Document 6w2dp8GDmMv1eXazNLab9nKB1

OLOnY (VoL 5M)| 3556 riwn in vivo nclcctlvrlj Inhibit* for 10*60 min t nuclnoplanmlc typt of "NA polymers.** in rat liver but the aynttiesU in vivo of all specie* of iear RNA remains blocked for several hours.-*J. T. L, 3 BROOKS, ROBERT D. Jr. and JAMES A. VICK. <Dep. Pharm* scow. , alter Reed Army Inst. Ret., Walter Reed Army Med. Cent.. Washington. D. C. 20012, USA.) Toaicological studies of bee venom in mice, doy;s and monkeys. AM BEE J 112(T): 250-251. 1972."Venom of Apis melhit ra was injected, either l.v, or .c.. Into experimental animals. l.V. infections caused a precipitous decrease In blood pres sure within 35 see In both doM and monkeys, ft also decreased heart rate and depressed respiration. Dosages of 5 mg/kg in dogs, or 2.5 mgin monkeys, t.v., caused death from cardiovascular failure. Similar responses were noted after s.c. injections, but median lethal dosages were higher: 200 mg/lcg in dogs and 50 mg/kg in monkeys. The former is equivalent to about 2000 bee stings. Smaller dosages were fatal to mice. Other physiological reactions are noted. --J. D. Hitchcock. 34772. ULANOVA, I. P., A. 1, KHALEPOand A. I. EIT1NCCN. (In*t, ind. Hyg Occup. Dis.. Acad. Med. Scl. USSR, Moscow, USSR.) Isaledovanle kumulyativnykh svoistv khimirheskikh socdineml ru porogovom urovne kak osnm a prounoiirovamyn khromcheskikh lntoksiXatstl. fStudy into cumulative propertied of chemical compounds at the thresh old loci ?i a basis lor prognostication ol chrome poisonings.! GIG TR PROF ZABOL 16(3) 36-19. ID72. | Engl. summ.| --CumuUtive properties of chemical compounds at the threshold of their acute action were analyzed. Cumulation coefficients were deduced from the integral test changes and with referen.e to the summary-threshold value fea turing the functional state of the nervous system. These coefficients proved to be much inferior to coefficients of cumulation determined with reference to the animal lethality figures. The cumulation coef ficients at the threshold level supported a well-marked cumulative ca pacity of benzene, carbon tetrachloride, m-aminobeniotrilluorlde and morpholine. This was supported by the data derived from chronic ex periments, considering CClq and benzene, also by the available clinical and hygienic observations. The estimated coefficient of correlation between the areas of chronic action and coefficients of cumulation for the substances under study at the threshold level was 0.99. This makes it possible to forecast possible developments of chronic poisoning. Ttas investigation time was cut down to a maximum of 1 mo,--J. P. K. '773. KOBUUYA, N. S.. i,. E. GEDYMIN, F. R". 'AKHOVSKII and O. P. ARKH1PCWA. (Cent. Res. Inst. Tubere., Mln^ fealth USSR. Moscow, USSR.) Izuchente pronitsaemosti glatogemanzhesktkh bar'erov pri razltchnykh rezhimakh giperbancheskoi cksigenatsu v eksperunente. 1 Permeability of histo-haematic barriers in different regimes of experimental hvperoaric oxygenation. I SUSP KH1R ANESTEZIOL 17(3): 31-33. Ulus. 1972. |tngi. 'sumnTj--Ex perimentally, 70 guinea pigs were subjected to 100% O; in therapeutic (1-2.2 up to 3 its) and toxic (4-5 ata) regimes of hyperbaric oxygena tion for 1-4 hr. Histology and radioactive indication (with streptomyctn-S^S ln 20,000 U/kg and with 14.2 uCi activity in 1 ml) were used to assess various permeability levels ln the histo-hematic barriers of the lungs, liver, kidneys, spleen, myocardium and brain. Toxic regimes were accompanied by a universal Increase ol vascular walls permeabil ity, conditioned by structural lesions of the histo-hematic barriers. With therapeutic regimes, vascular permeability rose only In the spleen, liver and kidneys, i.e., in the organs with an increasing functional ac tivity under hyperbaric oxygenation, and was not accompanied by histostructural changes of the main elements of the histo-hematic barrier. --J. L. S. 34774. CCNDER, D. W,, P. C- OLOFFS and Y. S. SZETO. (Pestol. Cent.. Dep. Biol. Sci.. Simon Fraser Ualv., Burnaby 2, B. C., Can.) GLC separation of hi'otachlor etaxide oxychlordane, a- and y-chiorttane, BULL ENVIRON CON TAM TOXICOL f(l):' 33-35."1972.