$X )ltrO % t Analytical Laboratory RepSotrutdoyn PTritelseence and Concentration of Potassium Perfluorooctanesulfonate in Serum and Liver of Sprague-Dawley Rats Exposed to PFOS via Gavage REPORT AMENDMENT NO. 1 Am1e9nAdpmrieln2t00D0ate: Performing Laboratory 3M Environmental Technology & Safety Services 3M Environmental Laboratory 935 Bush Avenue St.

AR226-2381 c- 8 EXWIRONMENTAL STATUS History Industrial Hygiene Engineering Changes Protective Equipment Air Monitoring Blood Sampling Long-Term and Short-Term Employees New Hires C-8 Material Balance Off-Plant Disposal In Product To River To Atmosphere Ground Level Modeling Results ENVIRONMENTAL ALTERNATIVES PIP Replace C -8 - C 7F 15CO2NB4 With TBSA - R fC H 2CH2S03H fine Powder EID09134I No Known Substitute Two Expensive Alternatives - Scrubbing of Vents - Conversion to Presumed Innocuous Compound C 7F 15C02NH4 C 7F 15H + C02 + N H 3 RJZQ26744 EID091341 8/ SI 6/27/78 6/12/79 8/13/79 9/79 11/12/79 C "8 REVIEW ' HISTORY BEGAN USE OF C-8 IN DISPERSION POLYMERIZATION, ` FEW PRECAUTIONS'IN HANDLING, ' `: ADVISED EMPLOYEES THAT 3M' FOUND ELEVATED ORGANIC FLUORINE LEVELS IN BLOOD OF WORKERS EXPOSED TO FLU0R1NATED SURFACTANTS, WE WOULD REVIEW OUR SITUATION, ADVISED EMPLOYEES THAT THE REVIEW WAS COMPLETE WITH NO PROBLEMS FOUND, AS AN ADDITIONAL STEP FLUORINE LEVELS IN SOME EMPLOYEES WOULD BE CHECKED.

AR226-2460 y w y w w w y w w w y tw * v> -- * w ?

AR226-2691 13 AR226-2691 DuPont EMSE Report No. 15-03 Study Title Accelerated Biodegradation of 8-2 Telomer B Alcohol- A preliminary Screening Study j I Test Guideline This study uses the concept o f OECD Guideline for Testing o f Chepiicals; Section 3: Inherent Biodegradability (1992).

AR226-2919 FOR DU PONT USE ONLY E .

P* M AA6 - Z l t f TRADE SECRET DuPont-8837 Study Title H-24616: In Vitro Dermal Penetration Through Rat Skin Laboratory Project ID: DuPont-8837 Test Guidelines: None were applicable Author: William J.

firK&k) -- 468 DuPont-11418 ftM U b -} * * 6 TRADE SECRET Study Title H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 1 of 5 Laboratory Project ID: DuPont-11418 Test Guidelines: U.S.

P H nu- aoif. 486 DuPont Haskell Laboratory for Health and Environmental Sciences M zu - i m TO: FROM: MRFIL] POCKET H-24921 J.

AR226-3347 Analytical challenges in determination of Telomer 8-2 Jcohol and Telomer-derived fluorosurfactants and polymets4n biological and environmental matrices.

AR226-3386 Development of a Mammalian Screen to Evaluate Absorption and Persistence of Fluorinated Chemicals C.

AKA _ m -o r 9 000130 Aknas- zvof s T itle: Bioanalytical Method Validation for the Quantitation o f Perfluorooctanoic A dd in Human Serum A uthors: David J.

RECYCLED & SGCOOO 9W )iV y 4 A R C - lf-39 July 29, 1982 TO: R.

