BACK TO MAIN 3M FLUOROCHEMICAL SUBMISSION TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE December 2001 Click on Study Title to View Report December 31, 2001 "Evaluation of the Northwest Bioanalytical Method Validation Reports for PFOS and Related Analytes in Human Serum or Plasma in Meeting the Requirements of the FDA ATTACHMENT TO LETTER OF 1/18/05 3M FLUOROCHEMICAL SUBMISSION Bioanalytical Method Validation," Quality Associates, Inc., QAI 405-503, December 31, 2001.

ADDITIONAL COMMENTS OF 3M COMPANY TO THE EPA SCIENCE ADVISORY BOARD PFOA REVIEW PANEL APRIL 18, 2005 CONTACT: JOHN L.

L a rry R .

WEORECt.

OuPonl WishinstKi Works P. 0.

September 17, 2004 By Certified Mail r, c~-o ?

AR226-1880 Overview of APFO/Telomer Active DuPont/DuPont-Sponsored Projects Presented to US EPA Robert W.

3M General Offices AR226-1895 3M Center St.

pH- A&frfi u )uPont Telomers CBI Information Meeting_________________ v ____________________ _____________________ ;______ January 31,2005 NAME ORGANIZATION TELEPHONE# E-MAIL ADDRESS "/Vllniii /c. 7^ J fp r/e c D -/-J/-o---o-- A*--.r-v--^--/-^--y*-/--0--D----z-A-------------------- 2>a?

AR226-1982 CC: H.

