ARR 3253 as --_ DuPon"atndHaEsnkveilrlonLmaebnotraaltoSrcyiefnocreHsealth AR2RE _3253 0 mrfmmrocker nas FROM: J.C.

Aragg - 3297. 479 ~ AR 226-3 297 `TRADE SECRET Study Title 'H-25499 and H-25500: Subchronic Toxicity 90-Day Gavage Study in Male Rats.

AR226-3359 3UNIVERSITAT 30SNABROCK J.

Biotransformation of ^C-Labeled Fluorotelomer Substances by Soil M Wane N,1, Szostek B.2, Buck R.C.3, Folsom P.W.1, Sulecki L.1, Powley C.2, Berti W.1, and Gannon J.T. 1 DuPont Central Research and Development, Newark, USA; 2 DuPont Haskell Laboratory; USA;3 DuPont Chemical Solu AR226-3364 Introduction Growing public interest in the environmental fate of fluorinated chemicals due to the global presence ofperfluorinated acids such as perfluorosulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). 8-2 TelomerB Alcohol (8-2 TBA, CP3(CF;,)(,CF:;CH:,CH20H) is a major raw material used in the manufacture of sales products (e.g. fluorosurfactants and fluoropolymers).

AR226-3379 Development Of A Biologically Based Model To Describe Perfluoroocta (PFOA) Kinetics P.M.

Fluoropolymer PTFE TFM-PTFE PVDF PFA Fluoroelastomer FFKM (Kalrez) FKM (Viton) Alternative Materials Polymer PE PP PA PVC PEEK PPS Elastomer EPDM Comparison of Fluoropolymers /Fluoroelastomers with alternative materials longterm neutral substances thermal stability shortterm neutral substances longterm agressive substances NaOH 50% < 60C NaOH 50% > 60C HCl < 60C chemical stability HCl H2SO4 > 60C < 60C H2SO4 > 60C HNO3 < 60C HNO3 > 60C -20C - 200C -20C - 260C -20C - 150C -20C - 200C -20C - 260C -20C - 150C -20C - 100C O O up to 60% O up to 70% -20C - 200C -20C - 260C -20C - 150C -10C - 260C -10C - 320C O only low O only low -10C - 150C -10C - 200C O O O O O concentration concentration 0C - 90C 0C - 110C 0C - 80C O up to 60% O up to 30% 0C - 90C 0C - 110C 0C - 80C O up to 5% O up to 60% 0C - 100C 0C - 60C O up to 40C O up to 40C 0C - 60C 0C - 60C 0C - 40C O up to 40C O up to 60% O up to 50% O only low O only low O only low O only low 0C - 250C 0C - 300C O concentration concentration concentration concentration 0C - 200C 0C - 260C O O O O -30C - 130C O O O O O Symbols Meaning Accept O with limitations Not fulfilled

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* - XYsi8 rheynRE.SEARCH Attachmen2t AR226~ 1774 Air Sampling Fluorochemical Report [ DuPont Washington Works -- Air Sampling Program Round 9 r Exygen Research Report No.

1 CHEMICAL RESISTANCE LIST A B C D E F G H I K L M N O P R S T U V W X Z Chemical resistance list This list uses a rating system to show the chemical resistance of various elastomer materials to different operating media.

SolubilitEystimateofFC-95 by use of XerlexTOC Analyzer WATER SOLUBILITY (BY ANALYSIS OF TOG) TEST SUBSTANCE Identity:Peffluorooctanesulfonatmea;y alsobe referredto as PFOS or FC-95. (1-Octanesulfoniaccid,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-p,otassium saltC,AS # 2795-39-3) Remarks field: The testsubstance isa whitepowder (3M Lot 583) of uncharactedzed purity.

FinalReport Salmonell-aEscherichicaoli/N4ammalian-Microsome ReverseMutationAssay withPFOS PREPARED FOR: 3M CorporateToxicology COVANCE STUDY NUMBER: 20784-0-409 C 0 V A14-@EC@- THE DEVELOPMEW SERVW.ESCOMPAW FINAL REPORT SALMONELLA ESCHERICHIACOLI/MANUAALIAN-MICROSOME REVERSE MUTATION ASSAY WITH PFOS AUTHOR Michael S.Mecchi,MS PERFORMING LABORATORY Covance LaboratorieIsnc.