While API is taking the lead to obtain commitments from various companies to participate (with an estimated cost of $1 00-150M/yr. for 5 years per company if 10-12 jOin/total study cost estimated to be $6.5MM over 5 years), the learnings from the study would be useful globally as well as for both our Chemicals and Oil Products businesses.

From: Sent: To: Cc: Subject: Attach: Lorraine Twerdok <Twerdokl@api.org> Tuesday, February 25, 2003 10:48 PM (GMT) Benzene consort comm (E-mail) <benzconsort-cc@api.org>; Benzene consort tech (Email) <benzconsort-tc@api.org>; Benzene OC listserve (E-mail) <BenzConsortOC@api.org> 'myron. c. harrison@exxonmobil. com' (E-mail)<myron.c.harrison@exxonmobil.com> SHS exec brief - 2125 revision China Benzene Paper API Exec Comm 2-25-03 Draft.doc SH ELL-MCCLU RG-054876 Draftfor March 18,2003 Meeting Fourth revision 2125103 Attachment For Action API Executive Committee Issue: The Benzene Health Research Consortium is seeking guidance on options to address a shortfall in funding the industry-sponsored Shanghai Health Study (SHS), A five-year project designed to investigate the potential health effects of benzene, the study sponsors have secured $16,5 million of the $22,8 million required to carry it to fruition, Although preparations for the research have begun, this $6,3 million funding gap - - if not closed - - will either compromise the study or lead to its demise, Background: Continued concern about the potential health effects of benzene is reflected by two recent studies that suggest a link between benzene exposure and certain cancers not previously associated with the chemical, The Consortium is thus sponsoring a five-year study in Shanghai, China, which could significantly decrease the uncertainty surrounding the issue, A joint investigation primarily managed by the University of Colorado and Fudan University, the SHS includes protocols developed with the assistance of a 12-member international scientific review panel and Chinese, European and American bio-ethics specialists, It also has strong support and active participation from Chinese universities, hospitals and regulatory agencies, The United States EPA has expressed interest in participation, The quality of Shanghai's occupational benzene exposure records offers an unprecedented opportunity, and perhaps the last of its kind, to conduct this type of study on the relationship between benzene exposure and the risk of certain blood diseases, The SHS will enhance industry's product stewardship, while providing the scientific, regulatory and business communities with better information on benzene, Project Status: Three inter-related studies are underway: (1) a Case-Control Epidemiology study; (2) a Disease Progression Study; and (3) a Molecular Epidemiology Study, Laboratory construction, technical training and exposure assessments are nearing completion and individual case acceptance will begin in spring, 2003, Legal and public affairs expertise has been retained to facilitate Consortium activities, Funding Status: Current funding for the program is projected to run out during the first quarter of 2004, Five companies (BP, ChevronTexaco, ConocoPhillips, ExxonMobil and Shell Chemical Company) have contributed $16,5 million, While the study was initiated with a modest shortfall, subsequent protocol enhancements recommended by independent scientific and ethics review panels led to the final budget of $22,8 million, The Consortium has made presentations to ACC, ARPEL, CONCAWE, IPIECA, and NPRA; held focused discussions with Dow Chemical Company, Marathon Ashland, and Sunoco, and approached AGIP-ENI, ARPEL, BASF, Citgo, Dupont, Lyondell-Equistar, Petronas, Statoil, and TotalFinaElf To date, none of these entities has agreed to join the Consortium and contribute funds, Implications of funding shortfall: The Consortium Technical Committee studied the impacts of a funding shortfall and determined that, at best, only one of the three studies could be completed with current funds, The reality, however, is that an unclosed gap would result in loss of Chinese collaboration, in which case none of the studies could be completed, In addition to the lost scientific and product stewardship opportunities, this situation could have public, regulatory and legal ramifications for the entire industry, At this point, Consortium members are not optimistic that additional companies will commit Given that the study would benefit the entire industry, the Consortium is requesting that API leadership consider whether API can provide support to eliminate the shortfall, Possible options include API (1) providing direct funding for the study; (2) underwriting the shortfall that is not met by ongoing recruitment efforts; or (3) leave the gap unfunded, SH ELL-MCCLU RG-OS4877 Draftfor March 18,2003 Meeting Fourth revision 2125103 For Action: The Executive Committee is requested to advise the Consortium of its' decision on SHS funding, SH ELL-MCCLU RG-054878

The appearance of oxygen as a heavy chemical leads to a broad review of the whole field of oxida tion reactions.