AR226-2051 BEST COPY AVAILABLE EID077205 EID 0 7 7 2 0 6

0- 148.0 0- 309.0 0- 456.0 0 - 609,0 " Qz ID 2851.0 m 2589.2 m 2397.5 m 2310.1 ill Calibration Sample Name Weight (g BLANK XXXXXX) 148,0 1.0000 309.0 1.0000 450.0 1.0000 609.0 1.0000 765.0 1.0000 1000.0 1.0000 1508.0 1.0000 1713.0 1,0000 178B.0 1.0000 2275.0 1.0000 C-SPsak C-10 Peak Corrected | b Height Height c-a I Correlation 6818 235105 xxxxxxxx calc pk 428512 226285 421952 148.0 308043 237791 801150 281.0 1101968 221769 1095539 384.3 1432967 251095 1425688 500.1 1593255 260053 1585716 556.2 2033812 297132 2025199 2695213 223986 2688720 710.3 943.1 2956715 263653 2949072 1034.4 3129804 258813 3122301 1095.1 3755512 325203 3746085 1313.9 0 .0 b 1.0 Correlation C8 PPM calc pk 148.0 157.8 281.0 304.3 384.3 418.0 500.1 545.5 556.2 607.3 710.3 777.0 943.1 1033.3 1034.4 1133.8 1095.1 1200.7 1313.9 1441.7 13271.7 b 1.0 Correlation C8 PPM calc pk 157.8 162,5 304.3 320.6 418.0 443.4 545.5 581.1 607.3 647.9 777.0 831,2 1033.3 1107,9 1133.8 1216.5 1200.7 1288.8 1441.7 1549.0 32424.0 b 45663.6 i 1.0 Correlation 1.0 Correlation C8 PPM calc pk C8 PPM calc pk 162.5 320.6 443.4 16Z9 327.0 454.5 162.9 327,0 454.5 158.8 339.6 4B0.0 581.1 597.4 597,4 637.4 647.9 666.7 666.7 713.7 831.2 856.9 856.9 923.2 1107.9 1144.1 11144.1 1239,6 1216.5 1256.8 1256.8 1363.7 1288.8 1331.8 13318 144S.O 1549.0 1601.8 10018 174-J.o FP 1 FP 2 FP 3 FP 4 FP 5 FP 6 FP 7 FP 8 FP FP 10 FP 11 FP 12 FP 13 FP. 14 FP 15 FP 16 FP 17 FP 16 FP 19 FP 20 FP 21 FP 22 FP 23 0.5306 0.5750 0.5065 0.5217 0.5291 0,5956 0.6646 0.5183 0.5769 0.5649 0.5310 0.4958 0.5018 0.5064 0.5281 0.5117 0.5254 0.5367 0.5000 0.5530 0.5040 0.5030 0.5235 C-10 Peak Height Haight 365704 273494 707118 288431 509686 255687 124408 237885 468182 263369 92261 249360 794733 260443 866019 311955 832620 224096 623556 249217 442922 235366 686492 241814 785379 233470 149563 386431 162522 315010 67592 321813 84557 407816 310507 332929 243504 331220 376969 350166 126814 325285 83503 338561 195321 314340 Corrected | Qz 148.0 0 8 calc pk CSPPM 357776 125.5 236.5 698757 245.1 420.2 502274 176.2 347.8 117512 41.2 79.0 460547 161.5 305.3 85032 29.8 50.1 787183 276.1 415.4 856976 300.6 579.9 826124 289.8 502.3 616332 216.2 382.7 436085 153.0 288.1 879482 238.3 480.7 778611 273.1 544.2 138361 48.5 95.8 153390 53.8 101.9 58263 20.4 39,9 72735 25.5 48.6 300856 105.5 196.6 233902 82.0 164.1 366818 128.7 232.7 117384 41.2 81.7 73689 25.8 48.9 186209 65.313 127.63S 2 : 309,0 calc pk CSPPM 133.1 250.8 284.7 460.4 188.9 372.9 40.3 77.2 172.7 326.5 27.7 46.5 298.9 449.7 325.8 628.7 313.9 544.2 232.9 412.3 163.3 307.5 257.3 519.0 295.6 589.0 .48.3 95.4 54.1 102.5 17,4 34,0 23.0 43.7 111.1 206.9 85.2 170.4 136.5 246.9 40.2 79.8 23.3 44.2 66.790 130.52G Or 456.0 S i 609.0 calc pk C8PPM calc pk C8 PPM 135.7 255.8 135.1 254.6 277.9 483.3 282.7 4917 196.0 386.9 197.7 390.2 35.5 68.0 31.1 59.6 178.6 337.5 179.6 339.4 21.9 36.8 17.0 28.6 314.8 473.7 3210 4 3 3 .0 343.9 663.5 3512 077.6 331.0 573.8 337.8 585.6 243.5 168.4 431.1 317.1 247.0 169.0 437.3 318.3 269.9 544.3 274,4 553.4 311.2 44.2 620.2 87.3 317,3 40.1 79.2 50.5 10.8 16.8 112.0 84.0 139.6 35.4 95.5 2 1 .1 32.0 208.6 168.' 252.2 70.3 46.6 6.6 117 110.5 815 , 139.0 31.0 88.3 10.7 22.3 205.8 163.0 2514 618 17,2 32.6 64.143 125.353 1 2 .1 60.839 23,0 118.895 Qi 19/ .1 1/ JL -1 .9 332.9 o o l .0 loo.o 2816 o4o .o 2 3 .0 1010 RQ A \O ,0 "/ .3 AR226-2090 RJZ042298 765.0 Qz 1000.0 0- 1508.0 0- 1713.0 0- 1788.0 2097.3 m 1981.5 m 1754,7 m 1662.1 m 1639.1 88929.4 b 120271.9 b 203748.1 b 241791.6 b 251744.0 1.0 Correlation 1.0 correlation 1.0 co irelatior 1.0 correlation 1.0 CALIBRATION C8PPM c a lc pk C8 PPM c a lc p k C8PPM c a lc p k C8 PPM c a lc pk C8PPM NAME 158.8 152.2 152.2 124.4 124.4 108.4 108.4 103.8 103.8 339.6 343.6 343.6 340.5 340.5 338.5 336.5 335.2 335.2 480.0 492.2 492.2 508.2 508.2 513.7 513.7 514.8 514.8 637.4 658.8 658.8 696.4 69a4 712.3 712.3 716.2 716.2 713.7 739.5 739,5 787.6 787.6 808.6 806.6 813.8 813.8 923.2 961.3 961.3 1038.0 1038.0 1073.0 1073.0 1082.0 1082.6 1239.6 1296.2 1296.2 1416.1 1416.1 1472.2 1472.2 1486.8 1486.8 1363.7 1427.6 1427.6 1564.5 1564.5 1828.8 1828.8 1645.6 1645.6 1446.3 1515.0 1515.0 1863.2 1663.2 1733.1 1733.1 1751.3 1751.3 1743.8 1829.8 1829.8 2018.7 2018.7 2108.4 2108.4 2131.9 2131.9 148.0 309.0 450.0 609.0 765.0 1000.0 1508.0 1713,0 1788.0 2275.0 7350 E765.0 C8PPM c a lc 241.6 St p k C8 PPM c a lc 119.9 225.9 k pk C8PPM c a lc 87.8 165.4 pk C8PPM c a lc 69.8 131.5 St 1788.0 SAM PLE pk C8PPM NAME 64.7 121.9 F P 1 505.7 291.9 507.7 282.1 490.6 274.9 478.1 27Z7 474.3 FP 2 389.1 192,8 380.6 170.1 335.9 156.7 309.4 152.8 301.8 F P 3 28.1 -1.4 -2.7 -49.1 -94.2 -74.8 -143.3 -81.9 -157.0 FP 4 334.9 171.7 324.6 146.3 276.6 131.6 248.8 127.4 240.8 FP 5 -3.1 -17.8 -29.9 -67.7 -113.6 -94.3 -158.4 -101.7 -170.8 FP 6 501.0 706.6 336.6 371,8 506,4 717,3 332.5 372.3 500.3 718.2 328.1 370.1 493.7 714.1 326.7 369.2 491.5 FP 7 712.4 FP 8 609,3 356,2 617.5 354.7 614.8 351.6 609.4 350.4 607.4 FP 9 445.2 250.3 443.2 235.1 416.2 225.3 398.9 222.4 393.8 FP 10 311.7 159.4 300.1 132.4 249.4 116.9 220.1 112.5 211.8 FP 11 567.9 282.2 569.2 271.1 546.8 263.3 531.1 261.0 526.3 FP 12 655.3 332.2 662.1 327.6 65Z9 323.0 643.6 321.4 640.6 FP 13 46.5 9.1 18.0 -37.3 -73.6 -62.2 -122.9 -69.2 -136.6 FP 14 5B.2 16.7 31.6 -28.7 -54.3 -53.2 -100.7 -80.0 -113.6 FP 15 -28.6 -31.3 -61.2 -82.9 -162.0 -110.4 -215.8 -118.0 -230.7 FP 16 -14.7 -24.0 45.7 -74.7 -142.1 -101.7 -193.6 -109.2 -207.9 FP 17 188.3 91.1 189.8 55.3 103.1 35.5 66.2 30.0 55.8 FP 18 138.2 57.3 114.7 17.2 34.4 -4.7 -9.5 -10.9 -21.8 FP 19 239.6 124,4 225.0 92.9i 168.0 75.2 136.0 70.2 127.6 FP 20 26.9 -1.5 -2.9 -49.2!

