Document NezddLdBkdk9vOmbk35a2BkgR
AR226-2765
FOR DU POST USE ONLY
Copies to:
HaclroiT t .E *
Pont de Nemours and Company
Haskell taboracer, far Toxicology a,,d Industrial Medicine
fcllcton Road, Newark, Delaware J9711
HASKELL LABORATORY REPORT NO. 329-81
Material Vested ' !--- ---
Octanoic acid, pentadecafluoto-,
ammonium salt*
;
Haskell No.
Other Codes C^8
tmsr^rrnkStudy Iniciated/ComDleced --r
*^CRfib Department Haskell Laboratory
ORAL LD50 TEST IN ,MICg
Procedure : The test material
Ab#y fintr1a-ga_s_t_r_lc in.tu-bation in ' 1 * * pension is corn oil, was administered
of female youn^ ^ " ^ 1 ^ 1 10 5 ! " C 6 8~ Up8 of m 1 *
6 roup.
1*1weighed and observed during f U - dav 1 f!?- ? ! survlvin* *0. wire
The LD50 y.lue ,,a8 c a l c S i f e J } r J
" * then " i c e d .
J. Finney.**
"suiatmd from ehe mortality data using the method of D.
Males
Dose ^B8/fcg)
4,000t
Average Body _ Weight fel
38
2,000t
38
1,000
38
750 31
500 36
250 30
! j
Suspension <*)
i
lis
10
A
3
2
1
Average Dose f o i L l
1.01 0.76 0.95 0.76 0.89 0.75
Mortality
10/10 10/10 10/10 10/10 4/10 1/10
LD50*** *57 mg/kg
1-
Company Sanitized. Doss not contain TSQA CBl
Results :
Dose (mg/kg)
Average Body Weight (a)
Females :
4 , 000t
35
2,000t
34
1,000
33
Suspension (%)
15 10 4
Average Dose (mL)
0.94 0.67 0.82
Mortality Ratio
10/10 10/10 10/10
LD50*** 457 mg/kg
750 25
3
0.62
10/10
500 33
2
0.82
4/10
250 24
1
0.60
1/10
Clinical Signs: Males: Stained and/or wet perineal area, weakness and weight loss in all surviving mice, eyes half closed at 1,000 and 250 mg/kg. Ruffled fur at 250 and 500 mg/kg, Ataxia at 1000, 500 and 250 mg/kg. Tremors at 500 and 750 mg/kg. All deaths occurred within 6 days after dbsing.
Females: Stained and/or wet perineal area, weakness and weight loss in all surviving mice. Eyes half d o s e d , stained face and tremors at 750 mg/kg. Ataxia at 500 mg/kg. Ruffled fur at 750 and 250 mg/kg. All deaths occurred within 7 days after dosing.
Summary: Ammonium perfluorooctanoate is moderately toxic when administered oraH y to young adult CD-I male and female mice; its LD50 for males and females is 457 mg/kg of body weight. Clinical signs included: stained and/or wet perinea' area, ataxia, tremors, weakness, ruffled fur, eyes half-closed and weight loss. All deaths occurred within 7 days after dosing.
Synonyms
perfluorooctanoate
Purity: ^
Contaminants
** Finney, D. J , , Problt Analysis, 3rd Ed,, 1971, Cambridge University Press.
2- Comps-r.;/ Sanitated. Dc to? contai* T&CA CB
ik*
95X Confidence Limits:
Males : Lower: Upper: Slope:
344 mg/kg 560 mg/kg 6.6
Females : Lower: Upper : Slope:
344 mg/kg
560 mg/kg 6.6
r
rnsn nd 2000 m8/ks dose level
LP50 data due to limitations o:
male and female computer.
were
not
calculated
In
Report by:
Hall Technician
Reviewed by :
0. Study Director
Approv" i b>" -----Gerald L. Kennedy
Chief, Acute Investigations Section
1981
3- -
Saw COtDPai^
oniain TS' noie
0033
