FILE NAME Talc TALC DATE 2010 Aug 3 DOC TALC494 DOCUMENT DESCRIPTION Legal - Declaration of M.

FILE NAME Talc TALC DATE 2014 DOC TALC134 DOCUMENT DESCRIPTION Journal Article - Talc Use and Ovarian Cancer- Epidemiology Between a Rock and a Hard Place DOI dju260 First published online September 11 2014 xs Published by Oxford University Press 2014 This work is written by a US Government employee and is in the public domain in the US Talc Use and Ovarian Cancer Epidemiology Between a Rock and a Hard Place Nicolas Wentzensen Sholom Wacholder Correspondence to Nicolas Wentzensen MD PhD MS Division of Cancer Epidemiology and Genetics National Cancer Drive Room E114 Bethesda MD 20892-9774 mail Institute 9609 Medical Center wentzenn@mail.nih.gov With over 14000 deaths in the United Stated each year ovarian cancer is the most lethal gynecologic cancer 1 Most ovarian can- cers are detected at late stage and have poor prognoses Given the failure at prevention of death by screening for ovarian cancer using CA and transvaginal ultrasound 2 finding potential preventive interventions has greatest promise of reducing ovarian cancer mortality Ample epidemiologic evidence suggesting that inflammation plays an important role in ovarian carcinogenesis include associa- Downlade tions of incessant ovulation endometriosis and pelvic inflamma- tory disease with increased ovarian cancer risk 3 and reduced risks from observed for regular aspirin users 4 Evidence on perineal talc use as a risk factor for ovarian can- cer is more equivocal Talc a metamorphic mineral composed of magnesium silicate that absorbs water is a common component of genital powders Naturally talc has similarities to and occurs with asbestos although early studies hypothesized that asbestos contamination of talc may have a causal role in ovarian carcinogen- htp:/jnci.oxfrdualsg/ esis later control studies reporting use after cosmetic prod- in medical or pharmacy records that could be used to confirm or supplant reported use Therefore reporting bias is of great concern in control studies Previous studies have argued that a stronger association observed for certain ovarian cancer subtypes speaks against reporting bias 8 However the clinical presentation and prognosis of ovarian cancer which varies by ovarian cancer subtype may differentially affect cases reporting Further the quantification of tale dose is very difficult Cosmetic perineal powders vary in talc content Talc can be applied as spray or powder either directly to the genital region using swabs or by application on diaphragms The amount of talc applied or making contact with the ovary may vary substantially by mode of application Particularly the cohort studies suffer from very limited exposure information The Nurses Health Study which previously reported on talc use collected only information on frequency of talc use per week 11 whereas the Women's Health Initiative 7 only collected information on duration of use not on frequency So far no epidemiologic study has demonstrated a response relationship between talc use and ovarian cancer risk ucts became asbestos in the United States continued to show associations In addition to the difficulties of talc exposure assessment ovarian by guest The biological basis of possible talc cancer is a challenging outcome because of its rarity and heteroge- carcinogenicity is not neity 12 There is increasing evidence supporting the hypothesis on understood Direct physical contact of tale with ovarian epithelium that ovarian cancers may derive from different cells of origin For May may cause chronic inflammation some studies have suggested ret- example some serous ovarian cancers supposedly originate in the rograde transport of talc particles through the reproductive tract fallopian tubes while some endometrioid 29 5 A mechanism that would not require direct contact of talc with cancers may originate in 2016 the tissue at risk is reduction of ectopic or orthotopic endometrial tissue 13 Reports of a stronger MUC1 antibodies which are association of talc use with serous ovarian cancers compared with associated with lower risk of ovarian cancer 6 other subtypes 8 might suggest that talc to the fallo- In this issue of the Journal Houghton and colleagues report on exposure pian tubes plays a role in carcinogenesis However the associations the association between perineal powder use and ovarian cancer with serous cancers are not consistent and experimental data are risk from the observational arm of the Women's Health Initiative lacking Even larger sample sizes and quality subtype data are WHI 7 Although several control studies have reported needed to establish specific associations associations between talc use and ovarian cancer risk 8-10 the Based on the evidence from epidemiologic studies in 2006 the only previous prospective evaluation of talc use and ovarian can- International Agency for Research on Cancer IARC classified cer risk did not find an association with ovarian cancer overall but geni- tal talc use as possibly carcinogenic to humans carcinogen group 2B with serous ovarian cancer the most common and most lethal sub- 14 The limited evidence for this recommendation based type 11 With over 400 cases the new study was well powered to was pri- marily on the control studies that showed increased risk of ovar- confirm previously reported effect sizes 7 However the authors ian cancer From a regulatory perspective cosmetic products do not found neither an association between perineal powder use with require review by the US Food and Drug Administration FDA but ovarian cancer overall nor with specific subtypes the FDA can act on evidence of harm related to cosmetic products Assessing the association between talc use and ovarian cancer While the FDA is currently monitoring potential health effects of cos- risk poses several challenges First and foremost assessment of talc metic talc use the activities have mainly focused on assuring that cos- exposure relies purely on report Talc use is not documented metic tale products are asbestos 15 Helpful recommendations inci.oxfordjournals.org JNCI [ Editorial 1 of2 to women will need to weigh the benefits of perineal talc use against the potential harms and the effective alternative products for reducing moisture absorption to prevent chafing and rashes no evaluation of term use of alternative products has been undertaken How do the results from Houghton et al 7 change the assessment of harm related to perineal talc use Overall the evidence regarding carcinogenicity of talc use remains inconclusive While reporting bias may explain the positive associations reported from control studies the limitations of cohort studies regarding possibil- exposure assessment still do not completely eliminate the ity that talc use is associated with ovarian cancer risk So where do we go from here Ideally we would want to have quality exposure data on talc use in a cohort setting with periodic updates on exposure These data are currently not available Ovarian cancer is rare and collecting these data prospectively will take time Behavioral exposures such as cosmetic talc use are very difficult to assess even though they are important for etiology and possibly public health Cohort studies need attentive participants long follow detailed histology and large sample size to be helpful control studies must avoid differential misclassification There does not seem to be an independent more objective data source that could be used to assess talc exposure With the current evidence it does not seem likely that additional conventional epidemiological studies will strengthen the evidence for or against talc carcinogenicity Other exposures face similar challenges of misclassification and reporting bias such as diet and physical activity One possible long shot for exposure assessment might be phone apps similar to those that can improve food frequency assessment or physical activity 16 These technologies could improve quantification of talc use providing detailed data on dose frequency and duration in cohort study participants Meanwhile cosmetic talc use has substantially decreased in the United States between 1982 and 2004 17 While the reasons are not clear it is possible that consumers already react to reports of potential harms despite the lack of clear evidence References 1.

