Document RJREogxKpEnkJ5rmZYVnjVdKB

S- ,Hi2* (it'd t*~~ KiikU J-. ''Vi. Sot. I97H, 1I 2). 113-21 (Eng). The distribution of >3 elements in 48 sample* of container glam wm dffd. using zpark mniry nuiM *perfnnneifr filled wlih Activities of the following hc|Mt ic mirrosn^/al enzymes, aminopvnnJ^ltd.. dcmethylaae [9037-89-8). prutrorcductatr (37205-39-3) UPP-fUKUK>nyllrnsferi and l.-leucyl d-naphlhylamidote 7' elev. detection. Ft. Mr. and At were the mott significant elements in different ini in* window from container rIsm. Foments writ homogeneously distributed within 1 container. The elemental rompn. of glass produced at I factory on consecutive were measured in both species; cytochrome P*sc (9635-31-2) and microsomal protein content* were also detd. The chungt-s in the levels of androgens, estrogens and corticoid hormones were measured in the circulating blood of control and treated group* V day* wm reasonably const, with time. The method may thus at weekly intervals. Results indicated (a) a significant increase also hr useful in identifying manufs. in the activities of all the enzymes measured exceptt.- leucyl d- ~ 90: IdTMy The use apark tnucre maaa spectrometry naphthylemidase, (h) cytochrome Pm and microsomal protein foe the analyst* and classification of small glass fragments. contents were increased in trout, but not in carp, (c) a significant , Locke, J.; Boaae, D.; Smalldon, K. W. (Home Off. Cent Res. redn. in the plasma levels of androgens, estrogens and rorticoida 7 KstaM , Akleemaeton/Keedini/Berks., KngU. J. Forensic Sri. in the treated groups, particularly at the end of the 4th wk end A Sue. 1*78, 180-2), >23 31 (For). Data accumulated from tho <d) there was a correlation between increased enzyme activities multi-element anal, of mg samples of various glasses ara end a decrease in plasma hormone levels. reviewed and a graphical procedure is described for the 90: 162801x Growth limitation of a coastal diatom by low chewyfication of modern window gist* The anal, method is zinc ioa activity. Anderson, M. A.; Morel. F. M. M.: Guillard. rslindad to include sample* weighing HN) ag I mg. The validity R. K. L. (Dep. Civ. Eng., Massachusetts Inst. Techno!., of the classification procedure ia then checked for these small Cambridge, Maaa.). Nature (London) 1978, 276(5683), 70 I psfiirka. Casework applications of the clauifieation scheme are (Eng). The growth rate of Thalaasiotira loeiss/fogii in Zn -limiting dhetmad. conditions was detd. by the Zn*4 activity rather than the tout Zn 00 182708s Hygienic significance ef an ion-osene complex concn. The range of Zn*4 activity over which T. writ*floan grew owda* eondtliona ef dwelling houses end public buildings. at its max. rata spanned only 2 orders of magnitude (10 * 10 *M). Oubernskii. Yu. D.; Ismailuve, D. I. (Inst Ooshch. Kommunal Thua.if any org. complexation of Zn occurred in unpolluted Gif. h. Sysina, Moscow, USSR). Yestn. Akad. Med. Neu* coastal water, growth of T. urtm/fogri mold easily he limited by USSR 1078, (M), 49 53 (Russ). A redn. of the natural Zn deficiency or in polluted situation where the Zn concn. immunobioL roactivity was obad. in rats kept in the premises could attain 100-200 times its natural value growth could be where Oi ennen. exceeded the permissible levels and in animate impaired by Zn toxicity. which wera exposed to chem. substances in conms. exceeding 90: 182862? Absorption, distribution, and excretion of hygienic requirements and U> artificial otonation at the level of IriphenyMIn acetala and stannic chloride in the guinea pig. Batumi counts, of Os <18 2Upg/m'). Animals kept in an atm. Nngamatsu, Kuninuke: Kido, Yatumasa; Urskubo. Coro; Aida, runtg. 