM FEMALE RATS GROUP : II-l - 0 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND UTERUS 660645 660646 660647 660648 660649 660650 660651 660652 660653 660654 660655 660656 660657 660658 660659 660660 660661 660662 216.6 227.0 232.4 216.8 257.4 206.2 238.8 249.2 230.2 218.4 220.8 230.1 285.7 229.6 265.3 284.7 242.7 222.6 8.720 8.918 11.372 9.924 11.231 8.126 9.351 11.983 9.501 8.664 8.723 9.079 14.561 9.657 10.343 12.805 11.366 9.028 1.811 2.059 2.088 2.060 2.305 1.999 1.986 2.264 1.929 2.110 2.128 2.243 2.582 2.218 2.365 2.453 2.302 1.760 0.018 0.019 0.017 0.015 0.021 0.017 0.020 0.022 0.022 0.028 0.015 0.025 0.018 0.025 0.018 0.021 0.015 0.023 0.756 0.699 0.447 0.485 0.600 0.508 0.296 0.488 0.317 0.564 0.366 0.463 0.502 0.530 0.400 0.600 0.433 0.363 OVARIES 0.093 0.140 0.160 0.192 0.126 0.172 0.123 ,1.987 0.107 0.117 0.107 0.111 0.190 0.184 0.166 0.189 0.181 0.106 BRAIN 1.823 1.902 1.499 1.895 1.893 1.810 1.734 1.819 1.851 1.741 1.863 1.809 1.844 1.939 1.783 2.045 1.874 1.729 DuPont-9763 444 Company Sanitized. Does not contain T S C A C B l H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AN D ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grains) FROM FEMALE RATS GROUP : IV-1 - 75 mg/kg/day ANIMAL NUMBER 660663 660664 660665 660666 660667 660668 660669 660670 660671 660672 660673 660674 660675 660676 660677 660678 660679 660680 FINAL BODY 234.3 195.2 240.6 252.4 197.5 195.7 225.8 223.2 207.5 240.6 266.8 219.1 235.8 241.3 264.2 238.1 210.5 213.2 LIVER 10.185 8.219 12.157 11.032 7.662 7.645 8.363 9.013 9.106 11.427 9.985 9.404 10.440 9.922 13.213 9.089 8.900 9.933 KIDNEYS 1.898 1.954 2.208 2.477 1.886 1.891 1.854 1.956 1.842 2.532 2.219 1.980 1.969 2.212 2.056 2.179 1.964 2.153 THYROID GLAND 0.024 0.013 0.012 0.019 0.013 0.023 0.024 0.017 0.013 0.022 0.008 0.020 0.030 0.010 0.014 0.029 0.020 0.017 UTERUS 0.720 0.515 0.350 0.445 0.396 0.406 0.420 0.492 0.830 0.624 0.356 0.336 0.883 0.584 0.358 0.694 0.404 0.351 OVARIES 0.112 0.130 0.121 0.147 0.112 0.100 0.109 0.148 0.134 0.126 0.135 0.110 0.110 0.110 0.095 0.143 0.120 0.097 BRAIN 1.826 1.645 1.915 2.006 1.818 1.857 1.746 2.027 1.829 1.831 1.836 1.926 1.766 1.900 1.746 1.901 1.766 1.748 DuPont-9763 445 Company Sanitized. Does not contain TS C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AN D ORGAN W EIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP : VI-1 - 500 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND UTERUS 660681 660682 660683 660684 660685 660686 660687 660688 660689 660690 660691 660692 660693 660694 660695 660696 660697 660698 660699 275.0 227.6 246.2 240.8 237.5 228.7 218.1 245.7 213.7 253.3 261.0 252.1 208.5 224.7 230.8 228.4 217.0 284.3 241.3 11.927 10.848 11.932 9.558 10.068 11.909 9.244 11.308 8.612 11.223 12.377 10.983 7.836 11.027 8.932 10.390 9.712 13.845 11.127 2.191 2.259 2.145 2.476 2.296 2.389 1.836 2.449 2.152 2.361 2.185 2.350 1.647 1.999 1.972 2.357 2.066 2.530 2.262 0.018 0.030 0.020 