FLAIR DOCUMENTS AR226-3477 AR226-3477 FLAIR Work and Medical Historiesfo r A ll Employees A nd A ll Years Tuesday, November 09, 2004 Page 1 o f 897 0600 0340-S Date o fSample C8 Concentration UTILITY POOL FILAMENTS SERF OPER 8/8/1984 3/1/1985 3/15/1988 9/26/2002 9/27/2002 0.05 0.05 0.2 0 0 157 362 1472 6780 6781 12/3/1979 5/16/1980 5/16/1980 3/4/1984 3/4/1984 Tuesday, November 09, 2004 JBidacied *Prlraity Page 2 o f 897 0600 UTILITY POOL 0340-S FILAMENTS SERF OPER 0442-S POWER SERF OPER 1540-S C&P COLOR AND SERF OPER 1560-S C&P COLOR AND PROC OPER 0500 MECHANIC 3/15/1994 0.46 3/6/1963 5/6/1963 5/6/1963 1/2/1967 1/2/1961 2/12/1968 2/12/1968 10/21/1968 10/21/1968 1/31/1912 1/31/1912 Tuesday, November 09, 2004 Page 3 o f 897 Date o fSample C8 Concentration 0600 UTILITY POOL 0340-S FILAMENTS SERF OPER 0940-S BUTACITE SERF OPER 0600 UTILITYPOOL 0340-S FILAMENTS SER F OPER 0940-S BUTACITE SERF OPER 0700 LABORA TORIAN 0002-W MILITR Y SER FICE WAGEROLL 0700 LABORAT0R1AN 0760-S TECH LAB SR LABN 0500 MECHANIC 0500 TF MECHANIC TEFLON 2/22/1982 0.83 2482 6/28/1963 7/2/1963 7/2/1963 9/26/1963 9/26/1963 10/18/1963 10/18/1963 1/17/1964 1/17/1964 2/27/1964 2/27/1964 3/25/1964 3/25/1964 8/20/1965 8/20/1965 1/17/1966 1/17/1966 12/19/1961 12/19/1968 1/25/1972 1/25/1972 5/8/1975 5/8/1975 Tuesday, November 09, 2004 Redacted - Fjv Page 4 o f 897 Begin Date End Date_ 0600 UTILITY POOL 6/17/1959 7/20/1959 0251-H ZYTEL CASTER BLENDER (DAYS) 7/20/1959 4/11/1960 0600 UTILITY POOL 4/11/1960 5/16/1960 0340-S FILAMENTS SERV OPER 5/16/1960 11/18/1960 0001-W NO WORK (LAY OFF) WAGEROLL 11/18/1960 11/13/1961 0600 UTILITY POOL 11/13/1961 12/4/1961 0340-S FILAMENTS SERV OPER 12/4/1961 5/14/1962 0340-S FILAMENTS SERV OPER 5/14/1962 7/7/1963 0340-S FILAMENTS SERV OPER 7/7/1963 3/6/1966 0250-H ZYTEL BLENDER 3/6/1966 5/1/1966 0245-H ZYTEL MATERIALS HANDLER AND SUPPLY CLERK 5/1/1966 2/26/1967 0250-H ZYTEL BLENDER 2/26/1967 4/2/1967 0240-S ZYTEL POLY SERV OPER 4/2/1967 7/2/1967 0250-S ZYTEL CASTER BLENDER 7/2/1967 12/24/1967 0240-S ZYTEL POLY SER V OPER 12/24/1967 1/5/1969 0442-S POWER SERV OPER 1/5/1969 8/29/1971 0457-H POWER DRIVER 8/29/1971 5/10/1974 1441-H MECHANICAL SER V OPER 5/10/1974 1/13/1975 Tuesday, November 09, 2004 P ftife-vv01 Page 5 o f 897 0500 MECHANIC 0500 TF MECHANIC TEFLON 1/21/1982 0.19 1/13/1975 4/30/1978 4/30/1978 1362 Tuesday, November 09, 2004 Redacted - Pr'vac; Page 6 of 897 Job Code Job Title Begin Date End Date Date o fSample C8 Concentration Days in Teflon at Time o f Sample 060 UTILITYPOOL V TM 1977 6/29/1977 0340-S FILAMENTS SERV OPER 6/29/1977 10/1/1977 0840-S FP TEFLON TFE SERV OPER FINE POWDER 10/1/1977 10/2/1977 0840-S TEFLON TFE SERV OPERJFINE PWDR-DISP SERV O 10/2/1977 6/1/1978 0844-S 0844-S 0866-S TEFLON COPOLYMERS FEP SERV OPER 6/1/1978 6/12/1978 TEFLON COPOLYMERS FEP SERV OPER 6/12/1978 9/25/1979 1-7 724 TEFLON COPOLY TEFZEL-TEL A OPER/DISP FIN O 1/2/1980 7/15/1981 0.98 1383 7/12/1982 0.77 1745 1/2/1980 Tuesday, November 09, 2004 n.

14) OECD 202-OPPTS 850.1010, 48-hour static acute toxicity test with the Cladoceran (daphnia magna), 454A-118A PERFLUOROBUTANE SULFONATE, POTASSIUM SALT (PFBS): A 48-HOUR STATIC ACUTE TOXICITY TEST WITH THE CLADOCEFAN (Daphnia magna) FINAL REPORT SANITIZED WILDLIFE INTERNATIONAL, LTD.

Project / Study Archive Request Shaded areas for Archivist use only Requestor Name Kent Lindstrom Phone 651 778-5352 Date 04/05/05 Request for: E Archival Retrieval Report IE!