FILE NAME Reddaway Manufacturing REDD DATE 2012 Apr 13 DOC REDD011 DOCUMENT DESCRIPTION Legal - Deposition - Todd Walker ERIK ROSS PHILLIPS ET AL vs ALBANY INTERNATIONAL CORP ET AL Todd Walker on 04/13/2012 Page 1 IN THE UNITED FOR THE EASTERN STATES DISTRICT COURT DISTRICT OF PENNSYLVANIA ERIK ROSS PHILLIPS and TINA LANDERS Spouse VS ALBANY INTERNATIONAL CORPORATION et al EDPA FILE NO 600074 CIVIL ACTION MDL 975 NO Friday April 13 2012 10 Videotaped Deposition of TODD WALKER 11 was taken pursuant to Notice at the law offices of 12 COZEN O'CONNOR 457 Haddonfield Road Suite 300 13 LibertyView Cherry Hill NJ 08002 on the above date 14 before DEBRA G.

FILE NAME: Ford (FD) DATE: 2016 DOC#: FD252 DOCUMENT DESCRIPTION: Article from Website - "Ford Spent $40 Million to Reshape Asbestos Science" Science ior Salo Ford spent $40 million to reshape asbestos science Stung by lawsuits, the automaker hired consultants to change the narrative on the risks of asbestos brakes By Jim M orris X e email 5.00 am, February 16,2016 ... : . > .

FILE NAME: Dana (DAN) DATE: 2012 DOC#: DAN011 DOCUMENT DESCRIPTION: Legal - Motion and Exhibits from Stuckart vs.

FILE NAME: Warren Pumps (WAR) DATE: 2012 Oct 12 DOC#: WAR010 DOCUMENT DESCRIPTION: Legal - Deposition of Roland Doktor Roland Doktor Volume II October 12, 2012 1 VOLUME 2 PAGES 109 - 228 2 EXHS. 22, 29 - 31 3 4 UNITED STATES DISTRICT COURT 5 WESTERN DISTRICT OF WASHINGTON 6 AT TACOMA 7 Q 'k-k'k-k'k'k'k'k'k'k'k'k'k'k'k Roland L.