0.028 0.018 0.017 0.020 0.016 0.018 0.026 0.019 0.026 0.009 0.011 0.020 0.023 0.018 0.009 0.016 0.289 0.385 0.474 0.788 0.341 0.463 0.392 0.483 0.851 0.438 0.418 0.488 0.608 0.463 0.479 0.861 0.337 0.796 0.536 OVARIES 0.115 0.145 0.147 0.201 0.115 0.170 0.126 0.138 0.144 0.184 0.127 0.242 0.134 0.155 0.121 0.143 0.101 0.132 0.184 BRAIN 1.854 1.824 1.833 1.867 1.903 1.830 1.818 1.882 1.803 2.180 1.851 2.074 1.652 1.959 1.870 1.843 1.819 1.928 1.858 DuPont-9763 446 Company SanitizedL Does not contain. TSCA.CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AN D ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORG A N WEIGHTS (grams) FROM FEMALE RATS GROUP : VIII-1 - 3500 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND UTERUS 660700 660701 660702 660703 660705 660706 660707 660708 660709 660710 660711 660712 660713 660714 238.3 230.3 196.0 254.5 205.8 211.3 218.6 214.2 240.1 230.8 209.9 252.7 243.1 211.0 11.876 10.870 9.057 10.831 10.040 .9.083 9.546 9.639 11.202 10.081 9.258 10.440 11.938 9.020 2.431 2.431 1.666 2.162 1.972 2.063 1.872 1.918 2.195 1.759 1.987 2.014 2.582 2.064 0.018 0.016 0.017 0.020 0.017 0.022 0.018 0.024 0.016 0.022 0.017 0.019 0.015 0.017 0.347 0.353 0.320 0.628 0.325 0.456 0.412 0.682 0.394 0.508 0.334 0.668 0.594 0.661 OVARIES 0.161 0.121 0.107 0.177 0.124 0.121 0.109 0.123 0.116 0.144 0.124 0.123 0.163 0.195 BRAIN 1.887 1.746 1.606 1.915 1.784 1.717 1.622 1.764 1.868 1.656 1.806 1.730 1.937 1.632 DuPont-9763 447 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM FEMALE RATS GROUP : II-l - 0 mg/kg/day ANIMAL NUMBER LIVER KIDNEYS THYROID GLAND UTERUS OVARIES 660645 660646 660647 660648 660649 660650 660651 660652 660653 660654 660655 660656 660657 660658 660659 660660 660661 660662 4.026 3.929 4.893 4.577 4.363 3.941 3.916 4.809 4.127 3.967 3.951 3.946 5.097 4.206 3.899 4.498 4.683 4.056 0.836 0.907 0.898 0.950 0.895 0.969 0.832 0.909 0.838 0.966 0.964 0.975 0.904 0.966 0.891 0.862 0.948 0.791 0.008 0.008 0.007 0.007 0.008 0.008 0.008 0.009 0.010 0.013 0.007 0.011 0.006 0.011 0.007 0.007 0.006 0.010 0.349 0.308 0.192 0.224 0.233 0.246 0.124 0.196 0.138 0.258 0.166 0.201 0.176 0.231 0.151 0.211 0.178 0.163 0.043 0.062 0.069 0.089 0.049 0.083 0.052 0.797 0.046 0.054 0.048 0.048 0.067 0.080 0.063 0.066 0.075 0.048 BRAIN 0.842 0.838 0.645 0.874 0.735 0.878 0.726 0.730 0.804 0.797 0.844 0.786 0.645 0.845 0.672 0.718 0.772 0.777 DuPont-9763 448 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM FEMALE RATS GROUP : IV-1 - 75 mg/kg/day ANIMAL NUMBER 660663 660664 660665 66.0666 660667 660668 660669 660670 660671 660672 660673 660674 660675 660676 660677 660678 660679 660680 LIVER 4.347 4.211 5.053 4.371 3.879 3.906 3.704 4.038 4.388 4.749 3.743 4.292 4.427 4.112 5.001 3.817 4.228 4.659 KIDNEYS 0.810 1.001 0.918 0.981 0.955 0.966 0.821 0.876 0.888 1.052 p.832 0.904 0.835 0.917 0.778 0.915 0.933 1.010 THYROID GLAND 0.010 0.007 0.005 0.008 0.007 0.012 0.011 0.008 0.006 