Draftfor March 18, 2003 Meeting First revision 1129103 Second revision 2/1103 Third revision 2118103 Attachment For Action API Executive Committee Issue: The Benzene Health Research Consortium is seeking guidance on options to address a shortfall in funding the industry-sponsored Shanghai Health Study (SHS), A five-year project designed to investigate the potential health effects of benzene, the study has secured $16,5 million of the $22,8 million required to carry it to fruition, Although preparations for the research have begun, this funding gap - - if not closed - - will either compromise the study or lead to its demise, Background: Continued concern about the potential health effects of benzene is reflected by two recent studies that suggest a link between benzene exposure and certain cancers not previously associated with the chemical, The Consortium is thus sponsoring a five-year study in Shanghai, China, which could significantly decrease the uncertainty surrounding the issue, A joint investigation primarily managed by the University of Colorado and Fudan University, the SHS includes protocols developed with the assistance of a 12-member international scientific review panel and Chinese, European and American bio-ethics specialists, It also has strong support and active participation from Chinese universities, hospitals and regulatory agencies, The USEPA has agreed to actively participate in the project The quality of Shanghai's occupational benzene exposure records offers an unprecedented opportunity, and perhaps the last of its kind, to study the relationship between benzene exposure and the risk of certain blood diseases, The SHS will enhance industry's product stewardship, while providing the scientific, regulatory and business communities with better information on benzene, Project Status: Three inter-related studies are underway: (1) a Case-Control Epidemiology study; (2) a Disease Progression Study; and (3) a Molecular Epidemiology Study, Laboratory construction, technical training and exposure assessments are nearing completion and individual case acceptance will begin in spring, 2003, Legal and public affairs expertise has been retained to facilitate Consortium activities, Funding Status: Current funding for the program is projected to run out during the first quarter of 2004, Five companies (BP, ChevronTexaco, ConocoPhillips, ExxonMobil and Shell Chemical Company) have contributed $16,5 million, The initial cost estimate for the study was $19,8 million; the study was initiated with a funding shortfall requiring recruitment of additional funding sponsors to fully fund the study, Subsequent protocol enhancements recommended by independent scientific and ethics review panels led to the final budget of $22,8 million as necessary to complete the five-year study, The Consortium has made presentations to IPIECA, CONCAWE, ARPEL, ACC, and NPRA; held focused discussions with Marathon Ashland, Dow Chemical Company, and Sunoco, and approached Citgo, Dupont, BASF, Lyondell-Equistar, TotalFinaElf, Statoil, AGIP-ENI, ARPEL and Petronas, To date, none of these entities has agreed to join the Consortium and contribute funds, Implications of funding shortfall: The Consortium Technical Committee has studied the impacts of a funding shortfall and determined that, at best, only one of the three studies could be completed with current funds, The reality, however, is that an unclosed gap would result in loss of Chinese collaboration, in which case none of the studies could be completed, In addition to the lost scientific and product stewardship opportunities, this situation could have public relations and legal ramifications, At this pOint, recruitment of additional members has been unsuccessful and Consortium members are not optimistic that any will commit Given that the study would benefit the entire industry, the Consortium is requesting that API leadership consider whether API can provide support to eliminate the current shortfall, Possible options include API (1) providing direct funding for the study; (2) underwrite the remaining shortfall while recruitment efforts continue with the expectation of being repaid in full or in part by the Consortium; or (3) provide no additional funding for the study, For Action: The Executive Committee is requested to advise the Consortium what assistance API can provide to eliminate the shortfall and allow the SHS to be completed, SHELL-MCCLURG-055614

Thus the chair of the > SRP > would have to call upon different members of his or her committee to lead > their discipline specific review discussion.

Both groups worked well together in this fashion at the August Asilomar meeting, and "topic lead" can be deferred to members having that specific expertise - with ethicists working ethics issues, as currently done within the science review panel for issues regarding biostatistics, molecular markers, industrial hygiene and other specialties.