1500-2000/cm* of light ions and l6-20pg Os/m* showed Yosnitaka; Ikeda, Yasukazu; Suzuki, Yasuo (Natl. Inst Hyg. on increased Immune potential and a higher tolerance to phy*. Sri., Tokvo. Japan). Nippon Eitteigaku Zosthi 1978, 30(3), loading. I- A. Masironi 406-96 (Japan). Percutaneous absorption of ll3Sn- labeled 18 111707a Identification of three sulfur-containing urinary fripheny/iPt acetate (I) (900-95-8) was studied in guinea pig*. etakalltas of slyreae in the rat. Seultcr- Herlege, Praneiaca; Of the dose, 3.04% and 7.9% were absorbed through the skin IMkeecrine, L. P. C.; Smeets, F. I,. M.; Ketdaars, H. C. J. and 16.3% and 12.4% were found in the applied area 1 and 2 (Inst Pharmacol., Univ. Nijmegen, Nijmegen, Neth.). days after application, resp. After s single s.r. injection of Xmubiotira 1078, 8(7), 413 18 (Kng). After edminiatretion of the radioactivity was found in the liver, kidney, and afyiroe {190*42-5] (2ft) mg/kg, daily for 3 wks, i.p.) to rats, 3 brain in large amts., thnuzh absorption from the injected site 8 runtg urinary ssctalmUtee were isolated and identified ee N Bcetol-S-d- phenyl- 2 hydroxyethyRrysteine (I),. N-arrtyl- V (2 tmrnyl-2-hydruxyrthyDcyuteine (11) [14510- 14-81 end Koceeded slowly. The Way retention of radiosctivity showed a ol. half time of 9.4 days, and -83% of the dose wss excreted in the feces within 20 davs of dosage. The radioective concn. ft acrfW o-Qdicny/ervfk.vsfcfne (III) ISIMM7-I], After a wax the highest in the bone and kidney after a single s.c. single mute of styrene (2S0 mg/kg) the totally excreted merespiuric injection of l,*SnCI*. No transfer to the brain was detected. rifle in the urine amounted to 10.7% of the doee. I, II, arid III Absorption from the injected site and excretion, whose main warn Mated in the mol ratio of 86:34:1. route was urinary, were greatly delayed. The bid. half time eras 00t 112711b The effects of sine and lead on 4-amiao)acvu= extd. to b* 26.5 days. diphenyliin [1011 95-6], and IIm4 dehydratase. Meredith, Pster A.; Moore. Michael R. -monophenyltin [2466- 68-0] were identified ee the chem. forms (StubMU Gen. Hasp.,' Univ. Glasgow, Glasgow, Scot.). of the radioactive compda. excreted in the feces after s single s.c. Woehem. See. Tram. 1078, 6(4), 7C0 2 (Bug). Erythrocyte injection of l-`'*Sn. R. Ishida 4 aswwolevulmate dehydratase (EC 4.2.I.24)(f) [9036-37-71 90: 162803a Comparative cytotoxic effects of hexavalent was msesursd in 25 Pb-expmed and 40 control subjects, and and triveleat chroxslwm compounds on cultured cells. winde Mead Pb and Zn concn*. detd. by flamelass at. absorption Susa, Nobuyuki; Furukawa, Yoshinori; Tsubaki, Seiichi (Sch. spri Uentry. Ph-expnaed patients showed decreased erythrocyte Anim. 9ri., Kltasato Univ., Aomori, Japan). Jpn. J. Vet Sri. I activity, aasecd. with elevated blood Pb. compared to control 1977, 38(3), 325-36 (Japan). After Hel*a ceils and rat embryo Kienta. Nonlinear, least squares regression anal, indicated that dnsx not affect ths 1 activity at normal physiol, concns wen preincubaled in Eads's min. essential medium at 37* for 1 day, the medium wee changed to e fresh one contg. a given irmessin industrial exposure to Zn, or disease states resulting in concn. of Cr compd. Fifty percent inhibitory doe* (IDae; pg/mL ilrvetad blood Zn levels, may effect the activity of I. medium) for cell growth was detd. IDm for Cr(Vl) in the culture 80i 162798a Metabolism of dihalometbaoe* to formaldehyde of HeLa cede were: NaiCrO* 0.34, KCnOi 0.58, NazCnOr 0.64, and tnarganls hoHde. II. Studies on the mechanism ef the KzCrOs 0.70, and VCrO 0.78. IDs* for Cr(III) in H*U cells Croatian. Ahmed, Ahmed B.: Anders, M. W. (Dep. Pharmacol., own: CrsfCiOih 4.0, <XAeO). 