AR226-2288 ^ -- " : ^ PM__________________ Chris EShoop 09/04/2002 12:49 ;^''-"^ ^/-: fc-.'

AR226-2349 U.S.

2195 Front Street Logan,OH43138 ONeEMi State of Ohio Envirwinieatal PiMtectioa Agency Southeast District Office TELfc (740) 38S-8B01 PAXs (740) 385-6460 AR226-2607 Bob Tatt, Governor Christopher Jones, Director May 13,2002 Mr.

AR226-3214 TRADE SECRET Study Title H-25134: Influence on Growth and Growth Rate of the Green Alga Selenastrum capricornutum Laboratory Project ID: DuPont-8863 AUTHOR: Terry Lee Sloman, B.S.

AR226-3389 Genetic Toxicology of 8-2 Telomer B Alcohol G.L.

3M Environmental L boratory FinalReport- AnalyticalStudy Single-doseDermal Absorption/ToxicitSytudy ofT-6049 inRabbits In-Vivo Study ReferenceNumber: HWI#6329-130 Study Number: AMDT-020895.1 Test Substance: FC-95 (T-6049) Name and Address of Sponsor: 3M SCD Division 367 Grove Street St.Paul,MN 55106 Name and Address of Testing Facility: 3M Environmental Technology & Services 935 Bush Avenue St.Paul,MN 55106 Method Numbers AMDT-M-1-0, AMDT-M-2-0, ANMT-M-4-0, AMDT-M-5-0, and Revisions: Thermal Extractionof Fluorideby Means of a Modi:fied Dohrmann DX2000 Organic Halide Analyzer-Liver FluorideMeasurement by Means of an Orion EA940 Expandable Ion Analyzer Extractionof Fluorochemicalsfrom Rabbit Liver Analysisof RabbitLiver ExtractforFluorochemicalsUsing ElectrosprayMass Spectrometry InitiationDate: See attachedprotocol Author: James D.

April27,2000 One GenerationReRroduction Study ofPFOS Mevalonic Acid/CholesteroClhallengeand NOEL InvestiL-atiionnRats Draft Study Outline Study ObjectivesT:hisstudywillserveasa follow-upstudytoCombined Oral(gavage FertilitDye,velol2mentaland Perinatal/PostnaRteaplroductionToxicityStudy of PFOS in Rats(ArgusProtocol418-008,3M studynumber T-6295.9).The objectiveosf thestudy areasfollows: 1) todeterminewhetherornotco-administratiofnmevalonicacidor cholesteroclan preventor antagonizetheadversematemal and fetaleffects(reducedmatemal body weightgain,increasedpercentstillbordne,creasedbirthweightand decreasedpup survivalo)bservedinthepreviousstudy;and 2) torefmetheno observedeffectlevel(NOEL).

Argus PK Outline 5/03/2000 One Generation ReiproductionStudy of PFOS in Rats Pharmacokinetic Analysis Study Outline Study Objectives:This studywillserveas a follow-upstudytoCombined Oral(gava2e) FertiliiDye.velopmentaland Perinatal/PostnaRteaplroductionToxiciiyStudyof PFOS i Rats(ArgusProtocol418-008,3M studynumber T-6295.9).The objectivoef thestudy isto gainadditionaplhannacokinetc(PK) dataon PFOS inpregnantratsand theirpups.

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NORTHERN KENTUCKY OFFICE SlilTE 340 1717 DIXIE HIGHWAY COVINGTON, KENTUCKY 41011.4704 606-331-2838 513-381-2838 FAX: 513-381-6613 DAYTON, OHIO OFFICE SUITE 900 110 NORTH MAIN STREET DAYTON, OHIO 45402-1786 937-228-2838 FAX: 937-226-2816 ROBERT A.

