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sf CAORM2P2AN6Y-1SA0N4I4TIZED Telomer Research Program Update and Status Report United States Environmental Protection Agency 18 December 2001 2 8 on z 33 z 3 s 33 = rime tre Comyn rrr \ Agenda + TRP General Update; TRP Meetings Radio-label Update + Pharmacokinetics Toxicology & Descriptive Biology Environmental Fat&e Effects + Summary Discussion and Path Forward teetarpm comp rtsgto g 2 SR o ZZ a8 5 2 Company Sanitize..

s5ke5m0 << AR 226 -- 1181 4 ( RECE:VE OMAYf1fe4 pc200eonifcs Cl1ar3i5es6tHoann,sWfoYr,d 2S5e30t1 (304) 5(5380.69)1$6508T-e4l2e5p5haFnaex West Virginia Department of Environmental Protection S Gover we -- TS T waCaS0 elcgey Robert A.

A DIETARY LCS0 STUDY WIpTrOHS:THE NORTHERN BOBWHITE Ar226 _0953 ALiT SN WILDLIFE INT3EMRLNAABTIROENQAULESLTTD.NO:PROUJ2E7C23T NO.: 454-103 Series 8U3S0.- EEncvoliorgoincmaelntEfaflecPtrsotTeecsttioGnuiAdgeelnicneys (draft) `OPPTS Number 850.2200 FIFRA Subdivision E, Section 71-2 OECD Guideline 205 . 3 2 23 T4 3S2E zE358% = AUTHORS: CSoeuarntPn.eyGaSl.laCgahseery JRoaaynmnoBn.dBLe.avVearns Hoven I STUDY COMPLETION: April 26,2000 SUBMITTED TO .

1 Table: Results from studies on PFSAs Substance (%), EC/CAS, formula study design, species, route of exposure, doses (guideline/similar to guideline/nonguideline), n animals Observed effects and remarks NO(A)EL (mg/kg bw/d) LO(A)EL (mg/kg bw/d) PFBS PFBS (97.9% pure, K+-salt) 2-generation Increased liver 100 reproduction study weight according to OECD (maternal) guideline 416 Increased 100 Sprague Dawley rats hepatocellular Gavage. 0, 30, 100, 300, hypertrophy (P 1000 mg/kg bw per day. and F1 adult males) Parental (F0) animals (males and females, Increased 100 n=29-30 per sex per incidence of group) dosed from 70 mild days prior to mating, microscopic females were continued findings in through gestation and kidney lactation.

TITLE: SAMPLE TRACKING OF WILDLIFE SAMPLES ANALYZED FOR CONCENTRATIONS OF PERFLUORINATED COMPOUNDS BY: John L.

AR226-1838 DuPont/3M Meeting with EPA August 25, 2004 1:00 PM-4:00:PM Agenda B ackgroundiObje.ctives Received OPPT NCIC 2004 SEP-3 Data Review Linear/Branched Study Worker Exposure Data Biology Review Path Forward `cA~ ~J~'L ~/~/0y.

26 November 2004 AR226-1889 To: Mary F.

AR226-2153 pzrr' r"*--'-~ ^ U-(%,.

AR226-2160 Chris E Shoop_ 07/12/2001 01:17 PM To: cc: Subject: Robert F Pinchot/DEV/AE/DuPont@DuPont, Debbie J Mulrdoney/AE/DuPont@DuPont David M Rural</AE/DuPont@DuPont, H David Ramsey/SBDuPontQDuPont, Stephen J Gissy/AE/DuPont@DuPont, Robert L Ritchey/CL/DuPont@DuPont, John J Mentink/CL/DuPont@DuPont.

AR226-2162 ^y H David Ramsey 07/16/2001 11:02 AM To: cc: Subject: Dawn D Jackson/CL/DuPont@DuPont, George A Ainsley/SE/DuPont@DuPont FW: Call From Jesse Hanshaw Three key notes - there are some of us who prefer the State and I both conduct modeling so it is more independent - Forwarded by H David Kamsey/SE/DuPont on 07/16/2001 11:01 AM -- John J Mentink 07/10/2001 08:30:49 AM To: cc: Subject: H David Ramsey/AE/DuPont@DuPont FW: Call From Jesse Hanshaw This is the note originally issued by Chris Shoop.

AR226-2196 From: To: cc Subject: Fred M Lentz on 08/28/2001 07:54 AM Ta-Wei Fu/SE/DuPont@DuPont Stephen J Gissy/AE/DuPont@DuPont, Oscar T Garza/AE/DuPont@DuPont, Robbin Banerjee/AE/DuPont@DuPont, Paul K Mathur/CL/DuPont@DuPont, David M Rurak/AE/DuPont@DuPont, Raymond C Butterworth/CL/DuPont@DuPont, John R Flynn/AE/DuPont@DuPont, Amy L Brown/AE/DuPontQDuPont, Thomas W Mahlberg/SE/DuPont@DuPont, Robert F Pinchot/DEV/AE/DuPont@DuPont, Chris E Shoop/AE/DuPont@DuPont, Roger J Zipfel/AE/DuPont@DuPont.

AR226-2216 Chris E Shoop 11^/2001^)3:08 PM To: ce: Subject Ralph M Aten/AE/DuPont@DuPont Debbie J Mulrooney/AE/DuPont@DuPont Particulate / C-8 Emissions from SemiwoiKs Ralph, In about August of this year 1 used information from the semiworks air permit application that you were preparing to provide data to the state on total C-8 emissions for the site.

AR226-2224 / Roger J Zipfel 12/07/2001 12:51 PM To: cc: Subject: Debbie J Mulrooney/AE/DuPont@DuPont Robert F Pinchot/DEWAE/DuPont@DuPont, Chris E Shoop/AE/DuPont@DuPont Re: Consent Order - Stack Parameters and Emissions Q Debbie, and Rob, 1 have added the distribution of C-8 as gas or paniculate to Debbie's spreadsheet.