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INTRA-COMPANY CORRESPONDE

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CHEMICALS AND PIGMENTS TECHNICAL SERVICE LABORATORY * CHESTNUT RUN LAB NOTE 81-9 MONASTRAL GREEN G, 6T-674-D - RESTANDARDIZATION Concurrent with consolidation of our phthalocyanine green line, we shall standardize GT-674-D.

t f/ l )i ii Air Lead~Blood Lead Models Donald A* HcCaughrart1 Two air lead-blood lead models have been constructed: .. \ Da model to describe the increase in blood lead from an ~ abrupt increase in air lead as experienced by persons in controlled environment experiments} 2) a model to describe . the contribution to the blood of airborne lead in the environment. 1, Abrupt Increase Model This model describes the average change in blood lead Concentration following an abrupt change in the concentra" tion of airborne lead- The avwage rate of change of blood lead is described by ft * A ~ B|i A is the average intake rate into the blood from all sources (pg/lQQ ml) Bp is the average removal rate from the blood from all sources (yg/100 ml) > Solving and reparametrizing, the model for the average blood lead concentration at time t Is: Lp for t < tq (pre-exposure) % Lg -- (I * Ip) expC- (t * tp)} l*(t) *< for tp < t < tf (during exposure) Ip + (lg * lp)exp(- }{I-xp{ |~~{tp*t0)}} for t > t^ (post exposure) X University of Washington, Seattle, Washington