--ClC | gas liquid chromatography) columns wwr* used to Identify and quantitate organochlortde pesticide residues. Such as 3% OV 1, 2% SE 30 plus t'i OF 1, or 2% OV 1 plus % OV 210. They did not satisfactorily sep arate the 00mpounds of o^hlorttine, y-chlordane oxychlordane and befXachlorepoxlde. Gas chromatograph Micro Tck MT 220 with Nl-63 electron cepture detector method was employed In this experiment. --4. P- K. 34775. WALTSCHEWA, W. (Forschungsinst. Arbeltsschutx. Berufskr., Btvd. Petko Nafwtov 34, Sofia. Bulg.), M. SLATEWA and I. MlCRAILCAV. Hodenveraenderungen bei weissen Ratten durch chronlache Verabreiehung von Nickelsulfat. [Teaticuiar chances due to long term administration of nickel sulfale in rata.I EXP PATHOL IjE.SAl OT7I): llA-JJO. Ulus. '1972. [tngl. summ.I--Following long-term . <-sulfate Intralcttuxi in rata, severe lesions in the germ cells * V ularl7 In spermlogenesis could be demonstrated. Very few changP ' observed In the livers and kidneys. Nickel sulfate had a sew lecl^ nxlous effect 00 testicular iBrenchyma.--A. B. M. 5^ M77g, BASALAEV, A. V., A. N. VAZfN and A. G. KOCHETKOV. (S'. M. Kirov Cork. Med. Inet., Gorki, USSR.) K pstogenesu limenenli, voaaikayushchlkb art dtltel'nom vosdetstvU vlnlfklilorida. (Pathogensata _ 3557 (Mar. 15. 1> a. TOX. of changes developing due to long-term nafvi<urr to the effect til vmylchioride.i rao nt prof /.aiiol TSflT: U '7. mut. mvl. (hm-i. summ.|--Rabbits and rats which Inhaled vmylrhlnride (ume m a nut- ' Imal permissible concentration (0.03-0.04 mit/ll. underwent a 4-mo. long all-round examination by jiiyaiolncical. biochemical, histomnrphologlca l and roentgenndcnsltometrtc methods. Ch.nntes in the tn-'electric activity Of the hypothalamus, hyperadrenalmemia and (unctionsi troubles of the cardiovascular system were disclosed Development Of resorptlve manifestations in the bone tissue was brought out mor phologically and osteoporosis--roentgenologtcally. An inference is drawn as to a key importance of hypothalamic dysfunction in the patho genesis of the disease, this dysfunction givin.: rise to neurohumoral and neurovascular troubles leading to the development of dystrophic pro cesses In the bone tissue,--P. L, W, 34777. BAZIH, SUZANNE and ALBERT DELAUNAY. (CNRS. Inst. Pasteur, Sent. Pathol, Exp., 92-Garches, Fr.l Action exercee pir d substances tathyrogenes sur te collagene de granulomes. [Action ex erted by lathvroccnlc substances on the collagen of granulomas 1 <T"h HEDD SEANCES ACAD SCI SER D SCI NAT (PARIS) 274(4). 618-420. 1972.--Polyvinyl sponges were Implanted s.c. in Wistar rats. Ten days later, penicillamine was given orally In a dose of 20 mg/ 100 g of weight. In another group. 0-mercsptoethylamlne was given in a dose of 0.5 mg/MO g, l.p. Granulomatous tissue surrounding the sptaiges and nor mal akin were extracted to give neutral and acid soluble collagen, col lagen labile at 60" and Insoluble collagen. Both drugs gave comparable results. They did not modify t. total collagen of normal skin, but de creased the collagen of granulomatous tissue slightly. Neufral soluble collagen was Increased and insoluble collagen decreased in both types of tissue. The labile collagen Increased in the granuloma and dimin ished In the skin. The acid soluble collagen increased 200% ln the granuloma and 30% ln the skin. Intermole-ular bonds ln collagen which are aenattive to lathyrogenn are compare' 1* In granuloma and in nor mal akin.