ifetrch 5, 1973 M$* liarjorie &*K* Inservice Education Coordinator Edgamoor Geriatric hospital Horth Mgemoor Drive Santee, California 92071 Dear He* Briggsi Vour letter o February 6, 1973 to the attention of the Food and Drug Administration hm been referred Iso me for reply* We are at present cxapilta$ information on various talc products, but this is not yet ready for release* Inhalation of large rraomat of eshastee, a# in occupational exposure, is kno&tt to increase the incidence of lung cancer and pwseothelfossa, e&peeially in heavy sobers of cigarettes* Aabeafcos is often found- as a. natural contaminont of talc; both are magnesium silicates, end aro geochemicalXy Infcercoarvcriifele* Taleoei* if seaa only tmder conditions of heavy exposure and talc has not been demonstrated of itself to bo careino^onic* the levels of the various types of asbestos found in talc vary depending upon the source frm. which the talc comas, and: the use for Which it is intended, i.s* ties in heavy Industry, food UqpmUmdt, cosmetic* Generally* the bat-tar grades of commtc and food talcs are reportedly free of ae~ bastes* Iveadlcss to- ay, the suppliers and cotaaercial users of talc are aware of the potential problems presented cad in the last year or so the industry lias made an effort to reduce or eliminate asbestos in talc as required* Two statements from 1971 report on Asbestos by the national Acatoay of Sciences are of interest there are levels of asbestos exposure that will not he associated vlth any detectable risk.

DETERMINATION OF ASBESTOS T"i TALC BY OPTICAL MICROSCOPY The six kinds of asbestos can he distinguish.ee] from talc and from each other by their refractive indices, other optical crystallographic properties, and morphology as determined with a polarizing- microscope (AOAC 1970 36.54136.543).

BETWEEN: SUBJECT: MEMORANDUM OF MEETING January 7, 1975 FDA Representatives Robert M.

DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE PUDLIC HEALTH SERVICE FOOD AND DRUG ADM INISTRATION W A S H IN G T O N , D .C . 20204 O ctober 6, 1971 To: P a r tic ip a n ts in "A sbestos and T a lc " D iscusicm S e s s io n a t FDA on August 3_p 197 X A ttach ed i s a s u g a r y o f om re ce n t D iscu ssio n Sees lux* cm "A&bestos and T a l c ," As warty o f yen I have requested submissions o f de t a i l e d a n a ly t ic a l procedures frees a l l o f the la b o r a to r ie s rep resen ted which perform each work.

DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE PUBLIC HEALTH SERVICE FOOD AND DRUG ADMINISTRATION WASHINGTON.

FILE NAME: Talc (TALC) DATE: 1972 May 15 DOC#: TALC069 DOCUMENT DESCRIPTION: Letter to the US House of Representatives from Barry Castleman VI May 15, 197a Me. faul 5, Sarbanes Congres* of tha Oaltad StttM House of Representatives Washington, D.C. 10515 Dear Mr.

FILE NAME: Talc (TALC) DATE: 1972 Mar 22 DOC#: TALC060 DOCUMENT DESCRIPTION: Letter to FDA from Barry Castleman Questioning What the FDA is Doing to Research the Carcinogenicity of Talcs March 22, 1972 food and Drug Adminia tratlon Department of '-calth, Education and Welfare 3600 Fishers Lane Hockville, "-laryland 20S52 Attention: i:r.

BABY PRODUCTS COMPANY RETURN RECEIPT REQUESTE R A R IT A N .

*1 X, th .i 28 June 1971 TO: Mr.

EXeCUTW SCRETARfAT Food and Drug A d -v ris tra tio n T A/fri!

!

N ovem ber 27, 1973 HFoeoadrinagndCDlerrukg A d m in istra tio n RR56oo0oc0mk vFi6ilsl-e8h,6e rMs aLryanlaen d 20852 Dear Sir: Enclosed are com m ents pertaining to the FDA publication in the F12e1d.e2r0a0l6R, epgairsategrr,a pVhoci.. 33, P#l1e8a8s,e Sneoptteemthbeeor r2ig8i,n a1l97c3o,pyS eisctitohne only one with photographs suitable for reproduction.

M m - pus FiA - o c/ c c M arie C .

F 'Ml N E W B R U N S W I C K .

FILE NAME: Talc (TALC) DATE: 1974 DOC#: TALC501 DOCUMENT DESCRIPTION: NIOSH Memo RE Proposed Regulation on Asbestos Particles in Food and Drugs 5* r r *r \ * \* - + \ r W * - A - V.