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Lab N2 L 1538 SBRTC-20 15-1052-8 TABLE OF CONTENTS SUMMARY 4 INTRODUCTION 5 MATERIALS 5-6 METHODS 6-7 RESULTS 7-9 CONCLUSION 9 RECORD STORAGE 9 PHOTOGRAPH OF THE TEST ARTICLE 10 1 Page 3 of 10 SHANGHAI BIOMATERIALS RESEARCH & TEST CENTER Add: 201, Building 2, No 427 Jumen Road, Shanghai, China Zip Code: 200023 TEL: 0086-21-63034903 FAX: 0 1.111113 Web site: www.sbrtc.com E-mail: ,163.com Lab Na L 1538 SBRTC-2015-1052-8 INTRODUCTION The purpose of this study was to evaluate the mutagenic potential of test article extracts based on quantitation of forward mutations at the thymidine kinase locus of L5178Y/Te" Mouse Lymphoma cells in the presence and absence of a metabolic activation system.

Lab Ns L 1538 TABLE OF CONTENTS SUMMARY INTRODUCTION MATERIALS METHODS DEVIATIONS RESULTS CONCLUSION RECORD STORAGE PHOTOGRAPH OF THE TEST ARTICLE APPENDIX SBRTC-2016-0335-1 3 4 4 5 8 8 10 .10 11 12 Page 3 of 13 SHANGHAI BIOMATERIALS RESEARCH & TEST CENTER Add: 201, Building 2, No 427 Jumen Road, Shanghai, China Zip Code: 200023 TEL: 0086-21-63034903 FAX: 0 Web site: www.sbrtc.com E-mail:111.111163.com Lab N2 L 1538 SBRTC-2016-0335-I INTRODUCTION The purpose of this study was to evaluate the potential for a local irritant response to material Milerect contact with muscle tissue.

Annex I - List of acronyms and abbreviations Acronym AC B CAS CF2 CF3 CfE CF3C(O)F CFF CLP CO2 COC COP CSR CTFE DNEL EC ECHA EEA EEAP EFCTC EFSA EINECS ELV EMA EPA ETF EU EV EVOH F-Gas FCM FP GLP GWP HCFC HCFO-1233zd(E) HF HFC HFC-125 HFC-134a HFC-143a HFC-227ea HFC-236fa HFC-245fa HFC-32 Explanation Airconditioning Bioaccumulation Chemical Abstracts Service Methylene Fully fluorinated methyl Call for Evidence Trifluoroacetyl Fluoride Cold Form Foils Classification, Labelling and Packaging Carbon dioxide Cyclic olefin copolymer Cyclic olefin polymer Chemical Safety Report Chlorotrifluoroethylene Derived No-Effect Level European Commission European Chemicals Agency European Economic Area Environmental Effects Assessment Panel European Fluorocarbons Technical Committee European Food Safety Authority European Inventory of Existing Chemical Substances End of Life of Vehicles Directive European Medicines Agency Environmental Protection Agency Extrudable thermoplastics films European Union Electric Vehicle Ethylene vinyl alcohol Fluorinated Gas Food Contact Materials rules Fluorinated Products Good Laboratory Practice Global Warming Potential Hydrochlorofluorocarbon (1E)-1-chloro-3,3,3-trifluoroprop-1-ene Hydrogen Fluoride Hydrofluorocarbon Pentafluoroethane 1,1,1,2-tetrafluoroethane 1,1,1-trifluoroethane 1,1,1,2,3,3,3-heptafluoropropane 1,1,1,3,3,3-hexafluoropropane 1,1,1,3,3-pentafluoropropane Difluoromethane 1 HFC-365mfc HFO HFO-1233zd HCFO-1233zd(E) HFO-1234yf HFO-1234ze(E) HFO-1336mzz(E) HFO-1336mzz(Z) Honeywell HSE IUPAC IVD IVDR LRTP MAC MDI MDR Mln MoE NOAEL NOEC OECD OTC P PBT PCTFE PET PFAS PFC PFOA PFOS PLC PNDT PNEC PP PTFE Proposal PVC PVDC RAC RAAF R&D REACH RHVAC RMM RMOA RO RRM SAP SEAC 1,1,1,3,3-pentafluorobutane Hydrofluoroolefin (1E)-1-chloro-3,3,3-trifluoroprop-1-ene Trans 1-Chloro-3,3,3-trifluoroprop-1-ene 2,3,3,3- tetrafluoroprop-1-ene Trans-1,3,3,3-tetrafluoroprop-1-ene Trans-1,1,1,4,4,4-hexafluorobut-2-ene (2Z)-1,1,1,4,4,4-hexafluorobut-2-ene Honeywell International Inc.