Cost Reduction--the Lock-on Feet and multiple motor positions of the Viking Universal Blower Assembly re duce inventory, eliminate dead blower stock, cut lead-time needed in ordering and reduce initial cost.

FERC is usually the Federal lead agency for licensed projects when an environmental impact statement (EIS) is to be prepared.

Both groups worked extremely well together in this fashion at the August Asilomar meeting, and "topic lead" can still be deferred to members having that specific expertise - as currently done with issues regarding biostatistics, molecular markers, industrial hygiene and other specialties within the science review panel.

Both groups worked well together in this fashion at the August Asilomar meeting, and "topic lead" can be deferred to members having that specific expertise - with ethicists working ethics issues, as currently done within the science review panel for issues regarding biostatistics, molecular markers, industrial hygiene and other specialties.

Both groups worked well together in this fashion at the August Asilomar meeting, and "topic lead" can be deferred to members having that specific expertise - with ethicists working ethics issues, as currently done within the science review panel for issues regarding biostatistics, molecular markers, industrial hygiene and other specialties.

For some time, we have also been a leading provider of lease financing services in selected markets through our wholly-owned subsidiary, Dana Credit Corporation (DCC).

Elements of Industrial Toxicology m industry due m part to the low vapor pres sure at room temperature and the relatively good warning propenties of this material Although animal data indicates that diphenyl has little irritating potenbal, it does indicate that diphenyl can be absorbed through the intact skin Contact with the skin should, therefore, be avoided to eliminate the pos sibility of systemic injury Because moder ate air concentrations of this material are irritating, voluntary exposure is limited to levels that are presumably not hazardous Epichlorohydnn is a primary raw mate rial in the production of epoxy and other res ins Its vapor is highly irritating to the eyes and respiratory tract Pulmonary edema and kidney damage may occur Animal experi ments with 500 ppm for 4 hr, and 62 ppm for 7 hr per day for 45 days, both produced deaths in the test groups Inhalations of 16 ppm for 7 hr per day for 90 days produced some bron chial imtabon in dogs and monkeys Epich lorohydnn was also shown to be highly toxic when ingested or applied for 24 hr to the skin of rats and rabbits In man, liquid epichlorohydnn produces a transient burning sensabon on first skin con tact, which may lead to blistenng and deepseated pain within several hours The liquid is also highly untabng to the eyes Some cases of sensibzabon to small quanbbes of epichlorohydnn have been reported See Hygtentc Guide Epoxy resins are condensabon products of epichlorohydnn and bisphenol-A or other polyhydne compounds The resin and a hardening or cunng agent (amines, perox ides, organic acid anhydndes, amine adducts, boron tnfluonde amines, amides, and poly amides) are usually mixed at the bme of use The chief health hazard is the ability of the amine hardeners to cause deimabbs Although the cunng agents exhibit some degree of toxicity, greater effort is required to prevent local irritation or sensibzabon dunng handling than would oidinanly be required to prevent systemic intoxication by the most toxic of them Cured epoxy resins are considered to be relabvely nontoxic See Industnal Data Sheet 533 and Hy gtentc Gutde Ethanol (ethyl alcohol) is an extremely versable and widely used solvent When ab sorbed into the body, it is rapidly metab olized so that heavy exposure is required to build up a substantial eoncentrahon in the bssues Exposure to a high concentrabon of the vapor will produce imtabon of the mucous membranes, headache, nervousness, dizziness, tremors, fatigue, nausea, and loss of consciousness If the exposure is exces sive and repeated, it may produce damage to the liver Those not accustomed to alcohol will be uncomfortable after prolonged expo sure to slightly over 1000 ppm See Industnal Data Sheet 391 and Hy gtentc Gutde Ethyl acetate is a volable, flammable sol vent of low toxicity Animals exposed to 2000 ppm for long penods show either no discomfort or irritation of the eyes and dry ness of the mouth as the only detectable effects See Hygtentc Gutde Ethyl acrylate.

///d 3/2 Lead Engr: L/s FOLLOW-UP PER ENGR.

A group of OECD Member countries have developed an informal understanding to co-ordinate efforts leading to preparation o f a screening level risk assessment on PFOS and its derivatives.