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m 478 TRADE SECRET Study Title H-25435: Repeated-Dose Dermal Toxicity 28-Day Study in Male Rats DuPont-11574 Test Guidelines: U.S.

tos b l ~ TRADE SECRET Study Title Hydrolytic Stability of H-25435 as a Function o f pH DuPont-14965 Test Guidelines: OECD Guideline 111 Author: Bogdan Szostek, Ph.D.

RECYCLED P'S m I v > C-8 T ' - AMMONIUM PEUFLUOROOCTANOATE CHRONOLOGICAL SUMMARY OF REPORTS Month/Year Sources June 1978 3M Co. discussion BVU UA Peonie 130 nu . ui Samples ?

ADVANCE UNEDITED DRAFT Decision POPRC-1/7 on perfluorooctane sulfonate The Persistent Organic Pollutants Review Committee, Having examined the proposal by Sweden, which is a Party to the Stockholm Convention on Persistent Organic Pollutants, to list perfluorooctane sulfonate and ninety-six potential perfluorooctane sulfonate precursors in Annex A to the Convention and applied the screening criteria specified in Annex D to the Convention, Noting that the perfluorooctane sulfonate anion does not have a Chemical Abstracts Service number and does not appear as an anion in the environment, but that the perfluorooctane sulfonate acid and its salts listed in the proposal have the following Chemical Abstracts Service numbers: (a) Acid 1763-23-1 (b) K+ salt 2795-39-3 (c) Li salt 29457-72-5 (d) NH4+ salt 29081-56-9 (e) Diethanolamine salt 70225-14-8 Decides, in accordance with paragraph 4 (a) of Article 8 of the Convention, that it is satisfied that the screening criteria have been fulfilled for perfluorooctane sulfonate, as set out in the evaluation contained in the annex to the present decision; Decides also, in accordance with paragraph 6 of Article 8 of the Convention and paragraph 29 of decision SC-1/7 of the Conference of the Parties to the Stockholm Convention, to establish an ad hoc working group to review the proposal further and to prepare a draft risk profile in accordance with Annex E to the Convention; Decidesfurther that issues related to the inclusion of potential perfluorooctane sulfonate precursors should be dealt with in developing the draft risk profile; Invites, in accordance with paragraph 4 (a) of Article 8 of the Convention, Parties and observers to submit to the Secretariat the information specified in Annex E in accordance with the format set out in annex [Y] to the report of its first meeting1before [Z], UNEP/POPS/POPRC. 1/10. 000243 P-2 Annex to decision POPRC-1/7 Evaluation of perfluorooctane sulfonate against the criteria of Annex D A.

AHAZG _ 06/ PFOA Acute Toxicity - J 000847 HAZLETON LABORATOIRES AMERCA.MC. 3301 KINSMAN BLVD..

3M Environmental Laboratory R126-0005 M ethod A nalysis of Potassium Perfluorooctanesulfonate or O ther Fluorochemicals in Serum Extracts U sing H PLC-Electrospray/M ass Spectrometry Method Number: ETS-8-5.1 Author: Lisa Clemen, Robert Wynne Approved By: 'L l Laboratory Manager Adoption Date: 03/01/99 Revision Date: <V / 2 C / Date Group Leader Technical Reviewer Date dh i / m Date 1.0 S c o p e a n d A p p l ic a t io n __________________________________________________________________ 1.1 Scope: This method describes the analysis of serum extracts for fluorochemical surfactants using HPLC-electrospray/mass spectrometry. 1.2 Applicable Compounds: Fluorochemical surfactants or other fluorinated compounds, or other ionizable compounds. 1.3 Matrices: Rabbit, rat, bovine, monkey, and human serum, or other fluids as designated in the validation report.

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M , 6 _ s t a t u s 'r e v i e w FLUOROCHEMICALS IN BLOOD 5/22/79, PGG On May 30, 1978, 3M informed Du Pont of findings of organic fluorocarbons in blood of employees exposed* to long-chain perfluoro surface-active materials.

AR226-2239 Phase Diagram of C-8 The phase diagram below shows the solid and vapor phases of C-8 as a function of temperature and pressure.

AR226-2765 FOR DU POST USE ONLY Copies to: HaclroiT t .E * Pont de Nemours and Company Haskell taboracer, far Toxicology a,,d Industrial Medicine fcllcton Road, Newark, Delaware J9711 HASKELL LABORATORY REPORT NO. 329-81 Material Vested ' !