62.0, Cr(NOa) 720, CrClj 10)0, Univ. Minnesota, Minneapolis, Minn.). Biochem. Pharmacoi. and CrBrs 1600. IDm in the culture of rat embryonic cells 100L 27(16), 202V 5 (Eng). Metab. of dibromomrtksne (I) showed a similar trend. K. Torii (74-86-8) by rat liver cytosol fractions yielded HCHO (86-66-6) 90: 162864a Load detoxificatfon by a copper-tolerant leaped. and Sr sa products; glutathtone (II) (76-18-8) was a cofactor Brown, B. B. (Dove Mar. Lab., Cullercoata, Engl.). Nature In this nacuen. Knsyme-catalysed nucleophilic attack by II on (London) 1078, 276(5666). 368-90 (Eng). Whan Pb- and I wan the 1st step in this fraction. The expected product of this Cu-tolerant Aaetlus meridianuo from the Hsyle river (cuntg. renrtfoa would be an S- bromomethyi-glutathion* intermediet* 0.10-0.25 mg Cu/L and <0.01 mg Pb/L) and Pb-tolerant which should undergo a rapid hydrolysis to yield S-hydroxya organisms from the Ganne) river (runtg. 0.19-0.36 mg Pb/L and methyl-ftutathionr (32266-67-01. This compd. was the 0.01-0.04 mg Cu/L) were exposed to snlns. contg. Cu or Pb or hrmimercantal af HCHo and II and provided a mechanism for Cu + Pb, tnt uptake of Cu oy Hsyle snimab wm considerably the formatran ef HCHO from dihaloreetkenee. II was required reduced by the addn. nf increasing bveb of Pb, and uptake of by this mechanism but was not consumed, and no primary Cu by Ganna) animals was lower than that of Hayle animals and HONS 0 0 9 1 1 3 isotope afflict was assn when 1-fi was used. S-Hydroxymethyl was apparently unaffected by addn. of increasing concns. of Pb. gfotaihimewm a suhrtrate for hepatic NAD-dependant formaldehyde Pb uptake by the Ganne) population wm lower than that of the dudhtgranee (III) (9628-84-41 wind) converted (ha heminwrcaptsl Hsyle. With const. Pb ana increasing Cu levels, uptake of Pb by af tl and HCHO to S-formyl- glutathione (86406-81-8), this Hayle animals was reduced at higher Cu concns., snd uptake of being eneymkaUy hydrolysed to aiaM n<M fta-ia-ai and II. Cu was not as marked at uptake Tn the 1st expt, suggesting that Thus, i Pb may be more preferentially bound than Cu. Pd uptake by the Ganne! population wae unaffected by increasing Cu Conors. |and Cu uptake was low compared with that of Hayle animals. I'hus, in A. mendianui, tolerance to Cu teem* to confer deranee to Pb. Pb wae present only in the cuproaomes nf the bpatopancreos of exposed animals and ia probably more readily ound than Cu, which was released into the lumen of the hepatopancraaa. Cu-tolarant isnoods from the Havle can _ ___________ liy intervale for 4 apparently detoxify Pb by storing the metal in the cuprnsomea to trout "and carp; srarhia oil was used as the control. at the expense of Cu. , nmp Joseph; Stull, __ rroctnr, William l.anedan; Miller, Irving Louis (Srirmr Spectrum, lnr.) Brit. 1,51$,Ml (Cl. G01N21/24), 28 Jun 1978. US Appl. 468382, 10 May 1974; 30 pp. A differentia) light scattering tpp. rs described for testing the sensitivity of susceptibility of bacteria U) antibiotic*. The To* of (he ntchty of radiant energy scattered at a no. of angular location* wm measured and compared with controls to give a differential wsttrring pattern. Thus, exponential- phase bacterial samples were incutated with a variety of antibiotics at differential conrns., dtld. with water and subjected to differential light scattering; min. inhibitory concna. of 0.02, 0.05, 0.05, and 0.002 pg/mL were detd. for (efrocyWin# (10-54-8], neomycin (1404-04-21. streptomycin [57-92-1], and penicillin [51-33-8], reap. 90; 95047b Synergistic microbiocUlal composition. Polony, Rudolf; Raeuchle. Adolf; Heirler, Frits (Ciba-Geicy A.