TestR esults AR226-2124 file:///C|/WINDOWS/TEMP/Monomets C-8 2-26-73 thru 8-5-81 9 pages.htm TestResults Sam ple Pt Range Concentration Range A ctio n Level Industrial Hygiene 2/26/73 100% 8/5/8' Sample Dt Sam ple# D uration Type Employee Name Pare BTO: LO C : 08 TEFLON 018 MONOMER ANALYZER COMPUTER ROOM 11/15/79 61389 2 11/26/79 61390 2 11/29/79 61391 Z C hem ical Cone U nit Percent C-8 0.0006 PPM 0.0% C-8 0.0003 PPM 0,0% C-8 0.0004 PPM 0.0% BTO: LOC: 08 TEFLON 023 TRAINING FACILITY (OLD PROD C.C.) 3/3/81 54817 Z 3/3/81 54818 2 3/16/81 54819 Z 3/17/81 54820 Z 3/18/81 54821 Z 3/18/81 54822 Z 3/19/81 54823 Z 3/19/81 54824 Z 3/27/81 54826 Z ' C-8 0.0004 PPM 0.0% C-8 0.0005 PPM 0.0% G-8 0.0002 PPM 0.0% 0 8 0.0008 PPM 0.0% C-8 0.0002 PPM 0.0% C-8 <0.0001 PPM 0.0% C-8 0.0003 PPM 0.0% C-8 0.0004 PPM 0.0% C-8 <0.0001 PPM 0.0% AJP007141 1of 16 BTO: LOG: 08 701 TEFLON FINE POWDER DRYER-EAST SIDE #2 8/28/2001 4:41 PM E ID 140383 TestResults ' 2/26/73 62670 9/3/74 62671 2/3/77 62672 2/16/78 62673 2/12/79 62674 12/13/79 62675 12/31/80 62676 8/5/81 62677 8/5/81 62678 file:///ClAVINDOWSrrEMP/Moaomf5rs C-8 2-26-73 thru 8-5-819 pages.htm Z C-8 <0,1 PPM 0.0% Z C-8 <0.1 PPM 0.0% z C-8 <0.1 PPM 0.0% z C-8 <0.1 PPM 0.0% z 0 8 <0.1 PPM 0,0% z 0 8 <0.0001 PPM 0.0% z 0 8 0.0073 PPM 0.0% z 0 8 0.0091 PPM 0.0% 2 0 8 0.0005 PPM 0.0% BTO : LOG : 08 TEFLON@ 702 FINE POWDER DRYER CONTROL ROOM (ALSO SEE TTF031 2/26/73 57136 z 08 9/3/74 57137 z 08 2/3/77 57138 z 08 Tuesday.

AR226-2185 EXPOSURE EVALUATION FOR NEW PROCESS AT FAYETTEVILLE SITE Prepared by DuPont Engineering Technology Debbie Mulrooney Cathie Barton August 20, 2001 EID293489 TABLE OF CONTENTS Executive Summary 1.

AR226-2225 Robert F Pinchot 12/07/2001 02:47 PM To: Roger J Zipfel/AE/DuPont@DuPont cc: Debbie J Mulrooney/AE/DuPont@DuPont, Chris E Shoop/AE/DuPont@DuPont Subject: Re: Consent Order - Stack Parameters and Emissions Q ' Roger, Do these data make sense to you?