570 FHE NE\S ENGLAND JOURNAL OF MLDK INF vpt When we saw him in 1970 the serum calcium was 6 2. and the phosphorus 5 8 mg per 100 ml.

This discussion is specifically addressed to the issues of dose response, threshold, and leading scientific principles and opinions, etc., as noted immediately above.

Michigan 48640 Exposure Jo vinyl chloride (VC) has been associated with various disease syndromes in man and animals, in workers exposed to high levels of VC, hepatic fibrosis associated with or leading to portal hypertension and angiosarcoma of the liver has been described.1 Vinyl chloride disease has also been associated with dermal induration, acro-osteolysis, splenomegaly and thrombocytopenia.2-5 In animals, VC exposure has been reported to cause several types of tumors.* In a recent report.

This will lead to an increase in the a fraction o: level of reactive metabolites and result in an increased reaction of these metabolites a wavelengi with intracellular macromolecules.

This discussion is specifically addressed to the issues of dose response, threshold, and leading scientific principles and opinions, etc., as noted immediately above.

T (DraTt) / ` A /- AS33ST0S TEXTftLE INSTITUTE Minutes - GENERAL MEETINGV^Beifruary I)., 1971 The RED CARPET INN, Charlotte, N.C.

OSHA SAMPLING DATA SHEET NO. 4 Substance: Lead and ils inorganic compounds (except lead ar senate).

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Several metabolites have been' found and several poten tial routes of metabolism have been illustrated, but which of these, if any, leads to carcinoma and other changes is not known.

The principle ef fect, however, is on the liver--possibly leading to atrophy, followed by death. _ PCB's are very persistent in the en vironment thus making them a long term threat.

This will lead to an increase in the level of reactive metabolites and result in an increased reaction of these metabolites with intra cellular macromolecules.

UNION CARBIDE CORPORATION Chemicals & Plastics 270 Park Avenue, New York, New York 10017 MEMORANDUM To: Members - OSHA Sub-Committee (See Attached Distribution List) From: A.

known metabolites, trichloroacetaldehyde, trichloroethanol and trichloroacetic acid Daniel [9] con ducted similar studies with 3f,Cl-labeled PER, and concluded that epoxidation, followed by a chloride shift, would lead to an acid chloride which would be rapidly hydrolyzed to trichloroacetic acid, the major metabolite of PER.

/*?

University of Louisville Louisville.