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FINAL REPORT ONE GENERATION REPRODUCTION STUDY OF PFOS - MEVALONIC ACID/CHOLESTEROL CHALLENGE AND NOEL INVESTIGATION IN RATS SPONSOR'S STUDY NUMBER: T-6295.25 FINAL REPORT DATE: 16 DECEMBER 2002 TITLE - ONE GENERATION REPRODUCTION STUDY OF PFOS - MEVALONIC ACED/CHOLESTEROL CHALLENGE AND NOEL INVESTIGATION IN RATS ARGUS STUDY NUMBER: 418-018 SPONSOR'S STUDY NUMBER: T-6295.25 TABLE OF CONTENTS SUBJECT PAGE I.

Toxicological Summary PFOS Dietary Chronic Definitive Reproductive Study: Northern Bobwhite Test Substance: Perfluorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro, potassium salt.

A R 2% -0 % \ Argus Research Laboratories, Inc. 905 Sheehy Drive, Building A Horsham, Pennsylvania 19044 T: (215) 443-8710 F: (215) 443-6587 PROTOCOL 418-008 SPONSOR'S STUDY NUMBER: 6295.9 STUDY TITLE: Combined Oral (Gavage) Fertility, Developmental and Perinatal/Postnatal Reproduction Toxicity Study of PFOS in Rats.

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INDEX TO TSCA SECTION 8(e) DOCKET SUBMISSION BY 3M COMPANY (AUGUST 17, 2004) I.

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A&M6-IHAO DuPont-13788 Review op Proliferative Lesions of t h e Exocrine Pancreas in Two Chronic Feeding Studies in Rats w ith A mmonium Perfluorooctanoate .

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