AR226-1486 ENVIRONMENTAL AND HEALTH ASSESSMENT OF PERFLUOROOCTANE SULFONIC ACID AND ITS SALTS August 20, 2003 Prepared by 3M in consultation with Jack Moore, D.V.M., DABT, Hollyhouse, Inc.

fid 6 - 1 3 ^ 7 SRPT T-76fci MIN 315/022356 PERFLUOROOCTANESULFONYL FLUORIDE (POSF) T 'lk k l.3 /A V/T0 MAMMALIAN CHROMOSOME ABERRATION TEST IN HUMAN LYM PHOCYTES Sponsor 3M Center 3M Corporate Toxicology Building 220-2E-02 St Paul MN 55133-3220 USA Page 1 of 31 Research Laboratory Huntingdon Life Sciences Ltd Woolley Road Alconbury Huntingdon Cambridgeshire PE28 4HS ENGLAND Report issued 22 October 2002 001542 MIN 315/022356 CONTENTS Page CONTENTS.......................................................................................................................... 2 COMPLIANCE WITH GOOD LABORATORY PRACTICE STANDARDS..................... 4 QUALITY ASSURANCE STATEMENT............................................................................. 5 RESPONSIBLE PERSONNEL............................................................................................. 6 SUMMARY.......................................................................................................................... 1 INTRODUCTION.................................................................................................................. 8 TEST SUBSTANCE.............................................................................................................. 10 EXPERIMENTAL PROCEDURE......................................................................................... 11 ASSESSMENT OF RESULTS.............................................................................................. 15 MAINTENANCE OF RECORDS......................................................................................... 15 RESULTS.............................................................................................................................. 16 CONCLUSION...................................................................................................................... 17 REFERENCES....................................................................................................................... 18 :2: 001543 MIN 315/022356 COMPLIANCE WITH GOOD LABORATORY PRACTICE STANDARDS The study described in this report was conducted in compliance with the following Good Laboratory Practice standards, with the exceptions stated below, and I consider the data generated to be valid.

Study No.

Katherine E .

Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendix E] 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats Page 1 of 68 Appendix E: Histopathological Findings Fraunhofer ITEM Final Report 01 G 00 0 02 [Appendix E] 28 Day Repeated Dermal Contact Study of 3M Test Articles in Sprague-Dawley Rats Page 2 of 68 Table 1: Summary of histopathological findings (all animals) FRAUNHOFER ITA 01G0002 Summary of histopathological fi ndi ngs (all animals) Page: 1 21-Aug-00 !

3 FLUOROCHEMICAL SUBMISSION 1987 Click a Month back to year menu TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE October

Experiment Mo.: Conducted At: Reviewed By: A ftlX -O H lM Primary Skin Irritation Test with T-3371 in Albino Rabbits 0883EB0079 Safety Evaluation Laboratory Riker Laboratories, Inc.

PFOA and Associated Salts Environmental Fate and Transport Title Technical Report Sum m ary - Assessm ent of the Bioaccum ulative Properties o f Ammonium Perfluorooctanate: Static (fish test) Laboratory or Author 3M Env.

/\@-3,3yts f 3 ( p PFOS: A REPRODUCTION STUDY WITH THE MALLARD FINAL REPORT WILDLIFE INTERNATIONAL, LTD.

AR226-2100 ?

Robert F Pinchot 07/09/2001 07:26 AM To: Catherine A Barton/AE/DuPont@ DuPont cc: Debbie J Mulrooney/AE/DuPont DuPont Subject: Re: ||) Cathie, Debbie, Sorry, I forgot to send that to you.

AR226-2212 C hris JE S hoop 11/07/2001 04:47 PM To: Debbie J Mulrooney/AE/DuPont@DuPont, Karl G Kronberg/AE/DuPont@DuPont cc: Subject: Data Sheet for Permitted Emissions CONFIDENTIAL COMMUNICATION Debbie, Here is the sheet I promised but I will need to have Kari complete the cells for FEP, and check the cells for PFA.

AR226-2228 I I lsa|l||lli NiSil l ls lp SSsgSS&S Is sSsSSssSssSsgS s s s s 1 kc; 1 S S ?

AR226-2230 Robert F Pinchot 12/11/2001 08:34 AM To: Debbie J Mulrooney/AE/DuPont@DuPont co: Chris E Shoop/AE/DuPont@DuPont, David M Rurak/AE/DuPont@DuPont Subject DRAFT for 815D Stack Diameter Change Requestoop Debbie, Please take a look at this.

AR226-2256 Chris E Shoop 02/18/2002 12:30 PM____________________________ _____ To: Debbie J Mulrooney/AE/DuPont@DuPont cc: Robert I Wevodau/SE/DuPont@DuPont, Robert F Pinchot/DEV/AE/DuPont@DuPont Subject: Re: Case 10 Questions O Debbie, The production rates in Case 10 were from forecasts for about 2007.