/\RJ2C,'018S oes^s PROTOCOL PFOS: A 96-HOUR TOXICITY TEST W ITH TH E M ARINE DIATOM (Skeletonema costatum) U .S.

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3M Chemicals 3M Center St.

Perfluorooctane Sulfonate: Current Summary of Human Sera, Health and Toxicology Data 3M January 21,1999 l 000014: January 21, 1999 TABLE OF CONTENTS EXECUTIVE SUMMARY............................................................................................................................. 3 I.

SPONSOR Elf Atochem S.A.

t r a d e SF.rRFT AR226-3095 Study Tide Laboratory Project ID: HLO-1998-01285 Data Requirements: Author: David Gabriel Study Completed on: April 17,1998 P erforming Laboratory: ConTox Ltd.

Severe Acute Respiratory Illness Linked to Use o f Shoe Sprays --Colorado, Novem ber 1993 P-1 Page l of 3 fit**6' 37^ Weekly November 26,1993 / 42(46);885-887 Severe Acute Respiratory Illness Linked to Use of Shoe Sprays -- Colorado, November 1993 On November 3, 1993, the Colorado Department of Health (CDH) was notified of acute respiratory illness in a Colorado woman following use of an aerosolized leather-shoe conditioner.

6 -- D&S5 ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE_______________________________________________ Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-603EF. (1Octanesulfonic acid) (CAS # 2795-39-3).

Pathology Review of Reported Tumorigenesis in a Two Year Study of FM-3924 in Rats November 25,1998 BY Pathology Associates International 6217 Centre Park Drive West Chester, Ohio 45069 Telephone (513) 779-9600 Fax (513) 779-9603 003099 Pathology Review of Tumors Reported in Rats Given FM-3924 Introduction: This report presents an independent assessment of tumorigenesis data obtained from a study to determine the chronic toxicity and carcinogenic potential of the fluorochemical FM-3924 in rats.

BACK TO MAIN Study Title Growth and Reproduction Toxicity Teat with N2803-2 and the rreshwater Alga, S1tnaetrua caprlcornutua Data Requirement) Guideline Number U.s.

BACK TO MAIN ACUTE TOXICITY TO AQUATIC INVERTEBRATES (FRESHWATER MUSSEL) REVISED Tissue analysis is now included.

AR^-Sg BIODEGRADATION TEST SUBSTANCE Identity: Perfluorooctanesulfonate, Lithium salt; may also be referred to as PFOS Li salt, FC-94, or FC-94-X. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, lithium salt, CAS # 29457-72-5) Remarks: The test sample is a mixture of the test substance in water (approximately 24.5% test substance and 75.5% water).

ACUTE TOXICITY TO FISH - /t / iw a f i-0111 TEST SUBSTANCE_______________________________________________ Identity: Perfluorooctanesulfonate, Lithium salt; may also be referred to as PFOS Li salt, FC-94, or FC-94-X. (1-Octanesulfonlc acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, lithium salt, CAS # 29457-72-5) Remarks: Test sample was taken from 3M production lot #1.

AR22-W* 0 STABILITY IN WATER (HYDROLYSIS) TEST SUBSTANCE Identity: N2-(N-methylperfluorooctanesulfonamido)-ethyl acrylate; may also be referred to as N-MeFOSEA, or MeFOSEA. (2-Propenoic acid, 2[[(heptadecafluorooctyl)sulfonyl]methylamino]ethyl ester, CAS # 25268-77-3) Remarks: Material is an amber, waxy solid, coded THAR3F2.

flRr& 'O 5G\ Summary PFOS Rat Two-Generation Reproduction Study Study Numbers: 3M T-6295.9, Argus 418-008 (in-life), FACT-TOX-012 (analytical).