clinical symptoms, in order ot relative frequency.4 included acneform lesions: severe pains in muscles of upper and lower extremities, shoulders and thorax on exertion, fatigue, nervousness and irritability, decrease in libido, dyspnea, vertigo and intolerance to cold On examination, all of the cases had chloracne Several were severely hyperpigmented. especially on the face Of the six workers ex amined in 1949 and 1950, four had liver enlargement and one had sensory loss in one foot Liver impairment as in dicated by hepatomegaly, tenderness and soreness in the right upper quadrant and epigastrium and a delayed pro thrombin time, was observed.3s * In 1953, four of the six workers examined in 1949 and 1950 were re-examined and six additional workers involved in the accident were also examined The findings in this later examination indicated a general regression ot both the cutaneous and noncutaneous symptoms which had been present earlier.

I PRELIMINARY STATEMENT .\ " This is one of 170 cases brought against Monsanto by current and former employees.

Monsanto FOR RELEASE IMMEDIATELY MONSANTO INDUSTRIAL CHEMICALS CO.

'f[/a 7 Human Health Effects of 2,4,5-T and Its Toxic Contaminants R.

> i nasui casorns oilfist c a n n o L January 25, 19^3 Minutes o f Meeting 1* She i-Sti o e e tlsg of the fed eral C ecolttec on Fest Control ygjj b e ll es J a s tir y 25* 1?

MEMORANDUM TO: FROM: DATE: RE: Montante Fil 5212(a) DLK A ugust 8, 1384 Reconciliation of plaintiff* pqut fo r chloracn document on 219 people w ith Zack/Suskind M ortality Study C ohort Som months ago p la in tiffs supplemented a rqust fo r production of raw data of m o rta lity studies b y p ro vid in g a lis t of 219 names fo r whom th e y sought certain Inform ation, including any record showing th a t ach Prson had (1) a "tru e cat o f chloracn" as d fln*d fn the Zack/Suskind m ortality stud y, o r (2) a diagnosis of chloracn, rash o r 2 ,4 ,5 -T rath subsequent to March 8, 1949, through th and o f 1952.

Claims Over 1949 Nitro Plant Blast Baffle State By CARLO J.

MEMORANDUM TO: FROM: DATE: RE: Montante File 212(a) DLK A u gu st 8, 1384 Reconciliation of plaintiff' raquatt for chloracne document on 219 people with Zeck/Susklnd Mortality Study Cohort Some month ago plaintiffs supplemented a request for production of raw data of mortality studies b y providing a list of 219 names for whom they sought certain Information, including any record showing that each person had (1) a "true cate of chloracne" as defined in the Zack/Suskind mortality study, or (2) a diagnosis of chloracn, rash or 2,4,5-T rash subsequent to March 8, 1949, through the end of 1952.

Zack/Suskind Study "The Mortality Experience of Workers Exposed to Tetrachlorodibenzodioxin in a Trichlorophenol Process Accident" Study Criteria Population: Start Date: End Date: Exclusions: Vital Status: All persons with chloracne which could be attributed to the 1949 TCP process accident.

ATTORNEY WORK PRODUCT 2,4-Dichlorophenoxyacetic Ac id(2,4-D) Ref: (1) Tent.

Key Dates - Monsanto Manufacture of 2,4,5-Tichlorophenol (2,4,5-T) 1948 3/8/49 19491953 19491969 1957 1972 7/10/76 6/78 8/14/78 12/78 Manufacture at Nitro initiated.

24rw 1rdrnrm * lk*-i March 4, 1940 ./ #/ ^ J !

FROM: DATE: RE: DLK A u g u s t 8, 1384 R econciliation of p la in tiffs ' req u e st fo r ch lo ra cn e documents on 219 people w ith Z a c k /S u sk in d M o rta lity S tu d y C o h o rt Soma monthe ago pi tin t if f a supplem ented a re q u e s t fo r p ro duction o f raw data of m ortality studies b y p ro v id in g a lis t o f 219 names fo r whom th e y sought certain Information, in clu d in g any record show ing that each p e rson had (1) a "tru e case o f chlo racne" as d e fin ed In th e Z a c k /S u sk in d m ortality study, o r (2) a diagnosis of chloracne, rash o r 2 ,4 ,5 -T rash su b seq u e n t to M arch 8, 1949, th ro u gh the end of 1952.

NAL M EDICINE N.

Approved : juiy u , i PREPAREDNESS STATEMENT RE: SKLIKOFF/MT.