2 i 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 TABLE I I INTERLABORATORY COMPARISON OF ANALYTICAL RESULTS FOR TREMOLITE IN COSMETIC TALCUM-TYPE POWDERS ________________________________ RESULTS___________________________ __________ N.

}V EMORANDUM U C '^ ' S --Z'-- DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE PUBLIC HEALTH SERVICE FOOD AND DRUG ADMINISTRATION TO George H.

FILE NAME: Talc (TALC) DATE: 2005 DOC#: TALC178 DOCUMENT DESCRIPTION: Letter in Medical Journal - A Case of Fulminant 'Talc Pneumoconiosis' Where is the Smoking Gun?

Selected Cosmetic Ingredients > Talc in Cosmetics Page 1 of 6 Home Cosmetics Product and Ingredient Safety Selected Cosmetic Ingredients C o sm etics Talc in Cosmetics Talc is an ingredient used in many cosmetics, from baby powder to blush.

mm mm FUNDAMENTAL AND APPLIED TOXICOLOGY 10, 369-384(1988) ISSUES 499 Possible Mechanisms to Explain Dust Overloading of the Lungs 506 P.

Mwrn DOM ESTIC O PER ATIN G COMPANY N E W B R U N S W I C K , N.

FD FORM 431 (5/73) P R E V I O U S E D I T I O N IS O B S O L E T E .

New York University Department of Chemistry 4 Washington Place, Room 410 New York, N.Y. 10003 Telephone: (212) 598-3427 ATTACHMENT TO TABLE I ` Memorandum to: Dr.

MEMORANDUM OF TELEPHONE CONVERSATION Friday, February 27, 1976 BETOEEN: Marion Burros Reporter The Washington Post and Heinz J.

TABLE 1 Instrum ental Methods -- C apabilities Instrum ents ______________ Method Morphology Optics D iffraction Chem ical Analysis* LM: light m icroscope DS: d is p e rsio n staining XRD: x -ra y diffraction SEM: scanning electron m icroscope TEM: transm ission electron m icroscope EMA: elec tro n m icroprobe EMMA: electro n m icro sco p em icroprobe analyzer IMA: ion m ic ro p ro b e >1 /on >5 /un NO >1 /un >1 /un NO ^ 0 . 005 m NO > 0. 001 /un NO >5 /un NO > 0 . 005 /un NO >5 /un NO NO NO YES NO YES NO YES NO NO NO YES YES NO** YES YES YES ^diffraction methods indirectly analyze chem ically by identifying the crystalline phase present; chem ical analysis by electron optical instrum ents may utilize energy o r wavelength dispersive x -ray analyzers **may be fitted with energy o r wavelength dispersive x -ray analyzers waiter c. mecrone associates, inc, @tmheicrosc pe Incorporating "Crystal Front" .

Comments on the proposed method of identifying chrysotile and amphibole in talc to be used in foods and drugs that are to be taken internally as described in the Federal Register, Food and Drug Administration, Vol. 38, No. 188, September 28, 1973, Section 121.2006C, pages 27079 27081.

-1 * E A medically oriented "detective story."

Attachment.

17 March 1995 David A.

sures of j 76). al Sciences 3 Pollution oscopy and t. 23, 704 Structural 977). and Their rization," J of this National Bureau of Standards Special Publication 506.