In other words, it is not known whether the exposure in those epidemiologic studies was in fact cosmetic talc not containing asbestiform fibers.

In other words, it is not known whether the exposure in those epidemiologic studies was in fact cosmetic talc not containing asbestiform fibers.

December 10, 1973 The Scientific Advisory Committee of the Cosmetic, Toiletry & Fragrance Association, 1625 Eye Street, N.W., Washington, D.C. 20006 at a meeting held on September 2, J1973, designated that a subcommittee be set up to study the optical microscopic method proposed by the Food and Drug Administration.

' December 10, 1973 The Scientific Advisory Committee of the Cosmetic, Toiletry & Fragrance Association, 1625 Eye Street, N.W., Washington, D.G. 20006 at a meeting held on September 2, 1973, designated that a subcommittee be set up to study the optical microscopic method proposed by the Food and Drug Administration.

December 10, 1973 The Scientific Advisory Committee of the Cosmetic, Toiletry & Fragrance Association, 1625 Eye Street, N.W., Washington, D.C. 20006 at a meeting held on September 2, 1973, designated that a subcommittee be set up to study the optical microscopic method proposed by the Food and Drug Administration.

' . ' December 10, 1973 The Scientific Advisory Committee of the Cosmetic, Toiletry & Fragrance Association, 1625 Eye Street, N.W., Washington, D.C. 20006 at a meeting held on September 2, 1973, designated that a subcommittee be set up to study the optical microscopic method proposed by the Food and Drug Administration.

In dustrial Ilvglene Association Journal. 29. 350-4 (1968).

Pharmacopoeia, which specifies impurity limits, and by the CTFA (Cosmetic, Toiletry, and Fragrance Association), which now also dictates that there should be no detectable fibrous amphiboles such as asbestiform tremolite.

Bailey Ph.D. > Page 3 of the talc According to the CTFA specification for cosmetic talc the balance of the talc may consist of other naturally occuring minerals such as calcite chlorite dolomite kaolin and magnesite Prior to the early 1970's there was some concern that talc mined and processed commercially could be contaminated by asbestos or asbestiform minerals Since that time however the cosmetic industry specification for talc has been tightened to virtually eliminate that concern For example a 1977 investigation of 46 talc samples by FDA revealed only 3 to contain asbestos tremolite or anthophyllite and even then the level was only 0.1 or less As mentioned earlier there are no premarket approval requirements under FDCA for cosmetics or their constituent raw materials Accordingly there are no mandated regulatory standards or specifications for the grade of talc that may be used in formulating cosmetic products However the Agency did note in its discussion concerning talc as a Category I skin protectant ingredient for the prevention of diaper rash c.f. 55 FR 25224 June 20 1990 ) that cosmetic talc should contain at least 90 platy talc having flat as opposed to fibrous particles that is free of detectable amounts of fibrous minerals including asbestos Other general talc specifications have been published by the Pharmacopoeia which specifies impurity limits and by the Cosmetic Toiletry and Fragrance Association which now U.S.

Pharmacopoeia, which specifies impurity limits, and by the CTFA (Cosmetic, Toiletry, and Fragrance Association), which now also dictates that there should be no detectable fibrous amphiboles such as asbestiform tremolite.

------------------------------- 30 Cosmetics ------------------------------------------ ------- ------- ----- ----------- ---------,------ 30 Correction Fluids ----:-->----- ----------------------------------------------*--------------------- ---30 Electronics ----------- ---------------------- ------------- --------;------- >-------- -------- --------- 30 Floor Coverings----- ------------------ ------------- --------------------------.-------------------------- 30 Leathers------------------ ---------------------------- -------------------------- ---------------- ------- 31 Printing Inks --------------------------- ---------------- -------------------------------------------------- -----31 Roofing -----

Target group of this questionnaire Questions are addressed to the whole supply chain including industry associations, importers, distributors and downstream users.

Furthermore, the Cosmetic, Toiletry and Fragrance Association, Inc.

Excluding operations associated with the di- ?

Relative Risks RR for Common Epithelial Ovarian Cancers Associated with Potential Talc Exposure from Contamination on Rubber Products Cases Controls Exposure Total No. % with exposure Total Pelvic surgery Pelvic surgery prior to 1950 Use of condomst Use of diaphragmt 215 215 169 169 78 36.3 51 23.7 19 11.2 37 21.9 215 215 191 191 * Adjusted for parity nulliparous parous and menopausal status pre- and postmenopausal No. % wi