NORTHERN KENTUCKY OFFICE SUITE 340 1717 DIXIE HIGHWAY COVINGTON, KENTUCKY 41011-4704 606-331-2838 513-381-2838 FAX: 513-381-6613 Ro b e r t a .

mm ndrea V Malinowski Corporate Counsel DuPont Legal D-7078 1007 Market Street Wilmington, Delaware 19898 Phone: 302-774-6443 Fax: 302-774-4812 e-mail: Andrea.V.Malmowski@usa.dupont.com M l 2 6 - 132.7 _ 0603- 00315 Mr.

NORTHERN KENTUCKY OFFICE SUITE 340 1717 DIXIE HIGHWAY COVINGTON, KENTUCKY 41011-4704 606-331-2838 513-381-2838 FAX: 513-381-6613 DAYTON, OHIO OFFICE SUITE 900 110 NORTH MAIN STREET DAYTON, OHIO 45402-1786 937-228-2838 FAX: 937-228-2816 Robert A.

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AR226-1744 STUDY TITLE Extraction of Potassium Perfluorooctanesulfonate from Red Blood Cells and Serum for Analysis Using HPLC-Electrospray/Mass Spectrometry DATA REQUIREMENTS Analytical Method Requirements STUDY DIRECTOR Sean Gallagher ANALYTICAL REPORT DATE June 2, 2003 PERFORMING LABORATORY / TESTING FACILITY Exygen Research 3058 Research Drive State College, PA 16801 Phone: 814-272-1039 STUDY SPONSOR 3M Environmental Technology and Safety Services Building 2-3E-09 PO Box 33331 St.

POSF 3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May 11, 2004 TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Click on Study Title to View Report Perfluorooctanesulfonyl fluoride Acute Toxicity 1.

3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May, 2004 INDEX OF 3M'S 2002-2004 AR-226 DOCKET SUBMISSIONS BY DATE Back to Menu February 2004 Click on Study Title to View Report February 24, 2004 February 24, 2004 Submission Cover Letter Final Report, Pharmacokinetic Study of Perfluorooctanesulfonyl Fluoride (POSF) Following a Single Oral Gavage Dose in Rats.

0100-/37% 37i l l UNITED STATES ENVIRONMENTAL PROTECTION AGENCY S WASHINGTON, D.C. 20460 AftSiSU -OG09 July 18, 2000 fa OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES NOTE TO FYI FILE by Terry O'Bryan/RAD/OPPT Reference: FYI-0600-01378 Submission Date: June 14, 2000 The above referenced FYI submission is 3M's response to EPA regarding three reports that appeared to be missing from their 5/4/00 submission (also FYI-01378).

AR226-1894 Reproductive Effects of C8 James Dahlgren, MD Pamela Anderson-Mahoney, PhD November 2004 Reproductive Hormones Male C8 Workers Increased PFOA Levels Lower Testosterone Prolactin Higher Estrogen Prolactin if high alcohol intake Health Study in Residents Near a Large C8 Source Methods 301 fem ales and 296 m ales with docum ented P F O A -E xp o su re >. 0.05 ug/L in drinking w ater standardized questionnaire SEER prevalence data were used for com p arison Demographics for Residential Study Participants A ge C ategory 20 - 34 35 - 4 4 45 - 54 55 - 64 65 - 80 G ender M ale Fem ale R ace/E thnicity W hite African Am erican Others Education Level L e s s th a n 9 th g r a d e 9 1 1 grade 12 lh/ V o c a t i o n a l / S o m e C o lle g e College Graduate N o. 105 104 135 154 80 284 294 558 6 9 17 59 430 65 /o 18.17 17.99 23.36 26.64 13.84 49.13 50.87 97.38 1.05 1.57 2.98 10.33 75.31 1 1.38 Demographics for Residential Study Participants a w-- t i H T i ~-i'll-- nHiMTinrin iiiiMi iii 'iWMiii[ T M "T rrfigrtB n'iii[iririT r-T '-g ^ ,;^ No. ' B ody M ass Index U nderw eight (<23) A verage (23 - 28) O verw eight (>28 ) 106 190 276 % 18.53 33.22 48.25 Sm oking Status N ever smoked S m o k e d less th a n 15 y e a rs S m o k e d m o re th an 15 y ears 252 60.58 72 17.31 92 22.12 W ork H istory Plant 1 Plant 2 N o plant w ork 54 9.42 19 3.32 500 87.26 Reproductive Cancers in Residents Near a C8 Source CANCER TYPE U terin e/C ervical Breast Prostate Number of Cancers 9 5 9 Observed R ates3 (per 100,000) 3,061 1,701 3,169 Expected R atesb (per 100,000) 96 1,579 1633 PR 33.12 1.12 1.96 C lc 1 7 .0 3 -6 4 .4 1 * 0 .4 6 -2 .7 1 0 .9 8 -3 .9 2 Uterine/Cervical Cancer in Residents Near a C8 Source Age Category 20-29 30-39 40-49 50-59 60+ # of C a n ce rs 0 2 2 3 2 N P R P-value 34 0 - 38 56.40 0.0002 64 25.02 0.0008 84 34.18 0.00001 74 31.83 0.0005 Total 9 294 Age at Menopause in Residents Near a C8 Source Age By Category 38 U .S .

AR226-1896 T-7483.1 ST-45 CONFIDENTIAL BUSINESS INFORMATION SUBJECT TO PROTECTION UNDER THE TOXIC SUBSTANCES CONTROL ACT AND OTHER LAWS HAS BEEN REDACTED FROM THIS DOCUMENT Title: Toxicokinetic Screen of FC Methyl Carboxamide (T-7483) In Rats.

AR226-2494 IQY- mm 1T123 08/31/01 11:01 0 :06/13 NO:150 nwrniicorr eHOfUMOV JwFant jBwse-II'SI'iiks w^%mai3-s2i?

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p' 3M /\-(tHP.6~ $S~7 3M ENVIRONMENTAL LABORATORY PROJECT NO.EOS-0442 Analytical Report Definitive Study: Quantitative Screening of Commercial Lots of Human Serum Obtained in 2004 for Endogenous Fluorochemicals Using Solid Phase Extraction and Liquid Chromatography/Tandem Mass Spectrometry Laboratory Request Number: E05-0442 Testing Laboratory 3M Environmental Health and Safety Operations 3M Environmental Laboratory 3M Environmental Laboratory Project Lead Mark E.

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Jean B.