A Pharmacokinetic Study of Potassium Perfluorooctanoate in the Cynomolgus Monkey Southern Research Institute Study ID: 9921.4 January 14,2003 Final Report on A Pharmacokinetic Study of Potassium Perfluorooctanoate in the Cynomolgus Monkey To: 3M Corporation P.O.

DuPont-15302 Study Title Ammonium Perfluorooctanoate: Age Effect on the PFOA Plasma Concentration in Post-Weaning Rats Following Oral Gavage T est Guidelines: None applicable Author: Paul M.

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SITE SCREENING LEVEL ASSESSMENTS FOR PFOA AND THE RELEVANCE OF SOIL SAMPLING Date: O ctober20,2003 Project No.: 18983753.00034 CO RPO RATE REMEDIATION GROUP An Alliance between DuPont and URS Diamond Barley Mill Plaza, Building 27 Wilmington, Delaware 19805 EXP001453 Site Screening Level Assessm ents for P FO A and the R elevance of Soil Sampling Table of Contents TABLE OF CONTENTS Executive Summary............................................................................................ 1.0 Introduction.................................................................................................................. 1 OO U* U ^ 2.0 Data Presentation..................... 2.1 Development o f a Generalized PFOA Screening Level Site Conceptual M odel........................................................................................................ 2.2 Laboratory Studies o f PFOA and Field Sample Verification................. 2.2.1 TTie Behavior o f PFOA in W ater.... ........................................... 2.2.2 Adsorption/Desorption o f Ammonium Perfluorooctanoate to Soil............................................................................................... 2.2.3 Little Hocking Water Association Investigation Results........... 2.2.4 Washington Works RFI Soil Sampling Results.......................... 3 3.0 Summary............................................................ ...................................................... io 4.0 References................................................................................................................. 11 Table 1 Table 2 Table 3 Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 TABLES Washington Works RFI Soil PFOA Results Washington Works RFI Surface Soil PFOA Results Washington Works RFI ADP SWMU Soil PFOA Results FIGURES PFOA Screening Level Assessment Model Comparison o f K ^'s for PFOA and Other Chemicals Little Hocking Water Association Well Field Soil PFOA Results Washington Works RFI Soil PFOA Results Washington Works RFI Surface Soil PFOA Results Washington Works RFI ADP SWMU Soil PFOA Results soil position paper4.doc Oct. 20, 03 Wilmington, DE EXP001454 I Site Screening Level A ssessm ents for PFO A and the Relevance of Soil Sampling Executive Summary EXECUTIVE SUMMARY DuPont's extensive implementation o f both media specific assessment modeling tools and comprehensive on-site and off-site soil, surface-water, and groundwater monitoring for perfluorooctanoate1at the Washington Works site in West Virginia allowed for compilation o f a generalized screening level assessment model.

0000025890-99-000028.txt at www.sec.gov --------- BEGIN PRIVACY-ENHANCED MESSAGE---------Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7zlT+B+twIDAQAB MIC-Info: RSA-MD5,RSA, VN4gRaeNaxoN2TRiZUlGA9JLsbSZBLKHZaZfx0hxwgl3rcCenusM4h/NF3199KQh aqkgsz27aTQCWoua76GMJQ== <SEC-DOCUMENT>0000025890-99-000028.txt : 19991108 <SEC-HEADER>0000025890-99-000028.hdr.sgml : 19991108 ACCESSION NUMBER: 0000025890-99-000028 CONFORMED SUBMISSION TYPE: 10-Q PUBLIC DOCUMENT COUNT: 3 CONFORMED PERIOD OF REPORT: 19990930 FILED AS OF DATE: 19991105 FILER: COMPANY DATA: COMPANY CONFORMED NAME: CENTRAL INDEX KEY: STANDARD INDUSTRIAL CLASSIFICATION: IRS NUMBER: STATE OF INCORPORATION: FISCAL YEAR END: CROWN CORK & SEAL CO INC 0000025890 METAL CANS [3411] 231526444 PA 1231 FILING VALUES: FORM TYPE: SEC ACT: SEC FILE NUMBER: FILM NUMBER: 10-Q 001-02227 99742358 BUSINESS ADDRESS: STREET 1: ONE CROWN WAY CITY: PHILADELPHIA STATE: PA ZIP: 19154 BUSINESS PHONE: 2156985100 </S EC-HEADER> <DOCUMENT> <TYPE>10-Q <SEQUENCE>1 <DESCRIPTION>THIRD QUARTER 1999 FORM 10-Q <TEXT> UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q [ X ] QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D)OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 1999 [ ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D)OF THE SECURITIES EXCHANGE ACT OF 1934 http://www.sec.gov/Archives/edgar/data/25890/0000025890-99-000028.txt 02/24/2000 0000025890-99-000028.txt at www.sec.gov Page 2 of 30 FOR THE TRANSITION PERIOD FROM TO COMMISSION FILE NUMBER 1-2227 CROWN CORK & SEAL COMPANY, INC.

_ IAA& Final Report on A Pharmacokinetic Study of Potassium Perfluorooctanoate in the Cynomolgus Monkey ./ To: 3M Corporation P.O.

HARTOLDMON0032151 3 1 STIPULATIONS 2 IT IS STIPULATED AND AGREED by the 3 parties, through their respective counsel, 4 that the deposition of SANDY SMITH may be 5 taken before Deborah Salers Garrett, CSR, RPR, 6 as Commissioner and Notary Public, Alabama at 7 Large, at Anniston, Alabama, on January 3, 8 2002, at 1:45 p.m. 9 IT IS STIPULATED AND AGREED that the 10 signature to and reading of the deposition by V 1 1 the witness is waived, the deposition to have 12 the same force and effect as if full 13 compliance were had with all laws and rules of 14 Court relating to the taking of depositions. 1 5 IT IS STIPULATED AND AGREED that it 16 shall not be necessary for any objections to 1 7 be made by counsel to any questions except as 1 8 to form or leading questions and that counsel 1 9 may make objections and assign grounds at the 2 0 time of trial or at the time said deposition 2 1 is offered in evidence or prior thereto. 2 2 IT IS STIPULATED AND AGREED that notice 2 3 of filing by the Commissioner is waived.

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G Model CBI-6096; No. of Pages 10 ARTICLE IN PRESS Chemico-Biological Interactions xxx (2009) xxxxxx Contents lists available at ScienceDirect Chemico-Biological Interactions journal homepage: www.elsevier.com/locate/chembioint Topoisomerase II inhibition by the bioactivated benzene metabolite hydroquinone involves multiple mechanisms Scott Mondrala 1, David A.

D u P o n t-15302 Study Title Ammonium Perfluorooctanoate: Age Effect on the PFOA Plasma Concentration in Post-Weaning Rats Following Oral Gavage Test Guidelines: None applicable AUTHOR: Paul M.

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