- .

Occupational and nonoccupational exposure to hepatotoxic agents can lead to acute, subacute, or chronic liver injury.

REFERENCE MATERIAL FOR THE SUMMARY OF THE HEALTH EFFECTS OF PCBS NOVEMBER 1981 BY ECOLOGY A$D ENVIRONMENT, INC.

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TOXICOLOGY AND APPLIED PHARMACOLOGY 62, J-IO (1982) of ed 701 The Effect of Repeated Vinyl Chloride Exposure on Rat Hepatic nd -Is.

TO: Distribution Interoffice Communication FROM: DATE: SUBJ: M.

AR226-1030A045 BACK TO MAIN 2=225 POTENTIAL FOR ENVIRONMENTAL IMPACT OF AFA-6 SURFACTANT A Report for: PANARCTIC OILS LTD.

The primary factors which have lead to this increase are most likely a combination of higher production and lack of effective control technology.

Notify the plant Environmental Protection Department, ext. 3144, to ensure enough lead time for governmental notification.

Since both the UCC and NIOSH studies selected samples of the UCC Texas City employee population to serve as "controls," both studies are subject to some degree of sampling error that could lead to spurious results.

Further, according to the BNL investigators, this strain of mouse apparently does not harbor Murine Leukemia Virus, leading BNL to suggest that the CBA/Ca strain may be an appropriate animal model for benzene 1eukemogenesis.

D Y K E M A , G O S S E T T .

Concern exists dial prolonged excessive exposure to organic solvents may lead to premature and persistent dementia in certain workers.

CHEVRON U.S.A.

It has become increasingly clear that 0194989 -2- 43-21(6046)A inhalation of asbestos fibers over an extended period of time can lead to a cancer of the lining of the lungs known as mesothelioma as well as lung cancer.