0.009 0.003 0.009 0.013 0.004 0.005 0.012 0.010 0.008 UTERUS 0.307 0.264 0.145 0.176 0.201 0.207 0.186 0.220 0.400 0.259 0.133 0.153 0.374 0.242 0.136 0.291 0.192 0.165 OVARIES 0.048 0.067 0.050 0.058 0.057 0.051 0.048 0.066 0.065 0.052 0.051 0.050 0.047 0.046 0.036 0.060 0.057 0.045 BRAIN 0.779 0.843 0.796 0.795 0.921 0.949 0.773 0.908 0.881 0.761 0.688 0.879 0.749 0.787 0.661 0.798 0.839 0.820 DuPont-9763 449 Company Sanitized Does not.contain TSC& C B I H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (% Of body weight) FROM FEMALE RATS GROUP : VI-1 - 500 mg/kg/day ANIMAL NUMBER 660681 660682 660683 660684 660685 660686 660687 660688 660689 660690 660691 660692 660693 660694 660695 660696 660697 660698 660699 LIVER 4.337 4.766 4.846 3.969 4.239 5.207 4.238 4.602 4.030 4.431 4.742 4.357 3.758 4.907 3.870 4.549 4.476 4.870 4.611 KIDNEYS 0.797 0.993 0.871 1.028 0.967 1.045 0.842 0.997 1.007 0.932 0.837 0.932 0.790 0.890 0.854 1.032 0.952 0.890 0.937 THYROID GLAND 0.007 0.013 0.008 0.012 0.008 0.007 0.009 0.007 0.008 0.010 0.007 0.010 0.004 0.005 0.009 0.010 0.008 0.003 0.007 UTERUS 0.105 0.169 0.193 0.327 0.144 0.202 0.180 0.197 0.398 0.173 0.160 0.194 0.292 0.206 0.208 0.377 0.155 0.280 0.222 OVARIES 0.042 0.064 0.060 0.083 0.048 0.074 0.058 0.056 0.067 0.073 0.049 0.096 0.064 0.069 0.052 0.063 0.047 0.046 0.076 BRAIN 0.674 0.801 0.745 0.775 0.801 0.800 0.834 0.766 0.844 0.861 0.709 0.823 0.792 0.872 0.810 0.807 0.838 0.678 0.770 DuPont-9763 450 Company Sanitized. Does not contain TS C A CBi H-25231: One-Generation Reproduction Study in Rats_______ INDIVIDUAL ANIMAL FINAL BODY AN D ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS {% of body weight) FROM FEMALE RATS GROUP : VIII-1 - 3500 mg/kg/day ANIMAL NUMBER LIVER KIDNEYS THYROID GLAND UTERUS OVARIES 660700 660701 660702 660703 660705 660706 660707 660708 660709 660710 660711 660712 660713 660714 4.984 4.720 4.621 4.256 4.879 4.299 4.367 4.500 4.666 4.368 4.411 4.131 4.911 4.275 1.020 1.056 0.850 0.850 0.958 0.976 0.856 0.895 0.914 0.762 0.947 0.797 1.062 0.978 0.008 0.007 0.009 0.008 0.008 0.010 0.008 0.011 0.007 0.010 0.008 0.008 0.006 0.008 0.146 0.153 0.163 0.247 0.158 0.216 0.188 0.318 0.164 0.220 0.159 0.264 0.244 0.313 0.068 0.053 0.055 0.070 0.060 0.057 0.050 0.057 0.048 0.062 0.059 0.049 0.067 0.092 BRAIN 0.792 0.758 0.819 0.752 0.867 0.813 0.742 0.824 0.778 0.718 0.860 0.685 0.797 0.773 DuPont-9763 451 Company Sanitized. Does not contain T S C A CB i ) H-25231: One-Generation Reproduction Study in Rats ) INDIVIDUAL ANIMAL FINAL BODY A N D ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP : II-l - 0 mg/kg/day ANIMAL NUMBER 660645 660646 660647 660648 660649 660650 660651 660652 660653 660654 660655 660656 660657 660658 660659 660660 660661 660662 LIVER KIDNEYS 4.783 4.689 7.586 5.237 5.933 4.490 5.393 6.588 5.133 4.976 4.682 5.019 7.896 " 4.980 5.801 6.262 6.065 5.222 0.993 1.083 1.393 1.087 1.218 1.104 1.145 1.245 1.042 1.212 