OPff- 9- 00 p.1 :3 6 95" TAFT, STETTINIUS & HOLLISTER LLP NORTHERN KENTUCKY OFFiCE CLEVELAND, OHIO OFFICE SUITE 340 3500 BP TOWER 1717 DIXIE HIGHWAY COVINGTON, KENTUC4K 25YW4A1L0N1U1T-4 S7 TR0E4EfTCSL UE ITV EE1L 80A0ND, OHIO 200 PUBLIC SQUARE 4l114-2302 650163--333611--22863386 CINCINNATI OHIO 45202-3957 FAX: 513-381-6613 , FAX2:16:-12641.2-24813a87o7 COLUMBUS, OHIO OFFICE DAYTON, OHIO OFFICE 513-381-2838 21 EAST STATE STREET SUITE 900 205 COLUMBUS, OHIO 432154221 110 NORTH MAIN FS AX :T 513-R 381 -E 0 ET 614-221-2836 DAYTON, OHIO 45402-1786 FAX :614-221-2007 937-228-28 3 8 FAX : 937-226-281 6 www.taftlaw.co m ROBERT A.

~rw _ loC~6 P. 16 f.s--o TAFT, STETTINIUS & HOLLISTER LL P NORTHERN KENTUCKY OFFICE CLEVELAND, OHIO OFFICE SUITE 171 7 COVINGTON, KIENTUCKYr 10114704 606-331 -2838 .381-2 3 FAX : 53 13-381-6613 340 3500 BP 425 WALNUT STREET, SUITE 1800 CINCINNATI, OHIO 45202-3957 TOWE R 200 PUBLIC SQUAR E CLEVELAND OHIO 114-2302 , 216-241-2838 FAX: 216-241-3707 COLUMBUS, OHIO OFFICE DAYTON, OHIO OFFICE 513-381-2838 21 EAST STATE STREET 11S 0 U NIO TR ET9 H0M 0 A FIA N X S:T 513R -381 -E 02E 05 T COLUMBUS, OHIO 43215-4221 614-221-2838 DAYTON, OHIO 454 02-1 937-228-2838 FAX : 937-228-2816 7 8 6 www .taftlaw .co m FAX :614-221-2007 -3 73 ROBERTA . (513) 357-9638 bilo tt@taftlaw.com BILOTT L /y October 2, 2006 C-) 4 FEDE L E RESS l ~~~~~~ Il I I ~ , II II ~ ~ I I ~ RA XP TSCA Document Processing Center (7407M) b E F A(,I -ll 1o11 111 b_1 , b[1 51 11ti,, =- EPA East - Room 6428 CD Attn : Section 8(e)/FYI -- U .S .

~J<7 .~ ~ - 3175~ Sanitized Version for th e AR-226 Public Electronic Docket (CBI and copy restricted documents removed) Index DOCUMENT DESCRIPTION NO.

0% Solom Water aEb6y034 LadYy3ol3e STL | - S1EEtTLsirDenpevnere fa rn | J---- PFOAIPFOS Analysis | -- SSSRormat n, | ee Aoim t" | September 8, 2007 rin oerzsows oz Table Of Contents Standard Deliverables i Report Contents Total Number of Pages pSTahrtesCaaonnfedhaiLsraStdaervDaaenrlddiDhveeeRrelpaobrwtlreCposacvekrlapgee.Tahrrecponosirdserecdotmprlelte [] nr lege ited hi Tobieof onreehesd + Table of Contents + Case Narrative + Executive Summ -Daeterctiyon Highlights + Methods Summary + Method/Analyst Summary + LotSample Summary + Analytical Resuls + QCDara Associaton Summary | + Chaln-of-Custody DEP2.SDWB-000222 | CasDe7HN2a90r3r0a8tive pTreeascsectnotreeddraniscehDwesinrvhaeptrohreitzmweeetrshooUdaSsnEaihPnzdAoicdstpefrdr.ohiDsedipomarananmaeoctseirosnsa1at1nds4ahaontannolelsmwseortrhke.odpsTrohSviudsemadmapolnneSspaacghe atashee1to assist in the mrpratonofthe resus.

ARDGOIE 7 EVALUATION OF MUTAGENICITY STUDIES DEVELOPED ON (PFOS) PERFLUOROOCTANE SULFONATE PREPARED BY PROF.