CHEMICALS RESEARCH FEB0 6 1978 Dr.

Last agala, on-again $6>bi1linn James Bar 6/*00 blue-collar workers to fumes that May the agency invoked emergency hydroelectric project in northwestern can lead to a rare form of liver cancer standards for 14 chemicals (BW- May PWA ships cattle to the known as angiosarcoma.

In addition,well-established metabolic pathways for formaldehyde afford very small amounts of methionine and serine ^ The fact that this study provides ample evidence for and C2 alkylation of intermediary metabolites suggests that this sort of chemical reaction may lead to the transcriptional changes of the RNA, DMA or other macromolecular cell constituents, which would appear to be responsible R&S 107608 i 6 for vinyl chloride-induced neoplasm.

While the emergency standard of five fibers per milliliter is at present based upon exposure to fibrosis, we should nonetheless take into account the fact that exposures to even small quantities of asbestos fibers over a short period of time may lead to the development of mesothelioma in a certain percentage of the exposed workers.

He also showed peak lead levels of approximately 4.5 ng/M3 during bloving operations.

Implementation of the proposed standard may have a severe economic impact upon the asbestos textile and friction products industries, leading to erosion of profit margins, loss of markets and, perhaps, loss of jobs. 6- - VH t MARY RECOMMKMOATI ON The asbestos industry has been handicapped in its effort., to (comment upon .this OSHA proposal for requlation of asbestos exposures in che factory by reason o( the; fact that it could not simultaneously study that counterpart regulation which OSHA has said it will issue pertaininq to the requlation of asbestos exposures in construction.

Uses of/Xrocl&rswhich lead to environmental contamination and 6annot be controlled will be discontinued.

The conditions which lead to discharges can also be prevented in most cases' by proper handling and transfer of vinyl chloride or materials containing vinyl chloride.

y MINUTES VINYL CHLORIDE SAFETY ASSOCIATION MEETING Philadelphia, Pennsylvania April 17 and 18, 1974 1.

.: rise to neurohumoral and neurovascular troubles leading to the development of dystrophic pro cesses In the bone tissue,--P.

. - Hazardous operations will include routine procedures such as reactor dismantlement as 'well as any unusual situation that leads to atmospheric concentrations above the EID10767 PZ-.

Case reports o asbestos deaths among factory workers appeared in British medical journals in the 1920's, leading to a government survey of the industry conditions and vrorkers' health.

The FDA has not formerly proposed the ban at this time but press releases and adverse publicity regarding the issue has created a worldwide problem since most other countries follow the FDA lead in regulating carcinogenic materials.

Indeed, it is biotransformation of VC or repair of the reasonable to expect the TWA exposures of lesion leading to development of angio 200 ppm and greater for 8 hr were common sarcoma, both of which are likely to be dis rather than the exceptions.

Thus the state ment by Edsall that MCA ",.. appears to have deliberately deceived NIOSH regard ing the true facts" is inaccurate and mis leading.