Quantities of talc in tissues and faeces of individual hamsters given a single neutronactivated dose by gavage as calculated from Co and from 46Sc data Total talc content g calculated from counts of Animal no 1 2 3 4 5 6 Sample GI tract Carcass Faeces GI tract Carcass Faeces GI tract Carcass Faeces GI tract Carcass Faeces GI tract Carcass Faeces GI tract Carcass Faeces 60Co x 944 67.6 1332 294 44.2 2232 615 25-9 2007 869 96-6 2637 633 60-9 3417 775 41.0 1495 46SC y 1007 57.8 1612 271 51.4 2346 730 27.4 2366 933 104.2 2980 663 65.3 3540 858 36-4 1666 Ratio / SD 0.94 -0.051 1.17 -0.077 0.83 -0.050 1.08 -0.115 0.86 -0.062 0.95 -0.012 0.84 -0.080 0.94 -0.151 0.85 -0.015 0.93 -0.080 0.93 -0.077 0.88 -0.014 0.95 -0.064 _ 0.93 -0.087 0.96 -0.014 0.90 -0.054 1.13 0.121 0.90 -0.059 GI tract = intestinal tract Corrected for control values JNJ 000262766 Absorption of ingested talc by hamsters 455 rays In addition 6Sc activity was used to estimate the quantity of talc in a number of samples to permit comparison of the sets of talc values obtained with the 46Sc tracer and with the 60Co tracer The advan- tage of using a pair of radioactive tracers to monitor the transfer of talc lies in observing two elements with different dissolution and transfer coefficients in bio- logical systems If the 60Co data and the Sc data lead to similar talc values it can be concluded with a high degree of probability that the radionuclides were transferred together by particulates An alternative situation producing the same 60Co ratio in the tissues as was observed in the talc would require these radionuclides to be leached and transferred in identical fashion The latter possibility is not - supported by past experience in our laboratory which has suggested that biological systems take up Co more readily than Sc L.

WORLDWIDE ENVIRONMENTAL PROTECTION GUIDELINES - 9/1/78 In early 1977, a set of Worldwide Environ mental Protection Guidelines was developed to insure the Corporatewide pursuit of an integrated approach to the management of Monsanto's impact on the environment.

Fallon, who has served in Congress since 1946, is leading advocate of nation's Federal highway program and was one of the.

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\s also known that components of PCB-mixturcs like those of Aroelor 1254 are rapidly absorbed through the skin, leading to enhancement of hepatic cytochrome P-4 50 and drug hydroxylation reactions after cutaneous administration [13).

V-<W'' O AMERICAN INDUSf^l AT HEALTH COUNCIL I07S CENTRAL PARK AVENUE SCARSDALE, NEW YORK 10583 (914) 725-1492 WtLWla.1 tf0 MINUTES OF MEETING STEERING COMMITTEE AMERICAN INDUSTRIAL HEALTH COUNCIL JANUARY 13, 1978 rB 8 -1978 U.

-r'" REPORT * TELEPHONE CONTACT AND VT"T OF ALICE HEINRICH .

Parameter Dissolved Oxygen pH Hardness (CaCO3) Alkalinity (CaCO3) Conductivity Total Ammonia (NH3) N03-N Ortho-Phosphate Aluminum Arsenic Cadmium Chromium Cobalt Copper Iron Lead Mercury Nickel Zinc DDVP Diazinon Disyston Methyl Parathion Malathion Ethyl Parathion Concentration 9.3 ppm 8.2 255 ppm 368 ppm 50 umhos/cm <0.05 ppm 0.15 ppm 0.10 ppm <0.01 ppm <0.001 ppm <0.001 ppm 0.001 ppm <0.001 ppm <0.01 ppm 0.012 ppm 0.009 ppm <0.0001 ppm 0.0157 ppm <0.01 ppm <40 ng/l <20 ng/l <20 ng/l <80 ng/l <110 ng/l <80 ng/l Amp MW CoT2ound .3M Sample No. 6 Antimycin A*** TABLE 2 The Acute Toxicity of 3M Sample No. 6 and Anti

On another tack I want to remind you that the FDA in full recognition i j I of the fact .that the problem of PCB's is broader than any single agency of government* recently took the lead in calling together six major Agencies of the i Federal Government.

A study was conducted at 20 gasoline bulk marketing terminals to determine benzene exposure levels to both Gulf and outside carrier personnel operating at these facilities.

Residues of Organochlorine Pesticides and Polychlorinated Biphenyls and Autopsy Data for Bald Eagles} 1971-721 Eugene Cromartie, William L.

c/t V Fxpcncnlin 35 (1979), Birkhauser Vcrlag, Basel (Schweiz) the mode of action of substances causing neuronal depolar ization.

Monsanto ) MONSANTO INDUSTRIAL CHEMICALS CO. 800 N.

TV Preview they said, represents one to Hi years--- 'and those are just the steps leading to hearings on the chemicals.

We now know from medical studies that asbestos exposure is a leading cause \ of cancer.