Chief Medical Unit Division of Industrial Hygiene and Safety Standards New York State Department of Labor HE FIELD FIELD of environmental cancer continues tafe - rrTt | ade ......... 10190 F thest three .. th tete -100- 1100 vernal 1881989 ciau to fill out special promise largely beranse here we are dealing with a few specific chemical and physical agents which it has been demonstrated can produer canver under certain circumstances and at specific primary sites of predilection predilection predilection In view of how little is known of the etiology of eancer in general this cannot fail to de impressive Unfortunately the number of environmental carcinogens so isolated is very small and little is known of the physiological ar chemical mechanisms involved Neverthe 1 the mere fart of the absorption into the bady at Unown UnowUn nown or suspreted carcinogens of exogetimus exogetimus origin provides au usual opportunity to study these mechanisms the processes of detoxification and conjugation for example or of storage and excretion Identification furthermore leads to wider Lowledge of environmental distribution and turn tives the precise comlitions provides hope for the cantra measures of exposure development This in of effer Laboratory experimentation has thus far 711- the Jenn Khairman New York State Deempational Caneer Committer The views expressed in this paper are entirely thusse of of the author wit in any sailbur an ollicial report of ..

therapeutic feature directed against the development of silicosis but which needs further research is the possibility of introducing an antidotal com- ponent into the lung to prevent the pernicious particles of silica from going into solution and causing aggressive nodular scars within the lung This in essence is the most satisfactory explanation for silicosis nr . : 5 a antidotal neutralization of this action may lead to the eradication of the disease and its disappearance from the roles of workmen's compensation acts On this point it has been commented on in medical circles that a paradoxical relationship exists between incidence of disease and litigious interest The current position of silicosis is an illustration of this expression ne The question of slowly developing complications following upon remote , exposures to noxious agents or pernicious dusts represents one of the plagues . which afflict the medical and legal professions It is one that requires care- 2 ful analysis with the expenditure of every effort to reconstruct the chain - 7-4-7 ~ -- events before precipitate legal decision is appendeAdn alleged -~__ relationship between lung cancer and silica pneumoconiosis has be

Public Health Service and Labor Stand ards Bureau), 182 Pathology of Trauma (M oritz), 89 Psychosomatic Case Book (Grinker and Robbins), 89 Verhandlungen der deutschen Gesellschaft fr Arbeits schutz, Vol. 1 (Mager, ed.), 90 Boron hydrides : See Decaborane; Pentaborane c Cancer: research grants, 87 Chemical industries : inclusion bodies in workers' blood, 192 Chemicals Marketing, health problems, 50 toxicity, range-finding data, 61 Chest diseases : Mclntyre-Saranac conference on, 454 Cobalt carbonyls : toxicity, 210 Copper : health hazards, 77 Correspondence, 254 Corticotropin: for lead colic, 491 Cortisone: for lead colic, 491 Cyclethrin: toxicity, 162 D Deaths: Simmons, James Stev ens, 548 D.

0 Z--:-- rp [=3 INDUSTRIAL HEALTH NEWS LITERATURE ABSTRACTS MEDICAL ENGINEERING CHEMICAL TOXICOLOGICAL LEGAL decisions and trends APRIL, 1957 (VoL 21, No. 4) INDUSTRIAL HYGIENE FOUNDATION MELLON INSTITUTE 4400 FIFTH AVENUE PITTSBURGH 13, PA.

Mar. 1957 Total Anthrocosilicosis Anthrax Carbon tetrachloride, with acute hepatitis Dermatitis 18 Lead 5 Platinosis Pneumoconio sis . 1 Pneumoconiosis (suspected) R

Mar. 1957 Total Anthrocosilicosis Anthrax Carbon tetrachloride, with acute hepatitis Dermatitis 18 Lead 5 Platinosis Pneumoconio sis 1 Pneumoconiosis (suspected) Re

Kehoe Director, Kettering LaboratoryUniversity of Cincinnati Cincinnati, Ohio Dear Bob: I appreciate your writing me in detail about the lead balance question.

Manfred Bov/ditch Director of Health & Safety Lead Industries Association lj.20 Lexington Avenue New York 17 N.

LEAD INDUSTRIES ASSOCIATION 420 Lexington Avenue NewYork17,N.Y.

It does not appear that any investi gation on our part Is indicated at the present time since there is no reason for believing that the natura of the man*s illness was such as to indicate exposure to lead tetraethyl.

The survey, with respect to exposure to lead oi' the reri engaged in these occupations extended, therefore, over the* period from :.'

Mjj^ptras suffering from lead poisoning or Addison's Disease, but cannot get any definite information from him or his family.

Kehoe: ' I am interested in obtaining a copy of your paper ''Experimental Inhalation of Lead by Human Subjects" given in Cincinnati on April 23.

Bex 121 Eroden, New Jersey Dear Doctor Eckardt: I have raised the matter of a discussion of the toxicity and potential health hazards of the organic lead compounds with the proper persons in Ethyl Corporation.

Cholak has replied for both cf us to the letters addressed to himself and to me (October 22) concerning the report on lead analyses, with particular reference to suggested changes in the text.