--M, D. $. 34778. KUDZINA, G. D, and D. I. GOLOVAN'. (A. N. Mzrreeva Kiev Res. Inst. Gen. Public Hyg,, Kiev, USSR.) Iravnltel'naya otsenka gerbttsidov gruppy khlorbenzolnoi kistoty saniUrao-toksikologtcheskim metodom i metodom kul'tur kletok. [Comparative sanitary-toxicolog ical and cell-culture evaluation of the chtorbenzoic acid herbicide group.I VRACH DELO 1. 125-128. IUua 1972. [Engl. summ.j--Data ol chronic sanitary-toxicological exponn-.ert on rabbits and a study ol the effect of ehlorbenxotc herbicide group Indicate that the results by these 2 methods concerning the toxicity of the herbicides coincided. The use of cell-culture method for rapid hygienic evaluation of the tox icity of some herbicides is promising aad further Investigations of this method are justified.--P. L. W. 34779. COOPER, PHILIP and STEPHEN H. TOUNS. (Dep. Surg., Bronx Veterans Admin. Hosp.. Bronx, N. Y, 10463, USA.) Relationship between smdting history and complications Immediately following sur gery tor duodenal ulcer! MT SINAI J MED 39(3): 287-392. 19i2.-- No evidence is given of an association between smoking and complica tions, nor between smoking and operative mortality, nor between smok ing and daya to discharge. The most obvious trend is probably predict able, namely, patients over 50 have more complications and a higher mortality rate than thoae under 50. In spite of the relatively large number of patienta Included ln this report the smoking habits, the age distribution, and disease rate In the population studied are quite likely to differ from the general population. Some inconsistencies were found between smoking histories taken on the same patient at different times. This may have resulted from the quality and accuracy of the informa tion given to the examiner by the patient. Few, if any, generalities should be drawn from this research. Results apply only to immediate postoperative findings and do not apply to long-range effects of smoking upon the patient after surgery for duodenal ulcer diseaee.--E. M. D. 34780. LISITSA, F. M. and L. A. MOTROVA. (Fac. Postgrad. Med.. Riga Med. Inst., Riga, USSR.) O klinicheskikh osobennostyakh alkogol'nykh potlnevritov. [Clinical traits of alcoholic polyneuritis.I ZH NEVROPATOL PSIKHIATft IM S S KOllSAKCWA 72(5): $47-651. 1972, (Engl, summ,|--The tralta of alcoholic polyneuritis In 27 pntients were studied. Four main clinical variants of the disease were distinguished. The most characteristic and troquent form ol alcoholic polyneuritis was the syndrome of sluggish paralysis In the parts of the lower extremi ties. A more common and mixed form of polyneuritis, sensorial and atactic forma, were rarely observed.--J. P. K. 34781. STEGER, ROBERT E. (Coop. Ext. Senr.. N. M. State Untv., Las Cruces, N, M., USA.) Native plants poisonous to humans. J RANGE MANAGE 25(1): 'll-72. 1973.--A summary is given of the toxic principles, the plant*, toxic porta, symptoms and some general comments for several commonly toxic plants In tbs U.S.A.--D. T. S. 24782. PARIS, RENE-RAYMOND and ANNE-MARIE TESSIER. (Fac. Pharm., Lab. Matters Med.. 4-ave. Observatolre, 75-Parts 6. Fr.) Presence de instances du groups dee Cucurbttacines chea diverse! Eupborblscees toxiques airtcatnea, notamment chea Maprounea membranarea Pax at K. Holm. [Presence of substances ol the group of cucurbitaclnes in various African toxic Eunborbiaceae especially in IF BOR 009795