Edgar regarding their shipping of tetraethyl lead to supply houses and individuals.

It seems that wo have no official responsibility but In view of the association of the Bow Company with the Ethyl Gasoline Corporation, and In view of the significance of any manufacturing difficulties, which may involve tetraethyl lead, 1 think we should examine into this and sanction either the recommendations made by Colvin, or make such modifications in them as seem to be indicated by the cIreumstances I am sending Mr, Lewis a copy of this letter and X suggest that both you and he let me have your suggestions as to how host I can take up this matter directly with the Dow people* I realize that sometimes the people within an organisation ere a little sensitive and It would be well, therefore, to deal directly with the right person* Either Dr, Bachle or X will look Into thia*and we may wish some further advice in connection with the equipment which Is being employed by Dow* Very truly yours.

This same critic ism applies to the series of results in this table beginning with the medical students and extending down to the tetraethyl lead workers - laboratory.

It Is quite apparent that the methods we have used in this country to pur our precautionary measures Into effect have been inadequate* I have a distinct feeling that there may be Inadequacies also outside of this country, and it gives me some anxiety to think that incidents of this sort may occur in connection with the cleaning of storage tanks in any part of the world* It seems quite certain that we shall have to set up some mechanism for taking this activity under our own supervision* we are in the process of setting up a mechanism for this purpose In this country* At present I do not consider it advisable to try to extend such a mechanism beyond our own province and X shall not make any reoesamend11ons on the subject until we have complete information as to the character and magnitude of the whole problem* As an illustration of what I mean, let me point out that all the oases of poisoning in this field have occurred In connection with tanks which have been used for mixing and which may, therefore, have con talned concentrated Fluid in the sludge at the bottom of the tank, as well as crystalline decomposition products of tetraethyl lead on the basis of the occurrence of eases we might assume that the danger Is confined to tanks that have been used for mixing as distinguished from tanks that have been used solely for the storage of finished leaded gasoline I am by no means certain that this oonelusion H# E# A# Boldero Is justified and until I m certain# I shall not wish to make any reoaurcendatlons of widespread application, on the other hand I consider It advisable# and 1 have so recommended to Sevan# that we take such steps as are feasible to remind the distributors of leaded gasoline abroad of the necessity of taking at least those precautions which have previously been recommended by us# 1 think you oil!

It Is quite apparent that the method we have used In this country to pur our precautionary measures into effect have been inadequate* I have a distinct feeling that there may be Inadequacies also outside of this country, and It gives me some anxiety to think that incidents of this sort may occur in connection with the cleaning of storage tanks in any part of the world* It seems quite co* tain that we shall have to set up seme mechanism for taking this activity under our own supervision* we are in the process of setting up a mechanism for this purpose In this country* At present I do not consider it advisable to try to extend such a mechanism beyond our own province and 1 shall not make any reoesamenda11ons on the subject until we have complete information as to the character and magnitude of the whole problem* As an illustration of what I mean* let me point out that all the cases of poisoning in this field have occurred in connection with tanks which have been used for mixing and which may, therefore, have eon* talned concentrated Fluid in the sludge at the bottom of the tank, as well as crystalline decomposition products of tetraethyl lead* -On the basis of the occurrence of eases we might assume that the danger Is confined to tanks that have been used for mixing as distinguished from tanks that have been used solely for the storage of finished leaded gasoline* I am by no means certain that this oonelusion H* E* A* Boldero -2 Is justified and until I am certain# I shall not wish to make any reoceamendatlons of widespread application.

During--the"''many years Ethyl Gasoline has been on the makt we have never had a single case of lead poisoning brought abouyiy association wit^^&^^^^Gasoline and we are naturally positive that |ifhe exposure f^f to No Nox Ethyl Gasoline did not brina^bout any s/^kness due to tetraethyl lead. __ We appreciate your calling this matter to our attention and we hope that you will continue to report any supposed cases of lead poisoning to us.

As to the article by Duvolr and Coste, I wonder if it would not be advisable to have instructions issued to our various medical consultants abroad that all articles on tetraethyl lead and leaded gasoline be submitted to you and by you to Edgar as Director of Research in order to make sure that no significant technical errors get into . the literature.by way of our own people, I shall raise this question with Edgar in New York tomorrow, and I dare say you will hear from him on the subject.

Kehoe: Your manuscript, Part T, on tetraethyl lead, has been read by a number of our editors.

Cm Pisohbeln by corresponding changes In the transportation and excretion of lead, therefore we can use lead trans portation and excretion as an adequate measure of the magnitude of exposure* If observations are made In close tine relationship to tho exposure* Now In the case of tetraethyl lead in gasoline we find that exposure to high concentrateons of lead in the gasoline either by way of akin contact or by inhalation results in lend absorption.

How In the case of tetraethyl lead in gasoline we find that exposure to high concentrations of lead In the gasoline either b y way of skin contact or by inhalation results in lead absorption.

Those which are excessively high in the tetraethyl lead building may well be the result of exposures of very short duration, and may not be significant.

Those which are excessively high in the tetraethyl lead building may well be the result of exposures of very short duration, and may not be significant.

I have never seen a case of lead poisoning that did not show stippling, except In a few instances which I have described in a series of cases of tetraethyl lead poisoning where the intoxication came on rapidly and was primarily a central nervous system 0011318 F.

As a part of the lead studies, the hygienic significance of the distribution and use of gasoline containing tetraethyl lead as a motor fuel has -,been tinder investigation.

As a part of the lead studies, the hygienic significance of the distribution and use of gasoline containing tetraethyl lead as a motor fuel has-been under investigation.