1.142 1.240 1.400 1.144 1.326 1.200 1.228 1.018 THYROID GLAND 0.010 0.010 0.011 0.008 0.011 0.009 0.012 0.012 0.012 0.016 0.008 0.014 0.010 0.013 0.010 0.010 0.008 0.013 UTERUS 0.415 0.368 0.298 0.256 0.317 0.281 0.171 0.268 0.171 0.324 0.196 0.256 0.272 0.273 0.224 0.293 0.231 0.210 OVARIES 0.051 0.074 0.107 0.101 0.067 0.095 0.071 1.092 0.058 0.067 0.057 0.061 0.103 0.095 0.093 0.092 0.097 0.061 DuPont-9763 452 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP : IV-1 - 75 mg/kg/day ANIMAL NUMBER LIVER KIDNEYS THYROID GLAND UTERUS OVARIES 660663 660664 660665 660666 660667 660668 660669 660670 660671 660672 660673 660674 660675 660676 660677 660678 660679 660680 5.578 4.996 6.348 5.500 4.215 4.117 4.790 4.446 4.979 6.241 5.438 4.883 5.912 5.222 7.568 4.781 5.040 5.682 1.039 1.188 1.153 1.235 1.037 1.018 1.062 0.965 1.007 '1.383 1.209 1.028 1.115 1.164 1.178 1.146 1.112 1.232 0.013 0.008 0.006 0.009 0.007 0.012 0.014 0.008 0.007 0.012 0.004 0.010 0.017 0.005 0.008 0.015 0.011 0.010 0.394 0.313 0.183 0.222 0.218 0.219 0.241 0.243 0.454 0.341 0.194 0.174 0.500 0.307 0.205 0.365 0.229 0.201 0.061 0.079 0.063 0.073 0.062 0.054 0.062 0.073 0.073 0.069 0.074 0.057 0.062 0.058 0.054 0.075 0.068 0.055 DuPont-9763 453 Company Sanitized. Does not contain T S C CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP : VI-1 - 500 mg/kg/day ANIMAL NUMBER 660681 660682 660683 660684 660685 660686 660687 660688 660689 660690 660691 660692 660693 660694 660695 660696 660697 660698 660699 LIVER 6.433 5.947 6.510 5.119 5.291 6.508 5.085 6.009 4.776 5.148 6.687 5.296 4.743 5.629 4.776 5.638 5.339 7.181 5.989 KIDNEYS 1.182 1.238 1.170 1.326 1.207 1.305 1.010 1.301 1.194 1.083 1.180 1.133 0.997 1.020 1.055 1.279 1.136 1.312 1.217 THYROID GLAND 0.010 0.016 0.011 0.015 0.009 0.009 0.011 0.009 0.010 0.012 0.010 0.013 0.005 0.006 0.011 0.012 0.010 0.005 0.009 UTERUS OVARIES 0.156 0.211 0.259 0.422 0.179 0.253 0.216 0.257 0.472 0.201 0.226 0.235 0.368 0.236 0.256 0.467 0.185 0.413 0.288 0.062 0.079 0.080 0.108 0.060 0.093 0.069 0.073 0.080 0.084 0.069 0.117 0.081 0.079 0.065 0.078 0.056 0.068 0.099 DuPont-9763 454 Company Sanitized. Does not contain T S C A CBI H-25231: One-Generation Reproduction Study in Rats INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP : VIII-1 - 3500 mg/kg/day ANIMAL NUMBER LIVER KIDNEYS THYROID GLAND UTERUS OVARIES 660700 660701 660702 660703 660705 660706 660707 660708 660709 660710 660711 660712 660713 660714 6.294 6.226 5.639 5.656 5.628 5.290 5.885 5.464 5.997 6.088 5.126 6.035 6.163 5.527 1.288 1.392 1.037 1.129 1.105 1.202 1.154 1.087 1.175 1.062 1.100 1.164 1.333 1.265 0.010 0.009 0.011 0.010 0.010 0.013 0.011 0.014 0.009 0.013 0.009 0.011 0.008 0.010 0.184 0.202 0.199 0.328 0.182 0.266 0.254 0.387 0.211 0.307 0.185 0.386 0.307 0.405 0.085 0.069 0.067 0.092 0.070 0.070 0.067 0.070 0.062 0.087 0.069 0.071 0.084 0.119 DuPont-9763 455 Company Sanitized. Does not contain T S C A CBI