Pathology Review of Reported Tumorigenesis in a Two Year Study ofFM-3924 in Rats November 25,1998 BY Pathology AssociatesInternational 6217 Centre Park Drive West Chester,Ohio 45069 Telephone (513)779-9600 Fax (513)779-9603 PathologyReview ofTumors ReportedinRatsGivenFM-3924 Introduction:Thisrepoprrtesenatnsindependaesnstessmeonftumorigenedsaitsa obtainedfrom a studytodeterminethechronictoxicitaynd carcinogenipcotentiaolfthe fluorochemicaFlM-3924 in ratsT.he study,entitle"dTwo Year (Diet)Toxicity/ CarcinogenicitSytudyof FluorochemicaFlM-3924 inRats,"was sponsoredby the3M Company, St.

Daniel Bough lnstifugeof Anatomy Department of Anatomy Office of &he Director and Chairman RECEIVT- =D NOV 2 2 TOXICOL@- _-y Philadelphia.19107 (215) 928-7820 November 19, 1982 Dr.

ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity:Perfluorooctanoiaccid,ammonium salt;may alsobe referredto as PFOA ammonium salt,Ammonium perfluorooctanoateP,FO, FC116, FC-1 26, FC-169,or FC-143.

MICROBICS MICROTOXO TEST SUBSTANCE TOXICITY TEST ldentfty:Perfluorooctanoiaccid,ammonium salt;may alsobe referredto as PFOA ammonium salt,Ammonium perfluorooctanoateP,FO, FC-1 16,FC-126, FC-169, or FC-143.

ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may also be referredtoas PFOS, FC-95, oras a component of FC-203CE. (1Octanesuffonicacid)(CAS # 2795-39-3).

TOXICITY TO AQUATIC PLANTS TEST SUB,9-TANCE Identity:Mixturecontainingperfluorooctanesulfonatwehich may also be referredtoas PFOS, FC-95, or as a component of FC-203FC. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO AQUATIC INVERTEBRATES TEST SUBSTANCE (DAPHNIA MAGNA) Identity:A mixturecontainingPerfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, oras a component ofFC-206A. (1Octanesulfoniaccid)(CAS # 2795-39-3).

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity:A mixturecontainingperfluorooctanesulfonatweh,ich may alsobe referredtoas PFOS, FC-95, or as a component of FX-60 1. (1Octanesulfoniaccid)(CAS # 2795-39-3).

interimReport#1 Epidemiology2,20-3W-05 MedicalDepartment 3M Company St.Paul,NIN 55144 Date: June8,2000 TitleD:eterminationofSerum Half-Livesof SeveralFluorochemicals Study StartDate: EstimatedDate of FinalReport: IRB Approval Date: ProtocolNumber # 0007 IRB Approval # 98095 Exempt XX Expedited June,2004 14 October 1998 PrincipalInvestigator: Co-investigators: Jean M.

3M MedicalDepartment Study:T-6295.7 Report No.

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