-G.) Swiss 604,523 (Cl. A01N9/2G). 15 Sep 1978. Appl. 75/16,278, 15 I>ec 1975; 5 pp. The antibacterial effects of halogenated c,"C5~~!)~c'. hvdroxvdiphenvl ether*, such as 2,4,4*- tnehloro-T-hydroxydiphenyl ether (I) (3380-34-51, for Pseudomonos aeruginosa were synergistically enhanced l>y the presence of anionic surfactants. For papers of related interest see also Section: 1 97342* Biologically active thiarolidinona. 974$Or Effect of 5 atacytidine on simian virus 40 DNA replication. I7492f Activity of derivatives and analogs of dapsone against Mycobacterium leprae. _ .. r germ cells ' l,m 4 eadtiVf Interaction of glycine with ethanol. 5 Agrochemicals. 6 98683f Modification of rat liver chromatin by n nitro-N-nitiwnfuanidine or N-ethyl N- mtm M , and template activity for UNA synthesis by K<m wr',,B KNA polymerase after reconstitution. ,w#< 967l6w Reaction of bisulfite with the 5 hv,jr J fruup in pyrimidines and in phage DNAs. *i 9912th Alcohol dehydrogenase from human and hm. 1 Substrate specificity with drals. ^*1 99174c Inhibition of Kscherichia coli ONA polym^^l association of the template with an N methylntaim micarbasone.copper complex. ` 10 Microbial Biochemistry. 11 Plant Biochemistry. 12 Nonmammaiian Biochemistry. 13 Mammalian Biochemistry. 14 Mammalian Pathological Biochemistry . 15 19161 Id Relation between cyclic AMP levels of Ivmpk J lymphocytes (especially 1' lymphocytes) and macro*' * the guinea pi*. !0(846w Potentiation of polymorphonuclear leukocyte <j functions by 2,3 dihydroxynenxnic acid. 10IS50r The effect of zinc chloride >n the redistnhm^l surface immunoglobulins in rat B lymphocytes. " 30 104137* Structures and zynthesis of some new n( 1(3*4, sesquiterpenoidl from the gorgonian coral (Vndoptet rigidn. 33 104247b Aminoglycoside antibiotics: studies directed l< the selective modification of hydroxyl groups: synthe**^ 3 -epipn>msmine end 3` epineamine. 1 63 92395s Evaluation of virucidal compounds for inartivstinaJ rhinovirus on hands. 3 79 9892$p A new narrow range acid-Has* indicator, 7 metlnt.4 5-hydroxy 1.4 naphthoquinone (7-melhvljugnlone). 4--TOXICOLOGY AvaiUW* e Uw (W|Hr iwtiMt flit* CA--,< Wefaffiraf AetieUie* tCBAO, Aw4 onW AgnruUurnI Chemttlry. "* F-cnitm Em-nmmrnt 90: 98046c Ncurobiology of lithium. Navon, Sofia (Fee. A review and discussion with 15 refs. Med , Univ. Buenos Aires, Buenos Aire*. Argent.). Medirina 90: 96056d Changes in the respiratory tract due to paragon 1 (Atmos Air)19718^g^j^jjJ0t^Sgsn^^reviejyjfij4^5 poisoning. Firtik, Micrzyslaw (Akad. Med.. Putnan. Pol)1 ' Br. 1978, 29(4), 325-6 (Pol). A review with 18 ref* .J: 190(94 General summary and conclusion* [ta the tealIII affect* of PCBs and PBBsJ. Kolbye, A. C,, Jr. (Bur. I Funds, Food Drug Adm.. Washington, 0. C ). Environ. Health J Pamper/. 1978, 24, 191 -8 (Kng). A review with 68 refs. oothe j OO. covering pathogenesis and pnthomorphol. of respiratory trsrt changes > people poisoned with paraquat chlorine (I chkinde) ta individual differences m cancer risk. Nebert, Dsme) (1910-42-5]. ,t. Grtsler (Natl. Inst. Child Health Hum. Dev., NIH, Bethesds. Md.). 