However, PCB has a solvent action (similar to paint thinner) on the fats and oils of the skin and prolonged contact may lead to drying and chapping of the skin.

The following hypothesis was put forward: dust particles interact with the pulmonary tissue dua to their pleso- electric properties, Ae a result of this, disturbances of tha tissue metabolic processes take place leading to the development of fibrosis.

Toxicological Advisor Division of Toxicological Evaluation Department of Health, Education, and Welfare Food and Drug Administration Washington, D.C. 20204 Dear Doctor Fitzhugh: We have finally completed the investigation of the lead-containing hair dye, and I am sending five copies of a report in. xvhich the experiment is described mid the results are detailed.

The principal effect, however, is on the livor (possibly leading to atrophy, followed by death). .

However, it would be my suggestion that if you wish to change the sequence of the papers that relate to lead in the air and to the general problem of air pollution, you might move Larsen's paper (V in the series) and fit it in between Mr.

Scllk condition that often leads to Dr.

' ~ The common uses of commercial PCB would not normally'. ' '^ lead to its release into the natural environment.

The common uses of commercial PCB would not normally lead to its release into the natural environment.

Isotopes; and the development of Mirtiioda leading to more precise localization of radiol*otnpe for therapeutic purpose# and resulting in a better uuderatnndiug of thit effect# of rudloleotopcs should they contaminate body structures ware diacutiud

a rogular floor eloaning program that would ba followed each shift of tha operation of this plant*^2 Cal ling for dust eorrac* tlon at tha Flatware Finishing Lina, especially at tha leading box station* Thaso nan ara continuously being subject to a concentration of dust at tha boxing and of this lino* Tha entire line condition Is not good*^rRoutcr area needs correcting* Batch mixing dust needs correcting* Tho hazardous oathod of feed in* batch to this dopart&nnt by a lift truck should bo dls* continued* ' Tho mothod of cooling no ids with large hlfib*pewcred__ fans on the floor of tho Froductlon Department should be die* continued and another method installed* This keeps a constant agitation of dust spread throughout tha production area.''.The amber of vehicles moving beek and forth in tha production area continuously stir up the dust* Some methods should be devised to aintnias this traffic and keep tho dust on tho floors at c minima*

Nona of tha compo nents have a history' of sensitisation in humane. we do recommend that prolonged or repeated skin contest be avoided since these fluids are excellent solvents for tha normally occurring fats snd oils on ths skin and prolonged exposure can lead to drying and cracking.

133.500 TOTAL 3.171,810 EDO Louisville ^ohm St Haas Miscellaneous TOTAL 2,798,193 191,500 ... 30 2,989.723 TON 1 (70) Avon Lake 1 (80) Louisville 38 (70) Louisville 1 (70) Akron 1 (70) Dewey & Almy (40) E.I.Dupont (40) Goodrich-Gulf 2 (80) Dow Badische 1 (80) International Latex TOTAL 44,140 136,700 1,669,840 43,800 28,660 3,500 1,050 274,100 68.500 2.270.290 SODIUM HYDROXIDE Commercial Solvents Miscellaneous Preston Chemical P B and S Charles Pfizer National Lead Olin Mathieson Allied Chemical Diamond Alkali E.

v~l_V American Brakeblok Division This Division, operating two plants, is one ol the United States- leading suppliers of friction materials for automotive, industrial and airborne use.

.- Although'rrloritVly/s* rgpdrts were received r 1960*concem|ng sukb classical * agents as lead (*4 reports), carton monoxide (SJ reperts), carbon tetraqtyoridft (17 reports), and mercury If?

Finally, a morphological study does not give any lead as regards functional damage