The applicants have been involved in the research that lead to the existing SAR for industrial fibres for over thirty years, and therefore we know and understand the literature on fibres and can explain its relevance to HARN.

FRANCIS J.

They recognise that cooperation among OHS stakeholders will lead to more efficient and effective prevention efforts.

Active research interests include: environmental health indicators and disease surveillance, childhood asthma, lead poisoning, reproductive and endocrine health hazards of sport fish consumption, arsenic in drinking water, chemical and nuclear terrorism, occupational and environmental respiratory disease, occupational fatalities, and occupational injuries to youth.

The applicants have been involved in the research that lead to the existing SAR for industrial fibres for over thirty years, and therefore we know and understand the literature on fibres and can explain its relevance to HARN.

Crane Co. objects to the Discovery Requests to the extent they are unduly burdensome and overbroad or seek information that is not relevant to this lawsuit and are not reasonably calculated to lead to the discovery of admissible evidence.

FILE NAME: Texaco (TEX) DATE: 2004 Jan 6 DOC#: TEX039 DOCUMENT DESCRIPTION: Legal - Deposition of Barry Castleman 1 i c s 1 SUPERIOR COURT OF WASHINGTON FOR SKAGIT COUNTY 2 VIRGINIA JAMESON, x 3 Individually and as Personal representative of the Estate 4 of RAY JAMESON, 5 Plaintiff, 02-2-01069-8 9 Tuesday, January 6, 2004 10 Rockville, Maryland 11 12 DEPOSITION OF: 13 BARRY CASTLEMAN.

DRAFT TOXICOLOGICAL PROFILE FOR ARSENIC U.S.

Journal of Peptide Science J.

Elucidation of the molecular mechanisms underlying RCC development leads to the identification of promising targets for tumor early diagnosis and the further development of targeted therapy based on the biological pathways that are deregulated in an individual.

On the other hand, DNA hypermethylation leads to silencing of tumor suppressor genes, including cell-cycle inhibitors, inducers of apoptosis, DNA repair genes, transcription factors, cell adhesion mediators, hormonal receptors and detoxifiers [1].

:~:: API oversight provided by General Committee on Special Programs SH ELL-MCCLU RG-065393 Shanghai Health Study Update :~::~:i::~::~: Hi9hIi9hts ::":: WHO classification of tumors applied :}:: Nutritional anemias identified :}:: Benzene Induced Dysplasia - indicates benzene may have a unique signature TSCA 8Ce) filed I::,:::::: Lab transferred to Fudan University School of Medicine ::':: Cinpathogen, a private company, replaced University of Colorado as lead institution SH ELL-MCCLU RG-065394 Shanghai Health Study Update Path Forward Case accrual completed Data analysis Publications International Benzene Symposium in Munich Benzene Health Research Consortium will disband SH ELL-MCCLU RG-065395 Benzene Health Research Consortium Sponsoring Companies ~ BP ~ Chevron ~ ConocoPhillips ~ ExxonMobil ~ Shell Chemical LP Marathon/Ashland providing additional support SH ELL-MCCLU RG-065396 Shanghai Health Study .:.

COMMENTS: IMS: IMT: PLW BETTY WATKINS/DC/USEPA/US Assigned Lead O PPTS Date Assigned 0 6 /2 0 /2 0 0 2 C o d e /S ta tu s ACTION Date C o m p leted by Assignee - Date Returned to OEX: - AX Correspondence Control No: AX-0205971 Office of the Surgeon G enerai O ffice of P ublic H ealth a n d Science SG T r a c k i n g //: __ R e f e e r a t ,D a t e : To: SG DSG COS ASH Bennett T hompson SCHOENFEIT) B.

The presence of the triple repeat leads to increased levels of gene expression and a reduction in DNA damage (15).

:~:: API oversight provided by General Committee on Special Programs SH ELL-MCCLU RG-065393 Shanghai Health Study Update :~::~:i::~::~: Hi9hIi9hts ::":: WHO classification of tumors applied :}:: Nutritional anemias identified :}:: Benzene Induced Dysplasia - indicates benzene may have a unique signature TSCA 8Ce) filed I::,:::::: Lab transferred to Fudan University School of Medicine ::':: Cinpathogen, a private company, replaced University of Colorado as lead institution SH ELL-MCCLU RG-065394 Shanghai Health Study Update Path Forward Case accrual completed Data analysis Publications International Benzene Symposium in Munich Benzene Health Research Consortium will disband SH ELL-MCCLU RG-065395 Benzene Health Research Consortium Sponsoring Companies ~ BP ~ Chevron ~ ConocoPhillips ~ ExxonMobil ~ Shell Chemical LP Marathon/Ashland providing additional support SH ELL-MCCLU RG-065396 Shanghai Health Study .:.