UNION CARBIDE CORPORATION ..Chemicals A Flastics 270 Park Avenue, New York, New York 10017 To: (See Attached Distribution List) Date: July 9, 1974 Subject: Comments on Proposed Standard For Occupational Exposure to VCM The testimony to date clearly established that an assessment of the risk of VCM exposure at any level was made impossible by the absence of medical knowledge.

This concept leads to a much more meaningful interpretation oE the dose-response data and permits more meaningful extrapo lations of that data.

/ BUSINESS CONFIDENTIAL V \frJj b> MONTHLY REPORT TO: FROM: Dr.

Thereupon, the Secretary stated that since the January 7, 1970 meeting and the recessed portion thereof held on January 9, 1970, the Executive Committee had occasion to examine closely into the matters of the proxy material, the Agreement of Consolidation, and all other .natters leading to the sub mission of a proposed Proxy Sta at and Notice of Annual Meeting to the Security?

It should be clearly understood that the Society does not take issue with the Food and Drug Adr.in- ist:ration's desire to prevent food contamination by sub stances such as lead or similar known toxic materials.

The EMC adopted the view that a "lead" sponsor should endeavor to act as coordinator to ensure coherent policy evolution and imple mentation.

R&S 004322 UNIVERSITY OF LOUISVILLE LOUISVILLE, KENTUCKY 40232 SCHOOL OF MEDICINE ' DEPARTM ENT OF M EDIC1N E DIGESTIVE DISEASES AND NUTRITION SECTION July 30, 1979 \ PJ L- WALNUT & PRESTON STREETS Mr.

The dangers of acute exposure to trichloro ethylene may be accentuated by visual disturbances and incoordination, which may lead to poor manual manipulation and, therefore, unsafe mechanical operation.6 Prolonged skin contact may cause local irritation and blister formation and, under industrial conditions, intermittent, repeated immersion of the hands in TCE has caused paralysis of the fingers.7 While TCE will penetrate the intact skin, it is considered unlikely that absorption of toxic quantities would occur by this route.8 Trichloroethylene is absorbed readily from the gastrointestinal tract, leading to respiratory failure or cardiac arrest causing death.

110412 CHEMICAL MANUFACTURERS ASSOCIATION December 13, 1979 To: Vinyl Chloride Research Coordinators Subject: Dr, Stafford's Letter Transmitting to NIOSH the Report Covering the Study Conducted by the Institute of Occupational Medicine (IOM) on "An Epidemiological Study of Respiratory Disease In Workers Exposed to PVC Dust" Gentlemen: In accord with advices given to him by the Legal Division of ICI Americas, and with an earlier recommendation made by the Vinyl Chloride Research Coordinators, Dr.

CHEMICAL MANUFACTURERS ASSOCIATION Chemicals August 30, 1979 FK CC To: Vinyl Chloride Project Panel Vinyl Chloride Research Coordinators Gentlemen: Enclosed is your copy of the quarterly report describing research completed under the CMA agreement with the University of Louisville for the 1979 - 80 fiscal year.

This lead GE to seek understanding of the scope, reproducibility, reliability and validity of the analytical procedures used by various investigators who reported finding PCB in concentrations as low as parts per billion.

The bid. half time eras 00t 112711b The effects of sine and lead on 4-amiao)acvu= extd. to b* 26.5 days.

APREG is known throughout Europe as a leading company in the friction materials industry and its products establish a standard of performance for German friction materials.

(It is estimated that, if evenly distributed, three ounces of dioxin could kill at least one million people i he company, subsequently Tcharged by the state with- opera ting a quick-cash scheme In which wastes were never properly treated, had also taken m discarded explosives: TNT. nifroglycenn and. for good measures, tetraethyl lead, which can ignite simply upon ex posure to the air Late in the evening of April 21. 1980 -- ironically, the eve of Earth Day -- the Chemical Control stock pile suddenly burst into flames reaching temperatures of up to 3.000 degrees.

15*14 CHtWSTW to. sc juiv/mn. com*, v.ooo MAY 1976 !