FILE NAME Lab Exposure LAB DATE 2018 DOC LAB001 DOCUMENT DESCRIPTION Abstract - Article in Medical Journal From Huff James NIEHS G huff1@niehs.nih.gov Date June 15 2018 at 2:38:42 PM EDT To Undisclosed recipients Subject Evaluation of airborne asbestos exposure from routine handling of containing wire gauze pads in the research laboratory Regulatory Toxicology and Pharmacology Volume 96 July 2018 Pages 135-141 Evaluation of airborne asbestos exposure from routine handling of containing wire gauze pads in the research laboratory Ediberto Garcia a Daniel Newfang a Jayme P.Coyle a Charles Blake b John W.Spencer c Leonard G.Burrelli c Giffe T.Johnson a Raymond D.Harbison a a Center for Environmental and Occupational Risk Analysis and Management Department of Environmental and Occupational Health College of Public Health University of South Florida 13201 Bruce B.

FILE NAME Brakes BRK DATE 2014 DOC BRK225 DOCUMENT DESCRIPTION Journal Article - Asbestos Exposure Among Transmission Mechanics in Automotive Repair Shops he- Ann Occup Hyg 2014 2014 1-15 1-15 meu093 The Chartered Society or Worker Hearn Profection Asbestos Exposure among Transmission Mechanics in Automotive Repair Shops Natalia Salazar Mar^>aFernanda Garc^>aPatrick N.

FILE NAME: Azrock-Domco (AZD) DATE: 2013 DOC#: AZD006 DOCUMENT DESCRIPTION: Barry Castleman Notes on Domco Hi ^ 2 .-4 7 G 'Z& n jr'^ }2. / 7-J0 # - stss.

FILE NAME: Hercules Chemical (HERC) DATE: 2014 DOC#: HERC032 DOCUMENT DESCRIPTION: Legal - Defendant Hercules Inc.'

FILE NAME Packings and Gaskets PAG DATE 2014 DOC PAG062 DOCUMENT DESCRIPTION Journal Article - Airborne Asbestos Associated with Gasket and Packing Replacement YRTPH No. of Pages 15 Model 5G Regulatory Toxicology and Pharmacology xxx 2014 XXX Contents lists available at ScienceDirect Regulatory Toxicology and Pharmacology journal homepage www.elsevier.com/locate/yrtph 3 Airborne asbestos exposures associated with gasket and packing 4 replacement A simulation study and analysis Q1 Amy K.

FILE NAME: KUB DATE: 2010 KUB030 DOC#: KUB030 DOCUMENT DESCRIPTION: Legal - Responses to Interrogatories Set One o r FAX 133/137 i 1 Thomas C.

FILE NAME: Talc (TALC) DATE: 2010 DOC#: TALC126 DOCUMENT DESCRIPTION: IARC Report Vol 3 on Talc TALC NOT CONTAINING ASBESTIFORM FIBRES 1.

FILE NAME: Engelhard (ENG) DATE: 2012 DOC#: ENG001 DOCUMENT DESCRIPTION: Legal - Declaration of John Templin in Support of Plaintiffs' Opposition to Defendant's Motion for Summary Judgment '2012 03:49 5627995531 MAS PAGE 1 2 tSigTeErmPHanE@NhMtla.wTQIGfTEicReMs.cAoNm(State Bar No. 112127) MIA MAITIS (State Bar No. 191027) 3 mLIaSttAis@BRhOtlaKwAoWffic(eSst.actoemBar No. 247422) 4 HbrAokRaOwW@IhTtlZaw&oTffIiGceEs.RcoMmAN, LLP 5 450 Sansome St., 3rdFloor 6 San Francisco, CA 94111 Tel: (415) 788-1588; Fax (415) 788-1598 7 Attorneys for Plaintiffs 8 9 SUPERIOR COURT OF CALIFORNIA 10 COUNTY OF SAN FRANCISCO - UNLIMITED JURISDICTION l 12 13 THOMAS RUBINO, Individually and as ) Case No.: CGC-08-274556 JSRu.c,cDesescoerd-einn-ti;nDteAreNstIEtoLCRAURBMININOE; aRnUdBDIONEOS. )) DECLARATION OF JOHN TEMPLIN IN 14 ONE through TEN, inclusive, )) SUPPORT OF PLAINTIFFS' OPPOSITION TO DEFENDANT BASF 15 Plaintiffs, )) CORPORATION'S MOTION FOR SUMMARY JUDGMENT AND/OR 16 AC andvSs., INC., et al, ) ADJUDICATION j 17 Defendants. ) 18 ) 19 _________ _ _ ________________ )) 20 21 I, John Templin, declare as follows: 22 1.

FILE NAME: Asbestos in Plastics (AIP) DATE: 2010 Sept DOC#: Al P001 DOCUMENT DESCRIPTION: Unpublished Consultant Report on Airborne Exposures from Sawing Asbestos Containing Resin Pipe <nJL