Document J3y7MVJg7x3az8vZjpd0VQqYa

Z - 7 REV. 1-80 d n w t) Hi tt|WO* ESfAlSHEDieO E . I. du Pont de N em ours & C ompany IN C O R PO R A T E D P. O . B o x 1217 P a r k e r s b u r g , W . V a . 2 6 io t POLYMER PRODUCTS DEPARTM ENT PERSONAL AND CONFIDENTIAL / O '/ CC: J . H. Todd G. T. Rosenlund R. 0 . B u rg e r O. F. Doughty D r. Y. L . Power G. H. S t o lt z R. N. T a y lo r P. T h is tle to n December 1, 1981 J . W. Raines Polymer P roducts Department W ilm ington - M 5625 C-8 BLOOD LEVELS IN FEMALES TRANSFERRED OUT OF THE TEFLON DIVISIONS WASHINGTON WORKS The a tta c h e d T a b le c o n ta in s C-8 in b lo o d da ta on e ig h te e n fem ales tr a n s fe r r e d o u t o f the TEFLON D iv is io n s a t W ashington Works around A p r il 1, 1981. The f o llo w in g o b s e rv a tio n s can be made: t There is an o v e r a ll downward tre n d in b lo o d C-8 le v e ls . This tren d is s t a t is t ic a lly s ig n ific a n t a t 0.05 le v e l using the p a ire d -t te s t. 0 B lood C-8 le v e ls dropped an average 15% o v e r an average 129-day p e rio d . 0 Rate o f C-8 e lim in a tio n v a rie s g r e a tly by in d iv id u a l. AJP001277 JGL/nsw 0337W Joseph G. L o sch ia vo There's a world of things we're doing something about nrtftl62 EID080677 C-8 BLOOD LEVELS IN FEMALES TRANSFERRED OUT OF TEFLON C-8 LEVEL WHEN AGE LEAVING TEFLON 32 0.140 27 0.192 27 0.570 33 1.300 24 0.110 27 0.110 27 0 .0 7 8 "' 37 2.400 27 5.100 23 0 .0 6 1 ' ' 29 0.270 31 0.190 26 0 .0 4 5 ^ 32 0 .450 27 0 .230 25 0 .092 *' 33 0 .019 28 2.500 C-8 LEVEL AFTER LEAVING TEFLON 0.086 0.120 0.390 0.980 0.086 0.091 0.065 2.000 4.400 0.053 0.240 0.170 0.041 0.410 0.210 0.092 0.019 2.600 NUMBER OF DAYS BETWEEN SAMPLES 143 127 140 126 128 133 148'"" 139 126 128 130 127 96 127 127 126 133 126 .o A AVERAGE = 129 days % CHANGE IN C-8 BLOOD LEVELS -3 8 .6 -37.5 -31.6 -2 4 .6 -2 1 .8 -17.3 -1 6 .7 ^ -16.7 -13.7 -1 3 .1 '''"" -n a -10.5 - 8 .9 /" - 8.9 - 8.7 0.0 / 0.0 " + 4.0 - i 8.P x i i .? -15.3 + 11.7* * The downward tre n d is s t a t i s t i c a l l y s i g n i f i c a n t a t 0 .0 5 le v e l u s in g th e p a ir e d - t t e s t . 12/1/81 0337W EID080678 000163 t o o <r v9 o N c^ Q OQ o o nOo o Cr 09 > o O OQ T LO O <6 o o Go 0 Oio cJ > V V) 2 XX X r X XX lo nf OQ *5 oo T5 o Oo o Q) T v9 CrT l-9 nee.rs o-ncL GJ\grm-s~hs In O Vo O J > o o o$ r - cr ^r O Os -- X- o lc.cJrinic.oJ- lii wj e- j8 C 'cop Vn te-3 - O S i 0 o r Lo -- T* J) c - O s o b o r - 1 /) -- lo V) r ir 03 ro l ls~\ \ < O. 000164 g S? 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