PFC's analyses.

ZVEI pager For a risk-based approach to PFAS - no blanket ban Competent authorities in five European countries earlier this year proposed a wide-ranging restriction on per- and polyfluorinated alkyl substances (PFAS) under the European chemicals regulation REACH.

Confirmation that there is no current alternative to TFA for peptide synthetic process Trifluoroacetic acid (TFA) is an essential reagent for the peptide synthesis process, either in liquid or solidphase fashion.

Estimation of the nb of sequences in PcPc using TFA for synthesis PcPc Data on May-23 nb* % using TFA nb using TFA Dipeptides 82 0% 0 mostly made by liquid phase not using TFA Tripeptides 116 50% 58 Tetrapeptides 113 90% 101 Pentapeptides 120 95% 114 Hexapeptides Heptapeptides 119 95% 79 95% 113 mostly made by SPPS (using TFA) 75 Octapeptides 64 95% 60 Nonapeptides 63 95% 59 Decapeptides 85 95% 80 Oligopeptides (>10AA) 303 10% 30 lower sequences made by SPPS, larger made by biotechno Polypeptides (>100AA) - 0% - mostly made by biotechnology total 1144 total using TFA 690 60% estimated values * these numbers are based on the peptidic "core name" (without prefix and suffix) and may be under evaluated (ex: tripeptide-1; acetyl-tripeptide-1; palmitoyl-tripeptide-1; copper tripeptide-1 are only one sequence in this count!)

Dutch Paper and Board industry input on the public consultation on restriction dossier to the European Chemicals Agency (ECHA) on per- and polyfluoroalkyl substances (PFAS).

Using 19F Solid State Nuclear Magnetic Resonance Method for the detection of fluorinated compounds in coated paper Authors: Locations: Mike Thijs Patric Bierganns Ernest Latelas Antwerp Technical Center (ATC) Wilmington Research Center (WRC) Date: 14/12/2021 Introduction: In a recent study on PFAS used in disposable food packaging (Strakov, et al., 2021), a value of 65 mg/kg dw was found in the paper sample NL-MCD-01.

Year Sample F41 F43 F44 F46 F48 F51 F60 F61 F64 F65 F77 F78 F86 F87 F88 F92 F94 F95 F99 F100 Year Statistics Number of values Minimum 25% Percentile Median 75% Percentile Maximum 5% Percentile 95% Percentile Mean Std.

Deadline Who 11/12/2020 Ramboll/ECHA 18/12/2020 Task ref SC2 (ECHA/2020/839) Universal PFAS restriction CfE summary table 28.02.2020 Ramboll/ECHA SC3 (ECHA/2020/875) emissions and costs over time 15.03.2020 Ramboll/ECHA SC5 (ECHA/2020/877) manufacturing/ export 22.03.2020 Ramboll/ECHA SC4 (ECHA/2020/876) disposal and cleaning Task description Deliverable: An Excel sheet with at least, for each of the 82 comments: - the name of the comment file - a summary of the comment (if short and focused) or a list of topics addressed (if long and covering several issues), highlighting if the comment is claimed confidential or not by segregating comments in two columns Deliverable: 1.

Finally, I would like to make sure that the SEA in WP7 will deliver the information needed. 3/2: Apologies I have to change the date of this meeting to the 16th of February.

Lab Na L 1538 TABLE OF CONTENTS SUMMARY INTRODUCTION MATERIALS METHODS DEVIATIONS RESULTS CONCLUSION RECORD STORAGE PHOTOGRAPH OF THE TEST ARTICLE SBRTC-2015-1052-4 4 5 5 5-7 7 7 8 8 8 Page 3 of 8 SHANGHAI BIOMATERIALS RESEARCH & TEST CENTER Add: 201, Building 2, Na 427 Jumen Road, Shanghai, China Zip Code: 200023 TEL: 0086-21-63034903 Web site: www.sbrtc.com MOM FAX: 00 E-mail: 163.com Lab Ng L 1538 SBRTC-2015-1052-4 Animal Management: Husbandry: Food: Water: Housing: Environmental: Personnel: Selection: Conditions conformed to "Laboratory animal-Requirements of environment and housing facilities"; "ISO 10993-2:2006: Biological evaluation of medical devices Part 2: Animal welfare requirements".

HONEYWELL ADVANCED LIMITED RIVERVIEW HOUSE HARVEY'S QUAY APARTMENTS LIMERICK V94R3DE IRELAND 25 May 2023 PFAS REACH Annex XV Restriction Report 1ST Public Consultation (22 March - 25 September 2023) Objective assessment of Trifluoroacetic acid (TFA) within the PFAS REACH Restriction Proposal 1.