BACK TO MAIN ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity: Perfluorooctanoic acid, ammonium salt; may also be referred to as PFOA ammonium salt, Ammonium perfluorooctanoate, PFO, FC-116, FC-126, FC-169, or FC-143.

sfweyrresss ros ron ro, ran ACRRb=1812 ERo.cTheecshtneirc,al Report: Liver Fluorocarbon Metabolites -- University of Tide: `SummaryofQuantitative Analysis of Fluorocarbon Metabolites in Rat Liver Samples.

AR226-2075 SEfiX-VOLAHLES ELfc :'"t.

TRADE SECRET AR226-3081 DuPontHL-1997-00867 Study Title H-22762: ORAL APPROXIMATE LETHAL DOSE (ALD) IN RATS LABORATORY PROJECT ID: HL-1997-00867 AUTHOR: Tracy A.

TRADE SECRET Study Title H-23004: SKIN IRRITATION TEST IN RABBITS LABORATORY PROJECT ID: HL-1997-01294 AR226-3085 AUTHOR: Tracy A.

DIETARY ACUTE NORTHERN BOBWHITE STUDY TEST SUBSTANCE Identity:Perfluorooctanesulfonatmea;y alsobe referredto as PFOS or FC-95. (1-Octanesulfoniacid,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-p,otassiumsalt,CAS # 2795-39-3) Remarks field: The testsubstance isa whitepowder.

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SU 3STANCE Identity:Mixturecontainingperfluorooctanesulfonawtheich may alsobe referredtoas PFOS, FC-95, or as a component of FC-203FC. (1Octanesuffoniaccid)(CAS # 2795-39-3).

PROTOCOL DETERMINATION OF THE WATER SOLUBILITY OF PFOS mw BY THE SHAKE FLASK METHOD ml `OECD GuidelineWfaortetrheSToelsutbiingloyf Chemicals, 105 of SM Lab Request No.

AR)6-02CH Pathology Review of Reported Tumorigenesis in a Two Year Study of FM-3924 in Rats November 25, 1998 BY Pathology Associates International 6217 Centre Park Drive West Chester, Ohio 45069 Telephone (513) 779-9600 Fax (513) 779-9603 603099 Pathology Review of Tumors Reported in Rats Given FM-3924 Introduction: This report presents an independent assessment of tumorigenesis data obtained from a study to determine the chronic toxicity and carcinogenic potential ofthe fluorochemical Carcinogenicity FM-3924 Study of in rats.

o AR22e-0431 `CORNING Hazleton MUTAGENICITY TEST ON T6564 ; MEACSHUIRNEISNEGHCAHMRSOTMEORSOOVMAARLYA(BCEHROR)ACTEILOLSN:S IN WITH A CONFIRMATORY ASSAY WITH MULTIPLE HARVESTS EINALREPORT : AUTHOR : Hemalatha Murl, Ph.D. .

AR226-3061 Study mio TOP Biocfflnpatibility Testing of S-22072.

TRADE SECRET AR226-3084 Study Title H-23004: ORAL APPROXIMATE LETHAL DOSE (ALD) IN RATS LABORATORY PROJECT ID: HL-1997-01291 AUTHOR: Tracy A.

Summary PFOS Rat Two-GenerationReproductionStudy StudyNumbers:3M T-6295.9,Argus418-008(in-lifFeA)C,T-TOX-012 (analytical).

PHYSICAUCHEMICAL PROPERTIES TEST SUBSTANCE Identity:[2-(N-Ethylperfluoroocetsaunlfonamido) ethylacrylate;may also be referredtoas B1228, D-1, ETFOSEA, or FX-13.(2-Propenoicacid,2[ethy[lheptadecafluorooctyl)slufonyl]amnio]ethylester,CAS # 423-825) Remarks:Materiiaslan ambersolid.

C 0 V AV -C@-E.@ THE DEVELOPMENT SERVICES CO#APANY Sponsors: APME Ad-Hoc APFO ToxicologyWorking Group PROTOCOL Study Mde: 26-Week CapsuleToxicityStudywithAmmonium Perfluorooctanoa(tAePFO) inCynomolgus Monkeys Date: September 23, 1998 PerforniingLaboratory: Covance LaboratoriesInc. 3301 Kinsman Boulevard Madison,Wisconsin 53704-2595 Laboratory Study Identification: ProposalNo. w6806a Covance 6329-231 Covance 6329-231 Page 2 Study 26-Week Capsule ToxicityStudy with Ammonium Cynomolgus Monkeys Perfluorooctanoate(APFO) in Purpose To assessthe effectof the testmaterialon criticaelnzyme levels,hormones, and other selectedbiochemical parameterswhen administereddailyby capsuleto cynomolgus monkeys for atleast26 weeks Sponsors APME Ad-Hoc APFO Toxicology Working Group Study Monitor Paul Lieder,PhD, DABT 3M Toxicology Services Building 220-2E-02,3M Center St.Paul, Minnesota, 55144-1000 Telephone No.: 612.737.2678 FacsimileNo.: 612.733.1773 AlternateStudy Monitor John Butenhoff,PhD, DABT 3M Telephone No.: 612.733.1962 FacsimileNo.: 612.733.1733 Sponsor's Representative David Farrar,PhD ICI Chemicals & Polymers Limited Occupational Health The Heath, Runcom, PO Box 13 Cheshire,WA7 4QF Telephone No.: 01928.513953 FacsimileNo.: 01928.515146 Study Location Covance LaboratoriesInc. 3301 Kinsman Boulevard Madison, Wisconsin 53704 Covance 6329-231 Page 3 Mailing Address: PO Box 7545-2595 Madison, Wisconsin 53707-7545 Study Director Peter J.Thomford, PhD Covance LaboratoriesInc.