90: 98057c Biochemistry and phyelologv af the effect d Aiorhimtt' 1976, 80(9), 1019-29 (Eng), A review with 35 refs. solfur dioxide on plants. Ztegler, Irmgara; Ziegler. H. rimo. 90: 98051y Rarly metabolic alterations in pulmonary tissue Biochare. Get. Strahlen- llmwehforsch.. Munich, Ger \. following administration of tonic agents. Kacew, S.; VDlOer 1978, 314, 219-23 (Ger). A review with 17 refs. Narbaitx, K. (Far. Med., Univ. Ottawa, Ottawa. Ont.J. Fed. 90: 98056f Drugs for suppression of alcohol. Barnicand, jVwr, Fed Am. Sire. Kxp. Biot. 1978, 37(1T>, 2489-95 (Eng). D.; Royer, R. J. (Rerv. ToiiwL, Cent. Hnsp. Univ. Nam-y, -O Nancy, Kr). Ann. Med. Nancy Et 1976, 17(Ort ), 1167 (i. 1191-2, 1)94 -8 (Fr). A review with 19 refs mainly emphasizing tha din. use and the mechanism of action of disulfiram [97-77-6] in the treatment of alcoholism. A review with 44 ref*, on chenes* In lung morphol. and motob. 90: MQSSg A review of recent literature on lend poisoning following the administration of Pb, Cd, chlarphenttrmine (2) 1. Analytical methods for lead In biological mirrish.' (461-78-9], and phentermint (122-09-0]. Horiguchi, Shumrhi; Shinaxawa, Kuso: Kiyota. Ikuko (Dep. 90: 96052* Bcoteslcological ospoeit of the European Evi= Prev. Med. Public Health, Osaka City Univ. Med. Sch., (husk*. ronmental Action Programmes. Smeets, J. (Div. Prev, PoUut Japan). Sumitomo Sangyo Eiset 1976, 14. 29-34 (Japan). u Nuisances, Air Chnm. Subsu, Comm. Bur. Communities, A review with 48 reft. t Brussels, Bel*.). Krotoxicel. Environ. Saf. 1978, 2(2), 143-50 90: 96050a Methodological aspects of post-mortem inves (Fjlg). A review discussion with no refs, on environmental tigations of human brain - with special reference to pollutants and their potential risks to humans. monoamines and related ensymes. Adulfamn, R . Gntifrirs, 90: 96093a Chemical and biological Implication of organic C. G.; WinMad, B. (Dep. Psychiatry, Univ Umw. Umea, compound* formed in slmnlntod and real urban atmospheres. Swed.). Neuro-Pnyrhopharmacol., Brae. Cungr Coll Ini Pitta, .lames N., Jr. (Dep. Chere., Univ. California Statswids Neuro IHyehopharmacnl.. 10th 1976 (Pub. 1978) 2. ).r97 64 .(Air PoHut Hen. Cent., Riverside, Calif.). Scotaxicot. Environ. (Eng). Edited by Deniker, Pierre; Radmtru- Thomas. >" . w Saf. 1078, 2(2). 199 217 (Bngl. A review with many refs, on Villeneuvc, Andre. Pergamon: Oiford, Engl. A rrtiew with 32 the formation and fata <tf several nitrogenous org. compds. in ref*. teal and simulated urban alms, end the mutagenic properties of 90: 96001b Distal axowopmhy: owe cewmiun type of aenrotexle ambient ore. particulates. . 90:180540 Use of structure-activity analysis in toxicology, beam, W. (Inst. Wirkstnffumh.. DAW. Berlin, B. Ger.). lesion. Spencer, Peter S.; Scbaumburc, Herbert H. (Rose K. Kennedy Cent., Albert Einstein Oil. Med., Bronx. N. Y >. EHP. Environ Health /Vrepcct 1976, 20. 97 105 (Eng). Arch, Exp. Veterinotrmed. 1978, 32(4), 579- 84 (Ger). A review with 18 refs, on neurotonic compds. and distal A review with 32 refs. axnmipathy. 90:96985c Conformational analysis in QSAH Investigations. 90: 98062c Strategy for the assessment of iteurobehaviornl Hupfinger, Anthony J. (Cam West. Reserve Univ., Shaker consequences of environmental factors. Hugh A, Heights. Ohio). ImliW Buhl (FfM) <(/. 5 ) 1977 (Pub. 19781. Cabe, Patrick A. (Usb. Behav. Neurol. Toxicol.. Nat Inst ` i 78 1046, Struct. Corrcl. Carctnug. Mutagen., 74-81 (Engl. MONS 009114